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Glimsite (Glimepiride)
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Glimsite

Glimsite is a sulfonylurea drug used to treat type 2 diabetes mellitus. First introduced in 1995, Glimsite is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control.

Other names for this medication:
Adglim, Aroglim, Axylim, Beglim, Bigonyl, Capril, Cgryl, Dezacor, Diaglim, Diagraph, Diamin, Diaset, Forme, Gepride, Geriglim, Gitae, Givov, Glimaday, Glimcare, Glimid, Glimifix, Glimitab, Glimiwa, Glimli, Glimlok, Glimpee, Glimpil, Glimpinor, Glipril, Gliri, Glymaran, Glynaran, Glypride, Matce, Merid, Metanorm, Metapride, Metglib, Pioglar, Pioglit, Repride, Roglimet, Sugamide, Voglow, Walaphage, Zulip

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Also known as: Glimepiride

Description

Amaryl (glimepiride) is an oral diabetes medicine that helps control blood sugar levels.

Amaryl is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes.

Insulin or other diabetes medicines are sometimes used in combination with Amaryl if needed.

Dosage

Usual Adult Dose for Diabetes Type 2:

Initial dose: 1 to 2 mg orally once a day Maintenance dose: Increase in 1 or 2 mg increments no more frequently than every 1 to 2 weeks based on glycemic response Maximum dose: 8 mg per day Comments: -Administer with breakfast or first main meal of the day. -In patients who are at increased risk for hypoglycemia, start with 1 mg orally once a day and titrate slowly. -When patients are being transferred to this drug from a longer half-life sulfonylurea, monitor 1 to 2 weeks for overlapping drug effect. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Usual Geriatric Dose for Diabetes Type 2:

Initial dose: 1 mg orally once a day; titrate slowly and monitor closely

Usual Pediatric Dose for Diabetes Type 2:

Not recommended because of adverse effects on body weight and hypoglycemia.

Detailed Amaryl dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An Amaryl overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, confusion, tremors, sweating, fast heart rate, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions).

Storage

Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Glimsite are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Amaryl if you are allergic to glimepiride, sulphonamides, or if you have:

an allergy to sulfa drugs; or diabetic ketoacidosis (call your doctor for treatment).

To make sure Amaryl is safe for you, tell your doctor if you have ever had:

heart disease; liver or kidney disease; or an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD).

Amaryl may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Follow your doctor's instructions about using Amaryl if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. However, you may need to stop taking Amaryl for a short time just before your due date.

Medications similar to glimepiride have caused severe hypoglycemia in newborn babies whose mothers used the medicine near the time of delivery. If you take glimepiride during pregnancy, stop taking this medicine at least 2 weeks before your due date.

If you breastfeed while taking glimepiride, call your doctor if your baby shows signs of hypoglycemia (extreme drowsiness, feeding problems, mottled skin, blue lips, feeling cold or jittery, or having a seizure).

Amaryl is not approved for use by anyone younger than 18 years old.

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In Isachsen, subjects completed the POMS and the Structured Interview Guide for the Hamilton Depression Rating Scale--Seasonal Affective Disorders Version (SIGH-SAD) each week. Body composition was determined using a dual-energy X-ray absorptiometer. Some of the compounds inhibited PtdIns-3-kinase at micromolar concentrations and below. RT-PCR and in situ analyses revealed that this in silico approach can effectively be used to identify potential BMP target genes. The integration of oral capecitabine into chemoradiation regimens for locally advanced rectal cancer: how successful have we been?.

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Phase I trial of phenoxodiol delivered by continuous intravenous infusion in patients with solid cancer. CHF 2206, a new potent vasodilating and antiaggregating drug as potential nitric oxide donor. If, however, a single chromosome remains in the cell but is detached from the spindle and kept in the cytoplasm, the spindle disassembles. Clinical and pathogenetic considerations on several cases of phocomelia. Thus, we are able to analyze the adequacy of the model and its structure by comparing the calculated fMRI signal with the experimental data which in turn provides promising insights into the neural base of the increase in the fMRI signal. A fixed source vaginal applicator for irradiation of carcinoma of the cervix uteri.

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Optimal number of chemotherapy courses in advanced nonseminomatous testicular carcinoma. In contrast, a similar affinity of astrocytes to ganglion cell somata was never observed. Given the fact that many infants, especially in developing countries, continue to be born without the benefit of perinatal ARVT, there will likely continue to be many older HIV-infected children in the same situation as those described in this follow-up study. In proposal I, substitution of lysine by alanine has been suggested to improve crystallization by reducing the entropic cost of ordering flexible side chains at crystal contacts. clavuligerus RNA revealed that bli was expressed as a 0.7-kb monocistronic transcript. The marketing of widely used consumer products inevitably results in some reports of adverse dermatologic reactions which are tentatively attributable through medical history to the use of these products. The fine-scale distribution of meiotic recombination events in the human genome can be inferred from patterns of haplotype diversity in human populations but directly studied only by high-resolution sperm typing. On congenital intersexes and their diagnosis and therapeutic possibilities. All these facts indicate that the adverse effects are the results of general toxicity and may not be due to the estrogenic function of the compound.

