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Rebetol (Ribavirin)
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Rebetol

Rebetol is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses. Rebetol is incorporated into viral RNA, thereby inhibiting viral RNA synthesis, inducing viral genome mutations, and inhibiting normal viral replication.

Other names for this medication:
Copegus, Ribavin, Ribavirin, Virazide, Virazole

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Also known as: Ribavirin

Description

Rebetol (ribavirin) is an antiviral medication that is used to treat chronic hepatitis C.

Rebetol is not effective when used alone. This medicine must be used in combination with interferon alfa or peginterferon alfa.

Rebetol is sometimes given to people taking other antiviral medications to treat hepatitis C.

Dosage

Rebetol is not effective when used alone and must be used in combination with other medications to treat hepatitis C.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take Rebetol with food.

Swallow the capsule whole and do not crush, chew, break, or open it. Tell your doctor if you have trouble swallowing the capsule.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Drink extra fluids while you are taking Rebetol to keep from getting dehydrated.

Rebetol can cause dry mouth, which could lead to tooth decay or gum disease. If you vomit while taking this medicine, rinse your mouth out with water to prevent damage to your teeth or gums. Be sure to have regular dental exams while you are taking this medication.

You will need frequent medical tests.

Store Rebetol capsules at room temperature away from moisture, heat, and light.

Store the liquid (oral solution) at room temperature or in the refrigerator.

Detailed Rebetol dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Rebetol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Rebetol if you are allergic to ribavirin, or if you have:

a hemoglobin blood cell disorder such as sickle-cell anemia or thalassemia; autoimmune hepatitis; moderate to severe kidney disease; if you are also taking didanosine; or if you are pregnant, or if you are a man whose sex partner is pregnant.

When you take Rebetol in combination with other medications: There may be other reasons you should not take the combination treatment. Tell your doctor about all your medical conditions.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

a blood cell disorder such as anemia (low red blood cells); heart problems, high blood pressure, or heart attack; breathing problems; vision problems (you may need an eye exam before taking ribavirin); diabetes; human immunodeficiency virus (HIV or AIDS) or a weak immune system; depression, mental illness, thoughts of hurting yourself or others; a thyroid disorder; kidney disease; an organ transplant; liver problems other than hepatitis C; or treatment for hepatitis C that did not work well.

Both men and women taking Rebetol should use effective birth control to prevent pregnancy. Ribavirin can cause birth defects, miscarriage, or death to an unborn baby if the mother or father is using this medicine.

If you are a woman, do not take Rebetol if you are pregnant. You will need to have a negative pregnancy test before taking this medicine. You will also need pregnancy tests during treatment and for 6 months after your last dose. If you are a man, do not take Rebetol if your sex partner is pregnant. Both men and women should keep using effective birth control for at least 6 months after the last dose of ribavirin. Tell your doctor right away if a pregnancy occurs while either the mother or the father is taking this medicine. Your name may be listed on a pregnancy registry to track the effects of ribavirin on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Rebetol capsules are not approved for use by anyone younger than 3 years old.

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Twenty human subjects received a differential Pavlovian conditioning training with five CSs, each one paired eight times with a specific US. Allocation of larval food resources affects adult morphology and fitness in holometabolous insects. Sheep given two doses of alum precipitated vaccine, or a dose of oil emulsion vaccine followed by a dose of alum precipitated vaccine, were resistant four weeks but not eight weeks later. Contribution on the plastic covering of large abdominal hernias with the skin flap. The meningocele was removed totally in the third operation, but infection of the wound and pneumonia developed, causing death. Repeated endotoxin treatment decreases immune and hypothalamo-pituitary-adrenal axis responses: effects of orchidectomy and testosterone therapy. Survey of family planning services provided to teenagers in five public health projects. This method provides the ability to monitor individually the incorporation of C7, C8, and C9 into the complex.

