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Zofran (Ondansetron)
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Zofran

Zofran is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.

Other names for this medication:
Acidom, Donrid, Doran, Emeset, Emtop, Lupisetron, Naucid, Odanse, Omcet, Ondansetron, Ondon, Onsett, Ontron, Onzil, Osetron, Pantorex, Periset, Rancet, Ranivir, Ranon, Renol, Renty, Supracetron, Tiron, Vomicare, Vomikind, Vomiven, Vomiz, Vorast, Voset, Xondmet, Zonda, Zondan, Zonde

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Also known as: Ondansetron

Description

Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Ondansetron is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy).

Ondansetron may be used for purposes not listed in this medication guide.

Dosage

This section provides information on the proper use of a number of products that contain ondansetron. It may not be specific to Zofran. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

To use the oral disintegrating tablet:

Make sure your hands are dry. Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet. Immediately place the tablet on top of the tongue. The tablet will dissolve in seconds, and you may swallow it with your saliva. You do not need to drink water or other liquid to swallow the tablet.

To use the oral soluble film:

Make sure your hands are clean and dry before and after using this medicine. Fold the pouch along the dotted line to expose the tear notch. While still folded, tear the pouch carefully along the edge and remove the film out from the pouch. Put the soluble film immediately on top of your tongue where it will dissolve in 4 to 20 seconds. Do not chew or swallow the film whole. Once the film is dissolved, you may swallow with or without water.

If you vomit within 30 minutes after using this medicine, take the same amount of medicine again. If vomiting continues, check with your doctor.

This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (oral disintegrating tablets, solution, or tablets): For prevention of moderate nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—At first, 8 milligrams (mg) taken 30 minutes before starting cancer treatment. The 8-mg dose is taken again 8 hours after the first dose. Then, the dose is 8 mg every 12 hours for 1 to 2 days. Children 4 to 11 years of age—At first, 4 mg taken 30 minutes before starting cancer treatment. The 4-mg dose is taken again 4 and 8 hours after the first dose. Then, the dose is 4 mg every 8 hours for 1 to 2 days. Children younger than 4 years of age—Use and dose must be determined by your doctor. For prevention of more severe nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—One 24-milligram (mg) tablet taken 30 minutes before starting cancer treatment. Children younger than 12 years of age—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after radiation treatment: Adults—At first, 8 milligrams (mg) taken 1 to 2 hours before radiation treatment. Then, the dose is 8 mg every 8 hours. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after surgery: Adults—16 milligrams (mg) one hour before anesthesia is given. Children—Use and dose must be determined by your doctor. For oral dosage form (soluble film): For prevention of moderate nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—At first, one 8-milligram (mg) film taken 30 minutes before starting cancer treatment. The second 8-mg film is taken 8 hours after the first dose. Then, one 8-mg film is taken two times a day (every 12 hours) for 1 to 2 days. Children 4 to 11 years of age—At first, one 4-milligram (mg) film taken 30 minutes before starting cancer treatment. The second and third 4-mg films are taken 4 and 8 hours after the first dose. Then, one 4-mg film is taken three times a day (every 8 hours) for 1 to 2 days. Children younger than 4 years of age—Use and dose must be determined by your doctor. For prevention of more severe nausea and vomiting after treatment with cancer medicines: Adults—24 milligrams (mg) or three 8-mg films taken 30 minutes before starting cancer treatment. Each film should be dissolved in the tongue before taking the next film. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after radiation treatment: Adults—One 8-milligram (mg) film three times a day. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after surgery: Adults—16 milligrams (mg) or two 8-mg films taken 1 hour before anesthesia is given. Each film should be dissolved in the tongue before taking the next film. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting.

Storage

Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the unused soluble film in the foil pouch until you ready to use it.

Detailed Zofran dosage information

Side effects

The most common side effects associated with Zofran are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies have not been performed on the relationship of age to the effects of ondansetron in children younger than 4 years of age. Safety and efficacy have not been established.

