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Trolec (Calcitriol)
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Trolec

Trolec is a synthetic physiologically-active analog of vitamin D, specifically the vitamin D3 form. Trolec regulates calcium in vivo by promoting absorption in the intestine, reabsorption in the kidneys, and, along with parathyroid hormone, regulation of bone growth. Trolec receptor-binding protein appears to exist in the mucosa of human intestine.

Other names for this medication:
Actical, Admax, Alfarich, Alphadol, Arachitol, Aristrol, Biocitral, Calasto, Calbec, Calbory, Calbovic, Calcigra, Calcikind, Calcimet, Calcor, Calday, Calgel, Calosto, Calsonic, Calvical, Carcal, Cholical, Citroj, Denscal, Devita, Dmcal, Duracal, Estovon, Ikmag, Koncal, Lctrol, Netxod, Ostriol, Primacal, Qpcal, Refirm, Rolsical, Romical, Septriol, Solbiocal, Statbone, Sunmic, Vezocal, Vitalpha

Similar Products:
Dilantin, Maxalt, Trandate, Aristocort, Sustiva, Retin, Cytoxan, Nolvadex

Also known as: Calcitriol

Description

Generic Trolec is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Trolec are intestine and bone. Generic Trolec receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Trolec may also act on the kidney and the parathyroid glands. Generic Trolec is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Trolec has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Trolec, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Trolec in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Trolec produces other independent beneficial effects. Trolec is also known as Calcitriol. Generic Trolec treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Trolec is Calcitriol. Brand name of Generic Trolec is Trolec.

Dosage

Generic Trolec is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Trolec suddenly.

Overdose

If you overdose Generic Trolec and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Trolec are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

If you are taking a dietary supplement without a prescription, carefully read and follow any precautions on the label. For these supplements, the following should be considered:

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Temporal stability as a moderator of relationships in the Theory of Planned Behaviour. Substance P in human cord blood and its degradation by placenta in vitro. Antibiotic-resistance patterns of Helicobacter pylori in Croatia: cohort study. We conclude that focus groups are an effective method of conducting exploratory research with adults with learning disabilities in the community, however, ability to participate with other members may be a limiting factor. Complex peroxisomes in the mouse preputial gland: serial sectioning and three-dimensional reconstruction studies. Our results demonstrated that decreased expression of PTEN correlated with poor overall survival in NSCLC patients and was indicative of a poor prognosis for disease-free survival and progression-free survival in patients with NSCLC. To investigate this further, DBA/2 mice were pretreated with porcine ACTH left undisturbed for 3 days, then challenged with morphine. Combining CEA and beta 2 microglobulin assays would enhance their usefulness in current practice. Prompt diagnosis and treatment are important because this disease can be associated with considerable morbidity and simple effective treatment is easily available.

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Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling. Relaxed synthesis of ribosomal RNA by a stringent strain of Escherichia coli. Left ventricular velocity of fiber shortening was elevated during the administration of dobutamine and dopamine when compared with measurements obtained with nitroprusside at the same left ventricular end-systolic circumferential wall stress. Administration of the pituitary hormone alpha-melanocyte-stimulating hormone (alpha-MSH) to mice was found to inhibit a number of IL-1 and TNF-inducible biologic responses in situ. The structures are poorly conserved even among the Apidae , suggesting little cross-reactivity among the protein portions. GLUT-5 is also found to be associated with the brush border of epithelial cells from fetal and normal adult human small intestine, but is absent from the colon. The PA63-LF/EF complex is internalized into the cytosol and causes different pathogenic responses in animals and cultured cells. An animal model for screening topical and systemic drugs for potential use in the treatment of psoriasis. Emerging research points to innate immune mechanisms in the neuropathological and behavioral consequences of heavy alcohol use.

