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Paxil (Paroxetine)

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Paxil is the most potent inhibitor of the reuptake of serotonin of all selective serotonin reuptake inhibitors (SSRIs) and has been studied in many randomised controlled trials (RCTs).

Other names for this medication:
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Decadron, Chloromycetin, Inderal, Paxil, Trileptal, Mysoline, Avodart, Nimotop, Klonopin

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Also known as: Paroxetine


Paxil (paroxetine) is an antidepressant that belongs to group of drugs called selective serotonin reuptake inhibitors (SSRIs). Paroxetine affects chemicals in the brain that may be unbalanced in people with depression, anxiety, or other disorders.

Paxil is used to treat depression, including major depressive disorder.

Paxil is also used to treat panic disorder, obsessive-compulsive disorder (OCD), anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).


Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Swallow the extended-release tablet whole and do not crush, chew, or break it.

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

Do not stop using Paxil CR suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture, heat, and light.

Detailed Paxil CR dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Paxil CR can be fatal.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Paxil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Paxil if you are allergic to paroxetine, or if you are also taking pimozide or thioridazine.

Do not use an MAO inhibitor within 14 days before or 14 days after you take paroxetine. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. After you stop taking Paxil you must wait at least 14 days before you start taking an MAO inhibitor.

To make sure Paxil is safe for you, tell your doctor if you have:

heart disease, high blood pressure, or a stroke; liver or kidney disease; a bleeding or blood clotting disorder; seizures or epilepsy; bipolar disorder (manic depression), drug addiction, or suicidal thoughts; narrow-angle glaucoma; or low levels of sodium in your blood.

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with paroxetine and cause a serious condition called serotonin syndrome.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking an SSRI antidepressant such as Paxil during pregnancy may cause serious lung problems or other complications in the baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine without your doctor's advice.

You should not breastfeed while using this medicine.

Paxil is not approved for use by anyone younger than 18 years old.

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Generally, alphaherpesvirus mutants that lack these glycoproteins are replication competent in cell culture but show a reduced capacity for cell-to-cell spread and hence smaller plaque sizes. Effect of counterions on lanthanum biosorption by Sargassum polycystum. The aim was to determine whether ischaemic preconditioning occurs through the actions of ATP sensitive potassium (KATP) channels during ischaemia and whether pharmacological antagonism of these channels can reverse the protective effect of preconditioning. Although ActVB can be isolated with some FMN bound, this form was not involved in the flavin reductase activity. However, prophylactic therapy requires a three- to five-fold greater annual amount of factor VIII than does on-demand therapy. It is recommended that alcoholism, like many other diseases, be approached through a broad program of professional and public education, research into epidemiology and study of more effective methods of prevention, treatment, and rehabilitation, and that patient services commensurate with the scope of the problem be provided. Objective evaluation of results of physical-therapeutic measures. There was no detectable clinical loosening of the components in any patient. There is an increasing population of immunocompromised patients with HIV, IV drug abuse, organ transplantation, and long-term steroid treatment developing spinal infections. We hypothesize that AIDS dementia may partially involve a perturbation of astrocyte function by gp120 that could indirectly impair neuronal function.

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A self-administered questionnaire was used to interview a sample of 2000 people, aged 18-49 years, chosen using a quota-sampling, considering age, sex, and level of education. The ToxR protein is a transmembrane protein that regulates the expression of several virulence factors of Vibrio cholerae. Both the elevated detection thresholds and the reduced amount of temporal summation in elderly subjects may be partially due to the decrease in the number of Pacinian corpuscles in the hand that occurs with aging. Choline uptake and acetylcholine synthesis in synaptosomes: investigations using two different labeled variants of choline. Age and smoking-adjusted lung cancer incidence in a Utah county with a steel mill.

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Cotinine did not induce significant changes on cellular density. Presumptive human hair matrix cells have been isolated from plucked anagen hair follicles and have been successfully propagated on 3T3 cell or normal human fibroblast feeder layers, giving rise to multilayered stratified KC cultures. Because these processes may play a role in diabetic retinopathy, the authors undertook this study to investigate the protective action of dorzolamide, an inhibitor of carbonic anhydrase, on retinal neural cells. The pivotal trials conducted so far have revealed a wide range of recanalization rates, an acceptable safety and, also, encouraging effects on neurologic outcome. Retrograde cardioplegia does not adequately perfuse the right ventricle. Intravenous iron is not associated with acute microbial growth in catheters or clinical infection. The demonstration of high densities in the first CT scan, the normal second CT scan, the blood tinged or xantochromic CSF and the normal blood haemoglobin levels are indicative of intracranial bleeding. Cross-sectional data of a cohort study in elderly men and women. Immunohistochemistry was also performed on human striatal sections obtained from the Stanley Foundation Neuropathology Consortium and on rat brain sections following 28 days of antipsychotic drug treatment.

