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Rical (Calcitriol)
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Rical

Rical is a synthetic version of Vitamin D3 used to treat calcium deficiency with hypoparathyroidism (decreased functioning of the parathyroid glands) and metabolic bone disease in people with chronic kidney failure.

Other names for this medication:
Alcee, Alfacalcirol, Alfacip, Alphadol, Arachitol, Aristrol, Bonetuf, Calbory, Calcibest, Calcigra, Calcirol, Calcor, Calday, Caldikind, Caldix, Calosto, Coecoral, Devita, Dmcal, Fovit, Koncal, Minroset, Netxod, Nutribone, Ostriol, Primacal, Rolsical, Septriol, Vezocal

Similar Products:
Ticlid, Suprax, Dulcolax, Valtrex, Lodine, Glucotrol

Also known as: Calcitriol

Description

Generic Rical is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Rical are intestine and bone. Generic Rical receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Rical may also act on the kidney and the parathyroid glands. Generic Rical is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Rical has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Rical, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Rical in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Rical produces other independent beneficial effects. Rical is also known as Calcitriol. Generic Rical treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Rical is Calcitriol. Brand name of Generic Rical is Rical.

Dosage

Generic Rical is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Rical suddenly.

Overdose

If you overdose Generic Rical and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Rical are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Problems in older adults have not been reported with intake of normal daily recommended amounts. Studies have shown that older adults may have lower blood levels of vitamin D than younger adults, especially those who have little exposure to sunlight. Your health care professional may recommend that you take a vitamin supplement that contains vitamin D.

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The smaller effects on antigenic sites of replacements at once-removed and even at more distant locations, which, when they become cumulative, could be considerable, are brought to attention, together with any influences of conformational readjustments that can take place as a result of evolutionary amino acid replacements. Functional expression of IL-9 receptor by human neutrophils from asthmatic donors: role in IL-8 release. These are the sixth and seventh reported cases of extraskeletal myxoid chondrosarcoma occurring in children. Cost-benefit analysis showed that the exchange treatment resulted in net financial savings. Ten of the 29 dogs showed positive responses to US Department of Agriculture (USDA) standard mammalian tuberculin. Rapid differentiation of Pseudomonas pseudomallei from Pseudomonas cepacia.

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To compare the lamina cribrosa (LC) thickness of healthy subjects and patients with unilateral branch retinal vein occlusion (BRVO), and to determine possible correlations between the LC thickness and the BRVO subtypes. Radioactive in vitro cholesterol efflux assay (CEA) is the gold standard for determination of efflux at cellular level. Increase in sister chromatid exchange rates in association with occupational exposure to N,N-dimethylformamide. Hapten-specific murine colony-forming B cells: in vitro response of colonies to fluoresceinated thymus independent antigens. The underlying disease was, however, proven to be carcinoma of ovarian origin with diffuse carcinomatosis. A linear dependence was also observed in the liquid expanded state but saturation is reached already at 10(-7) M polymyxin. Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein. The perfusates were collected every 10-20 minutes and assayed by high-performance liquid chromatography (HPLC) with electrochemical detection (ECD). Role of bacteria in bioaccumulation of mercury in the oyster Crassostrea virginica. The olfactory bulbs of adult and developing Monodelphis domestica were examined with a number of techniques.

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The demonstration of increased activities of both acid (cathepsins B, D, A) and neutral proteinases in tissue from experimental allergic encephalomyelitis (EAE) in animals and multiple sclerosis (MS, plaques) and the disappearance of myelin proteins implicate a role for proteolytic enzyme in myelin breakdown. Recently, male rats with unilateral electrolytic SMC lesions were found to have enhanced skilled reaching performance with the ipsilesional forelimb compared with sham-operated controls. One month later, when the patient was treated with natural beta-interferon, serum levels of interleukin-6 and gamma-globulin increased again. Effect of helper T cells on the primary in vitro production of delayed-type hypersensitivity to influenza virus. The association between estimated glomerular filtration rate (eGFR) and the risk of mortality among patients with coronary heart disease (CHD) is complex and still unclear. In addition, well-defined melanosomes were present in six of the seven lines whose ultrastructure were examined morphologically. In early anthropoid primates, areas S1, SR, and SC had differentiated into the fields now recognized as areas 3b, 3a, and 1.

