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Unidol (Tramadol)

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Unidol is an opioid (narcotic) pain reliever. It works by binding to mu-opiate receptors in the brain and changes how you feel and respond to pain. Unidol is usually started at 25 mg per day. After slowly raising the dose over several days, a typical dose would be 50 to 100 mg by mouth every 4 to 6 hours as needed for pain.

Other names for this medication:
Armadol, Arrestadol, Bestodol, Bolodol, Bramadol, Combitram, Cormadol, Didol, Dolstar, Drobit, Kevtram, Movon, Muzox, Neutram, Opidol, Ospidol, Painadol, Painex, Pentazen, Radol, Ramax, Sayodol, Servodol, Spasteez, Standol, Tradol, Traiz, Tramadex, Tramared, Tramasol, Tramataur, Tramed, Tramol, Tramospas, Trandy, Tranzat, Trapidol, Trasic, Trazac, Tromfil, Trugesic, Urgendol, Vegadol, Victadol, Zytram

Similar Products:
Lunesta, Vasotec, Phenergan, Lozol, Coumadin, Evista, Cardura, Decadron

Also known as: Tramadol


Ultram (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

Ultram is used to treat moderate to severe pain in adults.

The extended-release form of tramadol (Ultram ER) is for around-the-clock treatment of pain. Ultram ER is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Ultram: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Ultram is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Ultram dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Unidol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Ultram ER if you are allergic to it, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Ultram ER should not be given to a child younger than 12 years old. Ultram ER should not be given to anyone younger than 18 years old.

Do not give Ultram ER to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Ultram ER. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

Tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use Ultram ER during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using Ultram ER if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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There is a positive correlation between the jitter and the latency of the individual muscle fibre responses, possibly indicating that smaller diameter muscle fibres have slightly lower safety factor of neuromuscular transmission. When cells from pulmonary metastases are transplanted subcutaneously, the sensitivity of the resulting tumor closely resembles that of other subcutaneous tumors. Furthermore, the uv-mediated induction of lambda prophage was decreased after either addition of cyclic AMP or growth in cultural conditions where the level of this nucleotide was low. Chromosomal insertion of human papillomavirus 18 sequences in HeLa cells detected by nonisotopic in situ hybridization and reflection contrast microscopy. Today, SCCH is widely considered part of the synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome.

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RFA produces coagulative necrosis of tumor through local tissue heating. Diffuse reduced uptake in 99m-Tc-HM-PAO SPECT and high level of neuron-specific enolase in cerebrospinal fluid in the early stage of Creutzfeldt-Jakob disease. Computer-controlled motorized endoscopic grasper for in vivo measurement of soft tissue biomechanical characteristics. Detection and quantitation of recombinant granulocyte colony-stimulating factor charge isoforms: comparative analysis by cationic-exchange chromatography, isoelectric focusing gel electrophoresis, and peptide mapping. There was also a dramatic increase in the frequency with which the media depicted the entire bodies of the models from the 1960s to the 1990s.

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This led to the conclusion that LGC can inactivate the CTL generation in fresh T-cell populations and that fresh and activated responding cells have different susceptibilities to LGC interactions. Although the antiserum was shown to contain antibodies to both protein and carbohydrate determinants on the AT III molecule, studies comparing the effects of 7 M guanidine and periodate oxidation on the antigenicity of the AT III determinant also recognized on the thymocytes indicated that this shared antigenic determinant was carbohydrate in nature. REM sleep is impaired by a small amount of alcohol in young women sensitive to alcohol. Ventilator Management: A Systematic Approach to Choosing and Using New Modes. Regulation of p27 by S-phase kinase-associated protein 2 is associated with aggressiveness in non-small-cell lung cancer. Bacteriological diagnosis and antibiotic therapy of urinary tract infections. In addition there was a statistically significant (P less than 0.01) positive Spearman correlation between total C-cell numbers and age in males. Furthermore, functional studies showed that IL-9 stimulation of PMNs results in the release of IL-8 in a concentration-dependent manner.

