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Zolpel (Zolpidem)
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Zolpel

Zolpidem, sold as the brand name Ambien among others, is a sedative primarily used for the treatment of trouble sleeping. It usually works within 15 minutes, and has a short half-life of two to three hours. Zolpidem has not adequately demonstrated effectiveness in maintaining sleep, unless delivered in a controlled-release (CR) form. However, it is effective in initiating sleep. Its hypnotic effects are similar to those of the benzodiazepine class of drugs.

Other names for this medication:
Ambiz, Ambulax, Azold, Dactive, Getrest, Insom, Inzofresh, Isodem, Kayzole, Lipidem, Lopitas, Lypin, Nidra, Nitrest, Restem, Sobrium, Stilnoct, Syzol, Zanlop, Zedem, Zleep, Zodem, Zolax, Zolcent, Zoldem, Zolep, Zolit, Zolnex, Zolojet, Zolpel, Zolpiapt, Zolpidem, Zolpimist, Zolpirest, Zolpistar, Zolpitrac, Zolsoma, Zoltar, Zolway, Zopid

Similar Products:
Arcoxia, Flonase, Compazine, Cordarone, Aldactone

Also known as: Zolpidem

Description

Zolpel (zolpidem tartrate) is a gamma-aminobutyric acid (GABA) A agonist of the imidazopyridine class and is available in 5 mg and 10 mg strength tablets for oral administration.

Zolpidem tartrate is a white to off-white crystalline powder that is sparingly soluble in water, alcohol, and propylene glycol. It has a molecular weight of 764.88.

Each Zolpel tablet includes the following inactive ingredients: hydroxypropyl methylcellulose, lactose, magnesium stearate, micro-crystalline cellulose, polyethylene glycol, sodium starch glycolate, and titanium dioxide. The 5 mg tablet also contains FD&C Red No. 40, iron oxide colorant, and polysorbate 80.

Dosage

Take Ambien exactly as prescribed by your doctor. Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed.

The recommended doses of zolpidem are not the same in men and women, and this drug is not approved for use in children.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Zolpidem may be habit-forming. Misuse can cause addiction, overdose, or death. Selling or giving away this medicine is against the law.

Do not share this medication with another person, even if they have the same symptoms you have. The recommended doses of Ambien are not the same in men and women, and this drug is not approved for use in children. Misuse of this medication can result in dangerous side effects.

Never take this medicine if you do not have a full 7 to 8 hours to sleep before being active again.

Ambien is for short-term use only. Tell your doctor if your insomnia symptoms do not improve, or if they get worse after using this medication for 7 to 10 nights in a row. Do not take this medicine for longer than 4 or 5 weeks without your doctor's advice.

Do not stop using Ambien suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using the medicine.

Insomnia symptoms may also return after you stop taking Ambien, and may be even worse than before. Call your doctor if you still have worsened insomnia for the first few nights after you stop taking this medicine.

Do not crush, chew, or break an Ambien CR tablet. Swallow the pill whole.

Store at room temperature away from moisture and heat. Do not freeze.

Detailed Ambien dosage information

Overdose

In postmarketing experience of overdose with Zolpel tartrate alone, or in combination with CNS-depressant agents, impairment of consciousness ranging from somnolence to coma, cardiovascular and/or respiratory compromise, and fatal outcomes have been reported.

General symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate. Intravenous fluids should be administered as needed. Zolpel's sedative hypnotic effect was shown to be reduced by flumazenil and therefore may be useful; however, flumazenil administration may contribute to the appearance of neurological symptoms (convulsions). As in all cases of drug overdose, respiration, pulse, blood pressure, and other appropriate signs should be monitored and general supportive measures employed. Hypotension and CNS depression should be monitored and treated by appropriate medical intervention. Sedating drugs should be withheld following Zolpel overdosage, even if excitation occurs. The value of dialysis in the treatment of overdosage has not been determined, although hemodialysis studies in patients with renal failure receiving therapeutic doses have demonstrated that Zolpel is not dialyzable.

As with the management of all overdosage, the possibility of multiple drug ingestion should be considered. The physician may wish to consider contacting a poison control center for up-to-date information on the management of hypnotic drug product overdosage.

Storage

Store Zolpel at room temperature away from moisture, heat, and light.

Store the liquid form of Zolpel in the refrigerator.

Keep track of how many pills have been used from each new bottle of this medicine. Benzodiazepines are drugs of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

Side effects

The most common side effects associated with Zolpel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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Comparison of hydroelectrolytic exchange characterized by calculation of saturable fluxes at three levels of the rat intestine. Previous studies have suggested that subclinical abnormalities in thyroid-stimulating hormone levels are associated with detrimental effects on the cardiovascular system. Experiments with cyclotron-accelerated alpha-particles and deuterons. Here the authors have explored whether endogenous dopamine was also able to activate the receptors, thus enhancing GABA release. The clinical responsibilities and activities over 12-month periods of the Departments of Clinical Pharmacology of two London teaching hospitals have been analysed. A single short-term emotional-pain stress produced but a transient increase of the lipid peroxidation level. The patency of 50 cm long, 1.7 mm ID heparin-polyvinyl alcohol (PVA) coated SBS arterio-venous shunts in pigs at shear rates greater than 1000 s-1 was found to be not different from that of identical shunts coated with PVA but without heparin. R17 coat protein binding site: a convenient reporter for in vitro transcription. Inhibitory action of bradykinin on release of the adrenergic transmitter in the isolated lapine kidney.

