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Cardifen (Nifedipine)

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Cardifen is used to treat high blood pressure or angina (chest pain). For high blood pressure: Cardifen works by relaxing and expanding the blood vessels. This makes the blood flow more easily and lowers blood pressure. Lower blood pressure reduces the strain on your heart. For angina: Cardifen works by relaxing and expanding the arteries supplying the heart. This allows more blood and oxygen to reach the heart and decreases the strain on it. Your angina attacks will be less severe and less frequent if there is less strain on the heart.

Other names for this medication:
Antrolin, Aprical, Atanaal, Atenerate, Bresben, Cardalin, Cardipin, Cisday, Citilat, Conducil, Coracten, Coral, Corotrend, Epilat, Fedip, Ficard, Macorel, Marivolon, Milfadin, Myogard, Nifangin, Nifebene, Nifecardia, Nifeclair, Nifecor, Nifedate, Nifediac, Nifedigel, Nifedipina, Nifehexal, Nifeslow, Nifin, Niften, Nilol, Oxcord, Sepamit, Sidalat, Siopelmin, Tenif, Tensomax, Xepalat, Zenusin

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adalat OROS. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Cardifen and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Adalat dosage information

Side effects

The most common side effects associated with Cardifen are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


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While one-third of this group will experience additional febrile seizures, there is no significant increase in the incidence of later epilepsy or neurological sequelae. Spontaneous and induced immunity against exogenous Friend murine leukemia retrovirus infection is controlled by four H-2-linked host genes and a single non-H-2 gene. Forty patients were referred mainly from middle-sized or large hospitals between July 1992 and June 1993. When these same patients were sitting the STI failed to change, in striking contrast to the normal subjects and to the patients with COPD alone. The eyes were enucleated 4 hr, 1 day, or 1 wk after circulation was restored, at which times the electroretinogram b-wave was moderately reduced.

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Acceptability of medical abortion with methotrexate and misoprostol. To upscale these adaptation initiatives, there is a need to improve information exchange between CBOs, NGOs and academia. CTL adoptive immunotherapy concurrently mediates tumor regression and tumor escape. These findings show that residues of the zero layer do not play an essential role in NSF-mediated disassembly. Different receptor mechanism might hence explain the hepatic transport of IgA from blood to bile in the rat and perhaps be involved in the catabolism of IgA. Are rogue cells an indicator of cancer risk due to the action of bacterial restriction endonucleases?.

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These results indicated that the chemokine system might play an important role in the pathophysiology of ANKL and that chemokine receptor profiling might be a novel tool for discriminating ANKL cells from benign NK cells. CT modulation of the 5-HT4 response is different from its modulation of the 5-HT1A response. Follicles showing sings of atresia were negative for this enzyme. Linkages between sexual risk taking, substance use, and AIDS knowledge among pregnant adolescents and young mothers. A case of metastatic bronchogenic carcinoma to the gingiva in a 47-year-old male is reported. The increased positivity to self-faces relative to familiar faces between 500 and 700 ms was reduced in the attended relative to the unattended conditions, which arose from the fact that the amplitude to familiar faces during this time window was increased in the attended relative to the unattended conditions, whereas the event-related brain potential amplitude to self-faces was not influenced by attention. SDS-PAGE and silver staining of the purified receptor revealed numerous high-molecular-weight bands. After denervation, the autophagic vacuoles in chloroquine-treated muscle contained numerous glycogen particles and various heterogeneous materials.

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into nude mice, interferon-gamma alone exerted significant inhibitory activity against pulmonary metastasis in a dose-dependent manner, and cepharanthin alone also significantly inhibited metastasis. Hpt-13 is a Chinese hamster cell line deficient in hypoxanthine phosphoribosyltransferase (EC and sensitive to a medium containing 10(-4) M hypoxanthine, 5.5 X 10(-6) M aminopterin, and 10(-4) M thymidine. Insulin-like growth factor-II (IGF-II) was identified as one dominant member of the insulin family expressed by thymic epithelial and nurse cells. Unlike conventional electrokinetic treatment that uses boreholes or trenches for horizontal migration of heavy metals, the UESR technology, applying vertical non-uniform electric fields, caused upward transportation of heavy metals to the top surface of the treated soil. Metabolite maps of choline-containing compounds, total creatine consisting of creatine and phosphocreatine, N-acetyl aspartate (NAA), and lactate were obtained in 23 patients with acute and subacute cerebral infarctions 1-35 days after onset of symptoms. We present the first preparation of microarrays containing synthetic heparin oligosaccharides in order to elucidate the heparin-protein interactions involved in a variety of biological processes. No anaesthetic or analgesia was used and there was little or no bleeding or infant distress. Examples of excellent visualization of the ultrastructure of macromolecular complexes (nucleic acids, extracellular material, membranes etc.), small organisms (bacteria, algae, cyanobacteria and fungi) and large biological samples such as plant and animal tissue as well as the plant-pathogen (fungus) interface and infection structures are presented. Facial paralysis developed only on the inoculated side, even though HSV DNA was also present in the contralateral facial nerve.

