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Daklinza (Daclatasvir)
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Daklinza

Daklinza is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Daklinza should never be used without sofosbuvir. Daklinza and sofosbuvir may also be used with another antiviral medication (Daklinza).

Other names for this medication:
Daclatasvir

Similar Products:
Neurontin, Floxin, Rogaine, Hytrin, Prometrium, Ambien, Ilosone, Bactrim

Also known as: Daclatasvir

Description

Daklinza (daclatasvir) is an antiviral medicine that prevents hepatitis C virus (HCV) from multiplying in your body.

Daklinza is used in combination with other medications to treat chronic hepatitis C in adults.

Daklinza treats specific genotypes of hepatitis C, and only in certain people. Use only the medications prescribed for you. Do not share your medicine with other people.

Daklinza must be given in combination with other antiviral medications and should not be used alone. It is usually given with sofosbuvir, with or without ribavirin.

Daklinza is sometimes used in people who also have HIV. Daclatasvir is not a treatment for HIV or AIDS.

Dosage

Usual Adult Dose for Chronic Hepatitis C:

60 mg orally once a day Recommended Regimen and Duration of Therapy: Genotype 1: -Without cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Compensated (Child-Pugh A) cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Decompensated (Child-Pugh B or C) cirrhosis: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks -Posttransplant: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks Genotype 3: -Without cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Compensated (Child-Pugh A) or decompensated (Child-Pugh B or C) cirrhosis: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks -Posttransplant: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks Comments: -Dose recommendations also apply to HCV/HIV-1-coinfected patients. -Optimal duration of therapy has not been established for HCV genotype 3-infected patients with cirrhosis or for HCV genotype 1-infected patients with Child-Pugh C cirrhosis. -The manufacturer product information for sofosbuvir should be consulted regarding dosing. The manufacturer product information should be consulted regarding ribavirin dosing and dose adjustments (if applicable). Use: With sofosbuvir (with or without ribavirin), for the treatment chronic HCV genotype 1 or 3 infection

Detailed Daklinza dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Daklinza are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Daklinza if you are allergic to daclatasvir.

When taking Daklinza with other medicine: To make sure all medicines are safe for you, tell your doctor about all your medical conditions, and if you are pregnant or breastfeeding.

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with daclatasvir. Your doctor may change your treatment plan if you also use:

rifampin; St. John's wort; or seizure medicine - carbamazepine, phenytoin.

To make sure Daklinza is safe for you, tell your doctor if you have ever had:

hepatitis B; liver problems other than hepatitis C; a liver transplant; diabetes; heart disease; if you have recently used a heart rhythm medicine called amiodarone; or if you use a blood thinner (warfarin, Coumadin, Jantoven) and you have routine "INR" or prothrombin time tests.

Daklinza is sometimes used in combination with ribavirin. Both men and women using ribavirin should use effective birth control to prevent pregnancy. Ribavirin can cause birth defects, miscarriage, or death to an unborn baby if the mother or father is using this medicine.

You should not take ribavirin if you are pregnant, or if you are a man and your sex partner is pregnant. Use effective birth control to prevent pregnancy. Keep using birth control for at least 6 months after your last dose of ribavirin.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is using ribavirin.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Daklinza is not approved for use by anyone younger than 18 years old.

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The study led to identification of 22 inhibitors of parasitic cysteine proteases out of which 18 compounds were active against falcipain-2 and falcipain-3. Two other cats had a restricted lesion covering mainly the forelimb part of area 4. The doses were decided on the basis of suggestions in the literature. In the present review, biotransformation of HCH isomers, both under aerobic and anaerobic conditions, and their degradation pathways have been described. Follow-up SPECT revealed temporary hyperperfusion in the left temporal lobe, strongly suggesting that this unusual complication resulted from bypass flow into the brain tissue with chronic severe ischemia and impaired autoregulation. Because restricted knee ROM affects functional activities, knee ROM and knee function are regarded as the primary indicators of successful TKA. Angiogenic remodeling of the pododermal angioarchitecture was also the connectional reparative principle in pathologically altered claws. In this study the spinal N13 potential (recorded with anterior neck reference) showed a significant delay with enflurane anesthesia. This method is also applicable to detection of amines in other food samples. The aetiology is obscure, although previous irradiation is a possible risk factor.

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A comparative study of ERP correlates of psychometric and Piagetian intelligence measures in normal and hyperactive children. Each objective was rated as -1 (inappropriate), 0 (unsure), or 1 (appropriate). The elimination of keratin artifacts in immunoblots probed with polyclonal antibodies. Draining veins were found pouring into the superior sagittal sinus and also into the transverse sinus. The effect of the lipophilicity and polar properties of a cation on the transmembrane that carries this complex across BLM have been discussed. Factors in the prognosis for premature infants with very low birth weight. For the Isomer-K31 and -K164, the PEG-polymer attachment point is located in proximity to the binding interface, and the isomers display affinity in the range 150-520 nM in an enthalpy-driven binding process.

