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Levothroid (Levothyroxine)
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Levothroid

Levothroid is used to treat an underactive thyroid gland (hypothyroidism). It replaces or provides more thyroid hormone, which is normally produced by the thyroid gland. Low thyroid hormone levels can occur naturally or when the thyroid gland is injured by radiation/medications or removed by surgery.

Other names for this medication:
Eltroxin, Levothyroxine, Levoxyl, Roxin, Synox, Synthroid, Thyronorm, Thyrosec, Thyrowin, Thyrox, Unithroid

Similar Products:
Lanoxin, Estrace, Evista, Arava, Prevacid, Arimidex

Also known as: Levothyroxine

Description

Levothyroxine is used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormone. Levothyroxine is also used to help decrease the size of enlarged thyroid glands (also called a goiter) and to treat thyroid cancer.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Capsule, Liquid Filled
  • Solution
  • Tablet

Dosage

This section provides information on the proper use of a number of products that contain levothyroxine. It may not be specific to Levothroid. Please read with care.

This medicine will need to be taken for the rest of your life or your child's life. Do not stop taking this medicine or change your dose without first checking with your doctor. It may take several weeks before you start to notice that your symptoms are better.

It is best to take this medicine on an empty stomach. Take it with a full glass of water at least 30 minutes to 1 hour before eating breakfast.

Swallow the capsule whole. Do not cut or crush it. Also, if you are taking multiple strengths of this medicine, remove the capsules from the blisters in advance to help you identify the strength of each capsule.

For infants and children who cannot swallow the tablet form, the tablet can be crushed and mixed with a small amount of water (5 to 10 milliliters [mL] or 1 to 2 teaspoonfuls). You may use a spoon or dropper to give the mixture. Use the mixture right away and do not store it to use later.

If you are using the oral liquid:

This medicine should come with patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions. This medicine may be mixed with water or be given directly into the mouth. If mixed with water, squeeze the contents of 1 single unit-dose ampule into a glass or cup containing water. Stir and drink it immediately. Add some water to the glass or cup and drink the water. This will help get all of the medicine out of the glass or cup. Do not mix this medicine with any other liquid except water. Do not store the mixture for later use. If taken without water, squeeze the medicine directly into the mouth or into a spoon and swallow it immediately.

This medicine should be taken at least 4 hours before or 4 hours after these medicines: antacids (Maalox®, Mylanta®, Tums®), calcium supplements, stomach medicines (including lansoprazole, omeprazole, pantoprazole, Aciphex®, Dexilant®, Nexium®, Prevacid®, Prilosec®), cholestyramine (Prevalite®, Questran®), colesevelam (Welchol®), colestipol (Colestid®), iron supplements, Kayexalate®, orlistat (Alli®, Xenical®), simethicone (Gas-X®, Mylicon®), and sucralfate (Carafate®).

