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Kemadrin (Procyclidine)
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Kemadrin

Kemadrin is an anticholinergic drug principally used for the treatment of drug-induced parkinsonism, akathisia and acute dystonia; Parkinson disease; and idiopathic or secondary dystonia. It is used in patients with parkinsonism and akathisia, and to reduce the side effects of antipsychotic treatment given for schizophrenia.

Other names for this medication:
Axeps, Parklid, Procyclidine, Prodine, Propark, Relidrin, Sycline

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Mellaril, Flagyl, Norvasc, Abhigra, Cymbalta, Prograf, Lozol, Biaxin

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Also known as: Procyclidine

Description

Generic Kemadrin is used to treat parkinsonism and extrapyramidal dysfunction caused by tranquilizer therapy. In Parkinson's disease, the deficiency of dopamine causes overactivity of acetylcholine. This causes some of the symptoms of the disease. Generic Kemadrin works by blocking the receptors that acetylcholine acts on. This reduces the activity of the acetylcholine and helps restore the balance of acetylcholine and dopamine in the brain. In this way, Generic Kemadrin helps to control some of the symptoms of Parkinson's disease. Generic name of Generic Kemadrin is Procyclidine. Brand name of Generic Kemadrin is Kemadrin.

Dosage

Take Generic Kemardin tablets orally. Take Generic Kemadrin with or without food. Do not drink alcohol during Generic Kemadrin usage. Be careful if you drive or do anything that requires you to be awake and alert while using Generic Kemadrin. The dosage and the kind of medicine depend on the disease and its prescribed treatment. If you want to achieve most effective results do not stop taking Generic Kemadrin suddenly.

Overdose

If you overdose Generic Kemadrin and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature 15 and 30 degrees C (59 and 86 degrees F) away from away from moisture, light and heat. Do not store in the bathroom. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Kemadrin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Kemadrin if you are allergic to Generic Kemadrin components. Be careful with Generic Kemadrin if you are pregnant, planning to become pregnant or breast-feeding. Do not take Generic Kemadrin if you have closed angle glaucoma, have obstruction of the stomach or intestines, have urinary retention. Generic Kemardin is not recommended for children. Be careful if you are elderly aged person. Be careful with Generic Kemadrin if you have decreased kidney function, have decreased liver function; have the risk of glaucoma. Be careful with Generic Kemadrin if you take amantadine; antihistamines, eg. brompheniramine, chlorphenamine; antispasmodics, eg. hyoscine; antipsychotics, eg. chlorpromazine, clozapine; certain antisickness medicines, eg. promethazine, prochlorperazine, meclozine, cyclizine; certain medicines for abnormal heartbeats (antiarrhythmics), eg. disopyramide, propafenone; MAOI antidepressants, eg. Phenelzine; medicines for urinary incontinence, eg. oxybutynin, flavoxate, tolterodine, propiverine, trospium; memantine; muscle relaxants, eg baclofen; nefopam; other anticholinergics, eg. trihexyphenidyl, orphenadrine; tricyclic or related antidepressants, eg. amitriptyline, maprotiline. Avoid alcohol. Be careful when you are driving machine. It can be dangerous to stop Generic Kemadrin taking suddenly.

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Socially sensitive strategies for clinical intervention are offered. The purpose of this review is to describe the clinical presentation and pathophysiology of stress-related mucosal bleeding and review the strategies to prevent bleeding. Entamoeba histolytica and Entamoeba dispar, two human parasites, have many retrotransposons, but few DNA transposons. Effect of dietary sodium on airways responsiveness and its importance in the epidemiology of asthma: an evaluation in three areas of northern England. Breath pentane and plasma lipid peroxides in ischemic heart disease.

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The thyroid biological half-life of I-131 (Tbiol) was found to be increased significantly following lead and lithium treatments when given separately. burgdorferi uptake was reduced, with an average of 16 spirochetes per larvae acquired after 4 d of feeding, representing 1/195 of the counts in I. Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease. In the context of a simple decision analysis, they found that imbalances in the sample sizes for the data used to estimate the parameters among different strategies resulted in non-optimal decisions in the long run. The history of the development of radiographic scoring methods is reviewed. Narrowing of pulmonary arteries after ASO is associated with oval vessel diameters. The six techniques of laparoscopic repair are described and published experience for each of these is discussed. This relationship between p66shc, grb2, and sos1 provides a novel mechanism for the activation of rac1. Cyclic dimer of a fused porphyrin zinc complex as a novel host with two pi-electronically coupled binding sites. The patients also had smaller bilateral anterior and posterior fusiform gyrus gray matter volumes, compared to the healthy subjects.