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Metabolic effects on growth and muscle of soya-bean protein feeding in cod (Gadus morhua). A purified, structurally defined glycosylphosphatidylinositol (GPI) derived from the Variant Surface Glycoprotein (VSG) of Trypanosoma brucei, and its biosynthetic precursor P2, was able at submicromolar concentrations to regulate cytokine expression when added directly as pharmacological agonist to host macrophages, by activation of an endogenous protein tyrosine-kinase (PTK) mediated signal transduction pathway. Auxin controls local cytokinin biosynthesis in the nodal stem in apical dominance. Breast magnetic resonance imaging (MRI) is now at a stage where the evidence is suggesting widespread potential in the management of patients with known or suspected breast cancers. When gonadally intact, ATD males, but not controls, showed a clear nocturnal rhythmicity in partner preference behavior and sexual behavior. Histones H10 and H5 might be classified together in a histone category distinct from the usual H1.

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Rod-structure formation was examined by atomic force microscopy (AFM). We have shown previously that double-stranded siRNA molecules designed to target the HCV genome block gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells. In the field of medical informatics, there are many ongoing activities concerning XML. In this study, we addressed the question if androgen deprivation and prostatic involution would influence tenascin expression in the prostate. A study of results generated using the Abbott LCx-GC assay fails to reveal a performance-based rationale for the 2002 level 1 recall. Oral Candida albicans from patients infected with the human immunodeficiency virus and characterization of a genetically distinct subgroup of Candida albicans. Moreover, the cochlea can itself become the target of immune responses that damage hearing. coli sepsis observed in previously healthy mice was no longer present in mice with preexisting pancreatitis. We found that both fusion proteins specifically bound to SRP RNA as monomeric molecules folded into a heterodimer-like structure. Nitrogen and fluorine co-doping causes the absorption edge of TiO2 to shift to a lower energy region.

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Proteus syndrome is a congenital hamartomatous disorder characterized by partial overgrowth involving all germ layers. Enamel slabs from the two in situ groups exhibited lower hardness when compared to control. Until recently, there was a lack of emphasis on the importance of these issues and a lack of efforts in setting expectations and measuring performance. The cultural interpretation of the theme has been carried out by means of the qualitative methodology. The common bile acids of rat bile (chenodeoxycholic, hyodeoxycholic, cholic, alpha-muricholic, and beta-muricholic acids) are completely separated by a new thin-layer chromatographic system. APL (accreditation of prior learning)--vital link to the EN (enrolled nurse) conversion course. However, as the wheezing persisted a detailed evaluation was done which revealed a bronchogenic cyst. However, based on the kinetics of induction, we suggest that tamoxifen is much less effective at transcriptional activation of protooncogenes than other uterine agonists, e.g., estrogen. Two crystal structures of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveal protein-ligand interactions including a structural basis for observed antifolate resistance. Prostate-specific antigen screening for prostate cancer: no reduction in Gleason scores.

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The simple multiplicative formulation of the model in terms of the age, period, and cohort variables without resorting to the underlying biology also casts doubt on the interpretability of the model parameters. Expression, purification, and in vitro activity of an arterivirus main proteinase. A high-performance liquid column chromatographic technique is reported for the analysis of some tryptophan and phenylalanine acid metabolites in the urine. Use of fluorescamine as an effective blocking reagent to reduce the background in protein sequence analyses by the Beckman automated sequencer. However, it is not known whether Muc1 is a major mucin contributing to the increased mucus and why CF/Muc1-/- mice show lower mucus accumulation. Cell rounding is generally regarded as a cytoskeletal change exemplified by the mitotic state of monolayer cell cultures in which mitosis-specific phosphorylation was recently cited as the molecular mechanism. We propose a role for the LPH alpha domain within the pro-LPH molecule as an intramolecular chaperone during folding in the ER. Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2. Ethanol (1-6 oz of 95-proof) and secobarbital (30-300 mg) produced dose-related increases in vocalization by the subject who received active drug, while vocalization by the partner who received placebo only was not generally altered systematically.

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Thoracic three-dimensional spiral CT findings of an infant with spondylothoracic dysostosis. Homologs of Drosophila Fushi-Tarazu factor 1 map to mouse chromosome 2 and human chromosome 9q33. However, some major constraints are associated with its implementation, including the need of complicated procedures for device placement and removal. According to this point of view, it is logical to examine the feasibility of three successive hepatectomies for metastases. Nursing intervention with battered women can be a frustrating and discouraging experience, as battered women are trapped in a cycle of violence that is difficult to break. ELISA plates were coated with Myc-9 and reacted with the different avian mycoplasma antigens, which were detected with adsorbed polyclonal anti-mycoplasma serum followed by anti-rabbit enzyme-labeled conjugate antiserum. It demonstrated appropriate divergent validity with other clinical measures of response, as well as discriminant validity.

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Development of the VCaP androgen-independent model of prostate cancer. The aims of this study are to describe the relationships between IgG antibodies clozaril dose range to 17 oral organisms and atherosclerosis as indexed by carotid intima-medial wall thickness (IMT) and to evaluate the role of smoking. Home dialysis, home dialysis central, and what you can do today. Reference and working memory measures were distinct as assessed by a principal components analysis. Interferon regulatory factor 3 (IRF3) is a transcriptional factor that plays a crucial role in activation of innate immunity and inflammation in response to viral infection. These are following: propagation of nourishment rich in vitamin B and folic acid, recommendation for the day-to-day taking of 0.4 mg folic acid, improvement of the nutritive food value by adding such nutrients as folic acid. These effects are fragment-mass-specific and angiogenesis-type-specific. We have begun a systematic study of the differentiation-dependent life cycle of HPV31.

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