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The best approach in the management of this devastating condition is early diagnosis, adequate antibiotic treatment and radical surgical procedures, which may often need to be repeated several times. Methods for long term growth and cloning of T cells reactive with soluble antigens. The finding that metabolism of the TZD ring of troglitazone was catalyzed selectively by P450 3A enzymes is significant in light of the recent report that troglitazone is an inducer of this isoform in human hepatocytes. It is suggested that there are pathophysiological implications to the disaggregation of spectrin complexes in the cytoskeleton by hemin. In the present study, this experimental pedicle screw and plate system was subjected to rigorous pure moment flexibility testing in flexion-extension and lateral bending using an in vitro porcine lumbar spine model. Even when these compounds show antagonistic effects on human eosinophils, in vitro future studies will be necessary to investigate whether chemokine receptor antagonists and monoclonal antibodies are suitable in vivo in an animal model prior to studies in humans. FDG PET scans were performed 1 hour after injection of 15 mCi of F-18 deoxyglucose. Identification of 2,3-dihydroxybenzoic acid as a Brucella abortus siderophore.

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Does parasitism of Simulium damnosum by Mermithidae reduce the transmission of onchocerciasis?. Even after adjustment for other relevant variables, maternal alcohol use during early pregnancy (average ounces of absolute alcohol by self-report) was significantly related to infant weight and length at 8 months of age but not as strongly related to head circumference. Separation of pairs of C-24 epimeric sterols by glass capillary gas liquid chromatography. These changes which may well affect the capacity of neonatal hepatic drug metabolism. Digitized images of Feulgen-stained normal murine T and B lymphocytes were analyzed by the computer and microphotometry. A comparison of specific IgG antibody levels to the cell wall mannan of Candida albicans in normal individuals and in patients with primary antibody deficiency. Treatment with haptoglobin or hemopexin but not albumin improved the survival rate and attenuated SRBC-induced inflammation.

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Benzyl 2-acetamido-2-deoxy-alpha-d-mannofuranoside and related derivatives. Panax ginseng has been used in traditional oriental medicine for thousands of years. Proton pump inhibitor administration does not increase risk of nosocomial pneumonia or other nosocomial infections compared with H2RA therapy in the critically ill trauma patient. Thus, many surgeons have suggested augmenting the standard repair. Use of homozygosity mapping to identify a region on chromosome 1 bearing a defective gene that causes autosomal recessive homozygous hypercholesterolemia in two unrelated families. Response to chronic leukapheresis procedures and survival of chronic myelogenous leukemia patients. After chemical treatment we obtained six serologically active substances. Percutaneous tracheotomy may be useful in both surgical and intensive care settings, but is no replacement for the open procedure.

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Proliferative responses of spleen cells were comparable against env gp160, nef p27, and gag p25 recombinant proteins. Clinical value of the assessment of gynaecological tumour angiogenesis by transvaginal colour Doppler. The caregiver reaction assessment (CRA) for caregivers to persons with chronic physical and mental impairments. It is suggested that the extent of BAI1 and TIMP-2 expression in the gastric mucosa may be an important prognostic factor for predicting survival in gastric cancer. We could not find evidence of VZV, CMV, or HHV-6 in the pathogenesis of RALM, although most patients were previously infected by those viruses. In our study, we find that Mn-SOD activity was higher in nonaggressive (MCF-7) and aggressive (BT-549 and 11-9-14) breast cancer cell lines compared to that of nontumorigenic (MCF-12A and MCF-12F) mammary epithelial cell lines.

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Trigeminal motoneurons (Mo5), mesencephalic trigeminal neurons (Me5), supratrigeminal neurons (Su5), and intertrigeminal neurons (I5) are important constituents of the neural circuitry responsible for jaw movements. Parenchymal sparing surgery with a 3 cm threshold in patients with hereditary renal cancer appears to be an effective therapeutic option to maximize renal function while minimizing the risk of metastatic disease. Anti-CD4 and CD8 antibodies inhibit alternative, nonreceptor pathways of T cell triggering via Tp103 and Tp44 in the absence of class II positive accessory or target cells. To describe the longitudinal trajectory of lung function parameters, including FEV1, in patients with BOS after hematopoietic cell transplant. (Hesperiidae) locally inhabits the forested narrow gullies in the same vegetation zone. The authors describe two patients with secondary mania associated with right thalamic infarctions. A comparative study of the interaction of BLM with very low density lipoproteins (VLDL), influenza virus matrix protein (M-protein) and yeast invertase was carried out. The presence of phenolic compounds may have provided a positive influence on wine flavor, once the more preferred wines presented the greater phenolic content.

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The dose-response curve can be used to aid the design of protocols for detecting Salmonella in individual and pooled faecal specimens. Clinical signs and gross and microscopic lesions were more severe in Bx than in non-Bx chickens. Effectiveness of primary nursing in the care and satisfaction of adult inpatients: a systematic review protocol. Watery vacuolation in the acinar cells of the rat submandibular gland is described. The formation of parietal algogenous sites is thought to be primarily responsible for pain. This algorithm can be used in the management of neuropathic pain in the elderly to ensure timely and adequate treatment by a multidisciplinary team.

