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Xalatan (Latanoprost)

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Xalatan is a prostaglandin analog, which means that it is very similar to the prostaglandin hormones your body naturally makes. Prostaglandins help control how much fluid drains from the eye. Xalatan lowers eye pressure by causing more fluid to drain out of the eye.

Other names for this medication:
Ioprost, Ioptame, Lacoma, Lapros, Latanoprost, Latochek, Latocom, Xalacom

Similar Products:
Prometrium, Cenforce, Artane, Depakote, Catapres, Imdur, Omnicef

Also known as: Latanoprost


Xalatan (latanoprost) is classified as an ophthalmic glaucoma agent and lowers pressure inside the eye by increasing the amount of fluid that drains from the eye.

Xalatan eye drops are used to treat certain types of glaucoma and other causes of high pressure inside the eye.


Usual Adult Dose of Xalatan for Intraocular Hypertension:

One eye drop in the affected eye(s) once a day in the evening Comments: -If one dose is missed, treatment should continue with the next dose as normal. -The dose should not exceed one drop in the affected eye(s) daily as more frequent administration may lessen the intraocular pressure lowering effect. -Reduction of the intraocular pressure starts approximately 2 to 4 hours after the first administration with the maximum effect reached after 12 hours. -This drug may be used concomitantly with other topical ophthalmic drugs to lower intraocular pressure. -If more than one topical ophthalmic drug is being used, each one should be administered at least 5 minutes apart. Use: -Reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension

Usual Adult Dose of Xalatan for Glaucoma (Open Angle):

One eye drop in the affected eye(s) once a day in the evening Comments: -If one dose is missed, treatment should continue with the next dose as normal. -The dose should not exceed one drop in the affected eye(s) daily as more frequent administration may lessen the intraocular pressure lowering effect. -Reduction of the intraocular pressure starts approximately 2 to 4 hours after the first administration with the maximum effect reached after 12 hours. -This drug may be used concomitantly with other topical ophthalmic drugs to lower intraocular pressure. -If more than one topical ophthalmic drug is being used, each one should be administered at least 5 minutes apart. Use: -Reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension

Detailed Xalatan dosage information


An overdose of Xalatan is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Xalatan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Xalatan if you are allergic to latanoprost or benzalkonium chloride.

To make sure Xalatan is safe for you, tell your doctor if you have ever had:

swelling or an infection in your eye; herpes infection of the eyes; retinal detachment; or eye surgery or injury affecting the lens of your eye.

Xalatan may cause a gradual change in the color of your eyes or eyelids and lashes, usually an increase in brown pigment. You may also notice increased growth or thickness of your eyelashes. These changes occur slowly and you may not notice them for months or years. Color changes may be permanent even after your treatment ends, and may occur only in the eye being treated. This could result in a cosmetic difference in eye or eyelash color from one eye to the other.

It is not known whether Xalatan eye drops will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Tell your doctor if you are breastfeeding.

Xalatan is not approved for use by anyone younger than 18 years old.

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Ultrastructural changes in human endometrium with copper and nonmedicated IUDs in utero. The IL-5 preparation did not act as a B cell growth factor on the large (in vivo-activated) or small (resting) B cells after activation with polyclonal B cell activators. Qingkailing Injection might have significantly inhibit the decline in MMP induced by hypoxia-hypoglycemia and reoxygenation, and had effects of stable it and anti-neuronal apoptosis. However, there was also more GAL content, but not GAL mRNA, in the nucleus tractus solitarii (NTS) of SHR rats than WKY rats at both stages. Blood group antigen expression in malignant tumors of the thyroid: a parallel between medullary and nonmedullary carcinomas. The regional metabolism of lactate and pyruvate during exercise in patients with rheumatic heart disease.

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Hyperkalemia associated with potassium chloride administration in a cat. The present study describes a case of malacoplakia of the genitourinary tract arising in the seminal vesicle and prostate and reviews similar cases previously reported in the literature. In 18 other joints, the coronal images revealed a lateral or medial displacement that was not evident on sagittal images. Follow-up angiography approximately 3 months after angioplasty demonstrated no evidence of restenosis. Frequency bistability of a semiconductor laser under a frequency-dependent feedback. A total abdominal hysterectomy and unilateral salpingoopherectomy were performed successfully. There was, however, a significant prolongation of the latency in the presence of high pass noise. It was suggested that disturbance of the mechanisms of psychoneuroimmunomodulation in old and stressed animals could be prevented by changing the neurochemical pattern of the brain.

