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Coumadin (Warfarin)

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Coumadin is used to treat blood clots (such as in deep vein thrombosis-DVT or pulmonary embolus-PE) and/or to prevent new clots from forming in your body. Preventing harmful blood clots helps to reduce the risk of a stroke or heart attack.

Other names for this medication:
Jantoven, Lycobion, Sofarin, Uniwarfin, Warfarin

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Also known as: Warfarin


Coumadin (warfarin) is an anticoagulant (blood thinner). Warfarin reduces the formation of blood clots.

Coumadin is used to treat or prevent blood clots in veins or arteries, which can reduce the risk of stroke, heart attack, or other serious conditions.


Take Coumadin exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take warfarin in larger or smaller amounts or for longer than your doctor tells you to.

Take this medicine at the same time every day, with or without food. Never take a double dose.

Coumadin can make it easier for you to bleed. Seek emergency help if you have any bleeding that will not stop.

You will need frequent "INR" or prothrombin time tests (to measure your blood-clotting time and determine your warfarin dose). You must remain under the care of a doctor while taking Coumadin.

If you receive Coumadin in a hospital, call or visit your doctor 3 to 7 days after you leave the hospital. Your INR will need to be tested at that time. Do not miss any follow-up appointments.

Tell your doctor if you are sick with diarrhea, fever, chills, or flu symptoms, or if your body weight changes.

You may need to stop taking Coumadin 5 to 7 days before having any surgery, dental work, or a medical procedure. Call your doctor for instructions.

Wear a medical alert tag or carry an ID card stating that you take warfarin. Any medical care provider who treats you should know that you are taking this medicine.

Store at room temperature away from heat, moisture, and light.

Detailed Coumadin dosage information


If you overdose Coumadin and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Coumadin overdosage: round, small, red spots under the skin, painful menstruation, bruising, minor cuts bleeding, gums bleeding, bloody stools, heavy bleeding.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Coumadin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Coumadin if you are allergic to warfarin, or if:

you have very high blood pressure; you recently had or will have surgery on your brain, spine, or eye; you undergo a spinal tap or spinal anesthesia (epidural); or you cannot take warfarin on time every day.

You also should not take Coumadin if you are are prone to bleeding because of a medical condition, such as:

a blood cell disorder (such as low red blood cells or low platelets); ulcers or bleeding in your stomach, intestines, lungs, or urinary tract; an aneurysm or bleeding in the brain; or an infection of the lining of your heart.

Do not take Coumadin if you are pregnant, unless your doctor tells you to. Warfarin can cause birth defects, but preventing blood clots may outweigh any risks to the baby. If you are not pregnant, use effective birth control to prevent pregnancy while taking warfarin and for at least 1 month after your last dose. Tell your doctor right away if you become pregnant.

Coumadin can make you bleed more easily, especially if you have ever had:

high blood pressure or serious heart disease; kidney disease; cancer or low blood cell counts; an accident or surgery; bleeding in your stomach or intestines; a stroke; or if you are 65 or older.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

diabetes; congestive heart failure; liver disease, kidney disease (or if you are on dialysis); a hereditary clotting deficiency; or low blood platelets after receiving heparin.

It is not known whether warfarin passes into breast milk. Watch for signs of bruising or bleeding in the baby if you take Coumadin while you are breast-feeding a baby.

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Joint crack sound wave analysis of digital audio tape (DAT) recordings, taken from two skin mounted microphones positioned on either side of the cervical spine. The use of bone scintigraphy in the diagnostic management of scaphoid fractures is accurate, convenient for patients and cost-effective. After appropriate sound attenuation, there were no significant effects of exposure to the microwave pulses. To resolve these problems and to establish a model of cell-based therapy, prolongation of the life span of hMSCs without affecting differentiation capability is essential. Elafin is an elastase inhibitor with a unique structure, not related to the serpin family, which includes the neutrophil elastase inhibitor. Inflammatory markers in bronchoalveolar lavage fluid from human volunteers 2 hours after hydrogen fluoride exposure.

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A directed PPE may be more efficient, thereby allowing more time to address other important issues. Pulmonary tuberculosis, a disease largely limited to third-world populations only 15 years ago, is increasingly becoming a public health problem again in the U.S. The prostaglandin-E2 9-reductase (PGE2 9-reductase) activity in the corpus luteum of rabbits corresponds to a cytosolic, NADPH-dependent enzyme with a molecular mass of 36 kDa. Sedative and antistress action of a peptide complex isolated from human amnion. Notes and discussion the lexicon and sentence generation in aphasia. Difficulties may occur, however, during manipulation in the dorsal vascular bed of fingers, known only as a random venous network.