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Over the last decade, their development in the embryonic brain and spinal cord has been documented following the discovery of early oligodendroglial markers. Acute biliary tract disease associated with echovirus 11 infection. cruzi-exposed cells, but not from either cells or parasites cultured alone, were also capable of upregulating class I expression, indicating the involvement of a soluble factor. Status of oral rabies vaccination in wild carnivores in the United States. Regional differences in mucosal hemodynamics in experimental colonic injury in rats.

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Experimentally induced hypothermia (20 degrees C) for 60 minutes in dogs provokes a significant decrease in the platelet count, which reverses during subsequent rewarming, and the constant release of a heparin-like factor, which reacts as a specific inhibitor of factor Xa. Near infrared spectroscopy in the management of status epilepticus in a young infant. At present an aggressive anticoagulant regimen with heparin is recommended during the PTCA procedure. As for its application, ecological hygiene may be determined as a complex of medical preventive research subjects whose purpose is to maintain and promote health by preventing diseases and premature aging. The results are discussed with particular regard to earlier complications following surgery. The discussion focuses on key methodological differences between these studies and those that support claims that central coherence, prototype formation, and common feature processing are impaired in autism. The results demonstrated tTG expression on uterine pinopodes and lamellipodia of extravillous trophoblasts. Seven of the ten QTL associated with both CWC and ECB tunneling contributed to the negative correlations observed between these traits, while relatively few QTL effects were positively correlated. On the acid chromatographic separation of catecholamine metabolites on Amberlite CG 50.

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Tripropionin hydrolysis is increased by the presence of glass beads. The administration of recombinant human activated protein C (rhAPC), drotrecogin alfa (activated), Xigris, to patients with severe sepsis and sepsis-induced multi-organ failure reduced mortality in large clinical trials. It contains an analysis of the literature on sociology teaching in nursing education and briefly compares this with sociology teaching in the medical curriculum. Amoxycillin trihydrate was administered orally to 6 foals at dose rates of 13 mg/kg (low), 20 mg/kg (medium) and 30 mg/kg (high) and serum concentrations determined at intervals up to 8 h. Even when managed in a single center, IVF pregnancies carry a greater antenatal risk than matched controls. We have investigated the power spectral density (PSD) characteristics of spontaneous neuronal activities during paradoxical sleep (PS), including phasically firing PGO-on and tonically discharging type I-R neurons in the pontine tegmentum. Multidisciplinary team members who developed the CareMap also had higher levels of collaboration than other multidisciplinary staff on the experimental unit and their job satisfaction with quality of care increased under this new care delivery system. Videoradiourodynamics will be limited to patients with recurrent urinary incontinence following unsuccessful surgery.

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An extracellular serine protease, tissue plasminogen activator (tPA), is involved in remodeling various nonneural tissues and is associated with developing and regenerating neurons. The use of bacteriophage neutralization technique for the detection of anti-hapten antibody. Rapid and sensitive methods for measuring ethoxyresorufin-O-deethylase (EROD) induction and total intracellular porphyrin accumulation in cultured chicken embryo hepatocytes exposed to polychlorinated biphenyls (PCBs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are described. S proteins control rejection of incompatible pollen in Petunia inflata. Children who were slow to begin talking at age 2 but who, by age 4, had moved into the normal range in basic sentence structure production showed no statistically significant differences, in terms of several of the measures of narrative ability, from either normally speaking 4-year-olds or from the group with persistent delay. Airway aspiration of foreign materials in children and adults is probably more common than has been supposed. Normally pacemakers of this area seem to be a reserve mechanism of urine pushing through. Receptors that couple to 2 classes of G proteins increase cAMP and activate CFTR expressed in Xenopus oocytes.

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Complex biochemical studies in patients with chronic schizophrenia. Differential roentgen diagnosis of alcoholic intoxication of the heart and myocardial dystrophy. Several neuropeptides, calcitonin gene-related peptide (CGRP), galanin, neuropeptide Y (NPY), pituitary adenylate cyclase activating peptide (PACAP), substance P (SP), vasoactive intestinal polypeptide (VIP), the noradrenergic marker dopamine beta-hydroxylase (DBH) and the general neuroendocrine marker PGP 9.5 were localized by immunocytochemistry in the parathyroid glands of chicken, rat, guinea-pig, cat, dog and sheep. Rapid progression of multiple myeloma following G-CSF mobilization. The rations were based on corn silage, urea and a vitamin-mineral premix, either in the absence or presence of 0.77 g glyphosate per kg DM. Immunohistochemical analysis and in situ hybridization indicated that both G-CSF and G-CSF-R are expressed in mouse spongiotrophoblasts and placental labyrinths, and human placental cytotrophoblasts and syncytiotrophoblasts. Time-dependent imaging of blood-borne fluorescent beads revealed reduction of plasma velocity during pressure elevation.