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The effects of PR on initiational and promotional growth of DNA-damaged tissue is also discussed. The self-selected study population comprised 109 women who were 25-42 years old, including 26 women whose husbands had mild male-factor infertility. The 6-hourly group received an initial dose of 1 mg, followed by 2 mg at 6 hour intervals for a maximum of two additional doses if not in active labor. Volatile anaesthetics are known to influence GABAA-, glutamate-, and glycine- activated receptors, which are members of the same family of ligand-gated receptor-channel units. Imaging of severe forms of hematoma in the rectus abdominis under anticoagulants. A 34-year-old woman with bilateral recurrent ocular myositis for 2 years had developed cyclic vertical deviation 6 months after clinical remission. The Euler characteristic of a three-dimensional structure is a topological invariant, which reports the number of particles of a structure plus the number of enclosed cavities minus the connectivity. This study confirmed the healing and analgesic properties of roxatidine in duodenal ulcer disease.

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The average number of muscles examined by quantitative EMG varied from 0 to 4.3 in anterior horn cell disorders and from 0.0 to 4.5 in myopathies. These data support the hypothesis the MK-801 may reverse the differential changes in D1 and D2 agonist-induced motor responses which result from chronic treatment with levodopa. Detection of 2-eicosanol by gas chromatography-mass spectrometry in sputa from patients with pulmonary mycobacterial infections. Localization of the chemotactic region to a 140,000-molecular weight non-gelatin-binding fragment. The dorsiflexion and plantar flexion strength were quantitatively measured to determine the recovery of muscle strength, and recorded as a percentage of the strength of the contralateral extremity as well as by assigning a motor grade. From innovation to common practice: perinatal nursing pre-1970 to 2005. In conclusion, it is advisable to wash surgical gloves with sterile solutions and to limit enlarged bowel resections mostly in young people. Its goal is to improve specific aspects of ambulatory patient care: disease prevention, cancer detection, immunization compliance, risk management, outcomes monitoring, and patient education. We studied the influence of several cytokines on the expression of glutaminase, the major enzyme of intracellular glutamine metabolism in fibroblasts.

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When small numbers of cells are planted in such chambers, loss of carbon dioxide leads to an undesirable increase in pH and inhibits cell multiplication. Therapeutic trials of a new anabolizing steroid, norethandrolone (nilevar). aureus were recovered from glycerin preserved sclera for up to 12 hours, 1.5 days, and 8 days, respectively. Total exchangeable electrolytes in normonatraemic hypochloraemia. Benactyzine was found to differentially increase the number of errors performed during the spatial but not during the visual trials. Control of gill filament blood flow by serotonin in the rainbow trout, Oncorhynchus mykiss. By means of this technique, sleep spindles were localized in the time-frequency plane with high precision, and their intensities and time spans were found. Immunization resulted in the induction of both p18- and pN-specific antiviral cytotoxic T lymphocytes, irrespective of the number of amino acids separating the epitopes. Local anaesthetics failed to influence shape change except at concentrations much greater than those which inhibited aggregation. Leber hereditary optic neuropathy: biochemical lights in a blurry scenario.

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Community-based disaster preparedness (CBDP) approaches are increasingly important elements of vulnerability reduction and disaster management strategies. Our major goals in this study were to determine the prevalence of Helicobacter pylori among Israeli children with recurrent abdominal pain and to establish whether a link exists between eradication of Helicobacter pylori and the recovery from abdominal pain. The challenge of studying the disease effects of stressful work conditions. Numerous antidepressants are effective but most of them produce side effects. This paper describes the use of innovative teaching techniques in clinical teaching. Monitoring free digoxin following the administration of Fab may be of value in selected patients to guide additional Fab dosing, confirm possible rebound toxicity, or guide the reinitiation of digoxin therapy. These peak densities were correlated with high rainfall 4 months previously.

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A selection leading to the overtaking development of testicles and copulative apparatus regarding morphogenesis of ovary and vitellarium is based an earlier maturation of testicles and group copulation of proglottids with and underdeveloped ovary that is typical in original euandrogyne forms. In this article the authors describe surgical techniques in which the histological pseudocapsule is used as a surgical capsule during pituitary surgery. We report about successful treatment of a 60-year old patient with necrotizing fasciitis and multiple organ failure. Effects of angiotensin-converting enzyme inhibitors and bradykinin antagonism. Because (i) the association between FGFR-1 and Src-like kinases exhibits kinetics similar to those observed between the Src kinases and cortactin and (ii) the Src-SH2 domain is likely to be involved in the association with FGFR-1, we propose that the association of c-Src with activated FGF receptors may be responsible for the tyrosine phosphorylation of cortactin during the mid to late G1 phase of the cell cycle. Twenty-seven patients with CT findings positive for subarachnoid hemorrhage or intracranial aneurysm were evaluated with digital subtraction angiography or MR angiography within 12 hours of CT angiography.

