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Primacal (Calcitriol)
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Primacal

Primacal is a synthetic physiologically-active analog of vitamin D, specifically the vitamin D3 form. Primacal regulates calcium in vivo by promoting absorption in the intestine, reabsorption in the kidneys, and, along with parathyroid hormone, regulation of bone growth. Primacal receptor-binding protein appears to exist in the mucosa of human intestine.

Other names for this medication:
Alfabond, Alfacal, Alfacalcirol, Alfacip, Alfarich, Alphadol, Arachitol, Aristrol, Biocal, Bonestat, Bonetuf, Calcicare, Calcimet, Calcor, Calday, Caldikind, Calosto, Calsure, Caltive, Caltop, Calzem, Cholical, Denscal, Devita, Estovon, Lctrol, Minroset, Novadee, Ostonex, Primacal, Roical, Rolsical, Septriol, Trolec, Vitalpha

Similar Products:
Prevacid, Addyi, Lopid, Nizoral, Periactin, Provera, Antivert, Ticlid, Desyrel

Also known as: Calcitriol

Description

Generic Primacal is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Primacal are intestine and bone. Generic Primacal receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Primacal may also act on the kidney and the parathyroid glands. Generic Primacal is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Primacal has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Primacal, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Primacal in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Primacal produces other independent beneficial effects. Primacal is also known as Calcitriol. Generic Primacal treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Primacal is Calcitriol. Brand name of Generic Primacal is Primacal.

Dosage

Generic Primacal is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Primacal suddenly.

Overdose

If you overdose Generic Primacal and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Primacal are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Primacal if you are allergic to Generic Primacal components. Do not take Generic Primacal if you are pregnant, planning to become pregnant, or are breast-feeding. It is not known if this medication appears in breast milk. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Be careful with Generic Primacal if you have heart disease, kidney disease or kidney stones, coronary artery disease (hardening of the arteries). Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. It can be dangerous to stop Generic Primacal taking suddenly.

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In contrast, Fm theta was almost uniformly distributed in those who showed a larger amount of Fm theta. Overall, these transgenic models have proved very useful for elucidating the roles of 11beta-HSDs in vivo and will be a unique resource for investigating the importance of each enzyme in the diverse actions of glucocorticoids. To explore the effect and molecular mechanism of gallic acid (GA) on the cytostatic and cytotoxicity of hypertrophic scar fibroblasts (HSFs). Disease-specific quality-of-life measurement tools for haemophilia patients. Both CTIP1 and CTIP2 were expressed diffusely in the embryo at 10.5 days post-coitum (d.p.c.). In all OA synovium there was intense TSG-6 expression throughout the intimal layer, whereas in RA staining in this region was generally less pronounced and was absent at the synovial surface in tissues exhibiting significant inflammation. Fifty-one of these GPI proteins could be categorized as adhesive proteins, potentially implicated in fungus-host interactions or biofilm formation during the development of fungal infections.

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This material is expressed in low amounts after 13 days in culture. Hydatid cyst of the liver disclosed by metastatic subcutaneous localization. An increase of both specific activity and levels of free nucleotides and polyamines after 30 minutes of ischemia is observed. Transport of the amino acids, 1-amino cyclopentane-1-carboxylic acid and epsilon-aminocaproic acid, across intestinal mucosa in vitro. Histopathology of the lungs confirmed thrombus in two of the four primates, but no thromboembolus was identified in the other two. Influence of induced hypermagnesemia and hypocalcemia on neuromuscular blocking property of oxytetracycline in the horse. Investigations of novel sepsis treatments have proven ineffective in the past. Clinical analysis of 72 cases of meningococcal meningoencephalitis. Taken together, our model captures the effect of cellular properties on the coupling between hydrodynamic and receptor-ligand bond forces, and successfully explains the stable leukocyte rolling at a wide range of shear rates over that of rigid microspheres. Pretreatments with either IDE or DMI did not reduce the effect of APO on HVA levels.

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Fractionation of neutralising antibodies in serum of ducklings vaccinated with live duck hepatitis virus vaccine. This case highlights the importance of following health and safety guidelines at work, and above all common sense when working in hazardous situations. Time dependence of unipolar cathodal and anodal strength-interval curves. pylori eradication therapy between March 2013 and November 2015 with either vonoprazan-based triple therapy or conventional PPI-based triple therapy. In 2, the original cannulation site was the femoral artery, and the cannula was moved to the ascending aorta. Ambiguity and insufficiency observed in the usage of words were at times connected with the purpose of committee or workshop and the members of different origin. Topics included the dynamics of reef fish communities and the lingering impacts of coral bleaching. One such region, which we designate region A, has sequence similarity only to DNA polymerases that are sensitive to certain antiviral drugs. Subsequent binding studies confirmed that THALWHT-displaying phages bound much stronger than phages displaying control peptides to human airway epithelial cells.