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Their personality traits were measured using the Dimensional Assessment of Personality Pathology-Basic Questionnaire (DAPP-BQ). The Gauss modulus critically influences membrane processes that change topology, such as vesicle fission or fusion, and could therefore be of significant biological relevance in heterogeneous membranes. To evaluate changes in vertebral marrow signal intensity that occur over time in children undergoing craniospinal radiation therapy, specifically evaluating for the occurrence and timing of marrow regeneration. Molecular neuro-oncology and the development of targeted therapeutic strategies for brain tumors. In the present study, TNF alone was found to have antiviral activity against herpes simplex virus-1 (HSV-1). A birth weight for gestational age standard based on data in the Swedish Medical Birth Registry, 1985-1989. Inferior alveolar nerve transposition--an in vitro comparison between piezosurgery and conventional bur use.

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These findings suggest that endogenous opioid systems play a role in mediating the neurochemical and behavioral effects of amphetamine, but not those of cocaine. In spontaneously breathing rats, minute ventilation, respiratory frequency, and neuromuscular inspiratory drive were lower in dexmedetomidine group, which also presented hypercapnia, whereas tidal volume, inspiratory, expiratory, and total respiratory cycle times were higher in dexmedetomidine group compared to the PENTO group. Heart failure and diabetes mellitus are frequently associated, with diabetes potentiating the development of heart failure after other myocardial insults. In-vitro endometrial secretion of human interleukin for DA cells/leukaemia inhibitory factor by explant cultures from fertile and infertile women. The visual acuity 6 months after the injury was the final outcome measure. Twice-daily treatment for 14 d with the CB1-receptor agonist demonstrated significant changes in the expression of neuronal cytoskeletal proteins and in neuronal morphology, as evidenced by immunocytochemical and digital analysis studies. This residue was not phosphorylated by T-cell PTKs p56lck and p59fyn. Continuous versus discrete information processing in pattern recognition.

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A 35-year-old man with a ruptured latissimus dorsi tendon 6 weeks following surgical repair was referred for physical therapy to recover range of motion and strength sufficient for return to work as a police officer on the SWAT team. The most frequently isolated bacteria from chronic OM are Staphylococcus aureus, Pseudomonas aeruginosa and anaerobic bacteria. Activity scores were decreased by morphine, in both d-amphetamine and saline treated animals. This article discusses the relationship of migraine and personality and migraine and psychopathology. Physiological characteristics of the smooth muscles vessels of the small circle of blood circulation. On the basis of the FPI and a questionnaire about the occurrence of changes the therapeutic effects of a dynamic group psychotherapy were checked.

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The purpose of this study was to evaluate a test of virtual auditory localization including assessment of its ease does lipitor react with alcohol of administration and its sensitivity to differences in binaural performance in children and adults. Furthermore, the determinants of BMD in RA patients were investigated. Structure and expression of the cyclin A gene in human primary liver cancer. Incidence of acute traumatic hospitalized spinal cord injury in the United States, 1970-1977. Since humans are under ceaseless orthostatic stress, the mechanism to maintain arterial pressure (AP) under orthostatic stress against gravitational fluid shift is of great importance.