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Intracranial placement of a nasogastric tube after complex craniofacial trauma. OVCAR-3 cells were incubated with progesterone and mifepristone at concentrations ranging from 10(-3) to 10(-9) M. These results indicate that the pea and rat liver NTPases are structurally similar and that, in pea nuclei as in rat liver nuclei, the major NTPase is probably derived from a lamin precursor by proteolysis. We report a case and discuss the clinical presentation, radiographic and metabolic findings, and treatment. Randomised clinical studies with controls and quasi-experimental studies that evaluate group education interventions aimed at type-2 diabetes patients over 18 years old. Moreover, small vessels can be affected by various disease entities with overlapping radiologic features and a wide spectrum of clinical manifestations. Furthermore, injection of induced macrophages promoted tumor growth accompanied by immunosuppression in the rat tumor models, but injection of induced macrophages transfected with Stat3 decoy ODNs led to retarded tumor growth accompanied by immune activation. The measured interfacial width differs from the predictions of capillary wave theory with a progressively smaller deviation as the temperature is raised.

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Increased interest in the problems of librarianship by researchers in other areas, higher salaries for library school teachers and beginning librarians, and increased financial support for research and scholarships are given as encouraging signs of progress toward the solution of these problems. Lipid peroxidation in the rat brain under neurotization conditions. Two first cases of prenatal diagnosis of generalized cytochrome b5 reductase deficiency are presented. Se status, as expressed by plasma and erythrocyte concentrations and plasma and erythrocyte glutathione peroxidase activities (GPx), was significantly lower in vegetarians when compared to nonvegetarians. Reliable evidence is needed regarding the clinical characteristics of cancer in patients with this history to determine if a change in the diagnostic approach is needed. Integration of aqueous two-phase extraction and affinity precipitation for the purification of lactate dehydrogenase. The improvements in laparoscopic techniques have led to the development of laparoscopic assisted hysterectomy. Both PMA and IBMX were shown to act posttranscriptionally on IL-3, by extending the half-life of the mRNA. However, there is no significant dose response for autoimmune thyroid diseases.

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Because neurocognitive dysfunction is commonly accompanied by negative symptoms (avolition, alogia, and affective flattening) in schizophrenia, the authors hypothesized that the presence of the risk haplotype would be significantly associated with negative symptoms. Thus, an accurate description of 3D configuration is obtainable by a 5-mm section thickness. Enhancement of nonspecific resistance by liposome-encapsulated immunomodulators does not affect skin graft rejection in mice. Increased reactive nitrogen species (RNS) production has been suggested in the pathogenesis of rheumatoid arthritis (RA), osteoarthritis (OA) as well as in systemic lupus erythematosus (SLE). Macrophages first activated by in vivo or in vitro immunologic stimuli, however, display an enhanced capacity to generate oxygen intermediates beyond O(2)(-) and H(2)0(2), and are able to kill toxoplasmas or inhibit their intracellular replication (1, 2). Intensity modulated radiation therapy with multileaf collimators of different leaf widths: a comparison of achievable dose distributions. The reduction in grain shattering that led to cereal domestication involved genetic loci of large effect.

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The changes in craniofacial growth and development of dental occlusion were studied in children with juvenile chronic arthritis (JCA), and treatment with functional orthodontic appliances (activators) was tested in both JCA and healthy children with distal occlusion. This study employed a sequential design in which the influence of an asthma care path on hospital admissions, length of stay (LOS) in the emergency department, and return visits were evaluated for 1 year. Nonuniform spatial patterns of respiratory activity within biofilms during disinfection. The polymorphism at the HLA-DPB1 locus was investigated in 490 Austrian individuals. The Mayo Clinic computerized medical records database was searched for patients who had biopsy, excision, or autopsy diagnosis of pulmonary hamartomas from 1976 through 1992. The known analogues 2-5 were moderately active to the cell line, with IC(50) values of 34.0, 52.0, 48.0, and 40.0 microM, respectively.

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Effect of free and encapsulated Pseudomonas putida CC-FR2-4 and Bacillus subtilis CC-pg104 on plant growth under gnotobiotic conditions. Most data on maternal mortality in Zimbabwe has been urban hospital based. The association between metabolic atenolol 25mg tablet cost control and prevalent macrovascular disease in Type 2 diabetes: the VA Cooperative Study in diabetes. OT also increased the number of face grooming responses but did not affect the genital grooming. Training was done by repeatedly presenting a subset of memory displays, creating long-term memory traces for these displays. The relationship between HLA-A, B, DQ, and DR antigens and asbestos-induced lung disease.

