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Diovan (Valsartan)
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Diovan

Diovan is used in adults and in children 1 year of age and older alone or in combination with other medications to treat high blood pressure. It is also used in adults to treat heart failure (condition in which the heart is unable to pump enough blood to the rest of the body) and to improve survival after a heart attack.

Other names for this medication:
Alpertan, Alsart, Alsartan, Cardival, Codiovan, Cordinate, Corixil, Cotareg, Diovane, Kalpress, Miten, Nisis, Nisisco, Provas, Ramartan, Rixil, Sarteg, Sarval, Starval, Teval, Valitazin, Valpresan, Valpress, Valpression, Valsabela, Valsan, Valsaprex, Valsar, Valsartan, Valsartanum, Valturna, Valzaar, Valzek, Valzide, Varexan, Vartalan, Vasaten

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Also known as: Valsartan

Description

Hydrochlorothiazide is a diuretic (water pill). Valsartan is an angiotensin II receptor blocker (sometimes called an ARB blocker).

Diovan HCT is a combination medicine used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack.

Diovan HCT is given after other blood pressure medicines did not work or have stopped working.

Dosage

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 40 mg orally twice a day Maintenance dose: 80 to 160 mg twice a day. The dose should be increased to the highest dose tolerated by the patient.

Usual Adult Dose for Hypertension:

Initial dose: 80 to 160 mg orally once a day. Maintenance dose: 80 to 320 mg orally once a day

Usual Adult Dose for Myocardial Infarction:

Initial dose: 20 mg orally twice a day Maintenance dose: The initial dosage may be titrated upward within 7 days to 40 mg twice daily, with subsequent titrations to a target maintenance dose of 160 mg twice a day as tolerated by the patient. If symptomatic hypotension or renal dysfunction occurs, consideration should be given to a dosage reduction. Comment: Valsartan may be initiated as early as 12 hours after a myocardial infarction, and may be given with other standard postmyocardial infarction treatment, including thrombolytics, aspirin, beta blockers, and statins.

Usual Pediatric Dose for Hypertension:

6 to 16 years: Initial dose: 1.3 mg/kg once a day (up to 40 mg) Maintenance dose: up to 2.7 mg/kg (up to 160 mg) once a day titrated according to patient response Comments: If the calculated dosage does not correspond to the available tablet strengths, or if children are unable to swallow tablets, the use of a suspension (which can be prepared from the tablets) is recommended. The valsartan dose may need to be increased if the suspension is replaced by a tablet. No data are available in pediatric patients either undergoing dialysis or with a glomerular filtration rate less than 30 mL/min.

Detailed Diovan dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep your medicine container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Diovan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Diovan if you are allergic to Diovan components. Do not take Diovan if you're pregnant or you plan to have a baby, or you are a nursing mother. Diovan can harm your baby. Take Diovan with care if you are taking any other blood pressure medications: diuretic (water pill) such as amiloride (Midamor), spironolactone (Aldactone), triamterene (Dyrenium, Maxzide, Dyazide), angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), and trandolapril (Mavik); beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), propranolol (Inderal), ramipril (Altace). Be careful with Diovan if you suffer from or have a history of liver disease, kidney disease. Do not use potassium supplements or salt substitutes. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Do not stop taking Diovan suddenly.

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Influence of atropine on the depletion of vasoactive intestinal peptide, substance P and calcitonin gene-related peptide from rat parotid gland in response to parasympathetic nerve stimulation. Venous malformations are a common form of vascular anomaly that cause pain and disfigurement and can be life threatening if they involve critical organs. Comparison of the results from the two studies showed that the median peak pressures demonstrated similar patterns with the highest pressure in the forefoot under the second/third metatarsal heads and the toes taking gradually reduced pressure from the first to the fifth toe. This study serves to prevent spurious interpretation of AP-conjugate based binding assays, be they against purified lipids/lipid mixtures or tissue samples from which lipids have not been removed. meliloti has been proposed, whereby FixL acts as an oxygen sensor as the initial event in the cascade and transmits this information to FixJ. Perioperative stimulation of erythropoiesis with intravenous iron and erythropoietin reduces transfusion requirements in patients with hip fracture. Because the short- and long-term effects of CT treatment are not the same, the actions of CT are time and concentration dependent. These results confirm C/EBP isoforms expression in intestinal epithelial cells. Before loading, the bond system in combination with acid etching the dentin provided superior results.

