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Glyburide (Glibenclamide)
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Glyburide

Glyburide is an effective and affordable medication for lowering blood sugar, but it can sometimes make your blood sugar too low especially if you have kidney problems. Glyburide tells your pancreas to increase the amount of insulin it produces in your body. Insulin works to lower your blood sugar.

Other names for this medication:
Afdiex, Aviglen, Benclamet, Benformin, Betanase, Bionil, Combidos, Comdiab, Daocon, Diabetnil, Diabetrol, Diabnil, Duotrol, Euglucon, Eumet, Glibenclamide, Glibet, Glucomin, Gluconil, Glucored, Glucosafe, Glucosil, Glucotrac, Glunil, Glybenclamide, Glybid, Glybovin, Glybovine, Glycurb, Glycurub, Iscept, Melitus, Monomet, Secrin, Sugatrol, Sugnil, Sugronil, Symet, Triglycomet

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Trileptal, Skelaxin, Adipex, Dulcolax, Leukeran, Naprosyn, Zyvox, Diovan, Claritin

Also known as: Glibenclamide

Description

Glyburide is an oral diabetes medicine that helps control blood sugar levels.

Glyburide is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Glyburide is not for treating type 1 diabetes.

Dosage

Usual Adult Dose for Diabetes Type 2:

Doses provided as glyburide-metformin -As Initial Therapy in Patients with Inadequate Glycemic Control on Diet and Exercise Alone: Starting dose: 1.25 mg-250 mg orally once a day -Consider a starting dose of 1.25 mg-250 mg orally twice a day for patients with fasting blood glucose (FBG) greater than 200 mg/dL or HbA1c greater than 9% Maintenance Dose: Increase in increments of 1.25 mg-250 mg per day every 2 weeks up to the minimum effective dose to achieve glycemic control Maximum Initial Dose: 10 mg-2000 mg per day -Patients with Inadequate Glycemic Control on a Glyburide (or another Sulfonylurea) and/or Metformin: Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control Maximum Dose: 20 mg-2000 mg per day Comments: -Give with meals; 5 mg-500 mg dose should not be used as initial therapy due to an increased risk of hypoglycemia; initial doses should be conservative to avoid hypoglycemia largely due to glyburide and gastrointestinal side effects largely due to metformin. -For patients who are switching to combination therapy, initial doses should not exceed the daily dose of glyburide (or equivalent sulfonylurea) and metformin already being taken; the decision to switch to the nearest equivalent dose should be based on clinical judgement. -Addition of thiazolidinedione may be appropriate for patients not adequately controlled on glyburide-metformin; in patients experiencing hypoglycemia, consider reducing the dose of the glyburide component. -Monitor patients closely for signs and symptoms of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Detailed Glyburide/metformin dosage information

Overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include hypoglycemia symptoms as well as the following:

  • seizures
  • loss of consciousness

Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

Side effects

The most common side effects associated with Glyburide are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For glyburide, micronized, the following should be considered:

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A simplified mobilization protocol is described that requires only one apheresis to achieve rapid hematologic engraftment. Prostaglandin E2 (PGE2) downregulates interleukin (IL)-1alpha-induced IL-6 production via EP2/EP4 subtypes of PGE2 receptors in human periodontal ligament cells. Diagnosis and treatment of neonatal hypotension outside the transitional period. The 51Cr label was detected in the hemoglobin and in the low molecular weight compounds within the red blood cells. We report clinical and radiological findings and treatment strategies in four dialysed patients who developed brachial artery pseudoaneurysms.

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Prolonged respiratory support with extracorporeal membrane oxygenation in lung transplantation. Relationship between serum prostate specific antigen and the pattern of inflammation in both benign and malignant prostatic disease in Middle Eastern men. Recent evidence suggests that nitric oxide (NO) is a major messenger molecule regulating smooth muscle contractility. Effect of acute stress on the pituitrary gland: uptake of serine-1-C14 into ACTH. However, the addition of artificial tears to irregular eyes that have undergone penetrating keratoplasty created a more regular and symmetric surface and significantly altered the simulated keratometry values. In contrast, metal-metal prostheses of the McKee type implanted in the sixties, may still work perfectly today without any signs of osteolysis along the bone-cement interface, proving that metal-metal pairing is superior to prostheses with polyethylene cups and proving also that cement anchorage may be adequate for fixation. We present a comprehensive study for the statistical properties of random variables that describe the domain structure of a finite Ising chain with nearest-neighbor exchange interactions and free boundary conditions.

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Affinity tagging has been used in many global studies towards protein function. Utilization of thiothixene in the treatment of mania: Pilot study. Similarly, integrin-mediated adhesion to monolayers of decidual stromal cells could be blocked with mAbs to the alpha 5, alpha 6, beta 1 and beta 4 integrin subunits. More reporting should create more opportunities for system improvement. An assessment of the validity of the approach, for the broadband XUV radiation of asec pulses, is implemented through ab initio calculations modeling the spectral and temporal response of the two-XUV-photon He ionization detector employed.

