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Tofranil

Tofranil is used to treat depression. Tofranil belongs to a group of medicines known as tricyclic antidepressants (TCA). These medicines are thought to work by increasing the activity of a chemical called serotonin in the brain. This medicine is available only with your doctor's prescription.

Other names for this medication:
Antidep, Anxitab, Anxofit, Depforte, Depik, Depnil, Depof, Depranil, Deprid, Depsan, Depsin, Depsodep, Depsonil, Diamin, Diazariv, Elamin, Eldep, Elidep, Finezol, Imilor, Iminza, Imipra, Imipramine, Impramine, Impranit, Imprax, Imprim, Karthin, Lastinem, Libomin, Microdep, Prazep, Talendep, Toframine, Trydep

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Also known as: Imipramine

Description

Tofranil is a tricyclic antidepressant used to treat symptoms of depression. This medicine is sometimes used to treat bed-wetting in children ages 6 and older.

Dosage

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Tell your doctor if you have a planned surgery.

Call your doctor if your symptoms do not improve, or if they get worse.

You should not stop using Tofranil suddenly. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

Detailed Tofranil dosage information

Overdose

If you overdose Generic Tofranil and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Tofranil overdosage: agitation, bluish skin, convulsions, difficulty breathing, dilated pupils, drowsiness, heart failure, high fever, involuntary writhing or jerky movements, irregular or rapid heartbeat, lack of coordination, low blood pressure, overactive reflexes, restlessness, rigid muscles, shock, stupor, sweating, vomiting.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Tofranil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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The effect of IL-1ra on protein metabolism was examined in individual muscles (gastrocnemius, soleus, heart) containing different fiber types. Forty-one cases of chondrosarcoma from varying sites throughout the body, and treated exclusively by one of the authors (R.L.H.) from 1972 to 1990 were reviewed. Influence of the inflammation of subcutaneous tissue and sensitization on the distribution of Sr-90 in the body. Volume loading with hypertonic saline solution: endocrinologic and circulatory responses. The elastin increase was greater in C3H/HeJ than in C3H/HeN mice. Inactivation of G1 cyclin-CDK inhibitors by mitogenic growth factors may be one biochemical pathway underlying cell cycle commitment at the restriction point in G1. 4 In vitro experiments using sera from twenty-three healthy volunteers showed significant negative correlations (P less than 0.01) between age and percentage free haloperidol.

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This study aimed to evaluate magnetic resonance (MR) imaging appearances of 11 gastrointestinal stromal tumors in the abdomen and pelvis and compared them with some histological findings. However, tissue reactions induced by entrapped composite resin particles have not been thoroughly examined. Effect of treatment on liver function disturbance in patients with acute cholecystitis. The resulting guidelines, originally intended for our house staff, are presented here. The increase in the level of ROS, by addition of increasing X concentrations, did not enhance this effect proportionally. Changes in the activities of both kinases that are stable, i.e., not caused directly by allosteric effectors, correlate inversely with the changes in the activity states of the complexes that occur in different nutritional states. Our work provides insight into the evolution and distribution of SSRs in the two sequenced model plant genomes of monocots and dicots. We compare this mutation to a previously reported mutation in the amelogenin gene that causes a different disease phenotype. Moreover, the hydrophobic aminoxyls were more effective in preventing protein than lipid oxidation at low concentrations (1-20 microM).

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Excessive weight gain after pregnancy in urban areas: one important area to prevent diabetes. Moreover, we studied the effect of haploinsufficiency of the NCC determinant gene Sox9 in the NCC derived PF suture complex. The addition of 25 microg/kg butorphanol to bupivacaine resulted in superior analgesia with a longer period compared with caudal bupivacaine and butorphanol alone, without an increase of side effects. Continued fraction approximants are obtained from equivalent power series expansions of the change in quantum yield in terms of the fluorescent lifetimes or the steady-state fluorescence. monocytogenes surface protein, internalin, with its human receptor, E-cadherin. Liver damage markers like amino-acid transferases and alkaline phosphatase, oxidative damage markers indicating extent of lipid peroxidation, host antioxidant reserve indicators like reduced glutathione (GSH) and total thiol levels, GSH-dependent enzyme activities viz., glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase (GR) superoxide dismutase (SOD) and catalase (CAT) were measured by spectrophotometric techniques in four different groups namely (1) control, (2) black tea extract, (3) pesticide alone and (4) pretreatment with black tea extract followed by pesticide treatment. Therefore, our studies have shown that the regulatory mechanism that modulates the expression of alpha 2-MG mRNA in the rat testis is different from its counterpart in the brain and liver. Mole ratios of the neurohypophysial hormones in the vertebrate neural lobe. Early detection of major complications after abdominal aortic surgery: predictive value of sigmoid colon and gastric intramucosal pH monitoring.