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Most poliovirus (PV) strains, such as PV type 1/Mahoney, cannot infect the mouse central nervous system. These results were confirmed by experiments testing the binding of fragment-conjugated microspheres to substrate-coated L1 or to cell surface-expressed L1 on cultured neurons. On the renal tubular damage in hereditary tyrosinemia and on the formation of succinylacetoacetate and succinylacetone. Anti-venereal prophylaxis, total abolitionism and international associations. Rat liver mitochondrial phospholipase A2 is an endotoxin-stimulated membrane-associated enzyme of Kupffer cells which is released during liver perfusion. This association of Lyn with receptor components was stable in the detergent Brij 96, but was readily disrupted by Nonidet P-40, suggesting the involvement of hydrophobic interactions in stabilizing formation of the Lyn-receptor complex. Thus all three represent important targets for cardiovascular research. During operation, the product is brought in contact with a heat transfer surface that is rapidly and continuously scraped, thereby exposing the surface to the passage of untreated product.

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Tobacco etch potyvirus engineered to express the reporter protein beta-glucuronidase (TEV-GUS) was used for direct observation and quantitation of virus translocation in plants. SSTR3 expression was studied by reverse transcription coupled to polymerase chain reaction, whereas SSTR4 and SSTR5 expression was determined by ribonuclease protection assay. We examined the differentiation stage at which the PNH abnormality occurs, by means of flow cytometric analysis of HRF20 expression. 46 patients who underwent suprapubic prostatectomy were randomized to receive either (group A) Ticlopidine (2 x 250 mg daily) from the second preoperative day until the seventh postoperative day or (group B) placebo up till the day of surgery and further acenocoumarol against post-operatively and observed that the level and in particular the rise of the plasma fibrinogen concentration was not different in the two groups. Reducing the CO2 production (VCO2) is a plausible means to lower the ventilatory demand in the treatment of patients with COPD. Furthermore, we demonstrate that Hrb1p and additional putative Sky1p substrates, identified by computational approach, are not involved in mediating the spermine tolerant phenotype of sky1Delta cells. We present the case of an eighteen day old baby boy hospitalized with an abdominal mass, renal insufficiency and jaundice. Monosodium glutamate (MSG) administered to neonatal rats on postnatal days 1 to 10 caused a generalized degeneration of the inner retinal layers. Nitric oxide synthase inhibition blocks tolerance to the analgesic action of kappa-opiate receptor agonist in the rat.

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PTHrP mRNA was detected in all squamous cell carcinomas, expression being highest in the two patients with hypercalcaemia. It was derived from bacterial DNA contaminating Taq DNA polymerase, a phenomenon that was previously reported for amplification reactions with universal primer sets for bacterial 16S rRNA. This first description, to our knowledge, of a functionally significant GHSR mutation, which unveils the critical importance of the GHSR-associated constitutive activity, discloses an unusual pathogenic mechanism of growth failure in humans. Ferucarbotran-enhanced dynamic MR imaging can be used to successfully characterize the hemodynamics of focal hepatic lesions. A studies of cytotoxic cells in athymic nude mice demonstrate higher cytotoxic activity of NK cells and macrophages than in their euthymic counterparts.

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This measurement indirectly determined the arrival time of each x-ray pulse relative to an external pump laser pulse with a time resolution of better than 60 fs rms. Physical entrapment of adriamycin in AB block copolymer micelles. Dose-dependence of the rapid reappearance in blood of very small intravenous doses of Se75-selenite. Relation of Basal coronary nitric oxide activity to the burden of atherosclerosis. However, CD44v6, as opposed to CD44s, did not colocalise with the TCR/CD3 complex after CD3 cross-linking.

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Intention to learn influences the word frequency effect in recall but not in recognition memory. The relative growth of the neocortex parallels the emergence of complex cognitive functions across species. In summary, CReMM is a CHD protein expressed by osteoprogenitors, and we suggest it plays a role in mediating transcriptional response to hormones that coordinate osteoblast function. Thus, the whole blood effect begins with LPS activation of monocytes via cell membrane CD14 and results in endothelial cell activation by the effects of TNF and IL-1. The inhibitory effect was reversible, indicating that the peptide was not cytotoxic.