Cotton seed meal, dietary fiber, soybean flour (infant formula), or walnuts may affect the absorption of this medicine from your body. You may have to take this medicine at a different time of day from when you eat these foods. Talk with your doctor more about this if you have concerns.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (capsules): For hypothyroidism: Adults and children older than 12 years of age (growth and puberty complete)—Dose is based on body weight and must be determined by your doctor. The dose is usually 1.7 microgram (mcg) per kilogram (kg) of body weight per day but may be less in older adults. Children older than 12 years of age (growth and puberty incomplete)—Dose is based on body weight and must be determined by your doctor. The dose is usually 2 to 3 mcg per kg of body weight per day. Children 6 to 12 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 4 to 5 mcg per kg of body weight per day. Children younger than 6 years of age—Use is not recommended as your child might not be able to swallow the capsules. For thyroid cancer: Adults—Dose is based on body weight and must be determined by your doctor. The dose is usually more than 2 microgram (mcg) per kilogram (kg) of body weight per day. Children—Use and dose must be determined by your doctor. For oral dosage form (solution): For hypothyroidism: Adults and children older than 12 years of age (growth and puberty complete)—Dose is based on body weight and must be determined by your doctor. The starting dose is usually 1.7 microgram (mcg) per kilogram (kg) of body weight per day. Your doctor may adjust your dose as needed. Children older than 12 years of age (growth and puberty incomplete)—Dose is based on body weight and must be determined by your doctor. The dose is usually 2 to 3 mcg per kg of body weight per day. Children 6 to 12 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 4 to 5 mcg per kg of body weight per day. Children 1 to 5 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 5 to 6 mcg per kg of body weight per day. Children 6 to 12 months of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 6 to 8 mcg per kg of body weight per day. Children 3 to 6 months of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 8 to 10 mcg per kg of body weight per day. Children 0 to 3 months of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 10 to 15 mcg per kg of body weight per day. For thyroid cancer: Adults—Dose is based on body weight and must be determined by your doctor. The dose is usually more than 2 microgram (mcg) per kilogram (kg) of body weight per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablet): For hypothyroidism: Adults and children older than 12 years of age (growth and puberty complete)—Dose is based on body weight and must be determined by your doctor. The dose is usually 1.6 microgram (mcg) per kilogram (kg) of body weight per day but may be less in older adults. Children older than 12 years of age (growth and puberty incomplete)—Dose is based on body weight and must be determined by your doctor. The dose is usually 2 to 3 mcg per kg of body weight per day. Children 6 to 12 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 4 to 5 mcg per kg of body weight per day. Children 1 to 5 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 5 to 6 mcg per kg of body weight per day. Children 6 to 12 months of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 6 to 8 mcg per kg of body weight per day. Children 3 to 6 months of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 8 to 10 mcg per kg of body weight per day. Children 0 to 3 months of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 10 to 15 mcg per kg of body weight per day.

Overdose

If you overdose Generic Levothroid and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Side effects

The most common side effects associated with Levothroid are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of levothyroxine in children.

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The ts mutation which blocked the DNA synthesis also caused inhibition of viral yield, viral antigen expression and viral RNA synthesis at 39.5 degrees C. Meiotic maturation in cultured bovine oocytes is accompanied by remodeling of the cumulus cell cytoskeleton. Many protective processes are mediated through prostaglandins, whose synthesis is abolished by inhibition of the constitutive isoenzyme, cyclooxygenase I (COX I) or Prostaglandin H-Synthase1 (PGHS1). Changes in the correlations of dienic, trienic and oxodienic conjugates permit determining direction of metabolism of unsaturated lipids, degree of oxidation of fatty acids and peroxidation index. Major depression is often associated with disturbances in basal biological functions regulated by the hypothalamus. Differential distributions of the NMDA receptor channel subunit mRNAs in the mouse retina. The management comprised the assessment clinic, videofluoroscopy in 83 patients, and finally the appropriate treatment. Sera from RA patients were screened for predominant immunoreactions by blotting. However, a greater understanding of these systems may lead to the development of countermeasures against F. Circulating CD4 and CD8 T cells have little impact on host defense against experimental vaginal candidiasis.

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Self-set dieting rules: adherence and prediction of weight loss success. We have used a packing technique for surgical treatment of carotico-cavernous fistulas, which allows preservation of the flow in the internal carotid artery. Comparison of ventricular and lumbar cerebrospinal fluid T cells in non-inflammatory neurological disorder (NIND) patients. This Botanical Briefing highlights (a) the regulation of shade-avoidance responses by endogenous and exogenous factors and (b) current understanding of the molecular components involved in red to far-red ratio signal transduction. Because the malonate/MDMA combination acutely causes a synergistic increase of 5-HT and dopamine release, in this study we sought to determine whether pharmacological blockade of MDMA- and/or malonate-induced dopamine release prevents neurotoxicity. The geological formation, coating level, decorating materials and ventilation situation all affect the radon concentration in underground buildings. This seems to show high sensitivity, if not specificity, of the self-report questionnaires. All patients included in this study underwent a standard surgical procedure involving removal of a lamella (9 mm in diameter cut with the 250-microm microkeratome head) from the recipient cornea by means of a hand-driven microkeratome and suturing of a donor lamella (0.5 mm smaller in diameter than the removed corneal lamella, cut with the 350-microm microkeratome head) obtained from a cornea mounted on an artificial anterior chamber. Intact antigen presentation for Epstein-Barr virus (EBV)-specific CTL by a lymphoblastoid cell line established from a patient with severe chronic active EBV infection. The patterns presented here depict the vast number of logical possibilities wherein the authenticity of these tests can be checked and the source of errors identified.