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Human T cells carry all the structural features required for an efficient response to murine retrovirally encoded superantigens. A bootstrap approach to estimating power for linkage heterogeneity. Management is often suboptimal with lack of urodynamic equipment in most fistula centres in developing countries. Phenotypic and morphologic changes of connective tissue and atherosclerosis of coronary arteries. Significant concentration dependent FITC-ANP binding at pretreatments of 10(-12) M suggest the presence of special receptor-dependent mechanisms which are responsible for the development of hormonal imprinting. Response to unexpected target changes during sustained visual tracking in schizophrenic patients. Embryo transfer was carried out 3 days after detection of the endogenous LH surge in group A and on day 3 of progesterone administration in group B. Both recall and recognition measures for the stimuli were obtained. (Critical review of the literature and histological and histochemical observations on 3 cases).

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Efficient gene silencing and cell differentiation using siRNA in mouse and monkey ES cells. The primary effectiveness outcome was the number of depression-free weeks (HAD-D less than 8, with interpolation of intervening values) and the primary cost outcome total direct NHS costs. Microfluidics is of special interest for handling very small sample amounts, with minimal concerns related to sample loss and cross-contamination, problems typical for standard fluidic manipulations. A poly(HEMA) sponge for restoration of articular cartilage defects. The remaining 7 patients were followed for an average of 24 months postoperatively. With regard to differential diagnosis a birth trauma should also be kept in mind, so that the history of the delivery is important. The planning target volume was created by adding a 1-cm margin to the clinical target volume. However, TRPM8 protein localization of nerve terminals in sensory organs remains unknown.

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Several hours later, when his serum ethanol level had declined, he developed severe acidosis with an elevated anion gap. Dystrophin-glycoprotein complex: molecular organization and critical roles in skeletal muscle. The most important environmental factor that affects the radiosensitivity of cutaneous melanoma cells appears to be the partial pressure of oxygen in their immediate environment. Protection against herpes simplex virus-induced eye disease after vaccination with seven individually expressed herpes simplex virus 1 glycoproteins. We demonstrated that CsA and NIM811 affect survival of human and murine melanoma cells and induce morphological changes, alterations in nuclear morphology and an internucleosomal DNA fragmentation, consistent with an apoptotic type of death. Osler-Weber-Rendu disease (hereditary hemorrhagic telangiectagia) is a rare vascular disorder which is characterized clinically by inherited telangiectasia of skin, mucous membrane and recurrent hemorrhage. The trigger for the process of myelin formation during neural development has long been a mystery. Cross-sectional descriptive survey of all allopathic EMRPs accredited by the EM Residency Review Committee (RRC-EM) as of July 1, 1993. ING3 has been shown to modulate p53-mediated transcription, cell cycle control, and apoptosis, possibly by modulating the NuA4 complex histone acetyltransferase activity. Varying the concentrations of aniline, PAMPS, and hydrogen peroxide as reagents, favorable conditions for production of PANI were determined.

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We report the first measurements of single C60 molecules trapped in three terminal devices prepared by quench condensation of a gold source and drain electrode on top of an aluminium gate electrode covered with a thin oxide. Crystallization and preliminary X-ray crystallographic study of the extracellular domain of the 4-1BB ligand, a member of the TNF family. Bandgap widening of titania through semiconductor support interactions. The programme can easily be modified for the use of other telecobalt devices. Measuring just waist circumference is simpler and may provide greater accuracy for identifying insulin resistance. The presence of intracoronary thrombus associated with coronary stenoses is significantly underestimated by angiography. During World War II, biowarfare research was carried out by Japan, Germany, England, and the United States. Thus, it appears that ClC-3 Cl- channel mediates both cell proliferation and apoptosis through accelerative and inhibitory fashions, respectively. Milk progesterone profile at and after artificial insemination in repeat-breeding cows: effects on conception rate and embryonic death.

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This study was designed to determine whether the ability of interferon-gamma to upregulate the expression of a human tumor antigen improved the therapeutic efficacy of a radionuclide-conjugated monoclonal antibody. ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of locally recurrent or metastatic breast cancer (MBC). Nevertheless, progressive tsetse protonix 40 mg side effects eradication remains the long-term goal. Unusual case of tuberculofis of the submandibular salivary gland. Expression and mutation of soybean beta-amylase in Escherichia coli. Ciprofloxacin desensitization in a patient with cystic fibrosis. Within this broad phylogenetic sampling are examples of the major forms of structural diversity currently known for this class of rRNAs.