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In the wing bud the migration route is localized postaxially and in the leg bud preaxially. Therefore, measurement of gut motor activity should be a desired goal. ZAP-70 is associated with the phosphorylated antigen receptor and undergoes tyrosine phosphorylation following receptor activation. Anti-HCV antibodies were measured by first and second generation ELISA and became positive between one week and more than 6 months after infection. Six illustrative cases are reported to demonstrate the versatility of the Terry biopsy needle as a useful instrument for obtaining satisfactory biopsy specimens from the liver and from other tissues as well. Optimists had higher proactive behavior, less avoidant coping, and less depression: These variables mediated the linear optimism-disease progression relationship. Genetic correlations between lactational somatic cell score and udder type traits show that udders with good shape are less prone to subclinical mastitis. A theory is developed for predicting a second-order hot-image formation in high-power laser systems.

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Blood vessels associated with the lesion had widened Virchow-Robin spaces, occasionally with extravasated erythrocytes. Five patients underwent amputations at the metacarpal or phalangeal level, and one patient underwent below-elbow amputation. Unacclimated cultures were used to minimize the biotransformation of the toxic organic chemicals during the test. Changing pattern of admission and operation for duodenal ulcer in Scotland. Cytokine and growth factor mRNA expression patterns associated with the hypercontracted, hyperpigmented healing phenotype of red duroc pigs: a model of abnormal human scar development?. However, the contiguous deep component was a well-differentiated adenocarcinoma extending to the serosa and demonstrating the unusual features of a circumscribed lobulated topography and the absence of an inflammatory/desmoplastic stromal reaction.

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These models have different objectives but share many properties. Disseminated hyalohyphomycosis caused by a novel human pathogen, Fusarium napiforme. A rapid perfusion system was used to make rapid changes in anesthetic concentration during patch clamp recording to determine the kinetics of inhibition by anesthetics. Mandibular asymmetry in adult patients with unilateral degenerative joint disease. Dietary zinc intake was estimated with the food frequency questionnaire (FFQ). Experiments made with the use of the set of monoclonal antibodies (McAb) to different M. As a result, atheromas could not be identified by imaging because of the low target to non-target ratios. A case of mucinous carcinoma of the breast that demonstrated a good pathological response to neoadjuvant chemotherapy despite a poor clinical response.

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Bilateral retinal detachment following carotid-cavernous fistula. Our results confirm the importance of accurate methods of recording of perfusion events. The binding of the serotonin 5-hydroxytryptamine (5-HT)2 receptor agonists serotonin (5-HT) and 4-bromo-2,5-dimethoxyphenylisopropylamine is not affected by the presence of GTP analogs when the cloned 5-HT2 receptor is expressed in the 293 human embryonic kidney cell line. Salvage radical prostatectomy after failed transperineal cryotherapy: histologic findings from prostate whole-mount specimens correlated with intraoperative transrectal ultrasound images. We have investigated the structural features of collagen that are required for directional motility of mouse dermal fibroblasts, by analysing cell movement on two-dimensional collagen surfaces. We report three patients who developed unusually aggressive squamous cell carcinomas after receiving long-term azathioprine treatment for dermatological disorders. None of the cAMP analogs, forskolin, or 1,9-dideoxy-forskolin affected delta 9-THC or CP-55,940-induced antinociception produced by intrathecal (i.t.) or intracerebroventricular (i.c.v.) injections in mice.

