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Ultram (Tramadol)

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Ultram is used to help relieve moderate to moderately severe pain. Ultram is similar to opioid analgesics. It works in the brain to change how your body feels and responds to pain. Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Other names for this medication:
Avdol, Cormadol, Dolex, Dolmeri, Dolocet, Drobit, Hyperdol, Jpdol, Mandol, Nosdol, Novadol, Opigesic, Ospidol, Painex, Ramadol, Rimol, Soztram, Standol, Tolydol, Tradol, Tragesic, Tramagesic, Tramasol, Trapain, Trazac, Trydol

Similar Products:
Compazine, Lopid, Suprax, Clomid, Robaxin, Abhigra, Colcrys, Danocrine, Biaxin, Colospa

Also known as: Tramadol


Ultram (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

Ultram is used to treat moderate to severe pain in adults.

The extended-release form of tramadol (Ultram ER) is for around-the-clock treatment of pain. Ultram ER is not for use on an as-needed basis for pain.


Follow the directions on your prescription label and read all medication guides. Never use Ultram ER in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of Ultram ER.

Never share Ultram ER with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Stop taking all other opioid medications when you start taking Ultram ER.

Ultram ER can be taken with or without food, but take it the same way each time.

Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Never crush or break a Ultram ER pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death.

You may have withdrawal symptoms if you stop using Ultram ER suddenly. Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover Ultram ER. Just one dose can cause death in someone using it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash.

Detailed Ultram ER dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Ultram are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Ultram ER if you are allergic to it, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Ultram ER should not be given to a child younger than 12 years old. Ultram ER should not be given to anyone younger than 18 years old.

Do not give Ultram ER to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Ultram ER. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

Tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use Ultram ER during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using Ultram ER if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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On the other hand, the S-NO-Cap-induced increase in cGMP was unaffected by NTG tolerance. Prehospital thrombolytic therapy in patients with suspected acute myocardial infarction. Results show an association between the oxidative stress and the increases of B1 receptors and arterial blood pressure induced by AT II. Since all patients with macroscopic metastases to the paraaortic lymph nodes developed recurrent cancer and only a small percentage of those with microscopic metastases to the paraaortic lymph nodes survived disease-free at 5 years, improved survival for patients with paraaortic lymph node metastases will necessitate the addition of effective cytotoxic chemotherapy to pelvic and paraaortic radiation. Dilated cardiomyopathy (DCM) is characterized by nitric oxide (NO) deficiency and endothelial dysfunction.

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Morphologic regions of the multitendoned extrinsic finger muscles in the monkey forearm. Trastuzumab combined to chemotherapy had demonstrated significant improvement of time to progression and survival in metastatic breast cancer patient overexpressing HER-2. The ability of the free NC group to function as an anchoring point is demonstrated by the attachment of gold nanoparticles on PDI-covered Au and Pd. Mitogen-activated protein (MAP) kinase phosphorylation patterns induced by active Ras can vary and contribute to distinct cellular responses. Isolates of Theileria annulata collected from different parts of India show phenotypic and genetic diversity. An appraisal of the efficacy and substantivity of the new high-potency sunscreens. A 26-year-old male presented with a history of recurrent throat infections. The substitution of the human carboxy-terminal sequences into the mouse TERT protein is sufficient to confer immortalization and maintenance of telomere length and function.

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Efficacy of lactobionate-enriched cardioplegic solution in preserving compliance of cold-stored heart transplants. As the staining pattern of 3A5 is restricted, compared with other macrophage markers and the recognised epitope survives common fixation and embedding procedures, 3A5 is a valuable marker for histiocytes and macrophages in routine diagnostic applications. This effect of E1A 12S on E-cadherin expression is not at the transcriptional level. As started by different studies, the ulcerative colitis is predictive of mucosal dysplasia alterations and colo-rectal carcinoma. Ethics is a set of moral principles or values--a guiding philosophy for behavior. Proceedings of a satellite symposium associated with the 7th World Congress on Pain. These effects of a single dose of prazosin on left ventricular function were rapid in onset, maximal at 1 hour and sustained for the entire 6-hour period of observation. Attenuating effect exerted by the synovia on the Sanarelli-Shwartzman phenomenon. We tested whether arterial stiffness, evaluated as pulse wave velocity (PWV), is associated with cognitive impairment in older subjects, and whether PWV is increased at a comparable extent in older subjects with cortical or subcortical cerebral lesions when compared with age-matched controls referred for memory deficits.

