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Hetastarch treatment delayed myocardial edema development and attenuated myocardial creatine kinase efflux, thereby preserving diastolic function. Change from liver-type to muscle-type fructose metabolism in hepatomas. Comparative study of L forms and Mycoplasma with the electron microscope. The performance is optimized by fitting a small number of empirical parameters. The specific lipid alterations in plasma and four different tissues, as well as the activities of plasma lecithin-cholesterol acyltransferase (LCAT) and tissue lipolytic enzymes were determined in experimental nephrotic and control rats.
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The effects of the bradycardia-producing compound alinidine on action potentials and tension development in cardiac fibres. These replicas demonstrate that plate-like arrays are manifested on the external surface of the plasma membrane. Isolated L-HCs studied with whole-cell patch clamp responded to L-glu, kainate (KA), AMPA, or quisqualate (quis) with inward currents from a holding potential of -60 mV, associated with a conductance increase. Indices of glomerular and tubular function failed to clearly differentiate the drugs. All these agents were found to induce increased release of the three cytokines. By contrast, mice homozygous for the ICF mutations develop to term and some survive to adulthood. Cytokine receptor genes: structure, chromosomal location, and involvement in human disease.
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The mass transport and shear stress were related in a generalized result. X-ray diffraction from centrifugally oriented specimens of plant outer mitochondrial membranes suggests that these membrane contain prominent in-plane subunits. The lack of CREB-mediated transcriptional stimulation is due to the presence of a heat-stable inhibitor of PKA that prevents activation of PKA and subsequent CREB phosphorylation in the nucleus. FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. Purification and phosphate content of slow-twitch human myosin and its possible role in the maintenance of muscle function. Previously published PCR primers available for amplifying these sequences from environmental samples provide varying degrees of success at discriminating against plant DNA while maintaining a broad range of compatibility.
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Reliability of cerebral radioisotopic angiography and of directional Doppler C.W. The purified F26G is dimeric with a native apparent molecular weight of 110,000 consisting of subunits of 54,000 and 58,000. No Y-chromosome sequences were detected in any of the pregnancies where only female babies were delivered. Thus, the dopaminergic regulation of the sensorimotor-related striatum and the ventral striatum may be different. In addition, recommendations are proposed to improve the drug placement and promotion dimension of the marketing function in the pharmaceuticals industry.
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Value of multiple forceps biopsies in assessing the malignant potential of colonic polyps. Consequently, the presence of color signals at CDUS exams may be related to the features of tumor feeding vessels and therefore a negative CDUS exam cannot be considered as a reliable sign to exclude a malignant lesion. The preferential whitefly visitation, the differences between locations in relation to whitefly population, cassava mosaic disease, and the fresh root yield of cassava genotypes are discussed. Synthesis of amine- and thiol-modified nucleoside phosphoramidites for site-specific introduction of biophysical probes into RNA. Purine-based compounds have found new applications as inducers of interferon and lineage-committed cell dedifferentiation, agonists and antagonists of adenosine receptors, ligands of corticotropin-releasing hormone receptors, and as inhibitors of HSP90, Src kinase, p38alpha MAP kinase, sulfotransferases, phosphodiesterases, and Cdks. At this stage the myoepithelial cells produced phalloidin-positive spindle cytoplasmic processes. Nitric oxide is a pluripotential molecule that acts as both an autocrine and paracrine mediator of homoeostasis, and derangement of its metabolism can be linked with many pathophysiological events. Activation of the humoral branch of the immunological response is currently believed to play an important role in pathogenesis of chronic allograft nephropathy.
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In vitro induction of physiological maturation in Rana pipiens oocytes removed from their ovarian follicles. In 2h PCA test in animals immunized with large doses of the antigen a higher activity of PCA reaction illustrating the concentration of IgG1 antibodies was noted. The Escherichia coli rne gene affects a variety of bacterial functions, including the activity of RNase E. Effects of orthodontic treatment after adenoidectomy on jaw relations in the sagittal plane. Computational alanine scanning of a peptide bound to CDK6 protein. The effects of posture on gastric emptying, intragastric distribution, and appetite after ingestion of a meal containing oil and aqueous phases was evaluated. This reduction showed a true repellent effect for the compounds. The pol III RNA start site is observed not only in in vitro transcription reactions, but also in total RNA isolated from tissue culture cells, larvae, pupae and adult flies. Cross-linking and fluorescence study of the COOH- and NH2-terminal domains of intact caldesmon bound to actin.
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Generation of a monoclonal human single chain antibody fragment to hepatic stellate cells--a potential mechanism for targeting liver anti-fibrotic therapeutics. However, many recorded seizure-like events are not epileptic, even in children with epileptiform EEG abnormalities. Evaluation of cystography for detection of bladder carcinoma in mice: comparison with urinary cytology. Plasma copper concentration did not change in response to inoculation (as determined at 24 h postinjection). Vasovagal heart block following cataract surgery under local anesthesia. Exposure to nicotine resulted in increased postnatal body weight and fat pad weight and an increased amount of PVAT in the offspring. TNF-alpha inhibits glucose-induced insulin secretion in a pancreatic beta-cell line (INS-1).
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Adipocyte: a potential target for the treatment of atherosclerosis. High-sensitivity cytotoxicity assays refer to assays that can detect high levels of cell kill, to many powers of 10, and that can detect, ideally, a single remaining viable cell. Circadian rhythm of intestinal glucose absorption in fasting and fed rats. Transfection experiments demonstrate that ATF-1 is capable of antagonizing CREB-1-dependent activation, suggesting that the ability of CREB-1 to mediate a cAMP response is down-regulated by heterodimer formation with ATF-1. Identification of patients with preclinical diabetic cardiomyopathy should be a research and clinical priority. To investigate the mechanism of increased TRAIL sensitivity in HCC cells, we first examined surface expression of TRAIL and its receptors. The impact of subjective experiences with drug treatment on attitudes towards medication and compliance needs to be a main focus of interventions targeting attitudes towards pharmacological treatment. To determine whether inclusion of vitamin E into kidney storage solutions protects metabolism and tubular ultrastructure of stored rat kidney. SE induced in the presence of the NMDA antagonist MK-801 produced no delayed c-Jun expression in the hippocampus and nerve cell death did not occur in this region, although there was a delayed c-jun expression in the amygdala/piriform region, and cell death occurred in this area. In the first group, ventilation was controlled, after paralysis and tracheal intubation.
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Assessment of the role of follicle-stimulating hormone and prolactin in the control of testicular endocrine function in adult djungarian hamsters (Phodopus sungorus) exposed to either short or long photoperiod. In view of a deterioration in critical faculties and in the ability to compensate for loss of performance, due in particular to the multimorbidity commonly met with in old age, a general examination of the geriatric for fitness to drive is worth considering. Both peptides are distributed in the apical secretory compartment of antral mucus cells (SP) and goblet cells (ITF), and on the lumenal surface. Posterior interosseous nerve palsy as a complication of Monteggia fractures in children. As US looks north for health reform ideas, US companies bet Canadians will look south for insurance. Those compounds, structurally related to previously described potassium channel openers such as the benzothiadiazine dioxide BPDZ 73, were tested as putative K(ATP) channel activators on the pancreatic endocrine tissue and on the vascular smooth muscle tissue.