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Teaching principles of cardiovascular function in a medical student laboratory. No significant alternations of the skin blood flow between normal controls and patients with progressive systemic sclerosis after linear polarized light irradiation were detected. Best results can be obtained with prompt surgical intervention, total removal of all prosthetic material and lower extremity revascularization by means of extra-anatomic bypass. IL-1 has no direct role in the IGF-1 non-responsive state during experimentally induced arthritis in mouse knee joints. A new algorithm for distorted fingerprints matching based on normalized fuzzy similarity measure.

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All newborn screening programs must exist within the limitations of their local environment in this regard. The firing of many cells within the PAG correlates with vocalization. Although the functional significance of tryptophan catabolism to trypanosomatids remains obscure, the pathway is quantitatively significant in all species examined thus far. In this report we discuss a patient with predominant right heart failure and pulmonary hypertension, caused by thyrotoxicosis due to Graves disease, which deteriorated to asystole, due to amiodarone administration for rapid atrial fibrillation. Fluorescent foci of infection were observed and counted using a fluorescence microscope, and viral titers were calculated as fluorescent focus units (FFU) per ml. Pseudomonas paucimobilis was isolated from blood of a man after surgery for occlusive vascular disease of his lower extremities. These proteins were not absorbed from distilled water (except peroxidase).

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Even where tumor cells were juxtaposed to bone surface, small and flat TRAPase-positive cells were shown to exist on the bone surface. Evaluation and management of the patient with LeFort facial fractures. Two methods of authenticating past criminal conduct by psychiatric inpatients: a comparison of clinical chart reports and criminal records. Ovarian hyperthecosis: in vivo and in vitro correlations of the androgen profile. Mechanical ventilation with different VTs causes consistent changes in histopathology, cell apoptosis and caspase-3 expression in rats, which support the presumption that cell apoptosis plays an important role in the pathogenesis of high VT ventilation-induced lung injury. Holmium: yttrium-aluminum-garnet laser for endoscopic lithotripsy. Our results indicate the involvement of estrogen in regulating p38 MAPK activity in endometrial cells, suggesting a nongenomic action of estrogen through this MAPK in the endometrium. A Chlamydomonas genomic library in yeast artificial chromosomes. In 13 patients, a liver biopsy was performed, always showing signs of chronic hepatitis, whose magnitude was higher in those with positive antibodies. We then introduce a well-collimated, higher intensity light source.

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A total of 118 unrelated postransplant kidney patients were enrolled into the study. Subsequent scintigram revealed abnormally high RI uptake in the whole liver and a hot spot in the middle antero-inferior segment of liver, which may be characteristic for such a condition. Bovine thyroglobulin bound to toxin A and inhibited its binding to the purified receptor. Studies employing other proteins, including human and bovine serum albumin, human lactoferrin, and rat ferritin, had no inhibitory effect on soluble receptors concentration, thus confirming the specificity of the findings. The patient was treated with cemented total hip arthroplasty and cancellous bone grafting of the central dome defect for stable cup fixation. Other vaccine formats also in development include attenuated live or replication-incompetent HSV-2 strains and technologies that target virus-specific CD8 T-cell responses. The yolk platelets of mature eggs and young embryonic cells of all amphibian species studied (Rana pipiens, Triturus cardizem cd 240 mg pyrrhogaster, Diemictylus viridescens, Rana nigromaculata, and Bufo vulgaris) have a superficial layer of fine particles or fibrils (ca.