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Regional gastric mucosal flow was measured by hydrogen clearance techniques during gastric cooling. Four children are described, (three black and one white, two boys and two girls) with type A postaxial polydactyly. The IgA anti-PPS 19F antibody activity in BAL after immunization with the well-adhering strain was higher than with the poorly adhering strain. The findings suggest that ADR is stably entrapped in PEO-PBLA micelles. Maternal influenza during the second trimester may impair fetal growth and predispose to obstetric complications and lower birth weight in a proportion of individuals destined to develop schizophrenia. The reduction is particularly marked in the dorsal horn and primarily affects the class of high affinity epibatidine binding sites thought to modulate nociceptive responses.

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Enhancements and justice: problems in determining the requirements of justice in a genetically transformed society. Indirect immunofluorescence in COS-1 cells against a heterologous epitope tag attached to the N-terminus of MPTP-PEST, together with cellular fractionation and Western-blot experiments from different murine cell lines, indicate that MPTP-PEST is a free cytosolic protein of 112 kDa. Oxidation of bovine serum albumin initiated by the Fenton reaction--effect of EDTA, tert-butylhydroperoxide and tetrahydrofuran. The results illustrate and help to explain the disturbances in propagation which have been reported to occur at regions of decreased excitability, regions with changing action potential duration, or regions with changing intercellular coupling. Chromatographic methods in the analysis of cholesterol and related lipids. Thus, human atherosclerotic plaques exhibit nonuniform patterns of type I collagen gene expression.

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I go on to discuss the findings of most relevance to psychology, critically analysing the most important conclusions. The radial artery is currently regarded as a useful vascular access site for coronary procedures. These cellular immune responses may be particularly important in targeting and controlling pathogenic cell populations. Additionally, the PNIS probe is portable, economical and is not dependent on operator-defined regions of interest. It has profound implications psychosocially to both parties, and is often erroneously viewed as an inevitable corollary of the ageing process, being one of the most damning hallmarks of decline, and a potent cause of rejection. Pulpal wound healing consists of stem/progenitor cells release from dental pulp niche after noxious stimuli such as caries, migration to the injured site, proliferation and differentiation into odontoblasts.

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The steady decline in tuberculosis case rate reversed in the mid-1980s, and tuberculosis cases have increased dramatically since that time. These data provide evidence for substantial proliferation within germinal centers before the initiation of somatic mutation and the subsequent selection of a significant frequency of mutated clonotypes into the memory compartment. To evaluate whether the talinolol double-peak is associated with processes of food absorption, a breakfast was served 1 h after administration of a fast disintegrating capsule. The most common primary cancers that metastasized to the orbit were lung cancer, and breast cancer. Many studies have suggested that there is an inverse relation between certain infections and the risk of asthma. The results suggest that vinclozolin virilizes females and directly or indirectly affects progesterone receptor expression. In this paper we present a technique for finding an appropriate parameterization of ultrasoft pseudopotentials for modeling mixed-valence materials. Fifty one patients underwent a complex treatment with prospidin in a total dose of 3,000-3,500 mg (in a daily dose of 100 mg) followed by near-focus X-ray therapy in a total dose of 3,000 Gy (a single dose being 500 Gy). Laryngotracheal complications after translaryngeal intubation and specifically tracheotomy are a common problem. A mAb against a novel 63 kDa membrane protein (p63) was produced that identifies a large tubular network of smooth membranes in the cytoplasm of primate cells.

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The hemodynamic effects of oral doses of prazosin and hydralazine were studied in the same group of patients with chronic congestive heart failure. Abnormal vascular function following ischemia-reperfusion injury. Tyrosine phosphorylation of Shc proteins and formation of Shc/Grb2 complex correlate to the transformation of NIH3T3 cells mediated by the point-mutation activated neu. By using a monoclonal antibody directed against an epitope located on glycoprotein B of bovine herpesvirus 1 (BHV1), a simple, convenient blocking enzyme-linked immunosorbent assay (ELISA) which combines a high sensitivity with a low false-positive rate has been developed. Expression of beta-galactosidase in neurons of dorsal root ganglia which are latently infected with herpes simplex virus type 1. The data available to date indicate that endocrine and pleiotropic para- and autocrine mechanisms of action are involved in a neuropeptide immune network, including GH, PRL and IGF-I as modulators of immune function. Under this regulatory provision, these certain veterans are eligible for VA hospital care, nursing home care, and outpatient medical bactrim dose in dogs services in the United States in the same manner and subject to the same terms and conditions as apply to U.S. To compare pregnancy and delivery complications of first births in women 35 years and older with women 25-29 years old. Herein the authors describe the components of a program implemented to promote professionalism and effective communication in their radiology department.

