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Wellbutrin (Bupropion)

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Wellbutrin works in depression by increasing the levels of chemical messengers in the brain that helps in regulating mood. The mechanism underlying its use in smoking addiction are not fully understood.

Other names for this medication:
Aplenzin, Budeprion, Bupdep, Bupraset, Bupron, Bupropion, Ession, Nicotex, Smoquit, Unidep, Zyban

Similar Products:
Elocon, Ativan, Adalat, Ultram, Valium, Minipress, Cleocin, Moduretic, Wellbutrin, Diamox

Also known as: Bupropion


Wellbutrin XL is an antidepressant used to treat major depressive disorder and seasonal affective disorder. The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects.


Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Too much of this medicine can increase your risk of a seizure.

You may take Wellbutrin SR with or without food.

Swallow the extended-release tablet whole and do not crush, chew, or break it.

You should not change your dose or stop using Wellbutrin SR suddenly, unless you have a seizure while taking this medicine. Stopping suddenly can cause unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

If you take Zyban to help you stop smoking, you may continue to smoke for about 1 week after you start the medicine. Set a date to quit smoking during the first 2 weeks of treatment. Talk to your doctor if you have trouble quitting after taking Zyban for 7 to 12 weeks.

Your doctor may prescribe a nicotine replacement product (such as patches or gum) to help you stop smoking. Start using the nicotine replacement product on the same day you stop (quit) smoking or using tobacco products.

Some people taking Wellbutrin SR (Wellbutrin or Zyban) have had high blood pressure that is severe, especially when also using a nicotine replacement product (patch or gum). Your blood pressure may need to be checked before and during treatment with this medicine.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

You may have nicotine withdrawal symptoms when you stop smoking, including: increased appetite, weight gain, trouble sleeping, trouble concentrating, slower heart rate, having the urge to smoke, and feeling anxious, restless, depressed, angry, frustrated, or irritated. These symptoms may occur with or without using medication such as Zyban.

Smoking cessation may also cause new or worsening mental health problems, such as depression.

This medicine may affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use Wellbutrin SR.

Store at room temperature away from moisture, heat, and light.

Detailed Wellbutrin SR dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Wellbutrin XL can be fatal. Overdose symptoms may include muscle stiffness, hallucinations, fast or uneven heartbeat, shallow breathing, or fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Imitrex dosage information

Side effects

The most common side effects associated with Wellbutrin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not use Wellbutrin if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

You should not take Wellbutrin if you are allergic to bupropion, or if you have:

a seizure disorder; an eating disorder such as anorexia or bulimia; or if you have suddenly stopped using alcohol, seizure medications, or a sedative (such as Xanax, Valium, Fiorinal, Klonopin, and others).

Do not use an MAO inhibitor within 14 days before or 14 days after you take bupropion. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Do not take Wellbutrin to treat more than one condition at a time. If you take bupropion for depression, do not also take this medicine to quit smoking.

Wellbutrin may cause seizures, especially if you have certain medical conditions or use certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

a head injury, seizures, or brain or spinal cord tumor; narrow-angle glaucoma; heart disease, high blood pressure, or a heart attack; diabetes; kidney or liver disease (especially cirrhosis); or depression, bipolar disorder or other mental illness; or if you drink alcohol.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using Wellbutrin. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Ask your doctor about taking Wellbutrin if you are pregnant. It is not known whether bupropion will harm an unborn baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking bupropion without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of bupropion on the baby.

It may not be safe to breastfeed while using Wellbutrin. Ask your doctor about any risk.

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Obstruction and stretch induce cyclooxygenase (COX)-2 expression and prostanoid synthesis in urinary tissues, causing pain, inflammation, hypercontractility, and cell proliferation. We have previously shown that morphine induces Fas expression and promotes Fas-mediated apoptosis. The Perdew-Zunger SIC seems to overcorrect many-electron systems. Purification and properties of 6-phosphogluconate dehydrogenase from beet leaves. Mucosal adaptation and destruction in response to lamina propria T cell activation in explants of human fetal intestine. It is suggested that the right hemisphere plays a certain role in the compensation processes in the serous meningitis. Recently, we experienced a case of abdominal cocoon in a 34-year-old female patient(Korean) who had never been abroad. When expressed in a recombinant baculovirus system, the protein exhibited hyaluronidase activity in a substrate-gel assay.