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3D and 4D NOESY experiments were then used to determine the secondary structure and global fold of Acanthamoeba profilin I. The results were discussed in relation to those of other workers. Peripheral blood lymphocytes were collected from the same donor at seven different time points during a 10-month period and tested for their proliferative responses against whole human S-antigen and 40 overlapping peptides derived from the sequence of this uveitogenic retinal protein. We studied 26 children with congenital hepatic fibrosis during the period 1971-1993. A survey of USC/RMH Family xanax 0 5 mg Medicine alumni indicated that a large proportion have remained in South Carolina, providing primary care especially in small towns and rural areas.

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Functional and structural characterization of the minimal Sec translocase of the hyperthermophile Thermotoga maritima. Zidovudine side effects as reported by black, Hispanic, and white/non-Hispanic patients with early HIV disease: combined analysis of two multicenter placebo-controlled trials. Albumin and transferrin synthesis are increased in H4 cells by danocrine dosage serum from analbuminemic or nephrotic rats. In addition, cortex was isolated from normal and diseased glomeruli to determine if mRNA levels altered with disease. This paper demonstrates the hydrophilic polymers (mainly based on hydroxyethyl methacrylate) as a tool of cell biology. Mechanistic and practical implications of the results are discussed. After 3 to 4 weeks of intensified insulin therapy, insulin-mediated glucose uptake by the liver significantly increased while peripheral glucose disposal did not change. Although visual acuity is unaffected, ensuring that the INR for these patients remains in the therapeutic range may be important to help prevent secondary systemic thrombotic and embolic disease. The main issue is whether the stroma component is a true sarcoma or a benign reactive lesion. An artificial riboflavin receptor prepared by a template analogue imprinting strategy.

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Our results show clearly that monitoring procedures are required to verify that the cultured cells are abnormal, particularly after passage. However, unlike tumor invasion, trophoblast invasion of the uterus is under strict control. The aim of this study was to evaluate the fluoride release from aged resin composites containing different types of fluoridated glass filler into both deionized distilled water and lactic acid solution. In the isolated rabbit trachea, electrical field stimulation (EFS) induced contraction that was inhibited by atropine or tetrodotoxin. During apoptosis, K18 is cleaved at two sites into three fragments, one of which is specifically recognized by the monoclonal antibody, M30.

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Close attention to positioning of the patient, reduction of the fracture, placement of the guide-wire, and insertion of the nail and of the proximal and distal locking screws is mandatory. The repair of X-ray-induced DNA damage related to the proliferating cell nuclear antigen (PCNA) was characterized in human diploid fibroblasts by an indirect immunofluorescence method. Botulinum toxin A is a relatively new, noninvasive treatment option for children with cerebral palsy, providing an effective, short-term intervention to reduce spasticity. Lower dose of rhBMP-2 achieves spine fusion when combined with an osteoconductive bulking agent in non-human primates. The MMN evoked by changes in speech sounds may indicate the detection of acoustic rather than phonetic changes. Surgical ablations of telencephalon or telencephalon plus habenular nuclei (HBN) have been performed for studying anatomical connections of the telencephalo-habenulo-interpeduncular system of the goldfish. Fourteen of 25 patients with gastrinoma had proliferative, hyperplastic lesions consisting of gastrin cells in the nontumorous duodenal mucosa, similar to the gastric enterochromaffin-like cell lesions observed in chronic atrophic gastritis. A chemosensitivity test was carried out with the histoculture drug response assay method using four drugs: mitomycin C, 5-fluorouracil, doxorubicin hydrochloride (ADM), and cisplatin (CDDP). Survivors of severe neonatal respiratory illness have significant pulmonary and neurodevelopmental impairment, regardless of the treatment used. Upregulated mRNA and protein expression of HIF-1alpha, NMDAR1, GluR2, GluR3, VEGF, eNOS, nNOS, and iNOS in the retina was observed in response to hypoxia.

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RE-1 silencer of transcription/neural restrictive silencer factor (REST/NRSF), a transcriptional repressor, binds to the RE-1 element present in many vertebrate genes. The scan-field was 300 microm x 300 microm in size and consisted of six separate scan lines. The tolerability, pharmacodynamic effects, and pharmacokinetics of belimumab (LymphoStat-B) were evaluated in cynomolgus monkeys. The results indicate that, the changing pattern in the DFA index of RR interval sequence from the healthy to the morbidity is different from those of the P-wave, QRS-wave and T-wave. The colloidopexic acitvity of the viteline entoderm of the chick after hatching. Although there is high intolerance to the treatment, closely-monitored low dose escalating Interferon and/ or Ribavirin therapy achieves good results. A case of a 32-year-old woman who developed acute mitral insufficiency after percutaneous mitral dilatation is presented. The purpose of this study was to determine the robustness of ketamine-induced developmental neurotoxicity using rhesus monkey frontal cortical cultures and also to determine if dysregulation of NMDA receptor subunits promotes ketamine-induced cell death.