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Antisense RNA to the first N-glycosylation gene, ALG7, inhibits protein N-glycosylation and secretion by Xenopus oocytes. We determine a generic phase diagram in terms of a characteristic filling factor and a dimensionless coupling constant. NF-kappa B binding peaks at 1 h after PH before declining and is not induced by sham operation. Because full pelvic refluxes occur only during rising urine flow, this mechanism would bring urine with decreasing osmolality into contact with the outer medullary areas facing the pelvic space. This study examines the hypothesis that the loss of medullary and cortical microvascular blood flow following SMA-SRACR is due to oxygen-derived free radical down-regulation of endogenous medullary and cortical nitric oxide synthesis. One patient went into cardiac arrest unrelated to the use of a NMB agent. There are several pitfalls in immunohistochemistry, regardless of whether monoclonal or polyclonal antibody reagents are used.

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Public knowledge and attitudes about AIDS among adults in Calcutta, India. Both patients underwent surgical thrombectomy and anastomotic reconstruction albenza cost in canada following institution of cardiopulmonary bypass, but died of multiorgan failure within 5 days of diagnosis. Effect of serum from tolerant mice on immunity and tolerance to a bacterial antigen. However, analysis of these plasma samples from stored blood components by gas chromatography/mass spectroscopy did not reveal any 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine. Trial of short treatment of brucellosis with tetracycline compound. These constructs and a plasmid encoding vesicular stomatitis virus glycoprotein (VSVG) were utilized along with GP2-293 cells to produce replication incompetent retrovirus particles pseudotyped with the VSVG envelope. There is current evidence from prospective randomized trials that carboplatin combined with either paclitaxel or gemcitabine confers a progression-free survival advantage over platinum monotherapy for patients with platinum-sensitive relapsed ovarian cancer. We compared shock wave lithotripsy (SWL) and ureteroscopy (URS) for the treatment of patients with small lower pole stones in a prospective, randomized, multicenter trial. These results indicate that there is a quantitative relationship between mucosal cell-mediated immunity and the pathological outcome and that large numbers of activated macrophages in the mucosa can result in tissue destruction. Anesthetic management for cesarean section and clipping of aneurysm in a pregnant woman with ruptured cerebral aneurysm.

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Consumption of water-insoluble phenolic products of lignin pyrolysis by the strain Penicillium tardum H-2. The transzonal projections (TZP), which are specialized extensions from granulosa cells that terminate on the oolema after crossing the zona pellucida, are major structural components necessary for oocyte-GC interaction. The forensic scientist often has to cope with problematic samples from the crime scene due to their minute size and thus the low amount of extractable DNA. (5) Glutamate itself did not decrease the epileptic manifestations. Experiments have shown that the responses are not electrical artifact, nor are they contaminated by auditory, somatosensory, or passive eye movement potentials. Activation of N-methyl-D-aspartate (NMDA) receptors in caudal nucleus tractus solitarii (cNTS) neurons elicited endogenous rhythmic activities. Aging is accompanied by changes in the various autonomic receptors in the cardiovascular system, as well as in the endothelium of the large arteries. Instances of this operation performed concomitantly with cardiac revascularization and carotid endarterectomy have been reported in fewer than 10 cases in the literature. Role of ascites in gastroesophageal reflux with comments on the pathogenesis of bleeding esophageal varices.

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The tumors of Japanese-Americans exhibit a greater uniformity of nuclear grade (NG), greater degrees of intratumoral lymphocytic infiltration (LI), and more conspicuous sinus histiocytosis (SH) in the regional lymph nodes. Axial methionine has much less influence on reduction potentials in a CuA center than in a blue copper center. We show that Kinase Suppressor of Ras 1 (KSR1), a molecular scaffold for the Raf/MEK/ERK cascade, is necessary for RasV12-induced senescence, and its disruption enhances primary MEF immortalization. Following corticosteroids the return of calcium to normal was more delayed. Continuing medical education current status and future prospects. Different modes of actions are observed for melittin, tachyplesin I, d-magainin 2, MSI-843, and a synthetic antibacterial oligomer, demonstrating that SFG is very zithromax dosage chlamydia effective in the study of AMPs and AMP-lipid bilayer interactions. Upon completion of the treatment with HSV-Tk1 vector producer cells and ganciclovir, the patient will be followed monthly for the first three months, then every two months for the next twenty-one months, and annually for life thereafter.

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Headaches, one of the commonest medical complaints in the general population, occur frequently in patients infected with the HIV-1. Two reported negative results, while one reported positive results but only at a single high dose. Glycated albumin modified by Amadori adducts modulates aortic endothelial cell biology. Rhinovirus enters but does not replicate inside monocytes and airway macrophages. Acquired platelet dysfunction associated with eosinophilia should therefore be considered in children who, after a visit to this region, have easy bruising and esoinophilia. Two had left ventricular aneurysms and one had both right and left ventricular infarcts. Study participants had blood drawn for fetal cell analysis before amniocentesis. Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells.

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