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The problems of diagnosis and treatment of avascular malignant tumour of the kidney are discussed on the basis of 5 cases. Results were correlated with the expression of three synaptic protein genes in the dentate gyrus. These models have outstanding potential, as they are highly responsive to dietary factors and pharmacological interventions. Dingchuantang decoction restores the imbalance of TH2/TH1 in mice infected by respiratory syncytial virus. Phylogenetic analysis of a highly specific association between ectosymbiotic, sulfur-oxidizing bacteria and a marine nematode. Duodenal and gastric ulcer prevention with misoprostol in arthritis patients taking NSAIDs.

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A study of the effects of frozen storage on the chemical and bacteriologic determination of isoniazid in whole and heart-deproteinized serum. From 2 weeks after electro-gene transfer, the nociceptive threshold was measured weekly using the paw-pressure test. Evaluation of soil bacterial biomass using environmental DNA extracted by slow-stirring method. Alterations of glucose homeostasis are observed including postabsorptive hyperglycemia concomitant with increased hepatic glucose production and hyperinsulinemia. This literature review is also addressed to researchers to provide ideas for further studies in this area. Germ cell development in embryos was studied using a strategy that allowed simultaneous labeling of pole cells with the determination of embryonic genotype. Anti-IFN-gamma, administered with RANTES, decreased the effects of RANTES on AHR after repeated challenge. While exposure to cat allergen during infancy is associated with sensitization (IgE), only in the very highly exposed children the likelihood of sensitization (IgE) is decreased and high IgG levels to cat without IgE were associated with low risk of wheeze. In contrast, alpha/beta ratios of CAFC day-6 and day-12 were relatively high (above 6 Gy) and are consistent with values obtained from acute marrow failure.

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Five residents have completed the 4-year residency program with enhanced obstetric training developed, and the results, in terms of procedural experience and examination scores, have been reviewed. Mutagenic activity and chemical analysis of airborne particulates collected in Pisa (Italy). A second-order nonlinear optical material prepared through in situ hydrothermal ligand synthesis. The results showed that in vitro or in vivo treatment of lymphocytes with galangin suppressed the induction of chromosome aberrations by bleomycin in a galangin dose-dependent manner. Confluent white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) appear to represent asymptomatic cerebral SVD. In the future, stereotactic craniotomy may facilitate aggressive surgical therapy for infectious aneurysms previously thought not suitable for direct operative approach. Interferon caused alterations of human cell response to bleomycin in vitro. Leishmania donovani flagellum-specific epitopes mediating host-parasite interactions.

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Fourier analysis and spatial representation in the visual cortex. Significant differences in electrophoretic karyotyping patterns were found among 27 strains of Y. These data indicate that the mxaAKL region is relatively highly conserved in methanotrophs, and that in most cases the mxaAKL genes are grouped together in the same order as in the facultative methanol utilizer Methylobacterium extorquens AM1. Some electrophysiological consequences of electrogenic sodium and potassium transport in cardiac muscle: a theoretical study. CYP2E1 mRNA expression was greatest in the oral epithelial cultures and detectable in all other epithelial cultures except for the HPV-18 immortalized keratinocyte cell line. The abundance of compatible Frankia strains in some areas was indicated by profuse nodulation of the host plants, whereas soil samples from other localities failed to result in nodulation.

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Reassortment of genome segments between reovirus defective interfering particles and infectious virus: construction of temperature-sensitive and attenuated viruses by rescue of mutations from DI particles. The reproductive potential of treated insects together with the biochemistry of their ovaries and testes were determined. The measurement was compared to c/b ratio obtained from normal hips. They further support a hypothesis that the increased appearance of atherogenic lipoproteins, particularly cholesterol-rich VLDL, may be associated with proteinuria and progressive glomerular injury. In all patients, DNA analysis provided additional evidence that the lymphocytosis was polyclonal, while in one patient who met all other symptomatic criteria the total lymphocyte count was normal. Extended release nicotinic acid - a novel oral agent for phosphate control. A careful history and evaluation in the Emergency Department (ED), along with liberal and timely use of ultrasonography, are critical for prompt diagnosis and treatment. We have focused our attention on human RECQ1, a DNA helicase whose cellular functions remain largely uncharacterized. Clozapine: a neuroleptic at risk of provoking neuroleptic malignant syndrome (NMS) or an alternative neuroleptic with positive NMS case histories?.