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Our study has demonstrated a different outcome of a mixed beta-adrenergic agonist on protein metabolism depending on the duration of the treatment and the route of administration. Both gallopamil and propranolol can be used in patients with coronary heart disease and moderately depressed left ventricular ejection fraction. These technologies will extend the limits of current molecular diagnostics and enable point-of-care diagnosis as well as the development of personalized medicine. Biosynthesis of 9-alpha,15-dihydroxy-11-ketoprost-13-enoic acid. Dose-response analysis demonstrated that methimazole causes olfactory mucosal damage at doses of 25 mg/kg ip and greater. Lipid peroxidation and antioxidant status were determined in tissue samples. Furthermore, by transfecting the mouse iNOS gene promoter into A-172 cells, transcriptional activation of the iNOS gene was detected in these cells upon stimulation with lipopolysaccharide and cytokines. Results of a randomized trial in a cooperative multi-institutional cancer group. Effects of arabinosylcytosine-substituted DNA on DNA/RNA hybrid stability and transcription by T7 RNA polymerase.

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Four cross-linked HIV Gag peptides prime the immune response to HIV proteins in mice. Rule D, which used PCR as the initial test, established the most useful algorithm: a positive PCR result followed by a positive culture in the second sample confirmed infected status, while two consecutive negative PCR results reconfirmed as negative at 6 months of age established uninfected status. Environmental aspects of staphylococcal infections acquired in hospitals. Several pathophysiological factors are involved in the development of complications, among which are hyperglycaemia per se, the consequent formation of advanced glycation end-products (AGEs) and the intracellular accumulation of sorbitol. It was combined with an impeller system in nine sheep for caval thrombectomy and with a hydrodynamic catheter for iliac thrombectomy in eight pigs after artificial induction of iliac or caval thrombosis. Application of rearrangement of the Amadori type of some polypeptides. However, based on prosecuted cases, three of 66 consecutive cases of intraoral gunshot wounds were found to be homicides. Growth was also possible on Fe(III) with the oxidation of propanol to propionate or butanol to butyrate if acetate was provided as a carbon source. Association of secondary syphilis and a circulating anti-coagulant.

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Blood flow and adenosine triphosphate (ATP) concentration were investigated simultaneously in tumour and adjacent tissue of six treated and six untreated amelanotic hamster melanomas (A-Mel-3) at 3, 12 or 24 h after multifocal application of HESW. Our results indicate sympathetic hyperactivity or an increased alpha-adrenergic input in asthmatics. Limbal LCD estimation outperforms other methods of measuring ACD as a screening tool for the detection of occludable drainage angles in the Chinese population of Singapore. The release of IMC from the beads decreased with the decreasing ratio of mannuronic acid (M) to guluronic acid (G) in alginate, and with the larger molecular weight of alginate. This is a specific chromosomal anomaly in testicular germ cell tumors.

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An assessment of the surgical treatment of adhesive small bowel obstruction in infants and children. After testing 10(8) cells at each dose point, 3 independent samples obtained with 50 Gy of X-irradiation and 6 independent samples obtained with 100 Gy of X-irradiation showed a rearranged RET oncogene amplified band. There were no significant differences in lengths of vas deferens and the distances from external ring to vassal extremity between the left and right in adults. Reduced inorganic sulfur speciation in drain sediments from acid sulfate soil landscapes. Intelligent materials that can undergo physical gelation in response to environmental stimuli have potential impacts in the bioengineering and biomedical fields where the entrapment of cellular or molecular species is desired. Elemental iron is an absolute requirement for adequate haemoglobin formation. However, reactions involved in the completion of nucleotide excision repair may be rate limiting, resulting in persistent structural damage to DNA. A variety of techniques have been developed and adopted, but while there have been some analyses of index properties using simulated data, the rationale for selecting a method remains poorly documented.