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Follow-up studies in 1992 revealed this mass to be a large descending thoracic aortic aneurysm, eroding the vertebral bodies of T3 through T6 and entering the spinal canal. We show here that despite encoding a sequence that varies somewhat from the p300-binding sequences of Ad5 E1A, the Ad12 E1A products associate with p300 with an affinity similar to that of the Ad5 E1A products. Cement-free hip endoprosthesis: PCA shaft prosthesis, 5-7-year results. Acetaminophen/oxycodone consumption was reduced in both drug groups compared with placebo, more so with parecoxib. Anthropometric data collected by Dupertuis and Dawson during the 1930s were analysed from 347 males and 261 females in 12 towns in three counties of western Ireland.

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The purpose of this study is to compare the performance of three methods, i.e., ammonium sulfate, polyethylene glycol (PEG) and protein A sepharose 4B in fractionation of thyroid stimulating immunoglobulin. Diagnosis requires ciliary studies that can be performed in newborn infants. Bone mineral content and body composition in postpubertal cyclist boys. The recent availability of intestinal transplantation now provides an additional therapeutic option for patients in whom all other forms of therapy fail. Intermittent ureteral obstruction in the evolution of a renal hydatid cyst. 1H,1H,2H,2H,-perfluorodecyltrichlorosilane (FDTS) monolayers are deposited on oxidized Si(100) surfaces from the vapor phase with various degrees of surface coverage. Asia is the major consumer of fertilizer nitrogen and energy in the world, and consequently shares a considerable proportion of the world creation of reactive nitrogen (Nr). Heterogeneity in the adrenomedullary storage of catecholamines, ATP, calcium and releasable dopamine beta-hydroxylase activity. A purified fraction of the inhibitor obtained by chromatography permitted survival of mice receiving lethal doses of Cytosine Arabinoside. This procedure is highly recommended for treatment of some patients with bile duct stones.

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It is well established that mutagens induce recombination in cultured cells and experimental organisms. The hyperacute rejection of whole cancer cells, modified to express alphaGal epitopes, could be exploited as a new cancer vaccine to treat human cancers. neoformans is mediated via mannose and beta-glucan receptors on the macrophage surface and that this process activates macrophages for enhanced phagocytosis of the encapsulated form via production of macrophage-derived cytokines. The subsequent clinical course of these patients showed no evidence of CNS malignancy. The results show that cultured Schwann cells continue to exhibit immunogenicity and are a critical factor in allograft survival. Serum inhibition of streptococcal diphosphopyridine nucleotidase in uncomplicated streptococcal pharyngitis and in rheumatic fever. The cribriform approach to the retrieval of palynological evidence from the turbinates of murder victims. Effects of amount of intake and stage of forage maturity on urinary allantoin excretion and estimated microbial crude protein synthesis in the rumen of steers. The amount of energy that can be stored depends not only on the degree of distension (distensibility), but also on the initial diameter of the vessel--two parameters actually determining the compliance of an artery. With increasing emphasis on paediatric eye diseases, amblyopia is at last getting its due importance as a cause of treatable correctable paediatric visual impairment which can have lifelong repercussions, both in terms of individual disability and financial burden to the society if not treated in time.

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Characterization of vitamin D3-responsive genes using an oligonucleotide microarray demonstrated that 220 genes were upregulated at more than threefold, and 84 genes were downregulated to less than one-third, compared with the testosterone-stimulated SC-3 cells. In agreement with our previous results, we found that in the cells overexpressing Tf, there was an increased O(4), GC, and MBP immunoreactivity. Intermittent vascular exclusion of the liver (without vena cava clamping) during major hepatectomy. enteritidis, and with another small plasmid from Salmonella typhimurium. To accomplish this, microarray analysis using Affymetrix microarrays was used to carry out an unbiased survey of the differences in gene expression profiles in the AM of phenotypically normal, approximately 20 pack-year smokers compared to healthy nonsmokers. Involvement of noradrenergic and 5-hydroxytryptaminergic systems in allylnitrile-induced head twitching. Research on the experimental production of glaucoma in the chick embryo.

