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Clindacyn (Clindamycin)
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Clindacyn

Clindacyn is used for treating serious infections caused by certain bacteria. Clindacyn is a lincomycin antibiotic. Clindacyn kills sensitive bacteria by stopping the production of essential proteins needed by the bacteria to survive.

Other names for this medication:
Anerocid, Aniclindan, Antirobe, Clendix, Clinacnyl, Clinaram, Clinda, Clindacyl, Clindagel, Clindal, Clindamicin, Clindamycine, Clindamycinum, Clindareach, Clindets, Clindexcin, Clindoral, Clinmas, Clintabs, Clintopic, Cutaclin, Dacin, Damiclin, Edason, Euroclin, Jutaclin, Klindamicin, Klindamycin, Klindan, Klitopsin, Lanacine, Lexis, Lindacyn, Lindan, Lindasol, Lisiken, Mediklin, Meneklin, Milorin, Opiclam, Ribomin, Zindaclin, Zindacline

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Also known as: Clindamycin

Description

Clindamycin belongs to the family of medicines called antibiotics. Topical clindamycin is used to help control acne. It may be used alone or with one or more other medicines that are used on the skin or taken by mouth for acne. Topical clindamycin may also be used for other problems as determined by your doctor.

Clindamycin is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain clindamycin. It may not be specific to Cleocin HCl. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Take the capsule with a full glass (8 ounces) of water. This is to prevent irritation of the esophagus (tube between the throat and stomach).

Measure the oral liquid correctly using the marked measuring spoon that comes with the package. The average household teaspoon may not hold the right amount of liquid.

To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. If you have a "strep'' infection, you should keep using this medicine for at least 10 days. This is especially important in "strep" infections. Serious heart problems could develop later if your infection is not cleared up completely. Also, if you stop taking this medicine too soon, your symptoms may return.

This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take each dose at evenly spaced times day and night. If you need help in planning the best times to take your medicine, check with your doctor.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules and solution): For treatment of bacterial infections: Adults—150 to 300 milligrams (mg) every 6 hours. For more severe infections, 300 to 450 mg every 6 hours. Children weighing 10 kilograms (kg) or more—Dose is based on body weight and must be determined by your doctor. The dose is usually 8 to 16 milligrams (mg) per kilogram (kg) of body weight per day, divided into 3 or 4 equal doses. For more severe infections, the dose is usually 16 to 25 mg per kg of body weight per day, divided into 3 or 4 equal doses. Children weighing 10 kg or less—Dose is based on body weight and must be determined by your doctor. The dose is usually 37.5 milligrams (mg) or 1/2 teaspoonful 3 times a day.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store Clindacyn at room temperature, between 68 to 77 degrees F (20 to 25 degrees C) in a tightly-closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Clindacyn out of the reach of children and away from pets.

Side effects

The most common side effects associated with Clindacyn are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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OA produced an approximately 30-fold increase in hepatic MT, but had no appreciable effects on MT levels of five other organs. Social recognition was inferred from the reduction in investigation time of a juvenile conspecific when this social stimulus was presented for the second time at different intervening intervals after the initial exposure. Suppression of enhanced NO production by sepiapterin reductase inhibitors such as cumaroles could provide pharmacologic means for therapeutic interventions in NO-mediated pathophysiologic events. Three clinical cases were tested for this study with various exponents set for tumor targets and sensitive structures. Micronema, normally free-living in soil and humus, rarely invades and reproduces in the central nervous system, kidneys, lungs, maxillae and nasal cavity of equines. On the other hand, bone marrow aspiration showed hemophagocytosis and the diagnosis of hemophagocytic syndrome (HPS) was also made. We report on a 45-year-old man with bacterial mitral valve endocarditis and valve-ring abscess following a staphylococcus aureus sepsis with septic shock and respiratory insufficiency. To study the effect of Epo on proliferation and differentiation of UT-7, we maintained the UT-7 cell culture for more than 6 months in the presence of Epo. Rapid cloning of any rearranged mouse immunoglobulin variable genes. These observations may have clinical relevance for the use of radiolabeled sFv as imaging agents.

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trachomatis LPS-induced apoptosis of sperm could be blocked with a pan-caspase inhibitor and a caspase-3 inhibitor. Relationships among characiform fishes inferred from analysis of nuclear and mitochondrial gene sequences. Oleic acid supplementation reduces oxidant-mediated dysfunction of cultured porcine pulmonary artery endothelial cells. Chromosomes of twenty cancer effusions: correlation of karyotypic, clinical, and pathologic aspects. However, factors that determine compliance are not well studied. The prevalence of atopy by family diathesis, prick tests, immunoglobulin E (IgE) concentrations, and personal history of allergic respiratory diseases was investigated in 144 trainee bakers and 81 students on a graphic artists course (mean age 15.4 years).