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Reverse transcriptase-polymerase chain reaction was utilized to examine the mRNA expression of multiple MMPs and TIMPs with and without IL-1 alpha, while Western blot analyses and zymography were utilized to examine their protein expression. Only few of the features typical for the human metabolic syndrome were observed in castrated male Sprague-Dawley rats. None of the SST2 alleles affects the expression or stability of G alpha. The injury risk for big air, snowboard cross, and halfpipe disciplines is high, while that for the snowboard slalom disciplines is lower. Using decision analysis, we compared the cost-effectiveness of dilation and evacuation and misoprostol induction of labor for second-trimester termination. In both models, a near complete reversal in hindpaw scores was observed as well as marked improvements in the histological scores. MRI-related heating was assessed with the stent in a gelled saline-filled phantom using a transmit/received RF body coil with a whole body averaged SAR of 2.0 W/kg.

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A greater percentage of neutrophils from normal calves bound C3b than did neutrophils from LAD-affected calves. The results of this preliminary study suggest that Megace OS is not an effective nutritional intervention to increase oral intake under usual NH care conditions, which is often characterized by inadequate feeding assistance. The definition of seven different regions allowed us to determine NAO or rhodamine 123 (Rh 123) uptakes in each compartment. The half lateral laryngectomy conserves one arytenoid and a half cricoid. Molecular genetic analyses identified a previously undescribed nucleotide substitution in CACNA1F that is predicted to encode an isoleucine to threonine substitution at CACNA1F residue 745. The ecological situation rapidly changing in the areas of large-scale economical development has influences on human regulatory systems in the North. Thus the platform seems to be a fast way for full-length cDNA sequence cloning of new genes. A set of psychophysical measurements was completed on 11 listeners with sensorineural hearing losses and 9 listeners with clinically normal hearing. With a degree of training, any of the three instruments could be used to assess psychosocial adjustment with some measure of confidence in the validity of the rating.

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Correct diagnosis and treatment of cervicitis by the general practitioner. Statistical albenza pediatric dosage pinworm observations on 3800 cases followed up for at least 10 years. Value of the photodynamic method in the diagnosis of superficial bladder tumors. These data indicate that the three human Ras proteins probably act through the same signal transduction pathway in NIH 3T3 cells and suggest that these mutations may confer similar phenotypes to other GTP/GDP-binding proteins. Three options were identified, including the continuation of local in-house provision with its associated variation in standards. Common to the four patients examined within the first 6 months postnatally was a marked delay of skeletal maturity. Multidrug resistance gene (mdr1) RNA levels in relation to P-glycoprotein content of leukemic cells from patients with acute leukemia. Physical factors, which are generally important for malaria, included rainfall, mosquito breeding and resting sites, their distance from human habitation, and elevation, though the latter was not statistically significant.

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To define the nuclear localization signals within IE180, we prepared truncated mutants of IE180 and analyzed their localization in the transfected cells by indirect immunofluorescence. Genetic variants of angiotensin converting enzyme and methylenetetrahydrofolate reductase may act in combination to increase migraine susceptibility. Currently, active agents include anthracyclines, taxanes, vinorelbine, and fluoropyrimidines. However, 17-AAG is difficult to formulate and displays weak activity against some tumors. CA 125 levels were lower in samples having normal sperm counts, and CA 125 and CA 19.9 levels were lower among couples who conceived compared with those who did not conceive. IL-6 levels were negatively associated with performance on the MMSE in this multiethnic cohort.

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In addition to the traditional 5-fluorouracil, newer anticancer drugs are available including irinotecan and oxaliplatin. We have developed an organ culture system in which rat fetal testis is grown on a filter floating on a synthetic medium containing no serum, hormones or biological factors. Endometrioid tumors of low malignant potential, transitional cell carcinoma, and psammocarcinoma are also reviewed. alpha-Synuclein positive neurons and glia appeared early, and their number was maximal during EAE exacerbations, but some expression was ticlopidine brand maintained throughout the course of EAE. Morphological changes in the vascular plexuses of the brain during the course of measles and tuberculous meningitis in children.

