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Glyburide (Glibenclamide)

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Glyburide is an effective and affordable medication for lowering blood sugar, but it can sometimes make your blood sugar too low especially if you have kidney problems. Glyburide tells your pancreas to increase the amount of insulin it produces in your body. Insulin works to lower your blood sugar.

Other names for this medication:
Afdiex, Aviglen, Benclamet, Benformin, Betanase, Bionil, Combidos, Comdiab, Daocon, Diabetnil, Diabetrol, Diabnil, Duotrol, Euglucon, Eumet, Glibenclamide, Glibet, Glucomin, Gluconil, Glucored, Glucosafe, Glucosil, Glucotrac, Glunil, Glybenclamide, Glybid, Glybovin, Glybovine, Glycurb, Glycurub, Iscept, Melitus, Monomet, Secrin, Sugatrol, Sugnil, Sugronil, Symet, Triglycomet

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Trileptal, Skelaxin, Adipex, Dulcolax, Leukeran, Naprosyn, Zyvox, Diovan, Claritin

Also known as: Glibenclamide


Glyburide is an oral diabetes medicine that helps control blood sugar levels.

Glyburide is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Glyburide is not for treating type 1 diabetes.


Usual Adult Dose for Diabetes Type 2:

Doses provided as glyburide-metformin -As Initial Therapy in Patients with Inadequate Glycemic Control on Diet and Exercise Alone: Starting dose: 1.25 mg-250 mg orally once a day -Consider a starting dose of 1.25 mg-250 mg orally twice a day for patients with fasting blood glucose (FBG) greater than 200 mg/dL or HbA1c greater than 9% Maintenance Dose: Increase in increments of 1.25 mg-250 mg per day every 2 weeks up to the minimum effective dose to achieve glycemic control Maximum Initial Dose: 10 mg-2000 mg per day -Patients with Inadequate Glycemic Control on a Glyburide (or another Sulfonylurea) and/or Metformin: Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control Maximum Dose: 20 mg-2000 mg per day Comments: -Give with meals; 5 mg-500 mg dose should not be used as initial therapy due to an increased risk of hypoglycemia; initial doses should be conservative to avoid hypoglycemia largely due to glyburide and gastrointestinal side effects largely due to metformin. -For patients who are switching to combination therapy, initial doses should not exceed the daily dose of glyburide (or equivalent sulfonylurea) and metformin already being taken; the decision to switch to the nearest equivalent dose should be based on clinical judgement. -Addition of thiazolidinedione may be appropriate for patients not adequately controlled on glyburide-metformin; in patients experiencing hypoglycemia, consider reducing the dose of the glyburide component. -Monitor patients closely for signs and symptoms of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Detailed Glyburide/metformin dosage information


In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include hypoglycemia symptoms as well as the following:

  • seizures
  • loss of consciousness


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program.

Side effects

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For glyburide, micronized, the following should be considered:

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A simplified mobilization protocol is described that requires only one apheresis to achieve rapid hematologic engraftment. Prostaglandin E2 (PGE2) downregulates interleukin (IL)-1alpha-induced IL-6 production via EP2/EP4 subtypes of PGE2 receptors in human periodontal ligament cells. Diagnosis and treatment of neonatal hypotension outside the transitional period. The 51Cr label was detected in the hemoglobin and in the low molecular weight compounds within the red blood cells. We report clinical and radiological findings and treatment strategies in four dialysed patients who developed brachial artery pseudoaneurysms.

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Prolonged respiratory support with extracorporeal membrane oxygenation in lung transplantation. Relationship between serum prostate specific antigen and the pattern of inflammation in both benign and malignant prostatic disease in Middle Eastern men. Recent evidence suggests that nitric oxide (NO) is a major messenger molecule regulating smooth muscle contractility. Effect of acute stress on the pituitrary gland: uptake of serine-1-C14 into ACTH. However, the addition of artificial tears to irregular eyes that have undergone penetrating keratoplasty created a more regular and symmetric surface and significantly altered the simulated keratometry values. In contrast, metal-metal prostheses of the McKee type implanted in the sixties, may still work perfectly today without any signs of osteolysis along the bone-cement interface, proving that metal-metal pairing is superior to prostheses with polyethylene cups and proving also that cement anchorage may be adequate for fixation. We present a comprehensive study for the statistical properties of random variables that describe the domain structure of a finite Ising chain with nearest-neighbor exchange interactions and free boundary conditions.