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Isolation and identification of a bacterium able to assimilate nitrate but not to respire it. To update a 1994 systematic review of the accuracy and reliability of symptoms and findings on neurological examination for the evaluation of patients with suspected stroke or transient ischemic attack. Male rats developed fatty liver after being fed an ethanol-containing diet for 31 days. Three additional findings provided evidence for this hypothesis: 1) SIDS infants born during months of low pollution lived longer than those born during months of high pollution. It is, however, apparent that the native protein circulates in serum as a lower molecular weight hexamer and as larger multimeric structures of high molecular weight (HMW). The improved glucose tolerance at breakfast, following an evening meal with barley kernels appeared to emanate from suppression of FFA levels, mediated by colonic fermentation of the specific indigestible carbohydrates present in this product, or, to the combination of the low-GI features and colonic fermentation. We have performed a study on the comparative structure of the thyroid gland in several species of mammals (rat, cat, dog, lamb, pig, cow, and man). The ability to keep a job, to do household chores, to participate in leisure activities and to maintain social relations is clearly impaired.

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Castration had no effect on the natural history or the etiology of the tumor. There was an approach-related abdominal hernia after wound infection. Effects of chronic pentobarbital treatment on the GABAA receptor complex in mammalian cortical neurons. The trauma patient who presents to the operating room averages three to six separate surgical procedures initially. It was shown that depletion of cholesterol in the responding strain of rats by lymph fistulation also was associated with a parallel increase in levels of HMG-CoA reductase activity and mRNA. No shorter-latency contextual cueing differences were observed in the ERPs. Intragraft IL-17 inhibition may be useful as an adjuvant therapy to systemic immunosuppression in heart transplantation. For zinc, rates of net secretion were somewhat greater in the cecum plus colon of rats in all age groups. The performance of morphological opening is in general poor with a substantial spatial-dependent bias.

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We raised antibodies against mouse TN-X fragments expressed in bacteria and used these antibodies to identify the TN-X protein in heart cell extracts and in the conditioned medium of a renal carcinoma cell line. Eight acromegalics (42-65 years) and 10 age-matched (33-63 years) normal subjects. Airborne bacterial 16S rDNA amplified by PCR were determined for their base sequences by DNA sequence analysis and classified by sequence-based homologies. Chloral hydrate is recombinogenic in the wing spot test in Drosophila melanogaster. Most quality assurance activities in clinical trials and daily practice are directed to structure and process parameters.

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The expression levels of collagen I and fibronectin in the transfected and untransfected endothelial cells were determined by Western blot. The capabilities of phenol adsorption were also examined for the CMC carbons prepared with various treatments. Electronic spectroscopy of cold, protonated tryptophan and tyrosine. Ophthalmic diagnosis and management of impending cerebrovascular lesions. Further necessary steps with regard to the determination of the validity of self-assessments are presented in outlines. In cryptogein-elicited tobacco leaves, we show that the oxylipin RES adducts to GSH are produced in correlation with GSH consumption, increase in glutathione S-transferase activity, and the appearance of the cell death symptoms. Diagnosis of aortic stenosis in older age groups using external carotid pulse recording and phonocardiography. We have used murine model systems to address two broadly defined questions about lymphocyte telomere biology: how is telomerase physiologically regulated in T cells responding to antigen challenge, and what is the effect of transcriptionally altered telomerase expression on telomere length and, consequently, on immune function?. Effects of temperature and time of exposure upon viability of ECHO viruses types 1, 2, 3, 5, and 20.

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When food is scarce, metabolism is reduced and body weight can be maintained indefinitely on less than one-half of normal intake. Bluetongue virus: production and study of viral antigen for serological diagnosis. In standard endothelial function tests, BOLD MRI detects a dissociation of tissue Hb oxygenation from blood flow. In a tandem study, we examined the yield of screening colonoscopy in women. Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene. Increased SPHK-1 (but not SPHK-2) mRNA levels were observed in synovial tissue from RA patients.