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The effectiveness of early orthodontic treatment for Medicaid-enrolled children in the mixed dentition was assessed and compared with results in a population of private-pay patients. Use of six main drug therapeutic groups across educational groups: self-reported survey and prescription records. Furthermore, atypical cribriform hyperplasia was almost exclusively found in cases with cribriform or solid type of invasive carcinoma. Long-term results of sclerecto-iridencleisis associated with cyclodialysis in the trachomatous patient with primary glaucoma. From October 2003 through April 2004, 27 patients had anterior cervical procedures: 22 one-level and 5 two-level operations. Oxidative stress response in yeast: glutathione peroxidase of Hansenula mrakii is bound to the membrane of both mitochondria and cytoplasm. Lethality and behavior tests revealed that the transgenic nematodes respond similarly to the wild-type N2 strain, indicating that they can be used in the same manner in soil testing. In this report a method is described by which thyroid hormones are chromatographically isolated from serum, with the simultaneous assessment of the incorporated radioactivity over a period of time. Milk yield and the duration of increase phase were not affected by milkability at either level.

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Retrospective study of the files of patients hospitalised in the University Hospital Centre of Rennes in 1998 for a Mycobacterium tuberculosis infection. The octapeptide (CCK-8) occurs in predominantly sulfated form (CCK-8S), and the tetrapeptide (CCK-4) occurs in smaller but significant quantities. The stethoscope: a source of diagnostic aid and conceptual errors in rheumatic heart disease. Purification of LamB proteins using continuous elution electrophoresis: a comparison with immunoaffinity chromatography. Ischemia causes substantial translocation of GLUT4 molecules to the plasma membrane of cardiac myocytes. Differential effects of the new class III agent dofetilide on potassium currents in guinea pig cardiomyocytes. Immunotherapy, immunochemotherapy and chemotherapy for American cutaneous leishmaniasis treatment. Results also showed that some LNGFR-positive fiber bundles contained tyrosine hydroxylase immunoreactivity. Incisional hernia is a frequent complication of abdominal surgery. Quality control of radiopharmaceuticals from the clinical aspect--a necessity?.

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We discuss various hypotheses on the harmful effects of sodium nitrite, such as denaturation of histamine-binding SH-group rich mucoproteins, direct toxicity on microvilli or inhibition of intestinal histaminase. Increased cutaneous blood flow was observed 15 minutes after skin flap construction in rats injected with ibuprofen (5 mg/kg) intraarterially before surgery compared with that in control rats. To determine the hemodynamic effects of lidocaine (administered IV to achieve 6 plasma concentrations) in isoflurane-anesthetized cats. All the echocardiographic features of a hypertrophic obstructive cardiomyopathy were detected, with an accurate noninvasive measure of the left ventricle outflow gradient. Prevalence of Lyme borrelia in ticks in Bratislava, Slovak Republic.

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Nonreentrant supraventricular tachycardia due to simultaneous conduction over fast and slow AV node pathways: successful treatment with radiofrequency ablation. We conducted zymography for detecting the activity of matrix metalloproteinases (MMPs) and reverse zymography for the activity of tissue inhibitors of metalloproteinases (TIMPs) in canine spontaneous and rat 7, 12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumor tissues. In addition to beta 1 subunit, alpha v chain formed heterodimers with beta 3 and beta 5 subunits. Ab initio calculations and Franck-Condon simulation of the absorption spectra of GeCl2 including anharmonicity. Cyclic voltammetry and UV-vis spectroelectrochemistry were used to probe the ground-state electronic properties of the neutral and charged species. Detection of the apoptosis-suppressing oncoprotein bcl-2 in ameloblastomas. Furthermore, MEMO inhibited the nuclear factor kappa B (NF-kappaB) activation induced by LPS, and this was associated with the prevention of degradation of the inhibitor kappaB (IkappaB), and subsequently with attenuated p65 protein in the nucleus.