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To include all symptoms, tongue manifestations and pulse presentations into case report form, and to compare the differences in these clinical parameters between effective and non-effective cases by multivariate analysis may be helpful to find more specific indications for therapeutic protocol of TCM. The analysis revealed the basal, T cell-specific promoter with a TATA and CAAT box 6000 bp upstream the translation start site. Total retinal Psd95 protein levels are significantly reduced which suggests Mpp4 to be involved in Psd95 turnover, whereas Veli3 proteins levels are not changed. Platelet/endothelial cell adhesion molecule-1 (CD31)-mediated cellular aggregation involves cell surface glycosaminoglycans. OepFAD2-1 transcript was strongly detected in very young seeds and in leaves, showing low levels in mesocarps, while the transcript of the OepFAD2-2 gene was moderately expressed in developing seeds, ripening mesocarp and leaves. Dynamic regulation of the human dopachrome tautomerase promoter by MITF, ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes. However, only tPA activity significantly increases in late phases of CL development.

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The results suggest that diesel exhaust contributes to the level of adducts. Three decades of the Ceylon Medical Journal--analysis using MEDLINE (PubMed). Study of the photocycle and charge motions of the bacteriorhodopsin mutant D96N. Using the second method, ovarian follicles were also visible using glass-bottom dishes under the stereomicroscope, although tissue thickness and density were limiting factors of its success. Increasing external osmolarity inhibited tyrosine phosphorylation of the PKC1 pathway MAP kinase, a response that was blocked by BCK1-20, a constitutively active mutant in an upstream protein kinase. The areas assessed by the questionnaire included demographics, screening, superficial disease and recurrence, surveillance, muscle-invasive disease, advanced disease, and adjuvant systemic chemotherapy. Proteins involved in protecting from stress-induced protein unfolding and aggregation, mitochondrial trafficking and refolding, and regulating apoptosis changed early in the disease process. The HODE level was about two to three orders higher than the F2-isoprostane level. Anatomo-clinical considerations apropos of 200 operated cases of goiter. When fibronectin synthesis, and consequently fibril formation, was inhibited by cycloheximide, large adhesion plaque-like structures were formed at the cell margin.

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Additionally, because homocysteine was been reported to mediate its effects through the NMDA receptor, the effect of MK801, an antagonist of this receptor, was also investigated. We report about 7 of our own cases, treated with surgery and radiotherapy (4) or with a combination of surgery, radiotherapy and chemotherapy (3) and discuss the clinical aspects, diagnosis and the different ways of treatment of malignant pleural mesothelioma and its influence on survival. Cardiovascular effects of infusions of epinephrine and angiotensin singly and in combination. Clinical and radiological findings are not enough for diagnostic and indication of orbital floor repair. Our current research efforts, therefore, concentrate on the characterization of this PA response, and on its pharmacological regulation. Laparoscopy-assisted vaginal hysterectomy (LAVH)--a comparison between vaginal and abdominal hysterectomy with reference to intra- and postoperative quality parameters. We detected p53-positive nuclei in 11 of 16, 23 of 29, and 23 of 31 samples of low-grade ED, high-grade ED, and ESC, respectively.

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Clinical islet autotransplantation after pancreatectomy: determinants of success and implications for allotransplantation?. However, 24-h incubation of melanoma cells in the presence of 150 micrograms of Polyerga per ml significantly reduced the number of tumor cell colonies in comparison to the corresponding cell cultures previously not exposed to Polyerga. Swarming behavior of Armigeres subalbatus was observed in Pondicherry, South India. Mechanical sutures by stapled anastomoses represent a remarkable improvement in gastro-intestinal surgery. Among those patients, who were non-smokers, and regularly visited their dentist, better dental status and oral hygiene could be observed.