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Although the prognosis of multivessel spasm is believed to be poor, this may not necessarily be so. Dynamics of epithelial cells in the corpus of the mouse stomach. Three recovered completely, but neurogenic bladder persisted in the remaining three. Cytotoxic agents are also being evaluated for their potential utility in the reduction of tissue bulk associated with these excessive scar states. Roy-Camille plate fixation appears to offer a stable surgical construct in the treatment of thoracic and lumbar spine instability. alpha 1 beta 1 and alpha 3 beta 1 integrins affected only the initial adherence (1 h after plating) of the cells to denatured type I collagen. This redox behavior is characteristic of surface-immobilized electroactive layers. Effects of CD11b/18 monoclonal antibody on rats with permanent middle cerebral artery occlusion.

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In female mammals, one X chromosome is transcriptionally silenced to achieve dosage compensation between XX females and XY males. Pathology of graft vascular disease after heart and heart-lung transplantation and its relationship to obliterative bronchiolitis. Sanitary-hydrotechnical anti-malarial works in the RSFSR during post-war years (1946-1955) and their effectiveness. As a result, hedonic states provoke behaviors in defense of homeostasis, then guide and terminate them. The diagnosis of VAP was established with protected specimen brush and/or bronchoalveolar lavage.

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Expression cassettes were created that contain a T7 promoter and that encode a single trans-acting ribozyme followed by either a hammerhead, hairpin, or hepatitis delta virus cis-acting ribozyme. These findings indicate that reduction of ODC activity in CyA- or ultraviolet B-treated human keratinocytes may contribute to the antiproliferative mechanism of these agents. A method using a 1-dimensional, thin-layer chromatographic technique for the separation of phospholipids in amniotic fluid is described. Betaine transport in rabbit renal brush-border membrane vesicles. Pathological samples were screened for the presence of p53 mutations using a single-strand conformational polymorphism assay. Few histochemical changes were observed in HE and PAS stained larvae after pressurization at 200 MPa and under. Cranial computed tomography (CT) revealed a low density area bilaterally at the neostriatum. The advent of the Area Health Education System offered the opportunity for the clinical education program to develop nontraditional clinical sites across the state. In addition, control of serum P in uremic patients is crucial in the prevention of vascular calcification.

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However, HES seems to be better in protecting the intestinal barrier function compared with mometasone furoate gel RS at 24 hours after fluid resuscitation. Detection of fundamental principles and a level of order for large-scale gene clustering on the Escherichia coli chromosome. Chemical effects of alkali on polymethylmethacrylate intraocular lenses. Optimization of the simultaneous saccharification and fermentation process using thermotolerant yeasts. Production of granulocyte colony-stimulating factor by head and neck carcinomas. Clinical usefulness of 123I-metaiodobenzylguanidine myocardial scintigraphy in diabetic patients with cardiac sympathetic nerve dysfunction.

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TGF-beta 1 was undetectable in the transplanted growth plate at 4 weeks after transplantation, at which time a morphological examination revealed metaplastically-transformed articular cartilage but no hypertrophic cartilage cells. The cytotoxicity was lower in strain combinations where NK susceptibility was inherited non-recessively, i.e. The clinical value of screening for paracetamol in patients with acute poisoning. Study on the factors correlated with the development of diaper rash of the newborn. Immunocytochemical co-localization of substance P and calcitonin gene-related peptide in afferent renal nerve soma of the rat. On the mechanism of action of cytochrome P450: evaluation of hydrogen abstraction in oxygen-dependent alcohol oxidation.

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Various functional and metabolic parameters have also been measured in isolated perfused hearts. Tissue distribution and seasonal, geographical, and species variation. Adenosinetriphosphate-dependent incorporation of C14-glucose into charoninsulfuric acids by a cell-free extract of the mucous gland of Charonia lampas. The levels of both deoxycortisols rose significantly after ACTH treatment. It is also noted that the activity of BO-2727 against the beta-lactamase-deficient strain was less affected by the loss of the D2 porin than was that of meropenem, indicating that BO-2727 in comparison with meropenem can overcome an intrinsic resistance caused by the loss of D2. The A1 region and the ventral medulla also project to the supraoptic nucleus. Our results suggest that low expression of nm23-H1 gene products may play important roles in tumor invasion, and that deltasone drug interaction this process is mediated in part by overexpression of MMP-2. The central aromatic residue in loop L2 of RecA interacts with DNA. To compare the discriminant validity of the DSM-IV and the ICD-10 classification of alcohol use disorders (AUD) with an alternative classification, the craving withdrawal model (CWM). The purpose of this study was to assess the effect of fluoride application at 3 different steps of the bonding process on the shear bond strength and bond failure site of a resin-modified glass ionomer cement.