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Clinical significance of gastric dysrhythmias is discussed in this paper, outlined as follows: (a) What is normal gastric myoelectrical activity and what is dysrhythmia?. Rifampicin and cyclosporine dosing in heart transplant recipients. Real-time blood-pool images of contrast enhanced ultrasound with Definity in the detection of tumour nodules in the liver. We describe the components of our hybrid modeling scheme and the diagnosis methodology, and then demonstrate the effectiveness of this methodology by building a detailed model of the reverse osmosis (RO) system of the water recovery system (WRS) of the ALS. Thus, it was hypothesised that impaired receptor revision contributes to autoimmune pathogenesis in JIA. The upper limbs of the child with the amyoplasia form of arthrogryposis are typically internally rotated at the shoulders, extended at the elbows, and flexed and deviated ulnarly at the wrists. To evaluate the incidence and extent of visual recovery in patients with giant cell arteritis (GCA) treated with high doses of systemic corticosteroids. Genetically related fibroblasts without GSH deficiency were used as a control. Bourbon significantly increased the incidence of sleep apnea in patients with intermittent sleep apnea. This improvement may potentially contribute to augmented left ventricular contractility in BIO 53.58 after training.

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Affinity tagging has been used in many global studies towards protein function. Utilization of thiothixene in the treatment of mania: Pilot study. Similarly, integrin-mediated adhesion to monolayers of decidual stromal cells could be blocked with mAbs to the alpha 5, alpha 6, beta 1 and beta 4 integrin subunits. More reporting should create more opportunities for system improvement. An assessment of the validity of the approach, for the broadband XUV radiation of asec pulses, is implemented through ab initio calculations modeling the spectral and temporal response of the two-XUV-photon He ionization detector employed.

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Role of discontinuous chlorination on microbial production by drinking water biofilms. Fractionation of an antiserum to progesterone by affinity chromatography: effect of pH, solvents and biospecific adsorbents. On each specimen, we digitized 47 landmarks and 144 semilandmarks on facial curves and the external neurocranial surface. Specific binding of IGF-I to pericytes was increased by the incubation with high glucose for both 8 and 24 h. On the leukocytes the main regulatory pathway for ICAM-mediated binding is believed to be a short-term regulation of the avidity of CD11/CD18. Relationship between amplicon composition and cytologic type of structures containing amplified DNA in murine P388 cells with multiple drug resistance. Nevertheless a marked advantage for azithromycin was observed in experimental local infections and with infections due to Gram-negative bacteria (Haemophilus influenzae, Branhamella catarrhalis).

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Department of Anaesthesia and Critical Care, Queen Elizabeth Hospital. This study proves that MRI, when adequately performed, is a very accurate tool to study, in a very short time, the pancreas and peripancreatic region, yielding much better results than all the other diagnostic imaging modalities. Effect of light and dark on secondary induction of cornea in tadpoles of Rana temporaria. Tissue thickness of human stomach measured on excised gastric specimens from obese patients. Development of an rRNA-targeted oligonucleotide probe specific for the genus Acinetobacter and its application for in situ monitoring in activated sludge. Thus, antiangiogenic therapies can potentiate the efficacy of standard anticancer therapies. In basal conditions, endothelial-neutrophil interaction is inhibited by negatively charged molecules present on endothelial cell membranes and by the production of numerous anti-inflammatory substances. Cyclosporin A and FK506 inhibit activation-induced cell death in the murine WEHI-231 B cell line. Underivatised alkaloid mixtures extracted from intact plants and in vitro cultures of Leucojum aestivum (Amaryllidaceae) were investigated by capillary GC-MS.