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Neither enzyme nor TIMP-1 was detected in histologically normal mucosa. Norepinephrine also induces AVP release from both the hypothalamus, as well as the amygdala. Fractures of the fifth metatarsal are treated conceptually based on anatomic location and character of the fracture site. Polarization microscopy of picrosirius red stained sections: a useful method for qualitative evaluation of intestinal wall collagen. The dissolution temperature for spherulitic material ranged between 100 and 130 degrees C. Derivatives of biphenyl, stilbene, azobenzene, and several polycondensed aromatic hydrocarbons. This method has been used successfully in the management of five patients with no stone recurrence in the dilated CBD at follow-up. We sought to investigate whether intrapleural topical application of cisplatin with a surgical carrier has a prolonged local tissue level in comparison with cisplatin solution while reducing systemic toxicity.

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Histologic examination revealed a continuous lining of ECs in the patent grafts, but thickening of the intima at the anastomoses was also observed. Purified Pan-2 was used to immunize Smith-Webster mice and a hybridoma was generated that produced a monoclonal antibody (Yae) that specifically recognized both native and denatured Pan-1 and Pan-2. Metabolism and disposition of 1-bromopropane in rats and mice following inhalation or intravenous administration. Preservation of laryngeal function in surgical treatment of posterior hypopharyngeal wall cancer. Here we test such models by using visual and haptic depth information. MR functional DWI could detect diffuse liver lesions earlier than conventional morphological imaging. In immunocompromised patients with cancer, the emergence of multidrug resistant P. Apoptotic cell death induced by beta-amyloid 1-42 peptide is cell type dependent. Therapeutic management of the cutaneous manifestations of the post-thrombotic syndrome.

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Effect of various fractionation procedures on beta-trace and gamma-trace proteins and methods for isolation of both proteins. Although chorion produces prostaglandins in response to interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha), and epidermal growth factor (EGF), little attention has been given to the mechanisms of action of prostaglandin biosynthesis in this tissue. In the review of modern data and ideas concerning the neurophysiological mechanisms and morphological foundations of the most essential communicative function of humans and monkeys, that of recognition of faces and their emotional expressions, the attention is focussed on its dynamic realization and structural provision. Histologic diagnosis is of primary importance in order to definitely discriminate the different kinds of periapical lesions. To enable comparison, expenses were calculated assuming a mean duration of survival of two years. Cholestyramine therapy in patients homozygous for familial hypercholesterolemia (familial hypercholesterolemic xanthomatosis).

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Development of a mechanistic understanding of how this cancer develops, spreads, and grows allows a tailored approach to all stages of treatment: prevention, adjuvant treatment, and therapy of advanced disease. The effects of cortisone on experimental nutritional steatosis of the liver. As an opportunistic pathogen it must be able to recognize its entry into host tissue and, in response, co-ordinately induce the expression of virulence factors. Patients with dorsal disc protrusions treated by laminectomy had the worst neurological outcome. The data are discussed in relation to the possible role of cell-substratum interaction in maintaining peritubular myoid cell functions. Gliotoxin inhibits transformation and its cytotoxic to turkey peripheral blood lymphocytes.

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Confirmation of hepatitis C infection: a comparison of five immunoblot assays. Endothelial lipopigment as an indicator of alpha-tocopherol deficiency in two equine neurodegenerative diseases. In an effort to understand factors underlying differences in the social organization of Pan troglodytes and P. In 16 patients the MCAP/BP was greater than 0.500, and none of the seven patients with neurologic deficit improved postoperatively. The algorithm predicted well a near-native arrangement of the input subunits for all cases in our data set, where the number of the subunits of the different target complexes varied from three to ten. The reversible change in albumin concentration seen in these individuals may be secondary to abrupt alterations in oncotic homeostasis. Lung cancer mortality rates in Ohio have declined among men of all ages as well as in specific age groups in the 1990s, and the rate of increase among middle-aged and elderly women has dropped over time. By this technique intestinal phosphate absorption has been shown to have two components: an initial rapid phase, which is completed by 3 h, and a slower more prolonged phase, which continues beyond 7 1/2 h. Prevalence of the factors varied widely among the samples, and since the samples were heterogeneous and the studies presented several methodological limitations, a summary mean was not calculated. The second patient was also infected with Streptococcus carrying exotoxin A.