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Prior sexual assault reported by male attenders at a department of genitourinary medicine. Subsequent fusion protein studies revealed that MB47 bound much more strongly to aa 3429-3523, 3429-3544, 3429-3565, and 3429-3590 than to aa 3429-3510. Decreased serum adiponectin in adolescents and young adults with familial primary hypercholesterolemia. The oxidation of natural polyamines by Myocobacterium smegmatis. In conclusion, Edinger Westphal cultures contain a diverse and varying population of non-neuronal cells loosely organized in large, overlapping islands of cell types and including oligodendrocytes, astrocytes, possibly fibroblasts, endothelial cells, pericytes and/or smooth muscle cells. Genotype of the mutant LDL receptor allele is associated with LDL particle size heterogeneity in familial hypercholesterolemia. It is a P450-type hemoprotein, containing a cysteine thiolate as its proximal heme ligand, but the exact cysteine residue involved in heme coordination has not been identified. Binding did not require clathrin and resisted extraction at both high and low ionic strength, consistent with an interaction with an SH3 domain. This consistency supports the reliability and validity of the diagnosis of multiple personality disorder across centers. Statistical analyses showed significant differences among most of the emotions studied.

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It also was found that the factors extracted could be reproduced reliably in two random subsamples and that the factor structure derived from the present sample corresponds to the previously reported data on the dimensionality of the Chinese GHQ-30. Afterwards, the right tympanic membrane developed a large perforation and sensory neural hearing loss occurred. Mixed-effects models often provide a useful data analytic strategy for attrition as do the pattern-mixture and propensity adjustments. To elucidate the role of platelet-associated IgG (PA-IgG) in the mechanism of thrombocytopenia associated with chronic liver disease. ASMA is a consistent and better marker than desmin for the detection of immature smooth muscle in pulmonary lymphangioleiomyomatosis. We have cloned a cDNA for the human type 1 inositol 1,4,5-trisphosphate receptor. The fluorescent dye Hoechst 33342 was injected intravenously to detect perfused tumor vessels. An indirect method for approximating caloric expenditure of physical activity. Induction of myoblast proliferation in L6 myoblast cultures by fetal serum of double-muscled and normal cattle. Establishment of cultures from cercariae and development until pairing.

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For transformants with constitutively active Sccdc42, polar tip growth of apical cells in the leading hyphae was normal but polar tip growth in side branches was altered, implying different regulation of polarity establishment in the two groups of apical cells. Reducing risks through quality improvement, infection control, and risk management. The diagnostic modality of choice is magnetic resonance imaging. Expansion of genes that encode MHC class I molecules in cyprinid fishes. Marked elevation of serum erythropoietin (sEPO) occurs following high dose chemotherapy for malignant disease. Using a co-immunoprecipitation approach, we have identified several DNA repair factors that are associated with RECQ1 in vivo. In 10 of the 15 patients the responses to carbon dioxide (PCO2) stimulation were also evaluated. Separation of arsenite and arsenate ions by paper chromatography. This phenomenon cannot be accounted for by nursing home placement, comorbidity, or mortality.

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Bovine spongiform encephalopathy in a Holstein cow born in the United Kingdom during September 1989. The importance of the acanthocephalan Polymorphus minutus as a parasite of domestic ducks in the United Kingdom. Histologically, no erosions or ulcers were observed in the gastric mucosa. Identification of a novel plasmid-mediated beta-lactamase with chromosomal cephalosporinase characteristics from Klebsiella pneumoniae. Clinical viral infections and temporal bone histologic studies of patients with AIDS.

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The authors also demonstrated excellent agreement between the predictions of their model and experimental data obtained from the serial injection of superparamagnetic contrast agent in a rat model. Mutational analysis of the varicella-zoster virus ORF62/63 intergenic region. In 48-h-deprived animals, MA elevated low baseline glucose concentrations to levels observed in MA-treated fed animals. They did not show a decline in psychotic symptoms, obstreperousness, or antisocial behavior. STAT5 signaling is required for the efficient induction and maintenance of CML in mice. The arm muscle circumference how to use phenergan syrup and corrected arm-muscle area were calculated using specific equations. Interaction of IP and PDE6delta was confirmed by co-immunoprecipitation in HEK293 cells, and in HEPG2 cells, which endogenously express neither IP nor PDE6delta. A transient increase in amplitude is the first to occur, followed by a latency prolongation and an amplitude decrease for both ABRs and SEPs.

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