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Effect of CS-US interval shift on classical conditioning of the nictitating membrane in the rabbit. We suggest a biological role of nucleolin in binding of GR in the nucleolus. In contrast to the in vitro results, anti-inflammatory activity was observed in all tests, except when inflammation was induced by snake venom PLA2. Cooperative motions of protein and hydration water molecules: molecular dynamics study of scytalone dehydratase. The results of our study indicate that strong purifying selection has intensely constrained PRNP over the long-term evolutionary history of the subfamily Bovinae, especially in regions considered to be of functional, structural, and pathogenic importance in humans as well as other mammals. A 61-year-old male patient, with a burned-out ankylosing spondylitis, developed polyarteritis in the right lower limb, associated with periosteal new bone formation in tibia and fibula. Differentiation Induces Dramatic Changes in miRNA Profile, Where Loss of Dicer Diverts Differentiating SH-SY5Y Cells Toward Senescence. Expression of genes inserted at the human beta-globin locus by homologous recombination.

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Male Har:(ICR)BR mice were housed 8 wk in wire bottom cages over paper, in wire bottom cages over an automatic cascade flushing system, or in solid-bottom plastic cages with bedding material. The amino acids targeted by GSK-3 comprise a hyperphosphorylated epitope first identified in plaques isolated from Alzheimer brain. Comparison between kinetics of in vivo development of specific antibody suppression and induction of cytotoxic cells detectable after in vitro boosting revealed no correlation between the two phenomena. Alpha-1-antitrypsin (AAT) deficiency is an inherited disorder associated with an increased prevalence of pulmonary emphysema. Type II cells may attain their adult size before type I cells do. Unlike conventional gene therapy, it uses replication competent viruses that are able to spread through tumor tissue by virtue of viral replication and concomitant cell lysis. Antimycin A inhibits the release of histamine and SRS-A in a dose dependant fashion, while causing a mild inhibition of SRS-A formation throughout the dose range studied. Here we present such images, and volume reconstructions in context with images obtained by other light, and electron microscopic techniques, such as laser scanning confocal, conventional wide-field fluorescence, thin section, and freeze-fracture electron microscopy. A case of multiple cerebrovascular and migraine episodes caused by the use of oral contraceptives.

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With obstruction to pulmonary vein flow, the velocity increases and becomes continuous. We discovered that miR-34b-5p, a member of the miR-34 family, increased significantly in flurothyl-treated rat hippocampus tissue. When stimulated by either ACTH or angiotensin II, there is no inhibition by ANP in the adenoma tissue, whereas normal tissue was inhibited. In one case there was also an angiomyolipomatous change in the retroperitoneal lymph nodes. Similar patterns of peripheral intracellular and surface staining for cathepsin B are seen in the human breast carcinoma lines MCF7 and BT20. Apparatus for thin-layer chromatography on plates with fixed layers. The successful results in the TC-VMC method are considered to be due to the nodal optimization of the wave functions. Genetic dissection of human stature in a large sample of multiplex pedigrees.

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At pH 2.5 the enzyme concentration versus velocity plot was non-linear and the activation by palmitic acid appeared to saturate between 32 and 48 muM concentration of the effector. The results of a combined dermatological and surgical treatment of varicose ulcers was studied in 100 patients. Are you feeding the rumor grapevine from this unsuspected source?. Phenomenological equations are represented in the form of an equivalent electrical circuit that can be used to deduce testable relations among measurable quantities. Statin therapy reduces adverse outcomes, with a minimal decrease in vessel stenosis. Pacemaker oversensing: a possible example of concealed ventricular extrasystoles. Intramedullary fixation is the mainstay of treatment for femur fractures in the adult trauma population. The major drawback has been that almost all researchers have invoked in their analyses, concepts from linear infinitesimal elasticity to explain the intracranial PVR. The EDB exon was predominantly included in FN1, while exon 2 was mostly skipped in BCL2A1. A feasibility study has been performed to investigate the possibility of using mailed thermoluminescence dosimetry (TLD) for external audits of clinical electron beams in Europe.

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Nonresponse bias and early versus all responders in mail and telephone surveys. Phosphate solubilization by fungi associated with legume root nodules. SEM observation revealed increased mucus secretion and shortening of cilium. Compared with the low-risk group, patients in the high-risk CHA2DS2-VASc group have much higher risk of ischemic stroke recurrence/TIA and death, approximately 3-fold and 13-fold, respectively. Allowing trainees to watch videos of themselves or an expert performing an endoscopic task enhances performance. Differences in the lectin binding pattern among species were also observed. Porous 3D graphene-based hybrid materials (3D GBHMs) are currently attractive nanomaterials employed in the field of energy.

