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Cosart (Losartan)

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Cosart belongs to a group of drugs called angiotensin II receptor antagonists (sometimes called ARB blockers). It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Cosart is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is also used to lower the risk of stroke in certain people with heart disease.

Other names for this medication:
Acetensa, Angioten, Cardoplus, Cardzaar, Corodin, Eklips, Gitox, Hilos, Hypozar, Lavestra, Logika, Loplac, Lorista, Losacar, Losacor, Losadel, Losadrac, Losagen, Losapres, Losarb, Losardil, Losargamma, Lospre, Lotan, Lotar, Lotim, Lozitan, Nefrotal, Ozarium, Psycholanz, Ranlozar, Rasoltan, Rosatan, Sartaxal, Sarvas, Simperten, Stadazar, Tarnasol, Tensartan, Zaart

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Also known as: Losartan


Cosart (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Cosart is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Cosart is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Cosart 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Cosart 25 mg, Cosart 50 mg, and Cosart 100 mg may also contain carnauba wax.


Take Cosart tablets orally with or without food. Do not crush or chew it. Take Cosart once or twice a day at the same time. If you want to achieve most effective results do not stop taking Cosart suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Cosart are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Cosart as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Cosart. Correct volume or salt depletion prior to administration of Cosart.

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Additionally glycolaldehyde induced DNA single-strand breaks in a dose range between 1 and 10 mM. Immunochemical and functional analyses together with family studies revealed a homozygous defect of the seventh component of complement in the boy. This study presents the normal values of the development of the fetal heart in second and third trimester that may provide useful background information for clinical approaches. eIF-3, the most structurally complex of the eIFs, has until recently eluded this approach. Trial of a new compound as a chemical radioprotector and its effect on melatonin. On the effects of a small virulent bacterial charge administered simultaneously with silica powder in animals vaccinated with BCG. Computer-assisted morphometry of the fibroblast/mesh surface ratio served to reflect the biological cell response.

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Cyclosporine increases the oxidizability of low-density lipoproteins in renal transplant recipients. Valproate has proved useful in the treatment of manic-depressive and schizoaffective disorders, usually in daily doses above 500 mg with corresponding blood levels in the range established for treatment of epilepsy (50-100 micrograms/mL). Ubc9 and SUMO-1 interacted with the caspase recruitment domain of procaspase-2 in its N-terminal. These findings indicate that incubation of human mammary artery with lipopolysaccharide resulted in the expression of an inducible NO synthase. It is likely that targeting cancer cell self-renewal pathways will result in more effective cancer therapies. To review the evidence for any difference in H pylori eradication rates between PUD and NUD patients. RNA synthesis in porcine blastomere nuclei introduced into in vitro matured ooplasm. Intravenous amiodarone is a relatively safe therapy for ventricular tachyarrhythmias refractory to other medications.

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Classification and diagnostic criteria for headache, cranial neuralgias and facial pain. Surgically amenable epilepsies in children and adolescents: clinical, imaging, electrophysiological, and post-surgical outcome data. Decline of muscle fiber conduction velocity during short-term high-dose methylprednisolone therapy. DNA fusions were constructed that encoded hybrid proteins consisting of carboxyl-terminal residues 233-267 or residues 238-267 of ricin A chain preceding mouse dihydrofolate reductase. However, little is known about the events that trigger the death of RPE cells at the subcellular level. A third group comprised all of the tested representatives of the RHDVa subtype and a Hungarian isolate from 2003.

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We have developed in vitro assays that reconstitute the precipitation out of solution of secretory granule content proteins of anterior pituitary gland and adrenal medulla. The tests are judged by how well they fulfil the criteria of being simple and quick to use, easy to replicate, relevant to the needs of the patient, objective and inexpensive to acquire. In conclusion, DNA binding activity of ATF-2 directed at both ATF/CRE and jun2TRE motifs is modulated in response to the extreme cellular stress of ischemia and reperfusion or reversible ATP depletion. This pictorial essay demonstrates MRI findings of various maternal diseases that can present as acute abdominal pain in pregnant patients. None of the MBP peptides predominated as T cell antigen among the MS patients or their unaffected family members. Polyhedral organelles compartmenting bacterial metabolic processes. In order to identify cortical areas that contribute to perceptual filling-in, we used functional magnetic resonance imaging to image activity in the visual cortex while subjects experienced filling-in. This phenotype is also expressed in various conditions when cells are synchronized, energy depleted or treated with the antimitotic drug benomyl.