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This article reviews the types of outcome measures that have been used to document improvement in cancer pain management. Catalytic role of the amino-terminal proline in 4-oxalocrotonate tautomerase: affinity labeling and heteronuclear NMR studies. difficile in children in the age group of 5-12 yr, this age group was selected. Lmna(LCO/LCO) mice were entirely healthy, and Lmna(LCO/LCO) cells displayed normal emerin targeting and exhibited only very minimal alterations in nuclear shape and nuclear deformability. Angiotensin stimulates vascular smooth-muscle cell growth via the induction of protooncogene and autocrine growth factor gene expressions. An additional survival analysis was performed to assess the results of the sixty-nine procedures that involved isolated use of a viable allograft (twenty of the thirty-nine medial allograft procedures and forty-nine of the sixty-one lateral allograft procedures) and of the thirteen viable medial meniscal allografts that were implanted in combination with a high tibial osteotomy in patients with initial varus malalignment of the lower limb.

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The input of the somatically mutated CDR1/CDR2 and of the CDR3 into antigen binding specificity. Constriction of the suprarenal aorta, with maintenance of a normal renal perfusion pressure, did prevent the inhibition of proximal transport during carotid artery occlusion, thus excluding an extrarenally produced natriuretic hormone as the mechanism. Efficacy of postoperative pain treatment regimens using both buprenorphine and papaveretum sequentially after abdominal hysterectomy. The biologic half-life of methionine in rat tracheal epithelium in vivo and in vitro was about 5 days. Repeated (four or 11 times) administration in vivo (during 5 or 18 days) of rapamycin at suboptimal doses (0.5-2.0 mg/kg/day) failed to eliminate the capacities to exhibit MLR as well as to generate CTL responses. An increase in intracellular Pi reduces sarcoplasmic reticular calcium loading and thus depresses the CICR. It occurs most commonly in young adult women who either are immigrants from areas where tuberculous is endemic or have histories of travel that are suggestive of exposure to Mycobacterium tuberculosis. Antifungal and/or zebeta medication brand anti-anaerobic treatment should also be considered. Recordings of nasal mucosa congestion were made with rhinostereometry. These results suggest that nonreferral for dialysis occurs in Ontario and that the act of referral, or nonreferral as the case may be, is influenced by both age and coexisting disease.

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A responsible gene of genetically obese (ob/ob) mouse has recently been isolated. The 26 members of the National Consensus Group on Clinical Skills in Emergency Medicine affiliated with an EM residency program were asked to circulate a survey to their residents during February and March 1994. CoCl2 was used as chemical hypoxia-inducing reagent to mimic tumor hypoxic microenvironment. These models could assist clinical decision-making on axillary node dissection and give guidance to pathologists on numbers of tissue sections to norvasc medication 10 mg examine. Cells transfected with the 48EF49 construct exhibited slowed growth when compared to parental AX3 cells and other GFP-NumA1 deletion mutants.

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Persistent limb atrophy in association with a giant congenital melanocytic nevus is described. A similar result was found for the ratio of brain to kidney mercury. Dynamics of aquaporins and water relations during hypocotyl elongation in Ricinus communis L. A differential scanning calorimeter technique was used to generate experimental data for volumetric shrinkage during cooling at 20 degrees C/min in adipose derived adult stem cells (ASCs) in the atenolol side effects 25 mg presence and absence of cryoprotective agents (CPAs). All 3 are: firstborn girls, tall and very thin with blue-green eyes. Evaluation of the cost of laparoscopic and open cholecystectomy. On condensation products of alpha-hydroxyalkyl-acylsulfides and secondary amines.

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Cloning and sequencing revealed that dMax contains a deletion spanning the basic region and helix 1 and the loop of the helix-loop-helix region, presumably as a result of alternative splicing of max RNA. Effect of plasmapheresis (PP), corticosteroids and cyclophosphamide in essential mixed polyclonal cryoglobulinaemia associated with glomerulonephritis. A recent case of mixed uterine and colic perforations associated with generalized peritonitis is reported, the lesions developing within the context of the digestive complications of the method known as aspiration for voluntary interruption of pregnancy. The majority of the pericytes were accompanied with the vessels in the claritin d generic name tumor. Our data, therefore, reveal both age-dependent and age-independent responses to UV-induced DNA damage. However, new therapies have been proposed that overcome this limitation of prodrug therapy. The aim of this study was to provide a comprehensive view of the impact on transplantation of pretransplant modality of treatment of ESRD using a multivariate analysis of the French database. These results demonstrate the complexity of proteolipid protein function in myelination. In addition, all positive HPV DNA PCR samples were further analyzed for genotyping of HPV genotype 16, 18 and 33.

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The clinical pilot study entailed the treatment of five children with advanced neuroblastoma using a combination of 131I metaiodobenzylguanidine (mIBG) and total body irradiation followed by bone marrow rescue. The results suggest that the actions of modulatory agents and second messengers on this neuron, and presumably other neurons, cannot be understood on the basis of their direct effects alone. The presence of a NADPH-generating system and the treatment of S2 with CO do not modify S2 activation of NOP. Visual cortex damage-induced growth of retinal axons into the lateral posterior nucleus of the cat. PPARdelta enhances fatty acid catabolism and energy uncoupling in adipose tissue and muscle, and it suppresses macrophage-derived inflammation.