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We report on a fetus presenting with some features of the OFDs but with additional global cerebral dysgenesis. The JNC V report has also added alpha-1 adrenergic blocking agents and the alpha-beta blocker labetalol to the list of drugs suitable for initial monotherapy in managing hypertension. Static magnetic fields produced by orally placed orthodontic rare earth magnets did not result in any change in human dental pulp or gingival tissue adjacent to the magnets. This is in contrast to humans and cattle where blood granulocytes express CD11c. Changes in Tc-99m radionuclide bone scan images and peripheralization of marrow hematopoietic activity associated with the administration of granulocyte colony stimulating factor as an adjunct to dose-intensified chemotherapy for breast cancer. A case of free fibula transfer for mandibular reconstruction in a cardiac transplant patient is described. Experience with the work of regional hospitals in the Altai Region following the reform.

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Here we report the isolation and primary structure of the first platyhelminth FMRFamide-related peptide (FaRP) from the tapeworm, Moniezia expansa. The subcommissural organ appeared to be unique showing neither capillary nor GLUT1 stain. Leukocyte reactions in irradiated rats to transfusion of heterologous blood. Non-isotopic in situ hybridization study for Epstein-Barr (EBV)-related small nuclear RNA (EBER-1) revealed positive signals in the nuclei of a few lymphocytes in the tumor stroma, while the tumor cell nuclei were not labeled. The majority of the other isolates identified to species were S zooepidemicus. (3) The children with unilateral hearing impairment performed best in the monaural direct condition or when facing the signal at zero degrees. Peer-reviewed clinical studies and review articles were selected from the PubMed database using the following relevant keywords: allergic rhinitis in combination with efficacy, wheal and flare, nasal challenge, park, cat room, or exposure unit. The final document was reviewed and approved by the Executive and Council of the SOGC.

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In chlorophyll fluorescence parameters, the significant increase of F(0) values and the decrease of F(V)/F(M) and Phi(II) values was recorded. Unrecognized retention of intraorbital graphite pencil fragments: the role of computerized tomography. Low density lipoprotein (LDL), the major carrier of plasma cholesterol, may enter the parenchyma of early multiple sclerosis (MS) lesions as a result of blood-brain barrier damage. Successful use of two rapid HCV assays in a high prevalence Romanian population. In the future, the models chosen by remote and island communities and healthcare providers are therefore likely to be determined by viability, sustainability and public acceptability rather than cost. This article aims to assist inpatient rehabilitation clinicians to choose appropriate measures. A boy presented at age 2.5 years with mild left ventricular hypertrophy and mild myopathy. Hemodilution therapy has no significant longterm effect on visual acuity and visual fields, but it seems to have a beneficial influence on the recurrence rate in the affected and on the involvement of the second eye.

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Infrarenal abdominal aortic aneurysm: factors influencing survival after operation performed over a 25-year period. We demonstrated that CIC could contain IgG and IgM antibodies reacting against PGL-I and SL-IV. Some findings applicable to clinical reconstructive surgery are: 1. An improved detection system applied to the study of serum lipoproteins after single-step density gradient ultracentrifugation. The evaluation of the work load in the basic jobs in an open-pit mine. Effect of a long-term treatment with lovastatin or fenofibrate on hepatic and cardiac ubiquinone levels in cardiomyopathic hamster. The major role of gC-2 may be to protect virus from complement-mediated neutralization. Antithrombotic therapy during percutaneous coronary interventions.