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Inhaled corticosteroids are the most effective agents for primary control of patients with persistent asthma. This study aims to evaluate the effect of ptxA and ptxB genes, which are important genes in the L-ascorbate phosphotransferase system (PTS) of Streptococcus mutans (S. Detection of these large genetic changes has an increasingly important role in determining patient diagnosis and care, including therapeutic selection. All first- or second-year students at a Canadian medical school were invited to provide written reflections on two comics regarding diabetes and participate in a focus group. The number of IgE-bearing lymphocytes in patients with drug-allergy was higher than that of the controls. The significant increase in adipose tissue glucose 6-phosphate after the glucose load seen in the non-diabetic but not in the diabetic subjects suggest that glucose uptake is decreased in the diabetic adipocyte. We determined the mRNA levels of c-jun and c-fos in the liver of C3H-H-2 degrees jvs mice. Soluble antigen preparations from Mycobacterium leprae are reported to inhibit the response to other stimuli, of peripheral blood mononuclear cells from lepromatous leprosy cases (BL/LL) and also from tuberculoid cases (TT/BL) and normal donors. The effect of bricanyl on placental circulation in late toxaemia of pregnancy.

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Desmoplastic infantile ganglioglioma is a very rare supratentorial tumor occurring in the first two years of life. These findings confirm that the antigenicity of the sites is inherent in their three-dimensional locations. The actin-activated ATPase properties of this hybrid were compared to those of the two fast S-1 isoenzymes, S-1(A1), fast muscle subfragment 1 which contains only the alkali-1 light chain, and S-1(A2), fast muscle myosin subfragment 1 which contains only the alkali-2 light chain. Drug therapy of diabetic neuropathies using high doses of hydroxocobalamin. The patient was referred to Toronto where ancrod (Arvin) was used to lower plasma fibrinogen level, allowing successful repair of a ventricular septal defect using cardiopulmonary bypass support. The role of the forensic odontologist in human rights investigations. To compare polypropylene mesh positioned onlay supported by omentum and/or peritoneum versus inlay implantation of polypropylene-based composite mesh in patients with complicated wide-defect ventral hernias.

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The Mexican Dietary and Physical Activity Guidelines: Moving Public Nutrition Forward in a Globalized World. Most studies dealt with mezlocillin-aminoglycoside combinations against enterobacteriacaea and Pseudomonas aeruginosa : the effect was predominantly synergistic, but a few antagonistic effects are reported. All men on a prostate biopsy waiting list were eligible for inclusion in an exploratory and interpretive study. Six of these had a relapse and all were detected by serial increases in plasma CEA. Follow-up of cancer in New Zealand: time to review the model of care. This case is similar to several others previously described, and it could possibly represent a distinct nosological form of osteoarthropathy. Policies aimed at improving these factors have an impact on the mental health status of society. Data from human cohorts support the possibility to modify breast milk composition by selected interventions and to impact health outcomes in offspring. Immunoreactive neurons were also present in the lateral and medial hypothalamus, and some thalamic, subthalamic and epithalamic nuclei.

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In contrast we show here that human Madrin-Darby Canine Kidney (pIgR)-transcytosis, in human Calu-3 and human pIgR- elavil 50 mg transfected MDCK cells, is not promoted by pIgA, as monitored by a continuous apical release of its secreted ectodomain. 14C-Methylated beta-casein as a substrate for plasmin, and its application to the study of milk protein transformations. Mucosal specimens from patients with chronic sinusitis have been immunohistologically investigated. Recent interest in cyst fluid analysis (CFA) for carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA), and the introduction of laparoscopic surgery (LS) in the management of hepatic cysts have resulted in sporadic reports of elevated CA 19-9 and CEA levels in intrahepatic biliary cystadenoma (IBC) CFA, and the application of LS in the management of simple cysts. These clinical observations are supported by new discoveries relating to the role of BLB in immunosuppression and inhibition of protein phosphorylation, resulting in the modulation of intracellular signaling pathways in vascular biology and cancer, among others.