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Normal duplex sonographic findings after TIPS placement and hemodynamic alterations indicating shunt failure have not yet been well described. At high concentrations (above 5 mM) and when intracellular reduced glutathione (GSH) lasix 40 mg uses in hindi was depleted, APAP caused severe cytotoxicity in MVh2E1-9, but not in MV-5 cells which lack CYP2E1. The present study examined relationships among gender, trait dominance, and cardiovascular reactivity assessed during dyadic social interactions between same-gender and same-ethnicity participants. Mutagen effects on male germ cells can be quantified by meiotic micronucleus induction in vitro. The data identify the acid sphingomyelinase and ceramide as key molecules for the infection of human cells with rhinoviruses. The 1992 Specialty Council on Pharmacotherapy, Board of Pharmaceutical Specialties.

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On ED 15 a lamination typical for embyronic CNS with ventricular, subventricular, intermediate layers and stratum zonale can be observed in the area of presumptive colliculus superior. We demonstrate here that Tax can induce translocation of members of the NF-kappa B family retained in the cytoplasm through interaction with either p105 or p100. Histamine binding proteins separated from human sera vasotec tablet by the chromatographic method. Careful heat administration techniques and thorough and accurate temperature monitoring have resulted in a uniform and closely controlled temperature distribution, allowing us to approach the limiting temperature value for possible damage both of the limb tissues and of the perfusate. Serotonin (5-HT) level, a marker of a severity of stress, increased after footshock application with a concomitant rise in its major metabolite-5-hydroxyindoleacetic acid (5-HIAA).

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As lin-35 is the worm ortholog of the mammalian tumor suppressor gene p105Rb, misregulation of RNAi may be important during human oncogenesis. An advanced childbearing age, a previous child with trisomy and the ultrasound detection of morphological anomalies in the foetus are situations that entail a significantly high risk of a foetal chromosomal anomaly. Nodulation experiments showed that the nodD3 gene under either promoter was functional in eliciting nodules on alfalfa. Cancellation rates, pregnancy rates per egg retrieval, per ET procedure, and luteal phase E2:P ratios of the treatment cycles are compared. In terms of a simple formal model, serial-order representations of the preceding responses are used in selecting the next response only for the small response set, and not for larger response sets. Acetone solution of the insecticide was painted onto leaves of the plant. Ischemia followed by reperfusion of the rat hind limb resulted in local evidence of injury, as robaxin medication class reflected in increased vascular permeability and hemorrhage in skeletal muscle as well as distant organ injury, as reflected by increased vascular permeability and hemorrhage in lung. The aim of the present study was to determine whether the results of TBT have to be taken into account when counseling pregnant women in central Europe. Preclinical and clinical aspects of biomodulation of 5-fluorouracil. Exposure to the formulation containing the inert ingredients plus the pheromone (no insecticide) significantly reduced male behavioral responses to an attracticide droplet in the wind tunnel 1 h but not 24 h after exposure, compared with males treated with inert ingredients alone.

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peroxidative stress in the form of vitamin E deficiency or the administration of iron nitrilotriacetate or carbon tetrachloride was imposed on rats fed an MDA-free diet. Influence of motivation on physical work capacity and performance. The following reports by key participants in this major change in health visiting practice underline the importance of training to prepare staff for the challenge. Like stress and depression, in fact the regulation of eating represents another example of the interplay between these three systems and it is secondary to a bidirectional dialogue between the center and the periphery. A new alkaline serine protease from alkalophilic Bacillus sp.: cloning, sequencing, and characterization of an intracellular protease. The permeability of liver and skin capillaries to lipids in the cat. Cloning and characterization of 2-C-methyl-D: -erythritol 2,4-cyclodiphosphate synthase (MECS) gene from Ginkgo biloba.

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In contrast, 4-HC at low concentrations (eg, 3 micrograms/mL) spared the majority of lymphoid cells suggesting that low concentration 4-HC combined with MoAb purging may be a desirable alternative to higher concentration 4-HC. We conclude that even relatively mild tonsillar enlargement can play an diflucan with yeast infection important role in the pathogenesis of obstructive sleep apnea. Both types of elastomeric chain produced the same clinical effects. Demonstration and determination of small ouantities of lignosulfonic acid. A progressive loss in the number of channels contributing to the peak current was observed with time following outside-out patch excision, i.e. The role of SLPI may be protection of the fetal membranes and cervical tissue.