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Adhesion of bacteria and of metastasizing tumour cells have much in common, especially the participation of lectins in this process. Antagonists of pre-anesthetic medication current state of the problem. AML: immunophenotypic heterogeneity and prognostic significance of c-kit expression. 24 hours after pancreaticography some of the animals still manifest high-grade hydropic damage to the ductal epithelium, including rupture of the apical cell-membrane focal lysis of cytoplasm, irreversible mitochondrial lesions and initial degeneration of the nucleus. Mass spectrometric identification of modified urinary nucleosides used as potential biomedical markers by LC-ITMS coupling. Muscle contraction: are the crossbridges independent force generators?. The aim of this study was to describe the pathophysiological changes in a model of dilated cardiomyopathy in turkey poults and to compare them to results obtained from failing human hearts. Sensitization of homologous and heterologous macrophages by cytophilic antibodies: inhibition of sensitization by normal serum. The abilities of platelet-derived growth factor (PDGF) and insulin-like growth factor (IGF-I) to regulate cAMP metabolism and mitogen-activated protein kinase (MAP kinase) activity were compared in human arterial smooth muscle cells (hSMC). Gentamicin-loaded microspheres for treatment of experimental Brucella abortus infection in mice.

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Brain metastasis of testicular yolk sac tumor with massive hemorrhage: case report. Candidate vaccine antigens that stimulate the cellular immune response of mice vaccinated with irradiated cercariae of Schistosoma mansoni. Firstly, analyzed the anti-proliferation effect of DHA on K562 cells and assessed the inhibitory effect on expression of VEGF in K562 cells. Pneumatic retinopexy is a procedure for reattaching the retina by injecting an expanding gas bubble and using either laser or cryopexy. There is no evidence of tumor transmission by transplantation of corneas from donor eyes with primary choroidal melanomas. All four had persistent disorders, and two had difficulties with mother/infant attachment. The plan for the future is to find therapeutic strategies that are specific for patients based on the specific biology of the disease.

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The role of gastric reflux in heartburn and diseases of the esophagus. The objective of this study was to define the optimal length of PEG chains to obtain the best tissue preservation. The screen which does not require elaborate continuous flow equipment nor special gas phase detects the activity of those compounds known to be effective against the parenteral stages of the parasite in mice. Preoperatively, sedation was observed in both groups, but children receiving OTFC had significantly less distress at time of separation from parents. However, the nature of these complexes and details of the molecular interactions are not fully understood. Effects of in vitro supplementation of bovine mammary gland macrophages and peripheral blood lymphocytes with alpha-tocopherol and sodium selenite: implications for udder defences. This suggests either that WS and NF1 are allelic or that phenotypes arise from mutations in very closely linked genes. Relaxin levels in 7 women with posterior pelvic and lumbar pain were also measured.

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We propose a possible antioxidant mechanism of action for lutein and lycopene that leads to formation of the oxidation products of these promising chemopreventive agents. In spite of the resulting potential for autocrine growth of Tera 2, we failed to observe such a situation. Lung cancer cell line CALU-1 was seeded on this artificial membrane and cell invasion was studied using the Fourier transform infrared (FTIR) imaging technique. Loco-regional treatment for esophageal cancer with bleomycin adsorbed to activated carbon particles. Demographic modeling methods were applied to data from a variety of sources, including surveys of mentally ill adults receiving public mental health services in New York State and demographic statistics on the general state population. Partial cDNA cloning and NGF regulation of a rat 5-HT3 receptor subunit. Consistent with the Na,K-ATPase cytoplasmic domain as being necessary for alpha/alpha interactions, the full-length alpha-subunit stably associates with an alpha N-terminal deletion mutant (delta Gly2-Leu273), but not with an alpha cytoplasmic deletion mutant (delta Arg350-Pro785). A total of 544 strains were studied (199 gonococci from male patients attending hospitals in the county of Avon, 204 unselected N gonorrhoeae isolates from male patients in Leeds, 20 strains referred to the Gonococcus Reference Unit because of difficulties with the Syva fluorescent antibody test (FAT), and 121 strains collected over a four year period which had not reacted with serotyping antibodies). ELC possess a light cytoplasm containing two types of granules: (i) numerous small granules, 50-110 nm in diameter, and (ii) single large granules, 290-860 nm in diameter. We have used the metamorphosis of the holometabolous insect, Manduca sexta, as a model to study effects of 20-hydroxyecdysone on the maturation of thoracic neuron membrane channel expression.

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Oligodendroglioma, ependymoma, choroid plexus papilloma, pituitary adenoma, and meningioma cells showed the same integrin pattern as their normal counterparts. Pediatric lung transplantation: expanding indications, 1985 to 1993. After giving their interpretation, they were informed of the correct meaning. The climate change scenarios used in this research are severe by climatological standards. Reverse redistribution on planar thallium scintigraphy: relationship to resting thallium uptake and long-term outcome. Patients with schizophrenia have long been observed to perform poorly on the Wisconsin Card Sorting Test (WCST). End stage renal disease requiring renal replacement therapy is a common complication of several renal diseases that are seen in the tropics.