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Because CD62L on T cells appears to be inhibitory for the development of anti-GBM Ab-induced GN, persistent expression of CD62L on CD4 T cells may explain, at least in part, the suppression of anti-GBM Ab-induced GN in the transgenic mice. Recombinant ILYS-3 protein was found to exhibit appropriate lytic activity against Gram-positive cell wall material. Determination of calcium, sodium, potassium and magnesium concentrations in human senile cataractous lenses. An autoradiographic study revealed time-dependent penetration of radiolabeled ITN from the surface of Minor MTS into the core. Assessment of elderly mobility using a remote multisensor monitoring system. Neuropeptides and central catecholamine systems: interactions in neuroendocrine and central cardiovascular regulation. These results suggest that (1) an opioid link mediates spinal 5-HT but not NE antinociception, and (2) 5-HT but not NE participates in spinal morphine analgesia.

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The expression patterns of cadherin-11 and N-cadherin in cells of the mouse osteoblastic cell line MC3T3-E1 showed that each cadherin was located independently of the cell-cell adhesion site and acted individually. Our study suggests that routine admission chest radiographs in uncomplicated asthmatics may be unnecessary. Activation of human and mouse 2-5A synthetases and mouse protein P1 kinase by nucleic acids. The ER and mitochondria exhibited seasonal variations in their pattern and content, that was minimal during winter. Time after stroke has a significant influence on urological findings. These results suggest that the reduction of PS produced by DDC and the absence of PS rebound may be due to a lowering in norepinephrine in the brain.

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Effects of temperature and tick weight on expression of autogeny in the argasid tick Ornithodoros parkeri Cooley (acari: Argasidae). Considerable inter-rater differences between and within these groups were found. Clinically, a mesiodistally applied force must exceed the frictional force to produce a tooth movement. The activity of adenylate cyclase was measured by stimulation at the site of the enzyme, the hormone receptors and the modulating G-proteins. An improved competitive protein binding assay for 1,25-dihydroxyvitamin D. The genetic and total variation estimated from the analysis of variance method decreased under this sudden thermal stress condition. These observations, combined with the effects of laser ablation, lead to the conclusion that one function of the excretory system is osmoregulation. Chemical nature of binding of serotonin in the central nervous system. Olfactory gas chromatography (GC-O) of a volatile wine extract, previously isolated by preparative gas chromatography, indicated the presence of a zone containing an intense honey descriptor.

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The formal declarative model constitutes the main governing principle in MedView, not only in the formalisation of clinical terms and concepts, but in visualisation models and in the design and implementation of individual tools and the system as a whole as well. However, in more distal segments 4 days after transection the concentration of JE mRNA was lower than that of control mice. Results of an interview with patients suffering from extreme, chronic anxieties. Taken together, these results may provide new avenues for understanding and advancing priming-induced responses to submergence tolerance in crop plants. Selective attentional bias to alcohol related stimuli in problem drinkers and non-problem drinkers. The effect of cannabinol delta1-tetrahydro-cannabinol clearance from the blood.

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Induction of mutation to streptomycin resistance in Micrococcus radiodurans. T cells bearing I-A can be enriched by a simple affinity procedure, and I-A-positive cells separated on a FACS are shown to retain antigen-specific reactivity. In view of these marked differences, comparative functional genomics may elucidate some of the molecular mechanism(s) behind these differences. Our previous results have shown that enhanced alpha responses to auditory task stimuli can be well synchronized with stimulus until 800-1000 ms. Immune and enzyme histochemical studies of a human hepatocellular carcinoma cell line producing hepatitis B surface antigen. Our results agree with previous studies on crustacean NF proteins that have reported negative immunoreactions against NF-H and NF-L subunits and positive immunoreactions against the mammalian NF-M subunit. In 1966 we saw 1, in 1973 2 cases of spontaneous rupture of the tibialis anterior-tendon. We report here the isolation of a mothbean (Vigna aconitifolia) cDNA clone encoding a bifunctional enzyme, delta 1-pyrroline-5-carboxylate synthetase (P5CS), with both gamma-glutamyl kinase and glutamic-gamma-semialdehyde dehydrogenase activities that catalyzes the first two steps in proline biosynthesis. These results suggest that AA might play an important role in reducing the mortality of tetanus.