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Preparation of gelatin microspheres containing lactic acid--effect of cross-linking on drug release. Dipole source localization in a case of epilepsia partialis continua without premyoclonic EEG spikes. Therefore, expression of a single gene appears to be responsible for conferring responsiveness to bradykinin in these tissues. LCLs from patients with RA displayed disease-specific Fas-mediated signal transduction impairment with consequent resistance to cell death. The hexokinase gene is required for transcriptional regulation of the glucose transporter gene RAG1 in Kluyveromyces lactis. Marking aids/surface markers do not have to be changed in different imaging methods. Quantitative Doppler flow velocity determinations were made combined with ultrasound estimation of the arterial diameter of the feeding vessel in arteriovenous fistulas of the arm used both for dialysis administration of cytostatics and parenteral nutrition. Nucleotide diphosphates substitute for nucleotide triphosphates in the exchange reaction. However, studies on the action and structure of the 3 human PPAR isotypes (PPARalpha, PPARdelta, and PPARgamma) suggest that these moieties are intimately involved in nutrient sensing and the regulation of carbohydrate and lipid metabolism. So, we have to carefully follow the patient in long-term periods.

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ducreyi strain, and for comparison purposes a non-capsulated Haemophilus influenzae strain, were inoculated intradermally, with and without co-administration of purified HdCDT. Expression profiles for mEH, CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2D6, CYP3A, and CYP2E1 were evaluated in these cultures in the presence or absence of a PAH inducer, using reverse transcriptase-coupled polymerase chain reaction analysis. A 23-year-old man was admitted for an aortic root aneurysm with mild aortic valve regurgitation (AR) and a small pressure gradient. Our present plates are only removed from the maxillary sinus wall and the alveolar ridge, after osteosynthesis in children, and in patients with local complications. The separations achieved for these analytes are comparable to those achieved on Whelk O2 column, while still inferior to those achieved on Daicel AD-H and OD-H columns.

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Separation was accomplished on a Waters Resolve C18, 5 microns, 300 mm x 3.9 mm I.D. Doxorubicin and cyclosporin A affect murine lymphoid cells expressing different antigenic determinants. The finite element method is used to represent the deformation field, and our implementation enables us to assign inhomogeneous material characteristics so that hard regions resist internal deformation whereas soft regions are more pliant. The Syk SH2 domain is predicted to bind to Tyr-hydrophilic-hydrophilic-Leu/Ile how often should you use tretinoin gel motifs like those repeated at 10-residue intervals in T- and B-cell receptor-associated proteins. These restrictions should be implemented prior to, during, and following neutropenia. Synthesis of modified tetrasaccharides as analog acceptor-inhibitors of N-acetylglucosaminyltransferase II. Pediatric disorders with autonomic dysfunction: what role for PHOX2B?. The developed MSPs were used to detect the paraffin-embedded slices that were pathologically diagnosed as HCC, hepatocirrhosis, hepatitis, and healthy. Paroxysmal dystonic choreoathetosis with chronic hemolytic anemia and morphologically abnormal erythrocytes. A factor was included for analyzing systems operating at low (10-101.3 kPa) pressure to reduce gas leakage and structural mass (e.g., inflatable greenhouses for space application).

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Unoxidized crystalline silicon, characterized by high purity, high homogeneity, sturdiness and an atomically flat surface, offers many advantages for the construction of electronic miniaturized biosensor arrays upon attachment of biomolecules (DNA, proteins or small organic compounds). In addition compensatory recruitment processes can be supposed because of changed spectral myoelectrical power in the calcitriol medication kidney low-frequency bands. Messenger RNA encoding the insulin-like growth factors and their binding proteins, in women with fibroids, pretreated with luteinizing hormone-releasing hormone agonists. Syntheses of 3alpha,7alpha,12alpha,25,26- and 3alpha,7alpha,12alpha,24,25-pentahydroxycoprostanes. Halothane and pertussis toxin-sensitive G proteins in airway smooth muscle. This study demonstrates the GAL antagonist properties of these agents on autonomic neuroeffector functions making them useful tools in elucidating further functions of endogenous GAL. Following cytokine exposure, secretion of Muc2, but not the mucin recognized by the 45M1 antibody (likely Muc5ac), was increased from the GPTE cells, with a concomitant increase in intracellular expression of both mucins. Immunization of mice lacking B cells demonstrated that B cells are critical for MALP-2-dependent improvement of T cell responses.