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Influence of ataxia telangiectasia gene dosage on bleomycin-induced chromosome breakage and inhibition of replication in human lymphoblastoid cell lines. A multicenter, fixed-flexible dose study of terazosin hydrochloride in the treatment of symptomatic benign prostatic hypertrophy. Trypsin/creatinine clearance ratio--a recently proposed screening test for pancreatic cancer--was assessed in 45 subjects (17 control subjects, 15 patients with pancreatic cancer, and 13 with chronic pancreatitis). Detailed studies of this complex interaction have placed mechanistic aspects of hormone action on a firm biochemical basis and permitted development of a number of receptor-based diagnostic and prognostic tests that are now in routine clinical use. To give useful insight into the impact of mid-spatial frequency structure on optical performance, the Strehl ratio is shown to correspond to the Fourier transform of a simple statistical characterization of the aberration in the exit pupil. Following the theoretical section (Sections I to V), Section VI will focus on practical control of staling. 31 observations of such tumours are described, which appeared 4 to 56 years after radiotherapy. Clonal dissemination of epidemic methicillin-resistant Staphylococcus aureus in Belgium and neighboring countries. The neurotoxic heme is usually detoxified by the constitutive heme oxygenase-2 (HO-2) and its inducible isoform HO-1(heat shock protein 32) resulting in the formation of biliverdin which becomes reduced to bilirubin, carbon monoxide (CO), and iron. This hypothesis is supported by studies of tracheae in other arthropods.

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Furthermore, rejection of the K1735-melanoma expressing MHC class I and II molecules was mediated by adoptively transferred H-2b anti-k CTL from immunized granzyme A and/or B-deficient mice. Taken together, these data show that JNK activation provides a molecular linkage from microtubule damages to the mitochondrial apoptotic machinery and also point to a pivotal role for the JNK/Bcl-2/PP1 complex in the control of apoptosis following paclitaxel treatment. Evaluation of suppressor immune regulatory function in idiopathic congestive cardiomyopathy and rheumatic heart disease. The aim of this project was to identify medication omissions and develop and implement strategies to reduce medication omissions in the targeted medical unit in compliance with best practice. Microsaccades aid vision by helping to strategically sample visual scenes. The consistent finding of the rlf-L-myc rearrangement in SCLC suggests that it may provide a selective advantage to the cells harboring it. Staphylococcus aureus grew in both cases and was sensitive to treatment with methicillin sodium. Inhibition of hBD-3, but not hBD-1 and hBD-2, mRNA expression by corticosteroids. Mobilization of the P family of transposable elements in Drosophila melanogaster occurs in the hybrid progeny of males from an element-bearing strain (P strain) and females from an element-free strain (M strain).

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Histological description of tumors developing in nude mice upon the administration of those cell lines to them has demonstrated that they correspond to human tumor strains they were derived from. Bone-specific delivery and sustained release of diclofenac, a non-steroidal anti-inflammatory drug, via bisphosphonic prodrug based on the Osteotropic Drug Delivery System (ODDS). Significance of multiple biopsies using the fiber bronchoscope in the morphological diagnosis of central cancer of the lung. It proved a valuable method for following serial changes in renal histology and can therefore be applied to the study of both spontaneous and experimental renal diseases in pigs. One of the most commonly utilized drug classes today is antidepressant therapy, which accounts for billions of dollars in spending.

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After a 7-day exposure to TPA, most of the cells became smaller and reminiscent of large or atypical lymphocytes. Hepatic arterial collaterals in Ivalon embolization of the hepatic artery. Alterations at the carboxyl terminus change assembly and secretion properties of the B subunit of Escherichia coli heat-labile enterotoxin. The fraction of the total thymidine uptake that was incorporated into DNA was reduced in the presence of 100 and 200 mM ethanol. Gamma-D-glutamylaminomethyl sulfonic acid (GAMS) distinguishes subtypes of glutamate receptor in the chick cochlear nucleus (nuc. The BCW provides a useful framework for integrating sources of evidence to inform intervention content and deciding which influences on behaviour to target. Total prevention of Rh hemolytic disease: possible or impossible?. Study data were compared among four groups: fetuses with normal uterofetoplacental Doppler values and those with any abnormal pulsatility index, each subdivided into small for gestational age (SGA) and appropriate for gestational age (AGA) by estimated fetal weight. DNA topoisomerases are enzymes that are able to link and unlink DNA strands.