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The recovery of the sleep-wakefulness cycle during arousal from hibernation in the long-tailed Arctic suslik Citellus parryi. Increased expression of the G gamma and A gamma globin genes associated with a mutation in the A gamma enhancer. Sodium intake and angiotensin in hypertension induced by chronic NO synthase inhibition in the rat. Second, very low energy x-ray and electron contaminants must be removed from the superficial beam before they reach the detector. A reparative dentin bridge was induced in rat molar teeth by pulp exposure and capping with calcium hydroxide. GD patients have significant exophthalmos and asymmetry compared to normal subjects. The data from a French case-control study of 495 patients with breast cancer and 542 control subjects interviewed in five French public hospitals, were analyzed to assess the effect of reproductive factors (age at menarche, age at first full-term pregnancy, the time interval between these two ages, and parity) on the risk of breast cancer. Roquefortine was also shown, for the first time, to be an important metabolic product of P.

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The effect of two methyluracil forms on the composition of lipids, the content of peroxidation products and the amount of lipid-soluble scavengers of free radicals was studied in rat liver and heart tissues. Reflex human papilloma virus infection testing detects the same proportion of cervical intraepithelial neoplasia grade 2-3 in young versus elderly women. The gemcitabine/carboplatin combination should be preferred in patients with underlying peripheral neuropathy. Lesion measurements may then be duplicated and growth or regression accurately established. Systems changes to improve dissemination and display of drug and patient data should make errors in the use of drugs less likely. Growth hormone (10 and 100 ng/ml) increased, but IGF-I and IGF-II were compazine suppository pediatric dose without effect on the concentration of glutamine in soleus muscle. Detection of spotted fever group (SFG) rickettsiae in Dermacentor reticulatus (Acari: Ixodidae) in Poland. CO2 laser vaporization resulted in complete removal of the treated nevus without any obvious scarring.

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We hypothesized that the changing environments of the epididymal lumen are established by differential gene expression among these segments. The purpose of this study was (a) to evaluate the incidence of paraaortic lymph node metastasis from zopiclone and alcohol adenocarcinoma of the endometrium clinically limited to the uterus (1971 FIGO Stages I and II) and (b) to report the 5 year disease-free survival of patients with histologically documented paraaortic lymph node metastasis from endometrial adenocarcinoma clinically limited to the uterus treated on two separate protocols. An investigation into the possible role of cytophilic antibody as the specific mediator of delayed-type hypersensitivity in the guinea-pig. The end points are tumor response in terms of tumor size, change in serum alpha-fetoprotein level, toxicity of treatment and overall survival. To study clinical features of fibrocalculous pancreatic diabetes from this clinic, to compare these with the published criteria of malnutrition-related diabetes mellitus, and to conduct serial follow-up of these patients to study difficulties in their treatment.

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Although back school is one of the treatment methods for patients with CLBP, its efficacy and appropriate style remain controversial. Recurrent leg ulcers, intra-alveolar hemorrhage, perforation of the nasal septum: primary antiphospholipid syndrome?. Therefore the concepts of the primary nature of functional and secondary nature of structural-morphological changes currently cannot be accepted to be correct, and the concept of functional diseases should be refuted as ungrounded. Genome-wide phylogenetic comparisons of species from the three major extant mammalian clades failed, however, to show any evidence of Nnat outside the eutherian lineage. Department of Endo-Gynecology, Royal Hospital for Women, Sydney, Australia. Hemoglobin adducts of N-substituted aryl compounds in albenza dosing exposure control and risk assessment. The patients who could remember the interview with the anaesthesiologist preferred the preoperative screening in the outpatient department. Prophylactic antibiotics may have a role in preventing recurrences of severe bacterial respiratory infections, and intravenous immunoglobulin may be useful in preventing serious bacterial infections in HIV-infected children. Computerized tomography guided needle biopsy of the cryolesion was performed 6 months postoperatively and repeated if MRI findings were abnormal. An interdisciplinary approach to research in biology and medicine and the research and development of biomedical systems.

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The unique combination of a wholly epidural tumor confined entirely to the sacral canal has not been previously described. A 68-year-old male presented with choroid plexus carcinoma in the left lateral ventricle manifesting as dysarthria and gait disturbance. Safety and efficacy of eletriptan in the treatment of acute migraine. In addition, groups are non-territorial and intermingle freely at times when exploiting food-rich patches of clumped prey, e.g. Nevertheless it may be the expression of an interaction between viral infection and atopic familial predisposition leading to lasting bronchial hyper-responsiveness.

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