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Structural analysis of cardiac beta myosin heavy chain gene in familial hypertrophic cardiomyopathy. High interocular corneal symmetry in average simulated keratometry, central corneal thickness floxin ear drops dosage , and posterior elevation. To determine levels of potential and actual dermal exposure to cyclophosphamide (CP) during performance of oncology-related tasks in hospitals and to investigate the relationship with potential sources and surface contamination levels of CP. The Asn161Ala mutant was more generally affected, although the acylation rates with cefuroxime and cefotaxime remained similar to those observed with the wild-type enzyme. Interestingly, H7, but not herbimycin A, inhibits pp90rsk activity in the in vitro kinase assays.

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High resolution of human evolutionary trees with polymorphic microsatellites. Monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP) 1alpha, growth-related gene product (GRO)-alpha and interleukin (IL)-8 were measured in 58 children with meningococcal sepsis or septic shock on admission and 24 hours thereafter. A small circular trace generated on the screen is focused around the photocell. We found 4 multivariate significant predictors for metastatic axillary involvement: Clinically positive axilla, peritumoural lymphatic vessel invasion, multicentric or zithromax dose kids multifocal tumours and a large number of past pregnancies. We demonstrate a new technique in a cadaveric specimen whereby the ALIF procedure is augmented with APS fixation using neuronavigation and fluoroscopy. Interferon-gamma destabilizes interleukin-1-induced granulocyte-macrophage colony-stimulating factor mRNA in murine vascular endothelial cells. This paper discusses how these schemes have evolved, the problems of standard setting and their validity as a measure of pathologists performance. Dietary restriction, polyamines and monocrotaline-induced pulmonary hypertension.

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SFME cells show reversible induction of the astrocyte-specific marker glial fibrillary acidic protein when cultured in the presence of TGF-beta or serum. Previous gene mapping studies in human and mouse have suggested that CD2, CD48, and CD58 arose by gene duplication. Intraglomerular and interstitial leukocyte infiltration, adhesion molecules, and interleukin-1 alpha expression in 15 cases of antineutrophil cytoplasmic autoantibody-associated renal vasculitis. Of 11,164 applicators screened, 994 families met the inclusion criteria. LPS-induced IL-6 production was further increased by NNA in a dose-dependent fashion. Control studies excluded an assay artifact as the explanation for the current findings. The degeneration of the dendrites of NGFR-immunoreactive neurons were reported to be extensively found in the basal forebrain nuclei, in contrast, degeneration of the cell body of NGFR-immunoreactive neurons was confined to those in the NBM and HNDB in the present study. Effects of repeated amphetamine administration on antisaccade in schizophrenia spectrum personality. It is emphasized that this involves brain abnormalities, which is a sequela of hypoxia or ischemia of systemic origin, rather than primary brain damages. Several case studies are presented to illustrate these characteristics.

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Electrophoretic mobility shift analysis (EMSA) of nuclear extracts from synoviocytes incubated with the STAT-1 decoy ODN in vitro revealed an inhibitory effect on STAT-1. The primary contraindications to knee fusion are bilateral involvement or an ipsilateral hip arthrodesis. Copper/zinc superoxide dismutase expression in the human central nervous system. Characterization of a human carcinoma cell line selected for resistance to the farnesyl transferase inhibitor 4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-b)-pyridin-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxamide (SCH66336). Diagnostic imaging provides great benefits to general practitioners in the diagnosis of a number of diseases. Increasing activity in the general population and the high demands placed on athletes have resulted in injuries to the hamstring muscle complex (HMC) being commonplace in sports. We analyzed the structural features of the perimysium collagen network in bovine Flexor carpi radialis muscle using various sample preparation methods and microscopy techniques.

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NRC-1) lacks both the NOPPP and the RuMP pathway but may possess a modified oxidative PPP (OPPP), the details of which are not yet known. Bacillus thuringiensis: fermentation process and risk assessment. Sequential CD134-CXCR4 interactions in feline immunodeficiency virus (FIV): soluble CD134 activates FIV Env for CXCR4-dependent entry and reveals a cryptic neutralization epitope. These results not only validated the mechanism established with non-essential extracellular enzymes, but will also constitute the basis for comparative studies of the low-affinity variants from penicillin-resistant strains. The induction of DSB appears to be highly dependent on the induction of interstrand cross-links since they are clearly present after treatments with 8-MOP plus 365 nm radiation (inducing monoadducts and cross-linking in DNA), but practically absent after treatment with 8-MOP plus 405 nm radiation (inducing predominantly monoadducts) at comparable levels of photoadducts. Conversely, the alpha212 variant consists primarily of the HBA2 gene sequence except for a segment of IVSII in which HBA2 -specific nucleotides at two sites have been replaced by HBA1-specific sequences. Contradictions in claimed medical principles from one case to the next were found and examples were cited for each expert. BFI was calculated by dividing maximal ICG absorption change by rise time. Evidence that the loss of brain catecholamine stores due to blockade of storage does not cause sedation. Transient sensitivity of intracellular psittacosis virus to x-rays.

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