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Glucophage (Metformin)

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Glucophage is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying the absorption of sugar (glucose) from the intestines, and increasing the body's sensitivity to insulin.

Other names for this medication:
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Also known as: Metformin


Glucophage (metformin) is an oral diabetes medicine that helps control blood sugar levels.

Glucophage is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Glucophage is sometimes used together with insulin or other medications, but metformin is not for treating type 1 diabetes.


Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take Glucophage XR with a meal, unless your doctor tells you otherwise. Some forms of metformin are taken only once daily with the evening meal. Follow your doctor's instructions.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Some tablets are made with a shell that is not absorbed or melted in the body. Part of this shell may appear in your stool. This is normal and will not make the medicine less effective.

You may have low blood sugar (hypoglycemia) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda).

Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.

Glucophage XR is only part of a complete treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

Store at room temperature away from moisture, heat, and light.

Your doctor may have you take extra vitamin B12 while you are taking Glucophage XR. Take only the amount of vitamin B12 that your doctor has prescribed.

Detailed Glucophage XR dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Glucophage are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use MetFORMIN (Eqv-Glucophage XR) if you are allergic to it, or if you have:

severe kidney disease; or metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment).

If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking MetFORMIN (Eqv-Glucophage XR). Be sure your caregivers know ahead of time that you are using this medication.

Tell your doctor if you have ever had:

kidney disease (your kidney function may need to be checked before you take this medicine); high ketone levels in your blood or urine; heart disease, congestive heart failure; liver disease; or if you also use insulin, or other oral diabetes medications.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

MetFORMIN (Eqv-Glucophage XR) may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

You should not breastfeed while using this medicine.

MetFORMIN (Eqv-Glucophage XR) should not be given to a child younger than 10 years old. Some forms of MetFORMIN (Eqv-Glucophage XR) are not approved for use by anyone younger than 18 years old.

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Caries prevention in infants and young children: which etiologic factors should we address?. Increased catalase expression diminished constitutive ROS and enhanced viability after treatment with hydrogen peroxide. The same approach could also be applied to identify LAB strains isolated from other food ecosystems. These findings indicate that living in close proximity to road vehicle traffic is associated with an increased risk of wheeze, but that other environmental factors are also likely to be important. Improvement in spermatocele function may occur if a microsurgical anastomosis is performed to the epididymis.

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A cosmid (pND320) bearing 42.5 kb of Escherichia coli chromosomal DNA, including the genes between xylE and ssb near minute 92 on the linkage map, was isolated by selection for complementation of a dnaB mutation. Radiation therapy is administered to approximately one third of patients with cancer as part of their treatment plan. The perfused guinea pig lung was found to contain about twice as much reduced glutathione as ascorbic acid. One patient developed retinal detachment, the retina could be reattached by episcleral buckling procedure. Effect of hypothermia on agglutinin production and on changes in blood serum protein fractions during vaccination. Our aim was to explore the association between knee height, knee pain, and knee OA. Protective order upheld against man for intentional HIV exposure. Biological study of a chelating agent with an affinity for calcium in the field of otology. The future for surgery and the surgical specialties through research and development.

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Role of blood flow and impaired autoregulation in the pathogenesis of diabetic retinopathy. MSCT angiography with retrospective ECG gating showed a coronary arterial malformation with fistulous communications to the coronary artery, pulmonary artery and the root of aorta. Distribution of dopamine-immunoreactive neurons and their relationships to transmitter and hypothalamic hormone-immunoreactive neuronal systems in the rat mediobasal hypothalamus. Disturbances in the perception of auditory sequence in children with minimal cerebral dysfunction. Amitriptyline therapy was slightly more effective in reducing pain at the end of the treatment period but was associated with more side effects. In seven patients with postoperative air leaks, standard or thin-section CT demonstrated the air-leak source in only one. Retinal neovascularization in diabetes has been thought to follow the release of local angiogenic factors in the retina. Tissue factor mRNA expression in the endothelium of an intact umbilical vein.