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Inhibition of purine metabolism in Ehrlich ascites carcinoma cells by phenanthridinium compounds related to ethidium bromide. By multiple regression analysis, age was the only significant factor identified for wound infection. Electrical stimulation as in kindling or brain self-stimulation, and electrophysiological recordings as in electroencephalography, electromiography, electrocardiography, in vivo voltammetry and even neuronal unit recording, are just examples of the electrophysiological methods that can be combined with drug self-administration and microdialysis using the present device. Important mediators of inflammation such as the cytokine tumor necrosis factor-alpha (TNF-alpha) and its superfamily member fibroblast-associated cell-surface ligand (FasL) have been implicated in apoptosis. To determine the effectiveness and cost-effectiveness of a return-to-work outpatient multidisciplinary treatment programme for sick-listed workers with non-specific upper extremity musculoskeletal complaints. Sixteen patients had malignant tumors, and 1 patient had a glomus tumor. By means of the Line Probe Assay, a hepatitis C virus type 5a infected serum from a Belgian patient was selected. The B-cell areas did not increase in activity during infection in the antilymphocyte serum-treated dogs, suggesting the need for an intact T-cell compartment for the lymphocytic proliferation that occurs in nonsuppressed infected dogs. We conclude that PCP can occur in patients who apparently do not have immunosuppression.

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The influence of illness duration on syndrome clarity and stability in functional psychosis: does the diagnosis emerge and stabilise with time?. Contrary to previous reviews, this study suggests that the influence of past functioning, including work history, diagnosis and psychiatric history, is outweighed by work performance in PVR. Both husbands are patients with HTLV-I norvasc amlodipine with alcohol -associated myelopathy/tropical spastic paraparesis (HAM/TSP), and the wives are asymptomatic HTLV-I carriers. To examine the value of calprotectin, a major granulocyte protein with bactericide properties, as an inflammatory marker in patients with reactive arthritis. A comperative study of media for detection of enterococci in water. Microcystins associated with Microcystis dominated blooms in the Southwest wetlands, Western Australia. Regulating estrogen is possibly one of the mechanisms of Yigu capsule in preventing and treating osteoporosis.

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A new daytime sleepiness scale was constructed on the basis of interviews with 96 apnea patients (the Rotterdam Daytime Sleepiness Scale) and included three subscales of Global Evaluation, Behavioral Impact, and Affected Life Domains. To study identical indexes of frontal sinus in different locative computer radiology. After almost a decade of applications, it is clear that each model has unique strengths and drawbacks when carrying out studies of the role of additional genes and environmental factors such as nutrition and lipid-lowering drugs. However, no consistent pattern has been exhibited, because heterotic effects on size vary with age and individual growth parameters are generally unknown. The vectorcardiographic evaluation of right ventricular hypertrophy. Some problems raised by the installation of hospital laboratories in several countries of the French Community: The influence of the state of health of the country on the emphasis to be put on that installation. Signs of apoptosis at high actinonin concentration included DNA fragmentation, exposure of phosphatidylserine and condensation of cell nuclei. Thymidine transport was also examined in lymphocytes from several AK x L recombinant inbred mouse strains derived from the cross AKR/J x C57L/J. The goals of disc arthroplasty are to remove the native nucleus pulposus and to preserve motion at that disc level. Absorbable polylactide screws were used for internal fixation of rotational acetabular osteotomy (RAO) in 28 dysplastic hips.

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Clozapine has proved effective in alleviating a wide range of psychiatric symptoms in schizophrenia. A critical review of long-term follow-up of patients entered onto eleven major randomized trials of advanced ovarian carcinoma has been performed. Acquired intestinal aganglionosis after a lytic infection with varicella-zoster virus. The pesticides, CAR, TDM, HEP, and CDN, displayed the most acute neurotoxicity and were active at lower proportions of their respective acute LD50 values than were the solvents or the industrial chemicals. Given the large number of patients who can be cured or receive palliation with radiation therapy, concern about PIS should not be a major factor influencing treatment decisions in patients with cancer. Duplex ultrasonography study in the diagnosis of cerebral, abdominal and peripheral artery stenoses. Analogues of peptide 9-21 of glycoprotein D of herpes simplex virus and their binding to group VII monoclonal antibodies. These preliminary results suggest that measurement of numerical chromosome aberrations using in situ hybridization in bladder cancer may offer a new objective and quantitative assay of the biological potential of individual tumours. Our data suggest that the extracellular domains of CD40 and Fas form functionally similar mono- and multimeric structures and that the extracellular domain of Fas participates in the regulation of Fas-specific signal transduction. Fifteen women between zofran dose po the ages of 23 and 25 performed a reaching activity that simulated moving a soup can from a cupboard to a counter.