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The specific goal of this study was to establish a simple histochemical technique by which the glycosaminoglycan (GAG) lining in the rabbit bladder can be routinely identified. The purpose of this study was to ascertain the release of HA by pipecuronium (PPB) by measuring both HA and N-MHA in the plasma. Although at early stages of drug development, A-I(M)/A-I(M) sHDL holds vast promise for the treatment of a variety of cardiovascular diseases in humans. Delle values which gave stable wine were dependent on time of alcohol addition, on strain of wine yeast, and on composition of wine spirits. In this respect the role of serum lipids and the dietary fat content are reviewed but definitive conclusions seem unwarranted.

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All lymph nodes included in the extended sentinel node dissection were negative for metastases. Here, we provide the first direct evidence for apoptotic cell death in the olfactory bulbs of rat pups during normal development and we also demonstrate that olfactory deprivation by unilateral naris occlusion causes a dramatic increase in apoptotic cell death in the glomerular and granule cell layers of the deprived bulb. Prostate cancer pathologic stage pT2b (2002 TNM staging system): does it exist?. Rifampin (600 mg once daily) or placebo was administered to 10 healthy subjects for 5 days. Concordantly, although the germline mutation was detected in all analyzed tumors, LOH 3p was only detected in the (peri)renal mass and most metastases. Control subjects were urology clinic patients who primarily presented with benign prostatic hypertrophy or impotence, who had no history of any cancer other than nonmelanoma skin cancer, and who were frequency matched to case patients on race, sex, and age (10-year age intervals). Furthermore, the ERP effects were compared for words with or without focal prominences. 52 patients completed a problem-oriented questionnaire with structured response alternatives.

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The effect of acute starvation for 48 hr on deiodination of a tracer dose of 131-I-thyroxine in the rat, compared with the effect of hydrocortisone. Interference free and simplyfied liquid chromatography-based determination of thiopurine S-methyltransferase activity in erythrocytes. Z-discs were isolated from Lethocerus (waterbug) flight muscle by removing the contractile proteins from myofibrils with a solution of high ionic strength. Atropine effectively blocked acetylcholine-induced coronary vasodilation but not vasodilation produced by adenosine. Observations on the mass vaccination of hospital staff and students. Persistent cognitive dysfunction was detected in patients treated for posterior fossa medulloblastoma and cerebellar astrocytoma. In November 1992, the New York State Department of Health was notified of a patient who underwent liver transplantation because of severe hepatitis that developed during the use of isoniazid (INH) preventive therapy (IPT) for latent tuberculous infection. The results of imaging studies using synthetic data derived from this model show that a priori information has been successfully incorporated into the image reconstruction process. In this study, development of an experimental method to evaluate friction and drag between the pulley and tendon under different loading conditions and joint configurations is considered. These strategies must recognize that immigrants and western natives attach different levels of importance to oral health and dental parameters.

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Femora were analyzed histologically and by ELISA of organ culture explant supernatants. The Bop promoter also directs transcription in the skeletal muscle lineage, but only cardiac expression is dependent on MEF2. The expression of sterol regulatory element-binding protein (SREBP-2), low density lipoprotein receptor, 3-hydroxy-3-methylglutaryl-CoA reductase, and SREBP-1c was transiently up-regulated by GW683965A in astrocytes but down-regulated by 24(S)-hydroxycholesterol, suggesting that cholesterol efflux and synthesis are regulated independently. Nitration of tyrosyl-residues from extra- and intracellular proteins in human whole blood. People with heart problems have had their lives extended considerably with the development of the prosthetic heart valve. Thirteen reported cases of renal pelvic sarcomatoid carcinoma have been documented since 1961, and all patients presented with metastatic disease or advanced renal parenchyma involvement. Trypsin-activated meprin was assayed with the protein substrate azocasein and three synthetic peptide substrates.

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Tyrosine and serine phosphorylation of dystrophin and the 58-kDa protein in the postsynaptic membrane of Torpedo electric organ. 6 inflamed sites in each gingivitis patient were sampled on paper strips and 12 sites, 6 with and 6 without attachment loss and periodontal pockets, were selected in each periodontitis patient. At innocuous stimulus levels the third source for stable period 3 was located near the vertex, possibly involving the supplementary motor cortex, whereas at noxious levels this source appears to be located in the cingulate cortex. Dietary nucleotides enhance plasma lecithin cholesterol acyl transferase activity and apolipoprotein A-IV concentration in preterm newborn infants. Causal paths in the treatment-seeking sample mirrored those in the community sample in that psychiatric symptoms (including posttraumatic stress disorder) were the sole factors contributing directly to attempted suicide.