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Footprint analysis of replicating murine leukemia virus reverse transcriptase. Characterization of fluorescently derivatized bovine tau protein and its localization and functions in cultured Chinese hamster ovary cells. A prospective database of 216 patients who underwent mastectomy with immediate reconstruction was established. A new series of pi-conjugated donor-acceptor compounds (1-6) with inherent redox centers have been prepared and studied with respect to their electronic properties. Natural product drugs that target the tubulin/microtubule system remain an important component in the therapeutic arsenal to treat many types of malignancies. Cross-validation of a brief vestibular disorientation test administered by a variety of personnel. To date, prudence favours any measure to prevent allergic contact dermatitis, be it through legal actions to outlaw the use of certain materials, or through avoiding personal contacts with these materials. It was found that Glehnia littoralis could inhibit the synthesis of TXA2 and increase the formation of PGI2.

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Expression of intercellular adhesion molecule 1 on pancreatic beta-cells accelerates beta-cell destruction by cytotoxic T-cells in murine autoimmune diabetes. An integron is a genetic unit that includes the determinants of the components of a site-specific recombination system capable of capturing and mobilizing genes that are contained in mobile elements called gene cassettes. Statistical analysis was performed with chi 2 analysis and Kaplan-Meier life tables. First comparative observations on the cardiac venous circulation in some ruminants. Moreover, the administration of disulfiram to neonatal mice decreased in vivo cell proliferation in the striatal SVZ. Metoclopramide blocks bromocriptine induced antihypertensive effect in hypertensive patients. Of these patients, 29 had normal coronary artery by angiography and from the rest patients presenting abnormal angiographic findings of the coronary artery, 60 were randomly selected to serve as the control group.

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Change in palatoglossus muscle activity in relation to swallowing volume during the transition from the oral phase to the pharyngeal phase. This plasticity contributes to generate a small hydrophobic pocket for the methyl group typical for RADH substrates, and a hydrophobic coat for the second, more variable and often aromatic, substituent. 5-fluorouracil, adriamycin, and mitomycin-C (Hi-FAM) chemotherapy for adenocarcinoma of the lung. PAS induced a significant, and similar, increase in motor cortical excitability in both the dominant and non-dominant hemispheres. The impact of gender differences has not been well described in patients hospitalized with acute decompensated heart failure (ADHF). N-substituents of the pyrrole ring had the effect on extra vivo activity. The SCA19 locus on chromosome 1p21-q21 was identified in a Dutch family in 2002. Percutaneous absorption: methods of study and factors which influence absorption.

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From 1993 to 2001, 806 consecutive patients with histology-proven nasopharyngeal carcinoma were registered at our department. Cation fluxes and cation channels in outer segment membranes of bovine retinal rods: contamination by antibiotics applied to cattle?. Supernatant from IL-4-transfected Chinese hamster ovary cells (0.5 mL, 30,000 U) or from untransfected cells was injected intraperitoneally on days 3 through 7. Optimum conditions were elaborated for the induction of specific suppressor T cells in vivo by peptide 6 (alpha 2 domain) in an intravenous dose of 33 micrograms to the tail vein or 100 micrograms to the orbital sinus, followed by testing the suppressor activity in inhibiting in vitro proliferation in the three-cell MLC in response to irradiated cells of the stimulator Kb (BL/6) in the absence of suppressed response to the foreign stimulator Kk (B10.BR). A 21-yr-old woman suffered from a four year history of right-sided temporomandibular joint pain and clicking, with limitation of mandibular opening. A computerized non-invasive method for the assessment of human facial volume. Papillary muscles from depleted animals demonstrated a marked suppression of depolarization-induced automaticity for maximum diastolic potentials less negative than -55 mV.

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Osteoporosis and several other bone disorders occur when there is an imbalance between the resorption and formation components of bone remodeling activity. Inhibition by morphine of the cardiovascular and behavioral responses evoked by centrally administered substance P in conscious rats. We report six additional patients with this unusual adverse effect. We discuss the gap between the parts list and topology models on one hand, and network logic and dynamic models, on the other hand. Administration of SE-immune lymphokines to chicks either 30 min or 6 days before SE challenge caused a significant reduction in SE organ invasion. Immuno-cytochemistry revealed that vimentin surrounded intracytoplasmic lipid droplets, and became distinct with an increase of lipid droplets through lipogenesis in the fat cells. Pelvic inflammatory disease due to Coccidioides immitis is rare. SARS-associated coronavirus (SARS-CoV) has been confirmed as the pathogen for severe acute respiratory syndrome (SARS). Schwannomas of the facial nerve can occur along any segment, but they frequently involve the geniculate ganglion and extend proximally or distally from there.