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A factor from HeLa cells promoting colonial growth of human singulair is a very successful expectorant drug that is used to treat asthma fibroblast-like cells in culture. The results fit well into our concept of peptide conjugates with lowered binding activity to DNA, which could be capable of unlimited extravascular distribution. Loss of YtkD but not of MutT increased the spontaneous mutation frequency of growing cells. Double-blind trials have also revealed the efficacy of ximelagatran in the secondary prevention of venous thromboembolism and shown the agent to be as effective as enoxaparin/warfarin in treating patients with acute deep vein thrombosis. Levonorgestrel implants (Norplant) have recently been approved for use in the United States. Serum from 20 children with urinary tract infections and proved cystitis cystica has been examined for antibody to a panel of established cell lines derived from normal urothelium and transitional cell carcinomas of the bladder. 200 consecutive hand assisted laparoscopic donor nephrectomies: evolution of operative technique and outcomes. Quantitative morphological criteria of uterine myoma development. The risks estimated in this paper reflect the behaviour of the road users studied and their prevalence on the roads under the conditions analysed.

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Inhibition of the MCP-1/CCR2 pathway may be a useful strategy for attenuating myocardial ischemia-reperfusion injury. Psammoma bodies in cytological vaginal smears in metastatic ovarian carcinoma. The influence of oxygen and helium upon ventricular fibrillation. We review the principles underlying safe and effective procedural sedation and analgesia and the spectrum of procedures for which it is currently done. Comparative evaluation with computerized tomography and magnetic resonance without contrast media. Although clpB1 appeared not to be under the control of virulence regulatory cascade of V. Corticosterone levels and behavioral responses were measured during EA stimulation. The National Institute for Occupational Safety and Health (NIOSH) conducted an industrial hygiene study of workers exposed to styrene monomer in the fiberglass reinforced plastic boat industry.

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Variables influencing neuropathic endpoints: the Rochester Diabetic Neuropathy Study of Healthy Subjects. A comparison of LH secretion and brain estradiol receptors in heterosexual and homosexual rams and female sheep. The fluctuations now contain both temporal and spatial information about the sample. They are also likely to provide invaluable tools for studying the mechanisms underlying growth and development in plants. Two of the protonix dose hearts examined were explants from heart transplant recipients with hypersensitivity myocarditis at the time of transplant and the third was from an autopsied patient with Churg-Strauss syndrome. There were 771 charts reviewed, of which, 149 cases were aged 54 years or younger, 203 were 55 to 64 years, 224 were 65 to 74 years, and 195 were aged 75 years or older.

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Studies on the absorption of practically water-insoluble drugs following injection. Anhydrous proton-conducting polymeric electrolytes for fuel cells. This would set the stage for public health surveillance of not only childhood diabetes but of all non-communicable diseases in the 21st century. Glycogen biosynthesis in leukocytes of normal and alloxan diabetic rats. In a sensitivity analysis, among the parameters investigated, initial allele frequency and density dependence were the two most important factors affecting the evolution of resistance. Retrospective studies found an association between past sexual, physical, or psychological abuse and functional gastrointestinal disorders (FGIDs). Our goal was to present three cases of pleomorphic xanthoastrocytoma (PXA) with unusual radiographic, clinical, and pathologic aspects. Treatment of microsomal membranes with phospholipase C sharply inhibited cytidylyltransferase activity in all three animal species.

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Diagnostic and therapeutic difficultes in pityriasis rubra pilaris--case report. We show that addition of cholesterol or 25-hydroxycholesterol to microsomal membranes in vitro blocks Sar1-dependent binding of the Sec23/24 complex to Scap, the SREBP escort protein. These findings confirmed the efficacy of this vaccine against heterologous stains classified as subtype B theolair 250 mg , and suggested that the vaccine exhibits broad efficacy against genetically diverse FIV. The last two experiments showed that performing attention-demanding visual search tasks that did not involve short-term memory did not lengthen simultaneously produced time intervals. Our data show that EGF-R binding capacity is the only parameter constantly raised in cell proliferation with respect to quiescent cells, and highlights the nonunivocal action of OH-FLU on androgen-induced effects.

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