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Cardon (Losartan)
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Cardon

Cardon belongs to a group of drugs called angiotensin II receptor antagonists (sometimes called ARB blockers). It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Cardon is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is also used to lower the risk of stroke in certain people with heart disease.

Other names for this medication:
Acetensa, Angioten, Biortan, Cardoplus, Cormac, Covance, Cozaarex, Eklips, Insaar, Lavestra, Losagen, Losalet, Losar, Losart, Losartax, Losartec, Lozar, Lozitan, Lyosan, Medzar, Myotan, Niten, Osartan, Ozarium, Ranlozar, Sanipresin, Sartens, Sortal, Tensaar, Tozaar, Zartan

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Also known as: Losartan

Description

Cozaar (losartan) belongs to a group of drugs called angiotensin II receptor antagonists (sometimes called ARB blockers). It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Cozaar is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is also used to lower the risk of stroke in certain people with heart disease.

Cozaar is also used to slow long-term kidney damage in people with type 2 diabetes who also have high blood pressure.

Dosage

Usual Adult Dose for Diabetic Nephropathy:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Adult Dose for Hypertension:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Pediatric Dose for Hypertension:

6 Years or Older: Initial dose: 0.7 mg/kg orally once a day (up to 50 mg total) Comments: -May be given as a tablet or suspension. -Doses above 1.4 mg/kg (or 100 mg) daily have not been studied in pediatric patients.

Detailed Cozaar dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Cardon are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Cardon if you are allergic to Cardon components. Do not take Cardon if you're pregnant or you plan to have a baby, or you are a nursing mother. Cardon can harm your baby. Do not use Cardon if you are taking salt substitutes or potassium supplements, other blood pressure medicine, diuretic (water pill). It can be dangerous to use Cardon if you suffer from or have a history of liver disease, kidney disease, heart failure. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Avoid machine driving. Do not stop taking Cardon suddenly.

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Because cyclosporin A and FK-506 are known to prevent PCD in T-cell hybridomas and thymocytes, we used these reagents, as well as rapamycin, to determine whether they alter the pathway leading to apoptosis in murine WEHI-231 cells following surface IgM cross-linking. We conclude that NO synthase is present in human granulosa-luteal cells and that NO inhibits estradiol secretion independent of cGMP by directly inhibiting aromatase. Active and passive movements of the limbs remote from and adjacent to the stimulated area significantly decreased pain SEPs in amplitude. Prevention of wasting disease by pregnancy associated with hypertrophy of the fetal thymus. 445 children presenting with bicycle related injuries during 15 April 1991 to 30 June 1992. When FMN is added to rat liver mitochondria or mitoplasts it is reduced at a rate of approx. In the BT549 human breast carcinoma cell line, the reintroduction of a wild type p53 tumor suppressor gene resulted in the stimulation of the secretion of an inhibitor of angiogenesis, thrombospondin-1, and as a result the cells lost their angiogenic phenotype and became able to suppress angiogenesis induced by the parental tumor line. P53 was minimally expressed in untreated lesions, and treatment with PTU and MMI did not enhance p53 expression in the psoriatic lesions. Three patients had the gastrointestinal form, 5 had respiratory prodromes while 1 child developed HUS during the course of varicella.

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cerevisiae wild type and rad 50, 51, 52 and 54 mutants in haploid and diploid strains were measured after gamma-ray and alpha-particle irradiation in stationary and exponential phase of growth. Transformation of a microfocal myocardial infarct into a macrofocal infarct--variant of exacerbation of ischemic heart disease (features of the clinical picture and prognosis). Cytochemical staining was carried out by standard methods using Feulgen, cuprolinic blue and PAS. An assessment was made of the amount of free fat and of the various cell shapes involved. The results showed both pressure tracings to be clinically identical. Direct molecular analysis of archival tumor tissue for loss of heterozygosity. Corticosteroids (CS) are very potent immunosuppressive agents and are widely used to treat inflammatory diseases.

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Sphingosine-1-phosphate induces COX-2 expression via PI3K/Akt and p42/p44 MAPK pathways in rat vascular smooth muscle cells. We have demonstrated by x-ray diffuse scattering that a bimolecular layer of a preformed three-tailed amphiphile, ferric stearate, drastically enhances capillary wave fluctuations on water surface due to a reduction in surface tension to 1 mN/m . These mammograms were read by 15 radiologists who specialize in screening mammography and were blinded to outcome. The recently characterized neurofibromatosis type 2 gene (NF2) has been shown to be mutated in two cases of sporadic meningioma, suggesting that this is the chromosome 22 gene which is involved in tumorigenesis. The purpose of our study was to determine urinary iodine as an indicator of iodine supplementation in Roma (Gypsy) neonates compared to majority population neonates. CD45-mediated regulation of extracellular calcium influx in a CD4-transfected human T cell line. Critically, the effect did not arise with nonfictive motion target sentences (e.g., The road is in the valley), as was demonstrated in three control studies. Elevated MSAFP and AFAFP appear to occur at a higher than expected frequency in pregnancies carrying an oculocerebrorenal syndrome fetus. Case history of a patient with demonstration of pathological anatomical slides. Assessment of intestinal blood-flux by laser Doppler fluxmetry in mice with altered intestinal iron absorption.

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Eight of 12 patients had evidence of MRI activity on 13 of 29 follow-up visits. A broad strategy for optimisation of the predictive ability of an ANN model is proposed. This PH domain also binds radiolabelled inositol-1,4,5-trisphosphate (IP3) and preincubation with IP3 inhibits binding to extracted brain membranes. Anatomical, histological and experimental data on the fluid circulation of the eye. Its structural organization consists of a complex weave of collagen fibers that surrounds and interconnects myocytes, groups of myocytes, muscle fibers and muscle bundles. There was no difference between LAD-affected and normal calves in percentage of neutrophils that bound endogenous IgG and IgM. After the end of the 3 weeks interval there were significant differences between treated and untreated animals detectable. This review tenormin 25 mg tablet will discuss the role of such immunotherapy following autologous bone marrow transplantation for myeloid leukemias, and will focus on recent experience and ongoing clinical trials using the novel immunomodulator Linomide.

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