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Intercellular interactions in which one cell sends a signal to another cell, inducing a change in function of the second cell, are common in morphogenesis, development, inflammation, and repair of the lung and other organs. To determine the reliability of Thai version of the medical outcomes study short-form survey version 2.0 (SF-36V2) in low back pain patients. Paraoxonase gene polymorphism and vitamin levels during pregnancy: Relationship with maternal oxidative stress and neonatal birthweights. Chemotherapy for malignancy, bone marrow transplants, trauma, and chronic illness increase the risk of immunocompromise and systemic fungal infections. Thus, although the cytokine receptor superfamily members do not have intrinsic protein tyrosine kinase activity, by coupling to activation of tyrosine phosphorylation they may affect cell growth by pathways that are common with the large family of growth factor receptors that contain intrinsic protein tyrosine kinase activity.

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Oral treatment of pernicious anaemia with vitamin B12 and desiccated hog duodenal extract. The dual endothelial binding capacity of mucosal blasts may help to explain the pathogenesis of reactive arthritis not uncommonly associated with inflammatory and infectious bowel disease. Miniature, rugged Chemfet sensors roxithromycin tablets 300mg have been developed by coating field-effect transistors with ion-sensitive membranes. Surgical intervention is the only possible curative method available, but the critical issue is probably to identify the exact timing during the course of pregnancy for such intervention, or the ability to control symptoms until delivery. Most of these have invoked direct recognition of one by the other, whether or not the anticodon was involved. Prohibitin antiproliferative activity and lack of heterozygosity in immortalized cell lines. Synthesis and biological evaluation of novel C-4 aziridine-bearing paclitaxel (taxol) analogs. Some data on examination of tissue perfusate in the study of toxemia in irradiated animals.

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Alternative spliced transcripts of mdig were detected in some lung cancer cell lines. Septic shock remains a serious disorder associated with high mortality. In adult human brain, astrocytes are infected by HIV and preferentially express HIV Nef and Rev proteins but are also sometimes productively infected. Nucleophilic substitution of 1-bromo hexadec- glucophage 500 mg dosage 2-yne 11 with 3 beta-mercaptoandrost-5-en-17-one followed by oxidation afforded 2c. The aluminium content of human serum determined by atomic absorption spectroscopy with a graphite furnace.

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Studies on cortical dynamics in athletes in various functional conditions. A celiac arteriogram taken 2 months postoperatively revealed that two small aneurysms had developed in the collateral vessels, indicating that increased blood flow through the collateral circulation could be responsible for the formation of secondary aneurysms. Estimation of the pulmonary capillary transport function in isolated rabbit lungs. Despite the unusual size of this tumor, first laparoscopic investigation permitted to avoid a median laparotomy. pPS11 is a promoter probe plasmid containing a promoterless lipase (Lip)-encoding gene (lip). cahirinus mice could be achieved through the odor released by the latter. Studies of poststreptococcal nephritis and other glomerular diseases.

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An additional group of neurones showed powerful excitatory responses to HDA stimulation (15 studied with extracellular and 35 with intracellular recording). Recent discoveries of causative genes of XP have uncovered the molecular mechanisms of nucleotide ambien brand name excision repair. ECHO-11 as a respiratory virus: quantitation of infection in man. The two groups had similar elevations in plasma ANP concentrations, but at baseline differed in terms of plasma sodium, plasma renin activity, and serum aldosterone. The origin of the strains or the presence of virulence-associated factors did not correlate with the ribotype. Intracellular transport and sorting of the oligodendrocyte transmembrane proteolipid protein. RP105(-/-) mice were severely impaired in hapten-specific Ab production against LPS or lipoproteins.

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The aim of this study was to determine whether an immunocompetent rat, tolerized and transplanted with a human hepatoma cell line (Huh 7 cells), could be used to sustain an HCV infection. Ought cancer treatments to be immune from socio-economic evaluation?. Insulin-like growth factor I (IGF-I), IGF-I receptors, and IGF binding proteins 1-4 in human uterine tissue: tissue localization and IGF-I action in endometrial stromal and myometrial smooth muscle cells in vitro. Furthermore, RCC may affect the cytotoxicity of LAK cells to HANKS-Pr. The purpose of this study is to compare turbo Proton Echo Planar Spectroscopic Imaging (t-PEPSI), an extremely fast sequence, with GRE sequence in the detection of DAI. The group II ELISA has several important applications, including assessment of environmental allergen biaxin related to penicillin exposure, monitoring of the efficacy of avoidance procedures, and standardization of commercial mite allergen extracts.

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