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However, greater pore concentrations on the air space were required in both environments to complete hatching. U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), an essential mammalian splicing factor, is composed of two subunits: a 65-kDa protein (U2AF65), which binds the pre-mRNA polypyrimidine tract and is required for in vitro splicing, and an associated 35-kDa protein (U2AF35). However, massive proteinuria was noted, and acute anuric renal failure unaccompanied by oedema or arterial hypertension developed. In this study we detail the temporal characteristics of this surge in the rat, and we provide comparative data documenting a similar surge-like appearance of testosterone in neonatal male mice, recently foaled male horses, and newborn human infants. I propose that beta-blockade prevents arrhythmic deaths in post-infarction patients in part by increasing levels of vagal cardiac inhibition. We describe a woman who was repeatedly tuberculin (PPD) skin test negative after exposure to smear-positive tuberculosis (TB), but developed active TB with a positive skin test 7 years later. Volunteers were treated with fibroblast interferon or placebo nose drops for four days. Pathogenesis of acute toxoplasmosis in specific-pathogen-free cats. An improved procedure for the rapid one-step-cloning of full-length viroid cDNA. The disorder is typically accompanied by fever, general fatigue, lymphadenopathy, and hepatosplenomegaly.

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In contrast to somatic lamins, neither goldfish nor Xenopus GV lamin contain conserved phosphorylation sites for nuclear transport, except the nuclear localization sequence. Here, we investigate different mechanisms that might control nuclear translocation of XMI-ER1. The concentrations of the several nucleotides in medium and muscle were calculated from the radioactivity observed in each fraction. Progesterone administration, however, had no effect on either alpha-receptor subtype. Efficacy of the preparations containing native and modified forms of catalase and superoxide dismutase as well as their covalent bienzyme conjugate containing catalase-dextran aldehyde-superoxide dismutase was studied in rats with simulated silicosis.

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Further, dextran plasma concentrations decreased in inverse proportion to increasing molecular weight. glyburide dose range This technique is based on libration induced stretching excitation of water molecules. It has been previously suggested that facial fat (primarily in the cheeks and neck) is strongly associated with visceral abdominal fat accumulation. All four patients photopatch tested with related chemicals showed cross-photosensitization with tiaprofenic acid and suprofen. HPLC analyses showed the highest isopeptide bond content in cells encysting for 21 h, indicating an important role for TGase early in encystation. The Sentinel blood culture system was evaluated in three centres. An exploration of the potential utility of fetal cardiovascular MRI as an adjunct to fetal echocardiography.

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Meanwhile the content of NFA and phospholipids did not experience any substantial changes. The intrauterine twin pregnancy continued normally to the 35th week of pregnancy, finished with normal vaginal delivery. In arthrosis the intraosseous pressure was normal, whereas intraosseous hypertension was present in necrosis. A rapid, sensitive and easily performed method for the measurement of caffeine in biological fluids by the technique of fluoroimmunoassay is described. Similarly, cutaneous delayed-type hypersensitivity, a typical Th1 response, was abolished in the IL-12-/-, mice but increased in the IFN-gammaR-/- mice. Transcranial and cephalometric radiographs, arthrograms, and mandibular movement recordings were obtained before treatment and after both repositioning therapy and orthodontic treatment. This set of specifically labeled melittins was used to study the structure and dynamics of melittin in aqueous solutions and when bound to neutral or negatively charged membranes. Streptococcus pyogenes toxins streptolysin S and streptolysin O, Clostridium tetani tetanolysin, Staphylococcus aureus alpha-toxin and Vibrio parahemolyticus hemolysin, all bacterial toxins that act on cell membranes, elicited a strong response from chromatophores. Activation of the ventrolateral periaqueductal gray reduces locomotion but amaryl 30 mg not mean arterial pressure in awake, freely moving rats.

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Objective neurological findings of impaired balance, reaction time, color vision, slotted pegboards and trials making were present in the three older children who could be tested. There was one death from pleural mesothelioma, 11 years after first taconite employment, in a man with long prior employment how to take prevacid tablet as a locomotive operator. Mapping of methionine-enkephalin-arg6-gly7-leu8 in the human diencephalon. Electron-microscopically, the generation of the lamellated granules and the thickened cellular envelope of a horny cell were noted in both regions. Among women, no significant elevations in risk were observed for persons who lived in the study area. The fungus was consistently reisolated from tissues of mice inoculated intravenously and intraperitoneally with conidial and mycelial suspensions from cultures of the fungus. Systematic analysis of data from a series of case-control studies. We favor planned staged excisions, using deep dermabrasion as a final step. A novel approach to quantifying human cells using a real time PCR assay was developed. aequizonata may be caused by a lack of reoxidation due to the absence of oxygen.