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It was concluded that both the EMLA patch and the Tegaderm/EMLA cream dressing provide effective dermal analgesia for venepuncture with a 0.8 mm (outer diameter) cannula. The presence of a leukemogenesis-associated antigen was investigated in an experimental model of adult T-cell leukemia in (B/J x Chbb:HM)F1 rabbits, where adult rabbits develop leukemia within 1-2 weeks following inoculation with HTLV-I-transformed syngeneic cell lines. The underlying theory of Gibbs sampling and TRI are presented along with the feature extraction and target classification via the RVM. Scope of a cooperation of the laryngologist-bronchologist for diagnosis and treatment of causes of persistent and recurrent cough in children. The inconsistent results from studies on bladder cancer in printing workers may point to a risk confined to a certain subgroup.

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Prevalence and diagnosis of parasites of the stomach and small intestine in horses in south-west England. The effect of water and protein on the nuclear gamma resonance spectrum of iron xanthogenate complexes. In this study the interaction between the glycoalkaloids alpha-chaconine, alpha-solanine and alpha-tomatine and sterols in model membranes was analysed systematically using techniques like membrane leakage, binding experiments, detergent extraction, electron microscopy, NMR and molecular modelling. Peak concentrations of CI were approximately 0.1-0.2 of those of CE. This approach will be applicable to construct a cDNA library suitable for subtraction, differential screening, and expression screening, especially for mRNA species present at very low concentrations in a few cells of a specific tissue. A comparison of the characteristics of the affected and unaffected flocks indicated that an increased risk of scrapie was associated with the larger flocks, the open flocks and the flocks that bought in lambs. Spontaneous motor activity and exploratory movement in mice were inhibited by oral administration of YPG-209 in a dose of 10 micrograms/kg. The specific uterine cell types in which estrogen induces c-fos messenger RNA (mRNA) expression, however, have not been identified in either mature or immature animals. None of distal type patients had extension of atrophy to the proximal muscles during a long course of their illness.

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After 12 weeks symptom scores-assessed according to the Madsen-Iversen scale were significantly reduced in the alfuzosin group and peak flow rate significantly increased compared to the placebo group. A phase I/II study was conducted to evaluate the dose limiting toxicity (DLT) and the maximum tolerated dose (MTD) of liposomal doxorubicin (Caelyx) combined with CDDP and RT for cervical cancer. Kinetic parameters of glutamine synthetase (GS) and glutamate synthase (glutamine-oxoglutarate aminotransferase) (GOGAT) activities, including initial velocity, pH, and temperature optima, as well as Km values, were estimated in Schizosaccharomyces pombe crude cell-free extracts. The LTAS were compared to the results of a perceptual evaluation of the voice qualities by a small group of expert listeners. Eye movement measurements revealed that there was no positive correlation between a perceptual flip and both saccades (microsaccades as well as larger saccades) and blinks that occurred prior to a perceptual flip. Relapsing bilateral uveitis and papilledema in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease).

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From 1984 to 1992 in Japan, 37 cases, including 2 cases of our own, have been reported to involve the percutaneous removal of foreign bodies from the cardiovascular system by catheter. Under low magnification, the entire retinal vasculature can be visualized at one time. One of the clusters consisted of genes whose expression was markedly upregulated in the irreversible model. Specimens of hair were exposed to concentration: 0.026, 0.21, and 2.7 mg Hg/m3 for 2-28 d. We conclude that p53 mutants may counter the negative regulators, such as WAF1/Cip1, by the elevation of positive cell cycle regulators, and the presence of WAF1/Cip1 in tumor cells is not sufficient for growth inhibition. Probe EUS for the diagnosis of invasion depth in superficial esophageal cancer: a comparison between a jelly-filled method and a water-filled balloon method. Immediately after behavioral studies, blood and brain specimens were collected for analysis of thiobarbituric acid reactive substances (TBARS) to measure the extent of free radical production. Geometric characterization of a singly charged oxygen vacancy on a single-crystalline MgO(001) film by electron paramagnetic resonance spectroscopy.

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