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Flagyl (Metronidazole)
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Flagyl

Flagyl eliminates bacteria and other microorganisms that cause infections of the reproductive system, gastrointestinal tract, skin, vagina, and other areas of the body. Antibiotics will not work for colds, flu, or other viral infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Other names for this medication:
Amotrex, Anamet, Anazol, Aristogyl, Asuzol, Birodogyl, Colpofilin, Elyzol, Emedal, Etron, Farnat, Filmet, Fladex, Fladystin, Flagystatine, Flazol, Ginerella, Ginkan, Gnostol, Grinazole, Gynotran, Kilpro, Medamet, Medazol, Metris, Metroderme, Metrogyl, Metronidazolum, Metronour, Metrosil, Metrovax, Minegyl, Monizole, Nalox, Novazole, Riazole, Robaz, Rosalox, Rosazol, Rozex, Stomorgyl, Suanatem, Supplin, Tricozyl, Trikozol, Venogyl

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Also known as: Metronidazole

Description

Flagyl (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Flagyl is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

In the Female. One-day treatment – two grams of Flagyl, given either as a single dose or in two divided doses of one gram each, given in the same day. Seven-day course of treatment – 250 mg three times daily for seven consecutive days. There is some indication from controlled comparative studies that cure rates as determined by vaginal smears and signs and symptoms, may be higher after a seven-day course of treatment than after a one-day treatment regimen.

The dosage regimen should be individualized. Single-dose treatment can assure compliance, especially if administered under supervision, in those patients who cannot be relied on to continue the seven-day regimen. A seven-day course of treatment may minimize reinfection by protecting the patient long enough for the sexual contacts to obtain appropriate treatment. Further, some patients may tolerate one treatment regimen better than the other.

Pregnant patients should not be treated during the first trimester In pregnant patients for whom alternative treatment has been inadequate, the one-day course of therapy should not be used, as it results in higher serum levels which can reach the fetal circulation.

When repeat courses of the drug are required, it is recommended that an interval of four to six weeks elapse between courses and that the presence of the trichomonad be reconfirmed by appropriate laboratory measures. Total and differential leukocyte counts should be made before and after re-treatment.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, and loss of balance or coordination.

Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Side effects

The most common side effects associated with Flagyl are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of metronidazole in the elderly. However, elderly patients are more likely to have unwanted effects and age-related liver problems, which may require caution and an adjustment in the dose for patients receiving metronidazole.

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Evidence for superantigen activity of the Bel 3 protein of the human foamy virus. Twenty-six patients with hydrocephalus secondary to chronic arachnoiditis due to meningeal cysticercosis were treated with a new ventriculoperitoneal shunt whose design is based on the rate of cerebrospinal fluid (CSF) production and shunt resistance rather than on ventricular pressure, which has been the principal parameter for most other shunting devices. The maturational theory of brain development and cerebral excitability in the multifactorially inherited manic-depressive psychosis and schizophrenia. However, the expression levels of the 6.0-hMet30 gene in the liver and serum increased after birth to reach adult levels at an age of 4 weeks, while expression of the 0.6-hMet30 gene remained at a low level after birth. Biochemical profiling in silico--predicting substrate specificities of large enzyme families. Small scale spatial variation and temporal heterogeneity in mosquito densities can have important consequences for disease transmission, but the extreme variation which is observed in populations of malaria vectors makes it difficult to obtain good predictions of densities for short time periods over limited areas.

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To evaluate whether changes in central ouabain-like activity (OLA) play a role in the effects of dietary sodium on sympathetic outflow and blood pressure (BP), the effects of high vs. CDH1 promoter SNPs (C-160A and G-347GA) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in 333 ESCC patients, 239 GCA patients, and 343 healthy controls. Unsaturated fatty acids incorporated in HDL in hypo- and hyperalphalipoproteinemia--relation to the HDL-cholesterol level. Plasma concentrations of sufentanil were measured by radioimmunoassay (limit of sensitivity 0.02 ng.ml-1). Since BaP1 is a P-I class metalloproteinase, these results indicate that the proteolytic domain of metalloproteinases per se can trigger specific inflammatory events. Studies have been conducted to assess the possible preventive effect of pyruvate against lens protein oxidation and consequent denaturation and insolubilization.

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Oligosaccharyl transferase (OT) catalyzes the cotranslational N-glycosylation of nascent polypeptides in the endoplasmic reticulum in all eukaryotic systems. New kinds of microneuroprotectors for microsurgery and endoscopy of cerebellopontine angle neurovascular decompression. Success in translational research: lessons from the development of bortezomib. Interleukin-12 mRNA levels in renal allograft fine-needle aspirates do not correlate with acute transplant rejection. Effectiveness and dropout rate of a very-low-calorie diet program. A clinical case of bilateral upper medial medullary infarction was reported. The baculovirus expressed N protein was concentrated in the cytoplasm of the insect cells and could be extracted at low salt concentration. In vivo comparison of preservation of murine islets of Langerhans. Ventricular tachycardia in arrhythmogenic right ventricular dysplasia/cardiomyopathy: clinical presentation, risk stratification and results of long-term follow-up. A reverse transcriptase polymerase chain reaction (RT-PCR) assay was developed for the detection and identification of aquatic birnaviruses.

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Review of the original specimen with new immunohistochemical staining showed that it was an inflammatory fibroblastic tumour. Significant inhibition of choroidal neovascularization (CNV) has been observed when cell surface associated uPA-uPAR activity is prevented with a specific inhibitor of this proteinase system. Through use of two HPLC separations--reversed-phase and anion-exchange--quantitation of all major purine nucleotides, nucleosides and bases is possible. Stimulus control, sleep restriction, sleep hygiene education and cognitive restructuring were the main treatment components. Rab3a, a small GTP-binding protein, undergoes fast anterograde transport but not retrograde transport in neurons. The sensory-perceptual explanation supported by Jackson and Klopfer (1977) and others remains a viable alternative to the social-perceptual explanation provided by Kuethe. The status of the autoflora and bactericidal capacity of the skin in patients receiving radiotherapy.

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Bethe-ansatz solutions lead to an inhomogeneous Tomonaga-Luttinger model for the low energy excitations. An important aspect of amplitude modulation cycles are the rise and fall times within the sound. MRI safety aspects and artifacts of atrial septal defect and patent foramen ovale occluders at 1.5 tesla: a phantom study. Four head and neck squamous cell carcinoma cell lines were incubated with varying concentrations of transforming growth factor-beta, and cytotoxicity was evaluated with a methylene blue colorimetric assay. Profile of immunoglobulin heavy chain variable gene repertoires and highly selective detection of malignant clonotypes in acute lymphoblastic leukemia. Catecholamine excretion rates in relation to life-styles in the male population of Otmoor, Oxfordshire.

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FMISO PET allowed for the qualitative and quantitative definition of hypoxic sub-areas which may correspond to a localization of local recurrences. Surgeons should carefully expose this space prior to placing sutures during sacral colpopexy. An oscillatory hierarchy controlling neuronal excitability and stimulus processing in the auditory cortex. To test whether national patterns of asthma drug use, particularly inhaled corticosteroids (ICS), are related to the rate of acute severe asthma exacerbations. Image splitting--a technique for measuring retinal vascular reactivity. In an attempt to estimate the onset of aging-associated mortality in humans, Swiss national survival and mortality data from 1978 to 1983 prograf generic cost without insurance were analyzed.

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