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Relationship between amitriptyline metabolism and polymorphic debrisoquine hydroxylation in native Chinese volunteers. After removal of the DNA using nucleases and high salt extraction, the RNA of the EGF-receptor appears to be associated with the nuclear matrix. The observed substantial decrease in plasma concentrations and effects of midazolam most likely results from induction of CYP3A4 by rifampin in both the gut wall and the liver. Reversed phase ion-pair chromatography (RP-IPC) of seven heterocyclic aromatic amines encompassing quinoline (IQ, MeIQ), quinoxaline (MeIQx), pyridine (PhIP) and carboline derivatives (AalphaC, Harman, Norharman) was carried out with formate as counter ion in an aqueous eluent with acetonitrile as organic modifier. As the catecholamines have long been implicated in attentional processes, the present investigation compared the effects of the mixed alpha 1/alpha 2 adrenoceptor agonist clonidine (CLO), the benzodiazepine diazepam (DZP), the D1/D2 antagonist haloperidol (HAL) and a low-tryptophan drink (Lo-TRP) on performance of tests of selective attention with distractors in four groups of young, healthy volunteers. The observations indicate that calcium ions are able to reverse the cardiodepression induced by chloroquine and quinine.

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The number of microorganisms removed after washing was less than the amount remaining on the surfaces. Moreover, chemoenzymatic strategies were developed to rationally engineer nonribosomal peptides products in order to increase or alter their bioactivities. We conclude that amelogenin and ameloblastin expression is enamel-specific, and suggest that these genes might be involved in the mineralization of enamel. We suggest that the wild-type unc-86 and lin-4 genes act to modify latent reiterative cell lineages, which are revealed when the activity of one of these genes is eliminated. Owing to its inconstancy, lumbar hyperlordosis cannot be considered as responsible for the mildness of the osteophyte formation in osteoporotic patients. Following splenectomy on day 297, parasitemia recurred in all animals, reaching levels of 1.9 x 10(5) to 2.7 x 10(6) organisms/mm3, and was associated with a moderately severe hemolytic anemia. The subunits of NF-kappa B, NFKB1 (formerly p50) and RelA (formerly p65), belong to a growing family of transcription factors that share extensive similarity to the c-rel proto-oncogene product. Such species yielded almost no sequence information under low-energy collision conditions, due to the localization of the ionizing protons on highly basic sites rather than on the peptide backbone. Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress.

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In addition, affective and anxiety comorbidity associated make it difficult the diagnosis. Eradication of Myc-overexpressing small cell lung cancer cells transfected with herpes simplex virus thymidine kinase gene containing Myc-Max response elements. Apparently, the effects of temperature shifts occurred at the level of reversible covalent enzymatic modifications. Neuropsychological assessment outcomes of nonacquired immunodeficiency syndrome patients with primary central nervous system lymphoma before and after blood-brain barrier disruption chemotherapy. A prospective, randomized, double-blind, placebo-controlled trial was undertaken to test the safety and efficacy of pilocarpine, particularly in reversing the decrease what antibiotic does not interact with methotrexate in the production of saliva and other manifestations of xerostomia.

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Hydrostatic pressure caused cell rounding (but not cell death), disruption of microtubules, collapse of intermediate filaments to a perinuclear location, collapse of actin stress fibers into globular aggregates in the cytoplasm, and the formation of several cardizem cd cost large elongated intranuclear actin inclusions. After LPS treatment, increased protein levels of IL-1beta, IL-6, IL-8, IL-10, TNF-alpha and MCP-1 were observed in the culture medium from the lesions measured with cytometric bead array. There are more complications during pregnancy without increased risks of graft lose. The interconnections between the metabolism of riboflavin and amino acids containing sulfur and tryptophan. Clinically stable inpatients in the Department of Internal Medicine, Department of Visceral Surgery and Department of Orthopaedics were included in the cross-sectional study. Ammonium sulfate has different effects on catalytic activities of different enzymes and shows protection on all enzymes studied during denaturation by guanidine hydrochloride. The positive diagnosis was much facilitated by the association with acneiform dermic tuberculids at face, intense and positive local reaction to PPD and a favourable therapeutic response to tuberculostatics. Thus, different concentrations of methyl jasmonate were required for induction of changes in the oxylipin pathway. The issue is more acute for countries where the cases of anthrax are often registered.

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