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Adducts to macromolecules in the biological monitoring of workers exposed to polycyclic aromatic hydrocarbons. Ligation of alpha 2M receptors with alpha 2M-methylamine stimulates the activities of phospholipase C, phospholipase A2, and protein kinase C in murine peritoneal macrophages. Correction of neutropenia with rHuG-CSF after loss of response to rHuGM-CSF following autologous bone marrow transplant. A new classification system for head injury based on the findings of computerized tomography was used in a population of 809 head injured patients. Surgical advancement of the mandible through sagittal ramus osteotomy. The patients of 130 consultants carrying out major maxillofacial surgery. Evaluation for a normal masculine urethra and in cases of obstruction due to prostatic hypertrophy. Exhaled nitric oxide was elevated in patients with moderate to severe asthma and with treatment decreased in the first week reaching to a near normal level by 4 weeks. During GPI biosynthesis, inositol in phosphatidylinositol becomes acylated.

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Development of coronary collateral vessels is described in a patient with coronary artery spasm associated with ST-segment depression. Effect of isotonic and hypertonic solutions of sodium chloride on the blood vessels of the lower extremities in man. B-mode ultrasound imaging of the common carotid arteries was used to measure common carotid IMT in 99 subjects. The seasonal effect was slight during the early months of life but became obvious at later ages. The aim of this study was to assess the influence of different seeding densities on the function of hybridoma cells (clone 1B5, IgG 2alpha) producing an anti-angiogenic monoclonal antibody (mAb), microencapsulated using a high-voltage electrostatic field.

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A thermodynamic approach to the hydration of sulphate-resisting Portland cement. The relationship between variation and rate of growth for chicken populations. A comparative study of intraoperative echography/cholangiography in the detection of calculi in the common bile duct. Selective activation of dopamine transmission in the shell of the nucleus accumbens by stress. This study focuses attention on ischemic heart disease and cerebrovascular risk factors about the frequency of silent brain infarction. At randomization and 1, 6 and 12 months after treatment, patients were evaluated for the development of a DTCH to autologous tumor and to autologous normal cells, obtained by mechanical and enzymatic dissociation of the surgical specimens. The patient had noticed a hard induration in the right breast twelve years previously and had a radical operation for right breast cancer. The treatment produced good results in all types of diseases considered, with a significant decrease in severity of symptoms being observed.

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The cloning and characterization of a soluble epoxide hydrolase in chicken. The Internet is also facilitating much more responsive and tailored services/products. When neomycin concentration was varied from 10 to 500 microM, the current noise level peaked between 50 and 100 microM. Therefore, the aim of this paper was to present a new flap design, the esthetic buccal flap (EBF), aimed at overcoming this potential problem while maintaining the optimal esthetic appearance. This study was performed to examine the effect of dobutamine stress echocardiography on mitral regurgitation and to test the hypothesis that mitral regurgitation will increase in patients with an ischemic response. Kawasaki syndrome and risk factors for coronary artery abnormalities: United States, 1994-2003. Army Veterinary Corps--from early military history to the space age. Morpholino-injected embryos have swimming abnormalities and develop altered head morphology, an expanded olfactory epithelium and disorganized peripheral axons. Following a hypertension symposium in New York City on February 2, 2005, a roundtable was convened to discuss the use of beta blockers in the management of hypertension.

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Golgi and Cajal: The neuron doctrine and the 100th anniversary of the 1906 Nobel Prize. This evidence suggests that dermatoglyphic asymmetry does reflect to some extent the degree to which the developing phenotype is controlled. X-irradiation, parallel with morphological changes, lead to rapid decrease of pyroantimonate precipitable calcium content and increase of the permeability of tight junctions indicated by the penetration of ruthenium red into the intercellular space. They highlight a potential hazard of hydroponic fodder production systems, which appear to favour A clavatus growth on sprouted grain, exacerbated in some cases by equipment malfunctions that increase operating temperatures. In the FRG there is no comprehensive cancer registry with national coverage for recording cancer patients of all ages (nationwide incidence rates are available only for childhood cancers). Features of this syndrome include hyperpyrexia, disseminated intravascular coagulation, convulsions, coma and muscle rigidity, which may not develop until 6 to 12 hours after overdose. Correlations between LI and MI showed that progression from the initial S-to M-phase is altered in exposed individuals. Additionally, no occurrence of Torsades de pointes was observed in any of the cases. Enhancement of inducible-type NO synthase gene transcription by protein synthesis inhibitors. Due to his ignorance of the late stage of pregnancy and of the potential consequences of the procedure, the male nurse had exposed the patient to risk of severe levaquin bladder infection trauma.

