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Phosphorylation mediates the function of many proteins and enzymes. The significance of the concept is interpreted in terms of trends characteristic of contemporary exploratory work. It is critical as new biomarkers are discovered, that quality specifications be developed prior to approval by regulatory agencies that give supported endorsement for the worldwide marketplace. Hypercoagulable state associated with a deficiency of protein C in a thoroughbred colt. Metabolism of polychlorinated phenols by Pseudomonas cepacia AC1100: determination of the first two steps and specific inhibitory effect of methimazole.
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Many toxicants (e.g., hepatotoxicants) of other organ systems and/or their oxidative metabolites have been identified as electrophiles and will react with cellular proteins by covalently binding nucleophilic amino acid residues. All surgical interventions on the neurocranium bear the risk of injury of the dura mater and development of a cerebrospinal fluid fistula. Distribution of histamine-, 5-hydroxytryptamine-, and tyrosine hydroxylase-immunoreactive neurons and nerve fibers in developing rat brain. Cytological effects of myleran on striated muscle of the chick embryo in ovo and the regenerating axolotl tail. This technique appears to be useful in selected cases, such as ventricular septal perforation with myocardial infarction in the subacute or chronic phase, especially in instances of inferoposterior infarction. By in vitro acid, base, and intestinal enzyme resistance tests, no methylene blue leakage was determined visually and by spectrophotometric analysis. Influence of amphetamine on some muscular exercises carried on by normal individuals. Regional cerebral blood flow (rCBF) in the conscious Fischer-344 rat was measured in 14 brain regions at 5 different ages. JM216, the first p.o.-administrable platinum complex possesses toxicities comparable to carboplatin in Phase I studies.
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We do not recommend adding routine transcranial Doppler ultrasonography in the test-battery for SSHL. Overall, earlier stages of cervical cancer are encountered during pregnancy compared with the general population. The residential treatment of individuals with eating disorders is a growing, variable, and largely unregulated enterprise. In the present in vitro study, we determined whether these cells could be stimulated by substance P (SP) and calcitonin gene-related peptide (CGRP), which are stored and released by sensory C fibers. Intracerebroventricularly injected KA and QA (100 nmol) induced spike discharges, and pCB-PzDA (100 nmol) suppressed electrocorticograms for one hour. MCF10AT: a model for the evolution of cancer from proliferative breast disease. The study, which was conducted between May 1998 and December 2000, was restricted to singleton pregnancies. Future directions may include earlier surgical intervention with adjuvant therapies reserved for aggressive recurrent disease. The model describes both the unpairing and unstacking parts of the spectroscopically determined experimental melting curves. These data indicate that, in birds, the neurotransmitter 5-HT serves as a link between the central nervous system and the immune system, and that interferon can modulate the inhibitory effect of 5-HT on the function of cytotoxic granulocytes.
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The value of liver scan in management of cancer of the large bowel. The DOPG-inserted form of rhG-CSF retains biological activity and shows remarkable stability, even under high-temperature conditions which lead to denaturation of rhG-CSF alone. The findings suggest that by using DSM-III-R criteria for adult personality disorders, one finds a considerable number of personality disorders in a young population with conduct disorder. Hemodynamic and histologic changes following microarteriorrhaphy. Iron uptake systems were identified by global expression profiling of Magnetospirillum magneticum AMB-1. Standards, options and recommendations for the practice of oncologic surgery. The potential role of the C terminus as a ligand for host cell recognition and the implications for sub-unit vaccine production are discussed. A model is proposed for cell type divergence, based on competition to become prespores, that involves mitochondrial replication in prespore cells and reduction of mitochondrial activity in prestalk cells. Calcified portal vein thromboemboli (CPVT) in six neonates are reported. Structural domain of apolipoprotein A-I involved in its interaction with cells.