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The resulting aFGF-heparin complex can bind to several receptor molecules, leading to FGFR dimerization. To obviate the latter problem, we sought an alternative reporter gene for which there would be no background staining in control animals. This enhancement was proven not to be an artifact due to the isolation protocol, by comparison of purified immune complexes with nonspecific protein purified from normal sera by identical or slightly modified isolation protocols. Effect of glucose and related compounds on phosphorylase and glycogen levels. Prostaglandin E1-mediated augmentation of human granulocyte-macrophage progenitor cell growth in vitro. Thirty alcohol-dependent patients and 30 control subjects with no alcohol problem or hepatic impairment were included in the study. Future work will likely solidify and further expand the role of nitazoxanide in the treatment of a wide range of intestinal pathogens. No survival advantage has yet been realized, although this may be seen as the technique is further refined and operative risk curtailed. Multiple occurrence of borderline hepatocellular nodules in human cirrhotic livers: possible multicentric origin of hepatocellular carcinoma. One patient died due to tumor recurrence, while the others are doing well with minimal seizure.

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Gender roles of 25 adolescent offspring of chronic schizophrenic mothers were explored in levaquin dosing adult a three-year study comprising family and individual interviews, as well as questionnaire data. Urgent thrombosis of a ruptured aneurysm followed by immediate postthrombotic administration of TPA may be a safe and reasonable means of preventing vasospasm and improving patient outcome. The data show that I(cp) correlates directly with the current frequency and the geometric parameters. Regions of epithelia that expressed the highest levels of the variant isoforms were those with a high rate of cell division. Immunohistochemically, the tumor was positive for lysozyme but negative for lactoferrin and PE-10 indicating that this tumor was possibly showing goblet cell differentiation. Animal research has provided important information on the pathogenesis of and neuropathologic responses to perinatal cerebral hypoxia-ischemia. Schistosoma: rate of glucose import is altered by acetylcholine interaction with tegumental acetylcholine receptors and acetylcholinesterase. Virus purified from interferon treated TC7 cells adsorbs and penetrates to the same extent as the control virus. In the later stages the mRNA was expressed in the most superficial region of the cortical plate, while the protein was expressed in the IMZ.

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A jump of dust density propagating through the dusty plasma structure has been observed. Plasminogen, fibrinogen, and fibrin/fibrinogen degradation product concentrations were increased in the menstrual fluid of patients with profuse uterine bleedings in comparison with patients with moderate menstrual discharge. At the early stages of erythroid development, the synthesis of spectrin, ankyrin and band 4.1 proteins is initiated before that of the band 3 protein. A rapid LC-MS method for determination of plasma anion profiles of acidotic patients. Quality management in the clinical laboratory consists of quality assurance and good laboratory practice. The particularly deleterious influence of a basic residue immediately C-terminal to the tyrosine is discussed in relation to the autophosphorylation properties of the regulatory loop regions of the insulin and epidermal growth factor receptor kinases. Using the sepiapterin reductase inhibitors phenprocoumon or dicumarol as BH4 synthesis inhibitors, we achieved a pronounced and selective suppression of induced NO production in cytokine-activated endothelial cells. The changes in motor pathway excitability, induced by pairs or trains of transcranial magnetic stimuli, were studied. Word-blindness--a survey of the literature and a report of twenty-eight cases.

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One of the complications of CPB is the systemic inflammatory response syndrome (SIRS). However, Cdk5 and GSK3beta bind to each other only in the presence of tau, suggesting that tau connects Cdk5 and GSK3beta. Factors affecting the localization of joints in rheumatoid arthritis. Recent taxonomic changes for anaerobic will zyrtec affect breastfeeding gram-positive and selected gram-negative organisms. Newer methods to monitor temperature have been introduced into the PACU that have been touted to be adequate for detecting clinically significant changes in temperature. Quenching of the tyrosyl free radical of ribonucleotide reductase by nitric oxide. Isolation and characterisation of a strain of Pseudomonas putida that can express a periplasmic nitrate reductase. Sensitivity of fructose diphosphate binding sites of yeast pyruvate kinase to pyruvate kinase antibodies. Alterations in circulating vasoactive substances in the critically ill--a comparison between survivors and non-survivors. Microvascular capillaroscopic abnormalities in rheumatoid arthritis patients.

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