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Allergic bronchopulmonary aspergillosis in an HIV-infected individual. Hepatic aryl hydrocarbon hydroxylase activities in coho salmon (Oncorhynchus kisutch) exposed to petroleum hydrocarbons. Multivariate analyses showed that differences in predisposing and enabling characteristics between single and married mothers accounted for very little of the relationship between family structure and service use. After 30 days new samples were obtained from 11 children from the first group and 16 children from the control group. Methods to integrate both general education and professional preparation are analyzed, and specific implications for nursing are discussed. A proximal activation of a ribosomal protein S6 kinase by insulin has provided insight into the regulation of this pathway. Mutant alleles at each of the nine nit (nitrate-nonutilizing) loci were assayed for nitrite reductase activity, for three partial activities of nitrate reductase, and for nitrite reductase activity. Accuracy of gamma probes in localizing radioactivity: in-vitro assessment and clinical implications.

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Services included imaging for staging and surveillance in low-risk disease, intensity-modulated radiation therapy (IMRT) after breast-conserving surgery, and extended fractionation schemes for palliation of bone metastases. With regard to the first group the development of atypical cells in these cases may be supposed to be connected with the presence of precursors of plasma cells. The concept of transmammary transmission is now well established, and while canine hookworm species are generally considered incapable of reaching maturity in man, they may well be capable of producing transient patent infections in neonates. coli genes (chlA, chlB, chlE and chlG) are also needed for enzymatic activity. In a retrospective review of 51 patients undergoing palliative procedures for carcinoma of the pancreas from 1974 to 1979, cholecystoenterostomy was as effective as choledochoenterostomy. Most notably, in all of the EU-8-induced tumors examined, the provirus was integrated in the c-myb locus, and in no tumors were c-myc integrations found. The staining of imatinib-resistant cell lines such as the mutated BaF/Bcr-AblT315I cell line or resistant CML patient cells, showed that hyperphosphorylation was not affected by imatinib treatment.

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Surgery is recommended in cases with deep-seated lesions causing massive hemorrhage, repetitive minor bleeding, or significant long-standing and progressive neurological disabilities. Its efficacy as an anti-fibrogenic drug was evaluated in relation to stellate cell activation. APC-treated animals also showed a trend towards a reduction in lesion size. Almost two thirds of all occupational diseases are detected in the latter half of life. Retrospective analysis of albumin-bound paclitaxel in the treatment of elderly patients with advanced non-small cell lung cancer. The traditional HAM-D17 version was compared with the shorter HAM-D6 and the longer HAM-D21 or HAM-D24 in a fixed-dose placebo-controlled vortioxetine study.

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The polymorph layer is the primary target for noradrenergic, serotonergic and cholinergic input to the hippocampal dentate region. Characterization of contralateral torques during static hip efforts in healthy subjects and subjects with hemiparesis. Study of mutagenic properties of various chemical substances in occupational exposure. Also, 11 patients with secondarily drug resistant, recurrent gynecologic cancer (8 ovarian and 3 uterine cancers) were treated with 240 mg toremifene daily for 1 week before each course of cytostatics. Pharmacokinetics of single-dose telmisartan 120 mg given during and between hemodialysis in subjects with severe renal insufficiency: comparison with healthy volunteers.

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In vitro dissolution of curium oxide using a phagolysosomal simulant solvent system. It induced significant neurontin overdose seizure decreases in the expression of PCNA, cyclin A, and PSA in LNCaP tumors. This study assessed the differences and similarities in the incidence and recurrence of shoulder and neck complaints with respect to work-related physical, psychosocial, and personal risk factors. Normal life experiences foster development and encourage psychological and social competence in children. Functional analysis of DR17(DR3)-restricted mycobacterial T cell epitopes reveals DR17-binding motif and enables the design of allele-specific competitor peptides. Coupling in rat hippocampal slices: dye transfer between CA1 pyramidal cells.

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They showed significant differences in their peak latencies at different scalp recording locations. A laboratory reference measure (2D video) was used for comparative analysis. The knowledge of urological dysfunction after stroke is based largely on the evaluation of symptomatic patients. Relationship between inductions of monooxygenase activity and gamma-glutamyltranspeptidase in rat hepatocyte primary cultures. This review describes the aetiological mechanisms of cancers and the production, structures, mechanisms of action, availability, and cellular and physiological anticancer activities of the food peptides.

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