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Preventable illness and out-of-area travel of children in New York counties. Through a series of experiments it was shown that these changes are unlikely to be non-specific consequences of training, but more probably reflect some aspect of the storage process. In 12 patients localisation of the parathyroid tumor was achieved pre-operatively. Neurological soft signs and cognitive functions: Amongst euthymic bipolar I disorder cases, non-affected first degree relatives and healthy controls. We also detected the products of two other new genes that we have named trbA and trbB. Participants included adolescents aged 12-16 years who participated in the National Health and Nutrition Examination Survey (NHANES) III. To evaluate the feasibility of percutaneous aortic valve replacement without cardiac arrest in animal experiments. The Self-Specific Activation Receptor SLAM Family Is Critical for NK Cell Education. When subjected to the stray field of a magnetized material, the mobile parts of the cantilevers deviate from their initial positions, which locally changes the light reflectivity on the magneto-optical surface, thus allowing to visualize the field lines.

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In SIP without microorganism isolation the use of a score system can be of utility in the taking of decisions. The decrease in total cerebellar RNA synthesis was reflected both in a reduced amount of Nissl substance, visible in cresyl violet-stained 10-micron-thick sections of cerebella, and in the total amount of cytoplasmic RNA isolated from individual cerebella from diseased animals compared with control littermates. Genomic insertion of human papillomavirus (HPV) sequences is associated with the genesis of cervical carcinoma, and HPV-induced incipient cellular alterations may also present a requisite for the establishment of cell lines such as HeLa. Consecutive genital specimens obtained at 6-month intervals were screened for HPV-33 and -35 by use of MY09-MY11. The recently published Heart Outcomes Prevention Evaluation trial (HOPE-3) demonstrated no benefit of lowering blood pressure with candesartan and hydrochlorothiazide in persons at intermediate cardiovascular risk and with adequate blood pressure control as determined by the enrolling physician.

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Interactions with the other troponin subunits and biological activity. The authors also discuss the present status of the possible indications, contraindications, advantages, disadvantages and future indications for its use. The pertinent anatomical zebeta medication 5 mg and physiological factors in the aetiology of compression neuropathy of the ulnar nerve have been summarized. Selective targeting of the injury location, behavioral testing, and the agents chosen to induce WM injury are all keys to successfully develop a mouse model and subsequent testing of therapeutic interventions against WM injury. Simplifying assumptions of the IgE-mediated skin reaction is the essence of the model. Pioneer in studies of juvenile headaches: William Henry Day (1830-1907). Early and late effects of wound healing on development of colon tumours in a model of colon carcinogenesis by 1,2-dimethylhydrazine in the rat. These methods are useful to investigate various chromosome polymorphisms, including B and sex chromosomes, as well as chromosomal duplications and deletions.

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Estimation of local diffusion of pollutants from a chimney: a prototype study employing an activated tracer. Role of the ophthalmologist in schools for the visually handicapped. To assess patient satisfaction, subjective long-term continence and complications after AMS 800 artificial urinary sphincter implantation. The proapoptotic effect of lauryl gallate is not dependent on DNA or protein synthesis, is not blocked by the chelation of calcium, and is not reverted by N-acetylcysteine. In a population of diverse races and ethnicities, expanded carrier screening may increase the detection of carrier status for a variety of potentially serious genetic conditions compared with current recommendations from professional societies. LCV forms predominated over the next 4 days, during which exponential growth was observed. In all cases, conventional X-rays, multidirectional tomography and contrast CT were nonconclusive. The proteolytically released SSB protein resisted elution from an ss DNA-cellulose column with 1 M NaCl. Intravenous phytate prevents aggressive CVC induced by vitamin D in rats.