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Salmonella and Shigella infections found in one hundred ninety-five cases of acute diarrhea. Factorial analysis and multiple regression showed that sleep complaints in the older group correlated less with severity of depression and had a less stable response to pharmacological treatment. Administration of the drug was associated with significant temporary neurologic improvement in five of six patients with incomplete spinal cord injury. The accessory immune function of GF cells was evaluated by their ability to elaborate proinflammatory cytokines following stimulation with lipopolysaccharides and interleukin-1 beta (IL-1 beta). Patients with RS3PE syndrome remitted completely within 3-36 months and the remission was maintained even after all medications were discontinued. The specific oxidase activity of ceruloplasmin (activity per unit mass of enzyme protein) was studied in plasma of pregnant women with gestosis, feto-placental insufficiency, postmature and in normal pregnancy. Tandem wire mesh stents for palliation of obstructing gastroduodenal adenocarcinoma. Thus, central and autonomic disturbances can lead to profound alterations in cardiac function manifested by cardiac arrhythmias and signs of myocardial injury.

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ESMO Minimum Clinical Recommendations for prophylaxis of chemotherapy- can you drink alcohol while on lamictal induced nausea and vomiting (NV). Enzymatic elimination of fluoride from alpha-fluoro-beta-alanine. in patients with mild/moderate, non-life-threatening carcinoid syndrome. Hybridomas were screened both by ELISA with synthetic peptides and by indirect immunofluorescence with cryostat sections of human kidneys. It is concluded that UVI should be a routine part of forensic medical examinations.

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Redox-sensitive transcription factors are activated, leading to responses involving inflammation, adhesion, migration, and additional reactive oxygen species generation. Evidence suggests that mitochondria of protozoans and plants contain nuclear-encoded tRNAs. stimulation at low doses and tendency to inhibition at higher doses. In normal animals, taurine was found primarily in medullary tubules, with minimal staining of proximal tubules and glomeruli. Anesthetic management for transurethral resection of the bladder in a 74-year-old man with uncorrected tetralogy of Fallot. Nearly two thirds of stroke survivors have deficits impairing ambulatory recovery. Whereas amoebapore was no longer capable of binding to phospholipid vesicles when its lysine residues were modified, the modification of the single histidine primarily affected oligomerization of the peptide upon membrane association.

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Gaussian-white distributed elastic constants, as well as those with long-range correlations with nondecaying power-law correlation functions, are considered. It is expected to be increased in diabetes mellitus and may be linked to the development of diabetic complications. Techniques for antifungal susceptibility testing of Candida albicans biofilms. Ventricular restoration--a surgical approach to reverse ventricular remodeling. Arginine differs from guandinine hydrochloride in the mode of interactions with proteins, which may be a primary reason why arginine is not a protein-denaturant. A significant increase in amlodipine norvasc 10 mg tablet cost both serum testosterone and LH was observed in the early stage at high dietary concentrations of procymidone without any lesion in gonadal systems in histopathology, whereas administration of cadmium chloride produced the expected substantial increase in serum LH and a concomitant decrease in serum testosterone with a marked damaging effect on gonadal systems.

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Bulk solute extrusion as a mechanism conferring solute uptake specificity by pinocytosis in Amoeba proteus. Confirmatory localization of pheochromocytoma has become a straightforward exercise owing to current radiological techniques. Female adult rabbits weighing 3.5-4.0 kg received a single injection of prednisolone at a dose of 4 mg/kgBW. Changes in angiogenic gene expression in a case of expanded capillary malformation: does an expanded capillary malformation grow?. Guideline limit volumes for dosing laboratory animals diovan classification drug by oral and parenteral routes in the preclinical stage of safety evaluation were agreed following discussions by the Toxicology Subcommittee of the Association of the British Pharmaceutical Industry. No oxyHb change was observed in 4 subjects, although they had good performances in the WCST. Pulmonary cavitary tuberculosis in the Armed Forces of the Netherlands. The purpose of this study was to decrease the rate of cesarean delivery for breech presentation through use of a protocol that calls for external cephalic version and selected vaginal delivery of the infant in breech position.

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