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Retrospective think-aloud procedures were used to elicit verbalizations, which were transcribed, coded, and analyzed. rIFN-alpha alone at concentrations of 250 IU/ml had no effect on the development of HeLa cell colonies, in combination with BLM, rIFN-alpha increased the already marked inhibition of HeLa cell colony formation caused by 1 microgram/ml BLM. Generalized hyperkeratoses in newborns and in infants and their therapeutic possibilities with cortisone. Treatment of murine leukaemia virus reverse transcriptase with benzophenone 4-maleimide inactivates DNA polymerase activity, but has no effect on the RNAase H function. Arp stimulates in vitro DNA-binding activity of the human transcription factor Jun and Fos by the reduction of a cysteine residue located in the DNA-binding domain. Some contemporary approaches suggest that inhibitory mechanisms play an important role in cognitive development. Twenty mothers had a recurrent (2 type 1, 18 type 2) and 4 an intermediate infection (primary type 2, prior infection with type 1), mostly asymptomatic. Sclerosing pancreatitis may sometimes present with biliary stricture due to bile duct involvement due to the inflammatory process. Compositional frequencies of amino acids in the proteins and the genetic code.

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We used a battery of anti-TR antibodies that recognize the amino-terminal, hinge, or carboxy-terminal regions of TRs to study changes in the epitope regions of in vitro translated TRs in electrophoretic mobility shift assays. The results are interpreted as support for the role of response monitoring in the development of the benefit-only pattern at short RSI, while the first-order repetition effect is explained as repetition priming. All of the steroids measured had peak production levels during proestrus. Serotonin- and histamine-affecting agents and experimental vascular sensitization. Thus there is little resistance to these first line drugs among M. The kinetics of blood clearance o isotopically labelled Salmonella entertidis by the reticulo-endothelial system in mice. However, PDA, when measured with a highly sensitive radioenzymatic method, showed quite different features from norepinephrine and epinephrine in some types of clinical hypertension, lower in essential hypertension and higher in primary aldosteronism and pheochromocytoma.

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Nineteen patients with essential hypertension received a single doses of foridone of 40 mg, then its course therapy in a dose of 90 mg/day for 2 weeks, then it was supplemented with dopegite in a dose of 750 mg/day for 2 weeks too. Oxidative stress generated by the hypoxanthine-xanthine oxidase system (HX-XO) induced a transient decrease in the levels of both ND4 and 12S rRNA. The sunburn cell: regulation of death and survival of the keratinocyte. Histologically, an angiocentric and angiodestructive pattern of infiltrate is often seen, but the cytological spectrum of the lymphoma cells is very broad. A decrease in the insulin level was followed by compensatory activation of glucagon- and somatostatine-producing systems which depended on the sex of animals. Cognitive mapping in rats: the role of the hippocampal and frontal system in retention and reversal. Production of an eosinophil migration factor in lymphocytes of mitogen-treated chick embryos. Pulmonary arterial hypertension frequently develops after a thromboembolic pulmonary event.

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Orbital differentiated fibroblasts became rounded and acquired lipid droplets. On subacute and chronic thyroiditis (with special reference to the subacute De Quervain-Giordanengo form). Determination of seven organosulfur compounds in garlic by high-performance liquid chromatography. Flory temperature and upper critical solution temperature of gelatin solutions. Cytokeratin II, which is also organized as fibrils along the long axis of the normal iris PECs, increases progressively during dedifferentiation, when it is organized as a thick band surrounding the nucleus. The purpose of this study is to investigate how different formulations of carboxymethylcellulose sodium (CMC) applied to the tear layer affect contrast sensitivity over time.

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Long-term follow-up of patients with hairy cell leukaemia treated with pentostatin: lymphocyte subpopulations and residual bone marrow infiltration. This suggests that different mutations in the p53 protein induce an overall conformational change that can be detected by various monoclonal antibodies directed toward the central part of the protein. Adult attachment styles and depression in lung cancer patients undergoing surgery during and after hospitalization. The treatment of experimental toxoplasmosis in mice with insoluble oxytetracycline. The decrease in CD5 surface antigen correlates inversely with the cell density required for maximal cell proliferation, and the diminished CD5 levels were unaltered by vitamin E presence during the aging process. The findings are discussed from the standpoint of the supposed functional heterogeneity of the GABA receptors in the mollusc nerve-muscle junction.

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