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The DiI labeling of olfactory fibres in chimeras revealed anomalies in the formation of the nerve from the chick graft. Does clinical presentation explain practice variability in the treatment of febrile infants?. We further show that high affinity binding of soluble fibronectin can be induced by either differentiation of the monocytic cell line THP-1 or by cross-linking the T cell receptor complexes on the T lymphoid cell line HUT-78. These results confirm the ability of Hicks method as a reliable tool in systematic research of the ischemically damaged synaptic contacts. These results indicated that chloride is not passively distributed diovan dosage strengths in rabbit papillary muscle. A 17-year-old XX male with constitutional delay of growth and development and genetic short stature is described. The entire hypothesized S1 binding pocket and subsets of it were subjected to saturation mutagenesis by this strategy, and screening yielded a number of mutant enzymes which have up to 150 times more activity (kcat/Km) towards CBZ-Lys-Leu-OH than the wild type enzyme. Rhabdomyosarcoma of the oral tissues--two new cases and literature review. Cutaneous hyperalgesia was induced with the heat/capsaicin sensitization model.

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Mechanical injury to the periradicular tissues can cause activation of several pathways of inflammation and release of nonspecific mediators. Impact of prehospital cardiac algorithms on ventricular fibrillation survival rates. Although the specific roles of nitric oxide (NO) in the heart in general and on cardiac mitochondria in particular remain controversial, it is now clear that both endogenous and exogenous sources of NO exert important modulatory effects on mitochondrial function. A reliable surveillance system is the key to early warning of a change in the health status of any animal population. Expression of CD43 on murine and human pluripotent hematopoietic stem cells. Perceptual load as a necessary condition for selective attention. The results indicate that at the level of resolution of the fluorescence microscope there is an extensive but not complete superposition of the filamentous distributions of the labels for tubulin/F-actin and vimentin/F-actin during interphase, suggesting that extensive association of the two filaments exists in these cells. In 4,724 fattening pigs with inflammation of the tail and embolic pneumonia, a bacteriological examination was made in accordance with the Meat Inspection Regulations.

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Statistical analysis was done using student t-test and Mann-Whitney U test. The replacement of Lys528 with various amino acids including Ala, Met, His and Arg caused a significant decrease in the enzymatic activity. Flow cytometry has been used to study the contents of macromolecular compounds and light-scatter parameters in batch and continuous cultures of a recombinant Escherichia coli strain that forms protein inclusion bodies. Analyses of polymethacrylate containing aluminum as well as phosphorus disclosed an unexpected artifact--aluminum inhibited the plasma ashing. The general hospital in the protection of public health in Sicily: current needs and future prospects.

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Labilization of DNA structure of peripheral blood leukocytes in patients with systemic lupus erythematosus. Analysis of the differences in the protein surface properties indicated that the endoglucanases tend to be more hydrophilic than the exoglucanases. The heart has been demonstrated not only to be a pumping organ but also an endocrine organ secreting atrial natriuretic peptide (ANP). These amides were prepared through condensation of an activated ester of the known intermediate acid 2 with the corresponding primary amine. Thus, the present data support the inclusion of all BDI items when measuring depression in MS. 1994 recipient of the Paul Kayser International Award of Merit in Retina Research. Intramuscular vs intradermal hepatitis B vaccination: a 6-year follow-up. Patients with isolated PRS (group I, 27 patients) and Stickler syndrome (group II, 32 patients) do not suffer from debilitating airway and feeding difficulties when compared to those with unique syndromes (group III, 16 patients) and recognized named syndromes (group IV, 15 patients). The mechanisms remain to be elucidated in detail, but the results do not favor the role of liver as the only or the major initiator of TCDD anorexia.

