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Cosart (Losartan)
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Cosart

Cosart belongs to a group of drugs called angiotensin II receptor antagonists (sometimes called ARB blockers). It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Cosart is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is also used to lower the risk of stroke in certain people with heart disease.

Other names for this medication:
Acetensa, Angioten, Cardoplus, Cardzaar, Corodin, Eklips, Gitox, Hilos, Hypozar, Lavestra, Logika, Loplac, Lorista, Losacar, Losacor, Losadel, Losadrac, Losagen, Losapres, Losarb, Losardil, Losargamma, Lospre, Lotan, Lotar, Lotim, Lozitan, Nefrotal, Ozarium, Psycholanz, Ranlozar, Rasoltan, Rosatan, Sartaxal, Sarvas, Simperten, Stadazar, Tarnasol, Tensartan, Zaart

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Also known as: Losartan

Description

Cosart (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Cosart is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Cosart is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Cosart 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Cosart 25 mg, Cosart 50 mg, and Cosart 100 mg may also contain carnauba wax.

Dosage

Take Cosart tablets orally with or without food. Do not crush or chew it. Take Cosart once or twice a day at the same time. If you want to achieve most effective results do not stop taking Cosart suddenly.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Cosart are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Cosart as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Cosart. Correct volume or salt depletion prior to administration of Cosart.

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Cyclosporine increases the oxidizability of low-density lipoproteins in renal transplant recipients. Valproate has proved useful in the treatment of manic-depressive and schizoaffective disorders, usually in daily doses above 500 mg with corresponding blood levels in the range established for treatment of epilepsy (50-100 micrograms/mL). Ubc9 and SUMO-1 interacted with the caspase recruitment domain of procaspase-2 in its N-terminal. These findings indicate that incubation of human mammary artery with lipopolysaccharide resulted in the expression of an inducible NO synthase. It is likely that targeting cancer cell self-renewal pathways will result in more effective cancer therapies. To review the evidence for any difference in H pylori eradication rates between PUD and NUD patients. RNA synthesis in porcine blastomere nuclei introduced into in vitro matured ooplasm. Intravenous amiodarone is a relatively safe therapy for ventricular tachyarrhythmias refractory to other medications.

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All lymph nodes included in the extended sentinel node dissection were negative for metastases. Here, we provide the first direct evidence for apoptotic cell death in the olfactory bulbs of rat pups during normal development and we also demonstrate that olfactory deprivation by unilateral naris occlusion causes a dramatic increase in apoptotic cell death in the glomerular and granule cell layers of the deprived bulb. Prostate cancer pathologic stage pT2b (2002 TNM staging system): does it exist?. Rifampin (600 mg once daily) or placebo was administered to 10 healthy subjects for 5 days. Concordantly, although the germline mutation was detected in all analyzed tumors, LOH 3p was only detected in the (peri)renal mass and most metastases. Control subjects were urology clinic patients who primarily presented with benign prostatic hypertrophy or impotence, who had no history of any cancer other than nonmelanoma skin cancer, and who were frequency matched to case patients on race, sex, and age (10-year age intervals). Furthermore, the ERP effects were compared for words with or without focal prominences. 52 patients completed a problem-oriented questionnaire with structured response alternatives.

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The effect of acute starvation for 48 hr on deiodination of a tracer dose of 131-I-thyroxine in the rat, compared with the effect of hydrocortisone. Interference free and simplyfied liquid chromatography-based determination of thiopurine S-methyltransferase activity in erythrocytes. Z-discs were isolated from Lethocerus (waterbug) flight muscle by removing the contractile proteins from myofibrils with a solution of high ionic strength. Atropine effectively blocked acetylcholine-induced coronary vasodilation but not vasodilation produced by adenosine. Observations on the mass vaccination of hospital staff and students. Persistent cognitive dysfunction was detected in patients treated for posterior fossa medulloblastoma and cerebellar astrocytoma. In November 1992, the New York State Department of Health was notified of a patient who underwent liver transplantation because of severe hepatitis that developed during the use of isoniazid (INH) preventive therapy (IPT) for latent tuberculous infection. The results of imaging studies using synthetic data derived from this model show that a priori information has been successfully incorporated into the image reconstruction process. In this study, development of an experimental method to evaluate friction and drag between the pulley and tendon under different loading conditions and joint configurations is considered. These strategies must recognize that immigrants and western natives attach different levels of importance to oral health and dental parameters.

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Intercellular interactions in which one cell sends a signal to another cell, inducing a change in function of the second cell, are common in morphogenesis, development, inflammation, and repair of the lung and other organs. To determine the reliability of Thai version of the medical outcomes study short-form survey version 2.0 (SF-36V2) in low back pain patients. Paraoxonase gene polymorphism and vitamin levels during pregnancy: Relationship with maternal oxidative stress and neonatal birthweights. Chemotherapy for malignancy, bone marrow transplants, trauma, and chronic illness increase the risk of immunocompromise and systemic fungal infections. Thus, although the cytokine receptor superfamily members do not have intrinsic protein tyrosine kinase activity, by coupling to activation of tyrosine phosphorylation they may affect cell growth by pathways that are common with the large family of growth factor receptors that contain intrinsic protein tyrosine kinase activity.

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