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Viagra

Viagra, an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Viagra is formulated as blue, film-coated rounded-diamond-shaped tablets equivalent to 25 mg, 50 mg and 100 mg of sildenafil for oral administration. In addition to the active ingredient, sildenafil citrate, each tablet contains the following inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose, triacetin, and FD & C Blue #2 aluminum lake.

Other names for this medication:
Caverta, Intagra, Kamagra, Penegra, Revatio, Silagra, Sildenafil, Sildenafila, Sildenafilo, Sildenafilum, Sildigra, Suhagra, Veega, Zenegra

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Also known as: Sildenafil

Description

Viagra is approved to treat erectile dysfunction (ED) in men. With ED, you have trouble getting and keeping an erection that’s firm enough to allow you to have sex.

What causes an erection?

When you’re sexually aroused, either through sexual thoughts or touch, your brain sends messages to your penis. These messages cause certain chemicals to be released in your penis.

One of these chemicals, called cyclic GMP, relaxes and widens certain blood vessels in your penis. Cyclic GMP also relaxes the muscles around the erectile tissue in your penis that’s called the corpus cavernosum. These actions allow blood to flow into the corpus cavernosum, which causes your penis to get hard and become erect.

What happens with ED?

ED can occur if you have certain problems that affect your body’s ability to have an erection. The condition can result from problems with messages being sent from your brain. ED can also result from problems with blood flow into your penis.

What does Viagra do for ED?

Viagra works to treat ED by helping you have and maintain an erection. The drug does this by improving blood flow into your penis when you’re sexually aroused.

Viagra is a type of drug called a phosphodiesterase type 5 (PDE5) inhibitor. It works by inhibiting (blocking) the action of an enzyme called PDE5. (An enzyme is a protein that helps chemical reactions to happen inside your body.)

Normally, an erection goes away when PDE5 breaks down the cyclic GMP in your penis. But Viagra blocks the action of PDE5, so it allows cyclic GMP to keep working for a longer period of time than usual. This action improves blood flow to your penis and helps you to have and keep an erection.

Does Viagra increase a man’s sex drive?

No, Viagra doesn’t directly increase your sex drive. And it doesn’t make you sexually aroused. However, some men find that if Viagra works to treat their erectile problem, it also increases their sexual confidence. And this may lead to an increased sex drive.

How can I tell if Viagra’s not working?

Viagra may not work for everyone, and it may not work every time you take it.

If you’re sexually aroused, Viagra should work to help you have or keep an erection within 30 minutes to 2 hours. But if you don’t get an erection within 4 hours after taking a dose, Viagra didn’t work for you this time.

If the drug doesn’t work for you, you shouldn’t take another dose until at least 24 hours later. And talk with your doctor if you feel Viagra isn’t helping to treat your ED. They may recommend that you try a different medication for your ED.

How can I get Viagra to work?

It’s important to remember that Viagra only works if you’re already sexually aroused. Arousal may involve having sexual thoughts, looking at sexual images, masturbating, or engaging in foreplay.

But if you feel anxious, nervous, depressed, or stressed, your body may not respond well to sexual stimulation. If this is the case, try to relax, make yourself comfortable, and take your time. In addition, it’s best to avoid drinking a lot of alcohol. This is because consuming large amounts of alcohol can make it more difficult for you to get an erection.

If you’re having trouble getting an erection, even while using Viagra, talk with your doctor.

Is Viagra a blood thinner?

No, Viagra isn’t a blood thinner. Instead, it belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. (A class of drugs describes a group of medications that work in a similar way.) Viagra works by inhibiting (blocking) the action of a certain enzyme in your body.

Since Viagra has been released onto the market, there have been a few reports of bleeding in people who’ve taken the drug. However, there’s no evidence that Viagra caused these bleeding problems.

It’s not known if Viagra is safe for use by people with a bleeding problem. If you have any bleeding problems, talk with your doctor about whether Viagra is safe for you.

Dosage

The starting dose is 50 mg. According to research, most men decide that 100 mg is a more effective dose if you are in a good state of health. Viagra (Pfizer) should be taken once a day, 30 minutes to 1 hour before sex. You can take Viagra (Pfizer) with or without food or alcohol. But if you want to get the quickest result you should avoid fat meals (fries or cheeseburgers) 2 hours before taking Viagra (Pfizer).

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Side effects

The most common side effects associated with Viagra are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Viagra if you are allergic to any of Viagra’s components. Do not take Viagra if you are also using organic nitrates, nitrate drugs for chest pain or heart condition (e.g., nitroglycerin, isosorbide dinitrate and isosorbide mononitrate), nitrates as amyl nitrate or nitrite ("poppers"). Do not take Viagra if you take other medications to treat erectile dysfunction or pulmonary arterial hypertension, such as riociguat (Adempas). Do not take Viagra if you are taking erythromycin, alpha-blockers, ketoconazole, itraconazole (Sporanox or Nizoral), ritonavir (Norvir) or indinavir (Crixivan). Do not consume alcohol while using Viagra, as it can lower your blood pressure, causing dizziness and rapid heart rate (tachycardia). Do not drive or operate machinery while taking the medication. Contact you doctor or health care professional right away if your erection lasts longer than 4 hours or if it becomes painful. Viagra does not protect you or your partner from sexually transmitted diseases or pregnancy. Viagra can be dangerous for children and women.