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The band frequencies are assigned to alpha-helix, beta-sheet, random and turn structure. We conclude that late-onset blind individuals do manifest cerebral reorganization, although its functional relevance to the task is less clear. At 48 hours post-dosing, basement membranes adjacent to crypts were covered by cuboidal enterocytes characterized ultrastructurally by sparse, irregularly shaped microvilli located on broad cytoplasmic protrusions and by numerous free ribosomes. Primary photoprocesses of undegraded phytochrome excited with red and blue light at 77 K. Nucleotide sequence of the human coronavirus 229E RNA polymerase locus. Endoscopic variceal ligation may affect cardiopulmonary function. Observations on the pulmonary circulation time: study of the relations between respiratory activity and pulmonary circulation time in anesthetized dogs. The detection of influenza A virus antigens in cultured cells by enzyme-linked immunosorbent assay. Ischemia-reperfusion (I/R) injury is a prime antigen-independent inflammatory factor in the dysfunction of liver transplants. Three hundred eighty-two patients were randomized to one of three treatments: (1) methotrexate (40 mg/m2) days 1 and 15, bleomycin (10 mg) and vincristine (2 mg) days 1, 8 and 15, cisplatin (50 mg/m2) day 4, repeated every 21 days, (2) cisplatin (100 mg/m2) and 5-FU (1 g/m2 x 4), repeated every 21 days, and (3) cisplatin (50 mg/m2) days 1 and 8, repeated every 28 days.

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The cis-acting elements controlling mouse IL-2R alpha transcription. MR imaging of the wrist will zithromax treat a bladder infection , a noninvasive means to observe median nerve, is useful for the diagnosis and the follow-up study of CTS. Our study reveals that the number of mast cells increased during the promotion period but that this alteration is confined to the 30-microns-wide strip below the epidermis. Hormonal regulation of complement components and receptors throughout the menstrual cycle. Thromboxane A2 receptor antagonist (ONO 3708) protects from liver damage induced by cholestasis and ischemia-reperfusion.

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The algorithms correctly detected a high proportion of isolated (328/333) and clustered (254/271) nuclei when applied to images of 2 microns prostate and breast cancer sections. The protein encoded by this mRNA contains the double catalytic domain characteristic of the JAK family kinases. Localization of the genetic defect in X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1) to the CD40 ligand gene. Chemodectomas are responsive to radiation therapy in human patients, and favorable response has also been reported in dogs. Each tile segment of the target can be zoomed up without loss of the high resolution. Secondary myelodysplastic syndrome following bone marrow transplantation: report of two cases. If, on the other hand, the reference frame is hand-centered, the deviations should vary with condition.

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Disappearance of the Q-deflection following myocardial infarction. The pathophysiology of carotid artery trauma, treatment options, and key acute care issues are discussed. The apoptotic index (AI) of neurons in spinal cord was detected by terminal deoxyribonucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) method. Before admittance to the psychotherapy program enquiries were made by means of a questionnaire, about what subject they would like to speak in the individual or group therapy sessions. Criteria of clinical feldene 20 mg capsule uses in urdu and radiological diagnosis in nonpuerperal acute phlogistic-like processes of the breast: considerations on 97 consecutive cases. The transmission of contrasts by the optical system of the eye and the retinal thresholds of contrast.

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CD36 is expressed in the endothelial cells of some human organs, but the ultrastructural localization of this molecule in the sinusoidal lining cells of human liver is not well established. The advantage of in situ hybridization is that it allows the identification of specific regions or cells expressing mRNAs to be identified. It has been reported that serum vitamin B12 levels assayed by saturation analysis methods may give misleadingly high results, so much so that the diagnosis of vitamin B12 deficiency may be obscured. These alterations may be important in the pathophysiologic response of the lungs to irritants. The plaster cast syndrome 2 cases of intestinal gastric emphysema. Walls of elongated carrot cells, in contrast, show a marked net orientation of microfibrils at right angles to the axis of elongation. A new method for determining the dissociation constant between macromolecules by gel permeation. The Psychoeducational Profile (PEP) has been used to assess the developmental functioning and behavior of autistic children in the West. In spite of its danger, neither veterinary nor human vaccines are available. The provision of access to quality health care services and the restraint of rapidly escalating health care costs are dominant policy issues.

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