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Chemotherapy of liver metastases is dependent on adequacy of tumor microcirculation. The effect of methandrostenolone on nitrogen excretion following open-heart surgery. The authors present a case of injury to the 4th lumbar root secondary to a gunshot wound. These results suggest that inorganic dust inhalation primes lung inflammatory cells in vivo and markedly enhances their capacity to release phenergan dosage in dogs toxic oxygen radicals. Parameters of effective test classification showed the PTSD measures to be helpful in correct identification of this disorder for the older groups. In the second study, adult ovariectomized rats received daily injection of dihydrotestosterone (DHT), nonaromatizable testosterone, at a dose of 2 mg/rat for 21 days. The pioneer of regional analgesia for pain relief in childbirth. Elimination of Topical Antibiotics for Intravitreous Injections and the Importance of Using Povidone-Iodine: Update From the Diabetic Retinopathy Clinical Research Network. In particular, few studies have highlighted the demographic and clinical predictors of response to surgical treatment. Treatment of the ribosomes and RNA fractions with ribonuclease destroyed their ability to stimulate the production of the helper factor in serum of treated mice.

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The use of this type of reversed-phase HPLC system for timolol determinations results in improved quality of chromatography, especially in terms of peak tailing and peak efficiency, in comparison to chromatography on bonded-phase silica. Comparisons could not be made with confidence concerning PGF either in uterine veins on days 14 and 15 or in ovarian veins on all days due to limited number of observations. OTA induced high levels of reactive oxygen species (ROS) and elevated levels of malondialdehyde, also loss of mitochondrial membrane potential was observed in a dose depended manner. Based on discovery of the hedgehog (Hh) signaling pathway and its role in the pathogenesis of BCCs, hytrin 10 mg smoothened (SMO) inhibitors have been developed with Sonidegib being the 2nd in class. These animals have deposits immunoreactive with anti-beta antibodies, but do not have X-34 deposits or deposits with a fibrillar ultrastructure. Anaerobic oxidation of amino acids by excited riboflavine derivatives. This together with some taxonomical discrepancies between methodologies suggest that the PGM platform is still pre-mature for its use in food traceability of complex highly processed products. To confirm such an interaction, spectroscopic imaging analyses (i.e., nanosecond fluorescence lifetime imaging and second harmonic generation light imaging) were performed in addition to biochemical and electron microscopic analyses in the present study.

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Method for purification of an insulin-like growth factor-binding protein produced by human HEP G2 hepatoma cells. Electron microscopic examination revealed few virus-like particles around virus inclusion bodies (VIB) in wild-type virus-infected cells and cytoskeletons. Increased cell surface expression of receptors for transforming growth factor-beta on osteoblasts from patients with Osteogenesis imperfecta. The focus is also on multistable multinuclear spin crossover compounds which are the subject of lively discussions within the spin crossover community. The caveolae membrane fraction of mesangial cells was isolated by sucrose gradient method and expression of PDGF receptor and TGF-beta receptor were detected by immunoblotting. As all the patients were operated upon, we were able to define diagnostic accuracy (DA) of CT in zyprexa dose adult determining the upper pole of the tumour, position of the tumour, invasion of trachea and bronchi, aorta, left auricle, vertebral column, pleura, pericardium and also abdominal invasion or thoracic lymph node. In the latter, tyrosine hydroxylase labeling was observed in some Fos-positive cells in the nucleus tractus solitarius and ventrolateral medulla. This peptide with structural homology to somatostatin was first isolated from the urophysis of fish and was recently found to bind to an orphan receptor in mouse and human.