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In preparation for a larger multicenter trial, three centers piloted a protocol for a randomized, double-blind, placebo-controlled trial of zithromax 250 mg cost intravenous recombinant tissue-type plasminogen activator begun within 3 hours of the onset of symptoms of acute stroke to test its feasibility and to explore trends. The purpose of the study was to determine the effects of bleomycin-mediated electrochemotherapy on several basal cell carcinomas (BCCs) in two patients with nevoid BCC syndrome. How reliable are serological tests in diagnosis of cysticercosis?. We show how, at the lowest order of approximation, the method can be used to obtain modified chemical rate equations where, in place of fundamental rate constants, effective rate coefficients appear. In fact, by encapsulating the kidney, it acts as a vacuum-flask, providing insulation for the kidney from two surrounding thermal areas, the warmer being on the interperitoneum and the cooler on the skin surface. The structural preferences of MgCl2 nanotubes are strongly dependent on the tube diameter. The second type designated f-cells were vimentin positive and showed rugose surfaces. Coculture of primary rat hepatocytes and nonparenchymal cells permits expression of insulin-like growth factor binding protein-3 in vitro. Recent reports have emphasized the importance of the rheumatic manifestations in leprosy, especially the lepromatous form. The action of fast carbon and heavier ions on biological materials.

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Examination of APCs from F1 mice (NOD x C57BL/6) indicated that efavirenz lamivudine and tenofovir disoproxil fumarate tablets 600mg 300 mg 300 mg the same APC expressed high levels of unstable I-Ag7 and normal amounts of stable class II molecules compared with the other haplotype (I-Ab). A non-radioactive, sensitive method for the detection of DNA fragmentation in apoptotic cells (rat pheochromocytoma PC12 and rat cortical cells). Acute compensation to abrupt occlusion of rat femoral artery is prevented by NO synthase inhibitors. Phosphorylation of Gi alpha 2 attenuates inhibitory adenylyl cyclase in neuroblastoma/glioma hybrid (NG-108-15) cells. Large amounts of nuclear proteins appeared to be transformed from nuclear proteins into certain structural proteins in keratinocytes.

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We discuss in detail microscopic aspects of the various contributions to the free energy gap of proteins and put emphasis on how a cosolvent may either enlarge or diminish this gap. The aim of the study is to compare the prevalence of depression in women surgically diagnosed with endometriosis according to the presence or absence of pelvic pain. Effect of Trypanosoma vivax infection on pregnancy and post-partum cyclicity in ewes. Graft survival were assessed by histological and electrophysiological techniques. Amiloride did not alter either the conductance or kinetics of these novobiocin channels. The optimization is facilitated by using a linear combination of atomic potentials (LCAP), a general framework that creates a continuous property landscape from an otherwise unlinked set of discrete molecular-property values. Furthermore, the expression of several NC marker genes known to be downregulated upon in vivo differentiation of NC derivatives, was observed to be present at lower levels at 3 weeks of PA6-hESC coculture than at 1 week. The result is a diffuse visual stimulus approximating band-limited white noise. It is likely that other vascular regions will be increasingly used. Formation of extraorganic ovarian nerves during the intrauterine period of human ontogeny.

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Exogenous catalase dramatically increased the O(2) uptake with glycerol, presumably by releasing inhibition caused by hydrogen peroxide. Fourteen patients who were repaired before 6 months of age were compared with 15 patients who were repaired after 6 months of age. Cerebral spinal fluid (CSF) was positive for squamous cells consistent with primary cervical squamous cell carcinoma. Effects of 4-aminopyrazolo (3, 4-d) pyrimidine in combination with guanine on nucleic acid and protein synthesis by Erlich ascites cells in culture. Gallopamil is well tolerated, exhibiting a low propensity for causing cardiovascular and gastrointestinal adverse effects, thus making it a suitable alternative to other calcium antagonists for the treatment of patients with ischaemic heart disease. PbTe nanocrystals are characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), and optical absorption. Bone marrow tissues were removed, and pluripotent reticulocyte cells with micronuclei, nuclear buds, and binuclear abnormalities were analyzed using an in situmicronuclei assay under light microscopy. Hyaluronectin (HN), a hyaluronan (hyaluronic acid, HA)-binding glycoprotein isolated from human brain, was studied in normal and atherosclerotic human arteries. Intrahepatic adoptive immunotherapy with autologous tumorcytotoxic macrophages in patients with cancer.

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These results imply that B10.D2 erythroid precursors are intrinsically resistant to Friend virus-stimulated erythropoiesis. L-Glutamate and norepinephrine are examples of a major excitatory neurotransmitter and a neuromodulator in the cerebral cortex, respectively. This paper refers to an operation technique which was developed 14 years ago and which removes the bottleneck. Absorption of volatile fatty acids from the reticulo-rumen and abomasum of sheep. We measured characteristics of LISWs used for gene transfection. Genital bacterial carriage during the last trimester of pregnancy and early-onset neonatal sepsis. Confirmation of these observations by prospective studies would provide novel therapeutic capabilities and clues about the mode of action of this controversial treatment.

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