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The mRNA expression of two ras-related genes, rho B and rho C, was analysed in human histological breast cancer specimens and in human breast cancer cell lines. Muscle IGF-I receptor (IGF-IR)-lysine-arginine (MKR) mice expressing dominant-negative mutant IGF-IRs in skeletal muscle are diabetic with insulin resistance in muscle, liver, and adipose tissue. Both the CB and IL groups significantly increased their knowledge scores from pretest to posttest and both significantly outperformed the control group. This suggests that the power law behavior gives a universal scaling whereby the distributions for the C--G content of the genes from all species are mapped onto a single function. Colorectal cancer and antiangiogenic therapy: what can be expected in clinical practice?. Here we report that similar epitopic changes can be induced in crude cell lysate by addition of vanadate anions at 1 mM final concentration. On the problem of pharmacological properties of Pulsatilla nigricans. Virtues and woes of AChE alternative splicing in stress-related neuropathologies. Metabolic imaging of ovarian tumors with carbon-11-methionine: a PET study. Expression of tie persisted in the lung capillaries of adult mice, but was decreased in the endocardium.
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The control of hemodynamic changes during surgical resection of abdominal aortic aneurysms (AAA) remains a challenge to anesthesiologists. A prospective randomised study of 50 patients with prolapsed thrombosed internal haemorrhoids was carried out using clinical and ultrasonic outcome measures. The classification and the pathogenesis of primary and secondary MODS are discussed. To determine the efficiency (and accuracy) of endoscopic repair versus transconjunctival repair for orbital floor fractures in a cadaveric model. This study used the diaphorase histochemical technique to detect the presence of nitric oxide synthase (NOS), the enzyme responsible for the production of nitric oxide, in the developing chick optic tectum. The pathologic changes of the gastric mucosa, the adrenal gland and the cardiac muscle cell were observed. Liver biopsies from 29 siblings of patients with Indian childhood cirrhosis (ICC) and from two age-matched controls were examined by routine light and transmission electron microscopy. This article presents a case of an orthotopic cardiac transplant in a patient with an upper cava vein duplication not diagnosed before undergoing surgery, and it compares the way it was handled to diverse techniques previously described.
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To define this latter mechanism, the nature of the prolactin receptor needs to be clearly defined. Accuracy of computed tomographic scanning in assessment of the mediastinum in bronchial carcinoma. Interestingly, while initiation of lagging-strand DNA synthesis of pUB110 occurred predominantly at a single position within SSOU, replication of pT181, pSN2 and pE194 plasmids initiated at multiple positions from SSOA. However, there is a difference in the male/female sex ratio of mortality between populations and its time trends and the reasons for these differences remain unclear. In injection of allogeneic erythrocytes treated with terrilytin of lysozyme (LTE) the most marked effect was produced by LTE injection in vibration-exposed rats (VER). A series of experiments is described in which attempts were made to produce an avian eosinophilia using various agents.
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Type I interferons (IFN) play a critical role in the Toll-like receptor (TLR)-mediated expression of B7 costimulatory family members. Evaluation of glucose monitoring devices in the hyperbaric chamber. The 4 mtDNA genes sequenced (1542 bp) showed consistent patterns, although there was more genetic variation in the protein-coding genes than in the structural RNA genes. The effect of a coloured adapting field on the spectral sensitivity of frog retinal elements. The sequence surrounding the translation initiation codon of the pea plastocyanin gene increases translational efficiency of a reporter gene. However, they exhibited similar bond strengths in caries-affected dentin. Students in two pairs of demographically similar high schools were assigned to receive either a special six-lesson AIDS-preventive curriculum (intervention group) or no formal AIDS-preventive curriculum (comparison group). The biochemical classification of mitochondrial diseases principally catalogues these nuclear defects. Screening of anti-simian immunodeficiency virus (SIV) drugs from Chinese medicinal herbs. Bovine natural killer activity against virally infected cells inhibited by monoclonal antibodies.
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Recommendations for the reporting of resected large intestinal carcinomas. One thousand thirty-four randomly selected individuals from primary care centers (PCC) were studied by a systematic sampling of all the out patient consultations over one year and to those to whom a semiquantitative questionnaire of frequency foodstuffs was given to estimate their normal diet. Risk factors associated with hemorrhagic bowel syndrome in dairy cattle. In contrast, c-erb B2 protein expression predicts a favorable response to therapy and improved survival. Two additional mutations at remote sites improve performance further, resulting in a final mutant enzyme with kinetic characteristics and coenzyme preference comparable to naturally occurring homologous NAD-dependent enzymes. Recurrence of pressure ulcers is a serious problem following myocutaneous flap surgery and can lead to prolonged and expensive hospitalization. The relative accuracy of a variety of medical diagnostic programs.