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The substrate (AMP) and co-factor (ATP)-dependent kinetic parameters of AMP-deaminase have been studied in the contralateral and denervated gastrocnemius muscles of frog, Rana hexadactyla. Patient 1 was treated for 17 months and remains well after 10 months without therapy. It offers a new and better understanding of hemodynamics and angioarchitecture in the endovascular management of VGM. Infrared spectroscopic studies of solvent-induced conformational changes in globular proteins. Human dermal microvascular endothelial cells in vitro: effect of cyclic AMP on cellular morphology and proliferation rate. Five patients with extremity tumors (four soft-tissue tumors and one osteogenic tumor) were studied. Similar studies in myocytes and nerve cell bodies are now being pursued. Annual consultation rates (per 1000 patients) according to psychiatric disorder and sociodemographic factors were calculated after adjustment for differing length of follow-up.

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Structure of the mouse 5-HT1C, 5-HT2 and stomach fundus serotonin receptor genes. Related to capacity of saliva secretion from the control group, no significant difference was observed between both groups. We studied sixty hypertensive patients, grouped according to the Joint National Committee stages of hypertension. Neuroendocrine regulation of cyclic AMP formation in osteoblastic cell lines (UMR-106-01, ROS 17/2.8, MC3T3-E1, and Saos-2) and primary bone cells. Western immunoblot and radioimmunoprecipitation assays suggested that all the MAbs recognize conformational epitopes on the virion surface. Because of the increase of laser applications in the treatment of laryngeal carcinoma, similar complications may be encountered.

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It would also address a huge unmet need for men who want to control their fertility. These endothelial changes were sharply delineated by the margins of the elastic tears. In contrast, the amplitude of the Sol-H-reflex increased in the middle extension phase. Multidrug resistance of cancer cells and pathogens is a serious clinical problem. Discrimination of genetic sex in embryos of d-rR strain of the medaka (Oryzias latipes). Photolysis of bromodeoxyuridine-substituted DNA is shown to be the main process determining the quality of differential staining under certain experimental conditions. Highly aligned multiwall carbon nanotubes (MWCNT) as fiber were modified with a conducting polymer via a simple dip coating method. In addition, the L2 portion of the HPV-6 L2-beta-galactosidase fusion protein appeared particularly immunogenic, since antibodies raised against this fusion protein were predominantly reactive with the L2 moiety. Deformation and displacement of the mitotic spindle during centrifugation of live cells block mitosis. CT examinations with conventional CT scanners are often performed with unnecessarily high radiation dose.

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To examine whether the foreign DNA can replicate, a plasmid containing a polyoma origin of replication was injected into newborn mice. Dental pulp cavity antisepsis: significance of a revived classic formula. The effects of intra-osseous dental anaesthesia on heart rate and blood pressure was examined in 17 healthy volunteers. Animal experiments have revealed much about location, mode and mechanism of action of oestrogens on the brain. Studies of the nutritional and immunologic composition of milk produced by women who delivered term or premature infants and who weaned their infants gradually from human milk have been studied to identify optimal donors. In this description of metaplasticity in the spinal dorsal horn, we report that a 50 Hz high-frequency tetanus, previously shown to elicit a potentiation of sciatic-evoked A-fiber spinal dorsal horn potentials, caused a depression when coupled with a more rapid rate of repetitive stimulation.

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As data for osteoporotic acetabular fractures are limited, we compared primary total hip replacement (THR) with ORIF for treating osteoporotic acetabular fractures, including those with posterior column instability. The operations included 3 main options: cranialization, obliteration or reconstruction of the frontal sinus. Characteristics of membrane transport losses during reticulocyte maturation. For a comparison of the kinetics of the cytotoxicity of dihydro-5-azacytidine hydrochloride (DHAzaCR) and 5-azacytidine (AzaCR) in L1210 leukemia, the spleen colony assay was used to determine the surviving fraction of normal hematopoietic colony-forming units (NCFU) and leukemia colony-forming units (LCFU). The augmented adherence was dose-, time-, and temperature-related and demonstrated kinetics characteristic of the adherence of single cells with increased affinity for monolayer cultures.

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