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The origins and geological history of the modern fauna of deep-sea echinoids is explored using a combination of palaeontological and molecular data. Airway viral infection may elicit GRO-alpha expression in the bronchial epithelium, which may be implicated in inflammatory and immune reactions. A comparative analysis of anterior chamber, iris-supported, capsule-fixated, and posterior chamber intraocular lenses following cataract extraction by phacoemulsification. Breast cancer prevention education at a shopping center in Israel: a student nurse community health project. We describe two cases of corrected transposition of great vessel (L Transposition). Therefore, transient changes in flow (less than 20 seconds) cannot be measured accurately, and it is difficult to determine the time course of changes in cerebral blood flow in response to a given stimulus. A statistically significant relationship between male lung and stomach cancer and female peritoneal, gall bladder, and esophageal cancer and asbestos counts in drinking water was determined in one epidemiology study.

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Patients with three or more British Thoracic Society criteria of severe pneumonia were studied. An audible, solid-state water-level alarm was developed for use with a detachable sensing probe that could be autoclaved. We report a case of successful management of expulsive suprachoroidal haemorrhage following cataract surgery. Kindling leads to long-term reduction in basal hippocampal NA release from the intrinsic locus coeruleus system as monitored using intracerebral microdialysis. Immunohistochemically, tenascin shows a characteristic and spatially restricted distribution. With respect to HPLC tandem detection, the fluorescence detector compared favourably to the UV and CD detector regarding linearity, sensitivity and selectivity. To identify the effect of stress on sympathetic reactivity, we evaluated the extracardiovascular and haemodynamic responses to various stressor agents using noninvasive techniques. The patient was treated successfully by excision of the central anomalous discoid portion of the menisci, using arthroscopic techniques. Induction of aberrations in bone marrow cells has observed for 3 months.

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All areas currently of clinical and research interest pertinent to this disease were discussed, ranging from basic epidemiologic issues to the definition of molecular defects in each of the three major types of epidermolysis bullosa and the potential for gene therapy. Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen that promotes angiogenesis in solid tumors, including brain tumors such as astrocytomas. Monoacylated MDP induced cytokines with similar profiles to BCG-CWS or -PGN, although their potency for induction of TNF-alpha, IL-12p40, and IL-6 was less than that of BCG-CWS or -PGN. Clinical pharmacology and general patient care in two teaching hospitals. Body mass index (kg/m2), based on self-reported weight and height, was compared between women with and without a mammogram in the past 2 years using logistic regression. NiCl2 and CoCl2 were found to upregulate these adhesion molecules on human umbilical singulair allergy medicine kids vein endothelial cells (HUVEC) in a dose- and time-dependent manner as could be demonstrated by flow cytometry and enzyme-linked immunosorbent assay. Effect of using a mexitil preparation in cardiac rhythm disorders. The women were recruited, counselled, interviewed, examined and tested for reproductive tract infections including HIV.

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311 medial femoral neck fractures (213 of them displaced) treated with a hip compression screw were studied retrospectively. Conflicting results have been reported on polymorphonuclear (PMN) cell responsiveness during senescence. The spatial resolution of the mechanism underlying these nonlinearities was typically higher than that of the center mechanism of these cells. Ro 42-1611 only slightly suppressed cytoadherence of infected erythrocytes to melanoma cells. The Bio-pump is still being used in a wide range of clinical applications such as open-heart surgery, left-heart bypass, extracorporeal membrane oxygenation, and supplementary circulation. In the present study using p130Cas-/- cells, and p130Cas-/- cells expressing variants of GFPp130Cas, we show that this docking protein, via its substrate domain, is responsible for subcellular targeting of YopH in eukaryotic cells.

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Previous research has demonstrated that human adults, human infants, and non-human animals can process numerical quantities through approximate representations of their magnitudes. The senior clinical manager of commercial occupational health providers completed a questionnaire. Material is taken from 70 patients having either ulcerated or non-ulcerated carcinoma, and from 10 patients with chronic stomach ulcer. Among them, three domains on the C-terminal side of the stalk region, i.e., (252-272), (276-330), and (336-346), were in the same heptad frame, although these potential coiled-coil domains were not self-sustaining individually. Acute abdominal syndromes with occlusive aspects and anticoagulant treatment. As one of the earliest antibiotics to be marketed after penicillin and streptomycin, and because of their convenient oral dosing, tetracyclines have achieved wide clinical usage. Recent studies have indicated that TGF-beta may be a significant mediator of the profound and prolonged immunosuppression found during graft versus host disease (GVHD) after allogeneic haematopoietic stem cell transplantation. The role of renal dopamine in the reduction of high blood pressure by beta 1-selective beta-blocker with intrinsic sympathomimetic activity in spontaneously hypertensive rats.

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