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Supernatants of nonadherent cells incubated with indomethacin (10(-6) M) alone augment NK activity. Total charges for services billed to Medicare Part A and Part B and total Medicare reimbursement. The evolution of mouse and human complement C3-binding proteins: divergence of form but conservation of function. In the 3 cases in which this view was obtained, the fracture was disclosed. The CCl4-induced type I spectral change, a tentative measure of binding to cytochrome(s) P-450, was also greater in microsomes from the inner than from the outer zones.

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The GTPase cozaar dose range activity of the 41,000-dalton protein is almost undetectable. Competing views of physician compensation incentives disclosure espoused. Coherent anti-Stokes Raman scattering imaging under ambient light. We review the literature and discuss the theoretical constructs that form the presumed impetus for these studies in light of the current methodological limitations. Near the viscosity minimum, we find exponential decay consistent with the Navier-Stokes equation, with significant deviations on finite length scales for larger viscosity values. Spinal Cord Ventral Horns and Lymphoid Organ Involvement in Powassan Virus Infection in a Mouse Model. The results indicate that biochemical and pharmacokinetic data may be of value for diagnostic classification and prediction of therapeutic outcome in drug-treated schizophrenic patients. The effects of the bound xenon on the protein structure are minor, and we observe a small overall reduction in refined isotropic atomic protein temperature factors.

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We have made antibodies against c-Kit with the synthetic peptides deduced from the murine c-kit gene and examined the role of c-Kit in erythropoiesis. A pediatric nurse practitioner course has been described in which 30 nurse trainees spent six seeks in an intensive training program followed by six months of preceptorship with a pediatrician in their own agency. The findings suggest that chronic occupational exposure to urban pollutants reduces resistance to physical effort and increases the risk of cardiovascular and respiratory changes including slight hypoxemia. This 205 kDa MAP is clearly distinct from previously reported MAPs as to molecular mass, heat stability, immunoreactivity, distribution among tissues or within a neuron, and the developmental aspect of the postnatal cerebellar cortex. Faecal samples from three volunteers were used in continuous culture experiments under varying conditions of pH, substrate concentration and dilution rates, seventy three different isolates cultured at steady state were then screened for phytic acid metabolism and identified through partial sequencing of their 16S rRNA genes (16S ribosomal ribonucleic acid).

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A single-strand-specific endonuclease which converted negatively supercoiled DNA to open-circular and linear DNA was purified to homogeneity with Hb-Sepharose 4B, DEAE Trisacryl M, HA-Ultrogel and PBE-94 chromatofocusing from extracts of Streptomyces tendae ATCC 31160. The assay determines plasmin activity by the cleavage of H-D-Val-Leu-Lys 4-aminomethyl coumarin under near physiological pH and ionic conditions with a sensitivity in the range of 5-100 mIU uPA/well at excitation 355 nm and what type of medication is levaquin emission 460 nm. Their QoL levels were measured with the Taiwan version of the Short Form of the World Health Organization Quality of Life questionnaire (WHOQOL-BREF). In this study, we aimed to compare the dimensions and form of palate in patients with schizophrenia with nonpsychiatric controls in a blinded manner. After eliminating patients for whom surgery was not elective, we examined symptom improvement. Therefore, lipid peroxidation is not a requisite for the induction of cell death.

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Incidence and clinical features of some complications of typhoid fever during levomycetin therapy. Recently, transposon-mutagenesis strategies have been developed to identify essential and pathogenicity-related genes in pathogenic microorganisms. OTA is classified as Group 2B carcinogen and is potently nephrotoxic, which is the basis for its regulation in some jurisdictions. Concomitant drug allergies, route of administration and composition of the ingested drug, familiar complaints of drug allergy, nasopharyngeal examination and lung function by spirometry and Acetylcholine tests were evaluated. Coactivation of Th1 and Th2 cells specific for the same Ag indicated that Th2 cells did not inhibit NO production, but were sensitive to NO induced by stimulated Th1 cells. Oral dehydroemetine (DHE) in intestinal and extra intestinal amebiasis. The apparent molecular weight of the enzyme was estimated as 135,000 daltons by FPLC. In sepsis beyond the neonatal period the quality of the acute phase protein is in numerous components still more distinct than in the postnatal period. This is believed to be due to an immaturity and/or an absence of GH receptors in many fetal tissues. Facilitation, or positive plant-plant interaction, has received increasing concern from ecologists over the last two decades.

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