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Regulation of neuronal gene expression is critical to central nervous system development. We prepared silicalite-1 microcrystal (MC) monolayers on a Si wafer using two different types of molecular linkages, namely, through chloropropyl (CP) groups and through CP/polyethylene imine/CP groups. Value of prostate cancer screening in a comprehensive community cancer center. Goblet cells in infected animals accumulated at the tips of the villi. Studies of Jurkat cells transfected with CD44H forms with truncations of the CD44 cytoplasmic domain demonstrated that the cytoplasmic COOH-terminal 52 amino acids were critical for binding of HA to the CD44 extracellular domain. Because both vasoconstrictors (via their induction of autocrine growth modulators) may influence the composition of the extracellular matrix of VSMC, the effects of the peptide vasoconstrictors on the (auto-) regulated feedback loops are of long-term structural importance.

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Distribution of apparent adenosinetriphosphatases in several tissues of the mouse. However, the HCV recovered from the patient 2 yr after the infection had a striking sequence similarity with the HCV recovered from albenza dosage one of the chimpanzees inoculated with the acute-phase virus, suggesting that the progenitor of the new strain was already present 2 yr earlier. The bases of Rh inheritance, RH gene and its evolution, the structure and function of Rh complex, as well as nonerythroid Rh homolog, have been determined. HCV core protein affects cell homeostasis, playing an important role in viral pathogenesis of HCC. Dentists and researchers could more effectively prevent and treat periodontal disease and relate pertinent research findings to specific disease initiation and progression.

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Meta-analyses aim to provide an overview of certain key questions such as optimal chemotherapy, dose-response relationships, and factors predicting long-term survival. We argue that this may be useful in eyes serving a single visual task. The experimental result demonstrated that the hydrolytic-aerobic process could raise the biodegradability of anthraquinone dye wastewater effectively. The algorithm enables objective and consistent identification and naming of specific components with minimal operator involvement, avoiding inaccuracies and variability resulting from differences in the criteria used by different operators, or by the same operator at different times. The Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED) study of more than 700 patients is the largest existing study of the accuracy of lung scintigraphy in the diagnosis of acute pulmonary embolism. They exhibited astrocytic as well as ependymal tanycytic features with apparent epithelial cell lineage. Viral replication was in evidence in at least one sample from all nine patients of the study. Apoptotic death of Listeria monocytogenes-infected human macrophages induced by lactoferricin B, a bovine lactoferrin-derived peptide. Direct examination of the aspirate from the swelling showed dematiaceous hyphae.

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Diet and the faecal microflora of infants, children and adults in rural Nigeria and urban U.K. The second part of this article aims to review the invasive and non-invasive strategies developed to circumvent the BBB and deliver drugs into the brain. Pharmacokinetics, effect and tolerance of isosorbide dinitrate and isosorbide-5-mononitrate in healthy persons. LPS/FNLP infusion led to elevated levels of the cytokines interleukin-6 ( what drugs does valium interact with IL-6) and tumor necrosis factor alpha (TNF alpha) in the sera. Pathological changes in the livers of rabbits infected with schistosome cercariae and treated with artemether or praziquantel in the early stage of infection. Detection of perfusion disturbances in digit replantation using near-infrared spectroscopy and serial quantitative fluoroscopy. Highly suspicious of early-PTLD, he was treated with reduction of immunosuppression, but no improvement on his larynx was observed. Two numerical examples are presented in order to demonstrate the applicability of the present method, where the first example traces a chemical reaction proceeded by thermal activation mechanism and the second examines tunneling mechanism mimicking a proton transfer reaction.

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Patients with organic growth hormone deficiency (GHD) or with structural hypothalamic-pituitary abnormalities may have additional anterior pituitary hormone deficits, and are at risk of developing complete or partial corticotropin (ACTH) deficiency. This fact was confirmed in experiments on mice having different haplotypes, such as CBA (k), C57BL/6 (b), BALB/c (d) and in nude mice with congenital thymic aplasia. There is little information on the incidence and natural history of neuropathy in patients with non-insulin-dependent diabetes mellitus (NIDDM). To facilitate the detection of adolescents with drug related difficulties. Collagenase synthesis was not stimulated in adult articular chondrocytes when explants were treated with either pure or crude interleukin-1. Effect of diazan on DNA, RNA, and protein synthesis in mouse L1210 leukemia cells sensitive and resistant to the drug. Raloxifene therapy significantly decreases cardiovascular risk markers LDL, total triglyceride and cholesterol.

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