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Preferences regarding CPR, hospitalization, and enteral tube feedings, and individual factors associated with CPR preferences. At the N-terminal region of the protein sequences potentially able to form DNA-binding domains defined as zinc-fingers were biaxin 500 mg found. Seven laboratories of the EORTC Receptor Study Group reported the distribution of oestrogen (ER) and progesterone receptors (PR) routinely assayed in breast cancer cytosols. Structural differences of tested antigens may be responsible for a conformation-determined access of antibodies to the shared epitopes. The interaction of dopamine and opioid receptors in the re-establishing of an amnesic and forgotten memory trace by quinpirole. These findings indicate a new level of intercellular communication in root nodule formation. The extent of inhibition was dependent on the phospholipid environment.

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This article presents two cases of clinical digoxin toxicity in the presence of normal or low serum digoxin levels. Our data suggests (1) AMA5 is another marker of the APS (2) in patients with SLE, AMA5 seems to be a marker of a subset of SLE. Early signal transduction events following G-CSF receptor activation were studied. Epidemiological evaluation of Neisseria meningitidis serogroup B by pulsed-field gel electrophoresis. Cellular constituents of heart muscle contain both constitutive and inducible nitric oxide (NO) signaling pathways that modulate the contractile properties of cardiac myocytes.

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Statistical observations on the cases of unnatural deaths examined at our department during the past 10 years. An ill-demarcated, zocor and alcohol consumption yellowish and elastic firm lesion measuring 60 x 35 x 20 mm in size was located in the peripheral part of the middle lobe of the right lung. In addition, decreased left ventricular diastolic compliance due to increased right ventricular (RV) volume also has to be considered (interdependence). Metabolic response of sheep skin to a chronic infusion of a variant of insulin-like growth factor I. The etiological pattern of childhood blindness in Saudi Arabia has changed from microbial keratitis to genetically determined diseases of the retina and optic nerve. Prospective cohort study of tuberculin sensitivity using the Mantoux technique (5 TU). The rostral end of the labeled cell column was located more rostrally for CeP and HP than for TP, CP and CE.

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Increase in rabbit corneal curvature by heated ring application. Tuberculosis is a chronic recurrent infection and inflammation is part of the disease which may remain undiagnosed for months. The onsager reciprocal relations in transformed coordinates: restriction of the rate of entropy production to positive definite forms. Septal efferent axon terminals identified by anterograde degeneration show multiple sites for modulation of neuropeptide Y-containing neurons in the rat dentate gyrus. CHL15--a new gene controlling the replication of chromosomes in saccharomycetes yeast: cloning, physical mapping, sequencing, and sequence analysis. Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. Mock treatment itself was associated with a variable L-selectin loss of monocytes but not lymphocytes or granulocytes. Ocular toxicity with blurred vision and centrocecal visual field defects have been rarely associated with long-term ibuprofen intake.

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Multilevel injury is more common in children 8 years of age and older than in younger children and infants. The resultant effective dose per CT examination ranged from 4.6 to 10.8 mSv for chest examination and from 6.7 to 13.3 mSv for upper abdominal examination. The test must have proven and reproducible analytical and clinical validity, and stand up to critical appraisal of clinical utility and cost-effectiveness. Does chronic experimental head-down tilt alter intramural innervation density of limb blood vessels?. We describe five patients, all with inflammatory arthropathy who developed cutaneous vasculitis, lupus-like disease or atypical serology after exposure to sulphasalazine. Clinical gestalt and the diagnosis of pulmonary embolism: does experience matter?. Preclinical and clinical studies indicate a role for AS ODNs (antisense oligonucleotides) as therapeutics for malignant diseases. cruzi strains, there were two different isozyme (possibly allozyme) types of the enzymes alanine aminotransferase (ALAT), fructokinase (FK), glucose-6-phosphate dehydrogenase (G6PDH), GOT, MDH and three types of ME.

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