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Role of discontinuous chlorination on microbial production by drinking water biofilms. Fractionation of an antiserum to progesterone by affinity chromatography: effect of pH, solvents and biospecific adsorbents. On each specimen, we digitized 47 landmarks and 144 semilandmarks on facial curves and the external neurocranial surface. Specific binding of IGF-I to pericytes was increased by the incubation with high glucose for both 8 and 24 h. On the leukocytes the main regulatory pathway for ICAM-mediated binding is believed to be a short-term regulation of the avidity of CD11/CD18. Relationship between amplicon composition and cytologic type of structures containing amplified DNA in murine P388 cells with multiple drug resistance. Nevertheless a marked advantage for azithromycin was observed in experimental local infections and with infections due to Gram-negative bacteria (Haemophilus influenzae, Branhamella catarrhalis).

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Department of Anaesthesia and Critical Care, Queen Elizabeth Hospital. This study proves that MRI, when adequately performed, is a very accurate tool to study, in a very short time, the pancreas and peripancreatic region, yielding much better results than all the other diagnostic imaging modalities. Effect of light and dark on secondary induction of cornea in tadpoles of Rana temporaria. Tissue thickness of human stomach measured on excised gastric specimens from obese patients. Development of an rRNA-targeted oligonucleotide probe specific for the genus Acinetobacter and its application for in situ monitoring in activated sludge. Thus, antiangiogenic therapies can potentiate the efficacy of standard anticancer therapies. In basal conditions, endothelial-neutrophil interaction is inhibited by negatively charged molecules present on endothelial cell membranes and by the production of numerous anti-inflammatory substances. Cyclosporin A and FK506 inhibit activation-induced cell death in the murine WEHI-231 B cell line. Underivatised alkaloid mixtures extracted from intact plants and in vitro cultures of Leucojum aestivum (Amaryllidaceae) were investigated by capillary GC-MS.

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Adducts to macromolecules in the biological monitoring of workers exposed to polycyclic aromatic hydrocarbons. Ligation of alpha 2M receptors with alpha 2M-methylamine stimulates the activities of phospholipase C, phospholipase A2, and protein kinase C in murine peritoneal macrophages. Correction of neutropenia with rHuG-CSF after loss of response to rHuGM-CSF following autologous bone marrow transplant. A new classification system for head injury based on the findings of computerized tomography was used in a population of 809 head injured patients. Surgical advancement of the mandible through sagittal ramus osteotomy. The patients of 130 consultants carrying out major maxillofacial surgery. Evaluation for a normal masculine urethra and in cases of obstruction due to prostatic hypertrophy. Exhaled nitric oxide was elevated in patients with moderate to severe asthma and with treatment decreased in the first week reaching to a near normal level by 4 weeks. During GPI biosynthesis, inositol in phosphatidylinositol becomes acylated.

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Development of coronary collateral vessels is described in a patient with coronary artery spasm associated with ST-segment depression. Effect of isotonic and hypertonic solutions of sodium chloride on the blood vessels of the lower extremities in man. B-mode ultrasound imaging of the common carotid arteries was used to measure common carotid IMT in 99 subjects. The seasonal effect was slight during the early months of life but became obvious at later ages. The aim of this study was to assess the influence of different seeding densities on the function of hybridoma cells (clone 1B5, IgG 2alpha) producing an anti-angiogenic monoclonal antibody (mAb), microencapsulated using a high-voltage electrostatic field.

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A thermodynamic approach to the hydration of sulphate-resisting Portland cement. The relationship between variation and rate of growth for chicken populations. A comparative study of intraoperative echography/cholangiography in the detection of calculi in the common bile duct. Selective activation of dopamine transmission in the shell of the nucleus accumbens by stress. This study focuses attention on ischemic heart disease and cerebrovascular risk factors about the frequency of silent brain infarction. At randomization and 1, 6 and 12 months after treatment, patients were evaluated for the development of a DTCH to autologous tumor and to autologous normal cells, obtained by mechanical and enzymatic dissociation of the surgical specimens. The patient had noticed a hard induration in the right breast twelve years previously and had a radical operation for right breast cancer. The treatment produced good results in all types of diseases considered, with a significant decrease in severity of symptoms being observed.

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The effect of the long-term alcoholization of rats on partial kidney functions under increasing hypo- and hyperosmolarity. Synthesis, characteristics and biological activity of pentacoordinated spirophosphoranes derived from amino acids. Recently we identified a unique region, residues 9-30 in the extracellular domain of the FSH receptor, capable of binding FSH but not LH or TSH. Cochrane column: commentary: interventions for preventing tobacco sales to minors. To develop cancer prevention and education programs that meet the unique needs of African Americans, nurses must be aware of barriers and cultural differences. To determine whether this was due to the genesis of 5-HT vantin medication class neurons, bromodeoxyuridine (BrdU) was injected into larval, metamorphosing, and postmetamorphic lampreys. Pseudomonas cepacia strain AC1100 grows luxuriantly on 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) but does not utilize phenoxyacetic acid.

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