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To characterize the current scope and practices of centers performing extracorporeal cardiopulmonary resuscitation (eCPR) on the undifferentiated patient with cardiac arrest in the emergency department. Kinetics of equilibrium labeling of the rat thyroid gland with 125-I. An 86-year-old woman developed acute kidney injury after colonoscopy. Anthelmintic drug niclosamide enhances the sensitivity of chronic myeloid leukemia cells to dasatinib through inhibiting Erk/Mnk1/eIF4E pathway. Our results demonstrate a trend for increased survival of first born premature infants when compared with offsprings of subsequent deliveries, and an association between advanced parity and the development of severe intraventricular hemorrhage. Xenon-delayed postconditioning attenuates spinal cord ischemia/reperfusion injury through activation AKT and ERK signaling pathways in rats. With regard to the slack movements, significant differences were found in the two extremity regions. The patient has an excellent clinical and radiographic result at final follow up. Our results suggest that lymphoblasts not only represent an excellent source for the purification of N-acetylglucosamine phosphotransferase, but in addition, represent a unique system for studying alternate mechanisms involved in the targeting of lysosomal enzymes. Different variants of flower structure are interpreted as a result of changes in the volume of meristem (space) and order of spatial pattern formation (time).

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Cytofilaments of intermediate size were present in these cells of electron microscopy and the distinctive hyaline appearance of cytoplasm is ascribed to large aggregates of these. Splenic rupture following foreign body perforation of the urinary bladder. In 18 studies of patients with known or suspected infection, polymorphonuclear leukocytes and bacterial were easily identifiable on Gram stain, and potential lower respiratory pathogens were recovered in concentrations greater than or equal to 10(6) colony-forming units (cfu)/ml. This organisation of transcriptional control signals is discussed with reference to the organisation of control signals in other yeast genes and in retroviral proviruses and other retro-elements. In the anesthetized rat the hypotensive effect of venodilators (sodium nitrite, glyceryl trinitrate, and molsidomine) was diminished after pretreatment with DHE, ve venoconstrictive agent which increases mean arterial pressure (MAP) and cardiac output (CO) in the pithed rat without affecting peripheral resistance (R).

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Specimens for this study were collected from 74 cadavers, including the autopsied cases of 44 males and pepcid ac 20 mg while pregnant 30 females, ranging in age from a prenatal stage of 22 weeks up to 84 years, from which cases with other nasal or paranasal diseases were excluded. The extensive increases shown in FC to the dlPFC are consistent with the idea that disinhibition of the dlPFC may be a key driver of the antidepressant and psychotomimetic effects of ketamine. In a planned analysis of the first 284 patients entered into the Dutch study, with a median follow-up approximately 7 years, both disease-free and overall survival were significantly improved in the high-dose therapy arm. Vestibular evoked myogenic potential (VEMP) has been applied for patients with vestibulo-cochlear disorders. With rare exception, ciliated cells entering mitosis lose their cilia, thereby freeing basal bodies to serve as centrosomes in the formation of high-fidelity mitotic spindles. Improved survival after brain metastases in non-seminomatous germ cell tumours with combined modality treatment.

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Evaluation of 1-year outcome after patients with chronic low back pain participated in an intensive functional restoration program associated with an ergonomic intervention on the workplace. The mode of action of benzoyl peroxide in acne is three-fold, i.e. The adsorbed enzyme activity was found to be quite stable in repeated experiments. In this study the rate of healing of granulating wounds on the backs of two species of animals, the rat and the guinea pig, has been studied when supplements of zinc salts were given in association with a normal diet. The degree and duration of sensitization increase with more intense noxious stimulation. The protein synthesis and the collagen synthesis by 2- to 7- panadol merah berapa mg week-old granulation tissue from implanted cylinders in bipedicle tube flaps on rabbits were measured in vitro by the incorporation of 14C-proline in proteins and in collagen hydroxyproline. Alterations in radiosensitivity of ascitic Ehrlich tumor under the influence of serial irradiation in vitro. However, at perfusion times from 5 sec to 20 min there was no appearance of inositol-(1,3,4,5)tetrakisphosphate or inositol-(1,3,4)trisphosphate. The results of this study will contribute to the more complete descriptions of the anatomy of the bovine adult, as well as of the embryological development of the animal. The mutant proteins are more resistant to thermal denaturation than wild-type CRABP in the absence of retinoic acid, but they are not as thermostable as the CRABP-retinoic acid complex.

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Although a range of protease inhibtors and use of uvs mutants can reduce the rate of decay of carbamoyl-phosphate synthetase activity, only glycerol can stabilize the native molecular weight. Male scent-induced analgesia in the deer mouse, Peromyscus maniculatus: involvement of benzodiazepine adalat xl blood pressure medication systems. The protein ratios between amylase and PSP in saliva, obtained by scanning of electrophoretic gel separations, were found to reflect genetic differences in salivary amylase production in strains YBR/Cv and C3H/As. Patellofemoral arthroplasties have been successfully used in the management of isolated patellofemoral joint (PFJ) osteoarthritis (OA). These data also indicate that the presence of FoxA proteins is not sufficient for binding but that additional mechanisms must govern the accessibility of FoxA proteins to their cognate binding sites within the H19 E1 enhancer. Studies on the liver lipids and serum cholesterol of chicks of different breeds.

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