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Segregation of neuron-type-specific synaptic connections in different strata is a characteristic feature shared by the olfactory bulb (OB) and retina. Traffic accidents, operational factors, and munitions and mines were evaluated to be the three most important risk factors, followed by occupational hygiene, living conditions (mold, fungi, dust), and general hygiene. Oral mercuric chloride leads to intestinal basement membrane (IBM) immune complex deposition and fecal protein loss. The reversed ultrastructural transformation, i.e., orthodox-to-condensed, which occurs during ADP-activated State III electron transport, is inhibited by DNP and parallels suppression of acceptor control and oxidative phosphorylation. Clinical outcomes included procedure time, patient pain, and operator satisfaction.

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Stems contain distinctly less P protein mRNA and the relative level in roots is very low but still clearly detectable. Today, I intend to discuss the 10 essential activities of a properly functioning quality assurance Unit (GAU). They rated, on a 5-point Likert scale, their agreement with each of 40 statements. Improving asthma documentation in a paediatric emergency department. We believe that this is a first report of adult-onset Sydenham chorea accompanied with psychiatric symptoms. This gene presents a 192 bp tandemly repeated motif and we show that the number of repeats can vary from 1 to about 24 among different strains, without apparently affecting the function of the encoded protein. Recovery of patients after four months or more in the persistent vegetative state. Some evidence is being reported that male rape survivors develop Post Traumatic Stress Disorder following the assault. This technique has been used for the last 4 years for excision of renal cancers, as well as certain difficult nephrectomies (pyonephrosis, repeated kidney operations), and for surgery on the renal vessels, the adrenals, and the peri-aortic lymphatics.

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In the evening, only the cigarette yield has an effect on COHb level. Molecular basis of sperm-egg membrane adhesion and fusion in mammals. The flaps were divided into three interproximal and two mid-buccal sites for analysis and the intracapillary and diffusion extent of dye fluorescence was accurately quantified by computerized planimetry. In order to quantitate DNA, RNA and glycogen contents of developing macrophages, blood monocytes were obtained from 19 healthy human subjects and examined after 0, 2, 4 and 6 days of suspension culture. On the nature of endogenous antiexcitatory factors in the cerebrospinal fluid of patients with demyelinating neurological disease. TNF (tumor necrosis factor) is a potent proinflammatory cytokine expressed by activated macrophages and lymphocytes that induces diverse cellular responses that can vary from apoptosis to the expression of genes involved in both early inflammatory and acquired immune responses. The little information available on the implications of this syndrome for anesthesia derive from the recent description of the disease. A pharmacological method to estimate buy permethrin cream over the counter the pKi of competitive inhibitors of agonist uptake processes in isolated tissues. Carotid phonoangiography and oculoplethysmography for noninvasive evaluation of carotid occlusive disease.

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A Fourier map of the electron density at 6 angstrom resolution obtained by x-ray diffraction. Nations which judge the risks as unacceptable face a concerted legal challenge on a series of levels, both domestic and international. The present study was performed to test the hypothesis that the adrenergic nervous system is capable of maintaining indexes of pump and contractile function in ambien dosage to sleep the normal range despite significant innate myocardial depression. Gel filtration of urine: a method to detect nephrotoxicity in rats. This paper represents the final document released by the Italian Society of Osteoporosis (S.I.OP.), on the occasion of its fifth annual meeting held in Padova, Italy (November 30-December 3, 1993).

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The effect of the long-term alcoholization of rats on partial kidney functions under increasing hypo- and hyperosmolarity. Synthesis, characteristics and biological activity of pentacoordinated spirophosphoranes derived from amino acids. Recently we identified a unique region, residues 9-30 in the extracellular domain of the FSH receptor, capable of binding FSH but not LH or TSH. Cochrane column: commentary: interventions for preventing tobacco sales to minors. To develop cancer prevention and education programs that meet the unique needs of African Americans, nurses must be aware of barriers and cultural differences. To determine whether this was due to the genesis of 5-HT vantin medication class neurons, bromodeoxyuridine (BrdU) was injected into larval, metamorphosing, and postmetamorphic lampreys. Pseudomonas cepacia strain AC1100 grows luxuriantly on 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) but does not utilize phenoxyacetic acid.

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