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Structural data show that these molecules interact with collagen fibrils and suggest that they might interact with cells. Risk of tuberculosis in the inadequate handling of refugees seeking asylum. Electrophysiology studies suggest that adult macaque primary visual cortex (V1) undergoes large-scale reorganization within a few months after retinal lesioning, but this issue has not been conclusively settled. The results provide evidence for deficits in the early stages of face perception in schizophrenia. Recent advances indicate that the small RNAs termed microRNAs play important roles in animal development and physiology. The present study was designed to compare cerebral hemodynamics assessed using the blood flow index (BFI) derived from the kinetics of the tracer dye indocyanine green (ICG) with transcranial Doppler ultrasound (TCD) in an established model of hemorrhagic shock. However, this practice raises food safety concerns, especially when manure is used on fruit and vegetable crops. Vero cytotoxin-producing E coli O157 infection associated with farms. Three mechanisms have been proposed to explain the neurotoxic effects, including rare proconvulsant activity, associated with quinolone therapy.

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Serum and red cell cholinesterase activities were determined in 2 groups of subjects namely:-I) a group of 10 patients who took organophosphate insecticide and were admitted into the hospital for treatment and II) a group of 65 workers from an organophosphate insecticide factory. In rat peritoneal mass cells induced by anti-immunoglobulin E (anti-IgE), contignasterol (1) inhibited histamine release in a dose-dependent manner. Urethral strictures following transurethral resection of the prostate. Egg yolk proteins obtained from 2-3-day-old fertilized channel catfish eggs were analyzed to determine if immunoglobulin (Ig) was present. Review of medical records, karyotyping, and collation of gene mutation analysis. The morphofunctional characteristics of the thrombocytes in patients with refractory tachyarrhythmias.

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Patient consciousness showed a significant and progressive improvement in the postoperative 1 month period. Factor VII gene polymorphisms contribute about one third of the factor VII level variation in plasma. No correlation was found between changes in communication induced by UV radiation and levels of cyclic AMP. Controlled-release preparation of indomethacin using calcium alginate gel. Finally, at least 10 RAPD primers appear to be necessary in order to develop reliable estimates of relatedness among annual Medicago accessions. Long-term results of a multicenter SAKK trial on high-dose ifosfamide and doxorubicin in advanced or metastatic gynecologic sarcomas. Further, when an eye movement is about to occur, more than a third of LIP neurons transiently shift the location of their receptive cytoxan chemotherapy drug fields. With the aid of a specially designed combination electrode for infants, 20-24 hr monitoring of esophageal pH was undertaken in 15 infants, aged 5 wk-11 mo.

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In the two models of ALI, FFHQ (60, 120, 240 mg/kg) was found to significantly decrease the serum transaminase (ALT, AST) activities. Resistance was shown by a 47 per cent reduction in flukes recovered from sheep treated in this way (P less than 0.05). Massive haemorrhage occurred during the fourth operation on day 48, and the patient was transfused with 31 phenotype compatible PRC, 21 fresh frozen plasma, 36 standard platelet concentrates (SPC), fibrinogen, factor VIII and anti-thrombin III. Mean ratio of extrasystoles in patients with ischemic heart disease. Expression of the cell membrane P-glycoprotein in tumour cells appears in vitro to be an important adverse prognostic factor concerning the effect of natural products. The results of cross-reactivity of antipeptide AB with ADH from other biological sources suggest that amino acid sequences (1-14), (93-115) and (265-276) contain common antigenic determinants for the corresponding ADH from animal sources. Here we present our studies using IGFBP-1 to inhibit growth of the breast cancer cell line MCF-7.

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The use of the plane-parallel chambers follows the 1983 AAPM protocol for absorbed dose calibrations of electrons, except that new energy-dependent Prepl values are given for the Capintec PS-033 and PTW-Markus chambers consistent with the consensus of reports in the literature. The rise of KC population counts due to the increased number of functional element play a positive role in clearance of intestinal dose of ethambutol in tuberculosis endotoxin and liver defence for ischemic and recirculatory organ damage. Association of CYP1A1 germ line polymorphisms with mutations of the p53 gene in lung cancer. The major advantages of recombinant antibodies are their rapid and easy generation against virtually any target. In North America and Europe around 140 persons die every year due to avalanches, approximately 35 in North America, 100 in the European Alps, and 5 in other parts of Europe. To investigate whether the prevalence of skin prick test (SPT) positivity in Danish children has changed from 1986 to 2001. Although many methods have been devised to inhibit reproduction, more acceptable alternatives are still needed. Previous investigations suggest that dietary sources of polycyclic aromatic hydrocarbons (PAHs) contribute to the PAH-DNA adduct load in peripheral white blood cells (WBCs). Prolonged thrombin time probably no contraindication to kidney biopsy. Waning of vaccine-induced immunity has been cited as one of the reasons for the observed epidemiologic trend.

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