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Charcot arthropathy of the spine with resulting paraparesis developing during pregnancy in a patient with congenital insensitivity to pain. Clan members interact less frequently than do wild dogs, but inter-clan contact rates may be high in high density populations. The insulin-like growth factor binding proteins (IGFBPs) comprise a family of six distinct proteins which modulate insulin-like growth factor action. In Experiment 1, we established that all of the individual cues were used in isolation. levaquin 750 mg iv infusion time Immunoperoxidase staining of tissue sections showed that neurocan, Ng-CAM, and N-CAM are all present at highest concentration in the molecular layer and fiber tracts of developing cerebellum. Combined treatment of anal fistula with modern and traditional methods in 120 cases. Treatment of an avulsed skin-flap involving the circumference of the entire lower leg: a case report. Pharmacologic considerations in the selection of a general anesthetic. USA 90, 507-511), but these more exposed regions are not conserved in polioviruses or minor receptor group rhinoviruses, suggesting some differences in receptor binding. These 13 also had a seroconversion from HBeAg to anti-HBe, and all became negative for serum DNA polymerase.

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Endomyocardial biopsy showed interstitial deposition of calcium oxalate. Sixty-five showed the presence of diastolic flow and all of them had good perinatal outcome, regardless the score of the different indexes. The experiments were performed in capillaries filled with a solution of liquified agarose, a replaceable sieving medium. These findings indicate that the in vivo antiaggregatory and prostacyclin releasing actions of endothelin-1 are not mediated by activation of the ETA receptor. A 72-year-old woman, who had a history of therapy with rectal adenocarcinoma, came to our hospital for visual loss in her right eye. Phosphorylation of tyrosine 537 on the human estrogen receptor is required for binding to an estrogen response element. Our findings attest to the fidelity of our array CGH methods to effectively examine material recovered from FFPE tissue specimens for microarray applications. In the presence of glucose, oxfenicine suppressed lipolysis without affecting the pacemaker and contractile activities. Even quite coarse angular mashing (18 angles out of 324 measured angles for 424 ps) does not significantly reduce image quality in terms of the contrast or noise.

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Oral misoprostol is as effective as intra-amniotic PGF2alpha for second trimester pregnancy termination when laminaria is inserted before treatment. Therefore, we wanted to investigate the effect of tibolone on the circulating levels of various selectins in postmenopausal women. Characterization of an esterase associated with purified preparations. The prognostic significance of cervico-vaginal cytology in endometrial cancer. Two cases of intrapulmonary lymph node associated with either progressive systemic sclerosis or idiopathic pulmonary fibrosis. Using an immune-tolerization/immunization procedure of generating antibody, two different cell-surface glycoproteins termed luminal epithelial antigen, LEA.92 and LEA.135 were identified. Dose survival of G0 lymphocytes irradiated in vitro: a test for a possible population bias in the cohort of atomic bomb survivors exposed to high doses. In this study, we characterized biochemical and immunogenic aspects of MH 99. Some biologic, immunogenic, and morphologic effects in mice after infection with a murine sarcoma virus. Exercise conditioning programs have been demonstrated to improve functional capacity, particularly in younger coronary patients.

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In the five mutants tested, alterations that weaken ATPase inhibition by recombinant epsilon affect its ability to restore proton impermeability to a similar extent, with one exception. The minimum time required to develop mature eggs after blood feeding was 54 and 60 h, and the survival rate was 0.93 and 0.88 in zoophilic and anthropophilic female mosquito populations, respectively. We designated the reference values of jitter and fiber density for frontalis muscle in healthy subjects older than 70 years. Relationships of condylar path angle with malocclusion and temporomandibular joint disturbances. MR imaging is an excellent modality for use in excluding acute appendicitis in pregnant women who present with acute abdominal pain and in whom a normal appendix is not visualized at US. Finally, IL-17E was detected in asthma in eosinophil-infiltrated bronchial submucosa. macroides in the control of Haemonchus contortus infective larvae. This is the first study to demonstrate that the interaction between beta-adrenoceptor activation, and the production of inflammatory mediators can be modulated in opposite ways by two inflammatory stimuli, namely, protein kinase C (PKC)-activating phorbol myristyl acetate (PMA) and lipopolysaccharide (LPS). No change in the oxidase reaction of any of the six strains was noted. A cDNA selection approach, already performed with a previous partial contig, has been extended to cover the whole region.

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A continuous flow of liquid was passed through the bead-bed at a constant rate. C2-G71 in the acceptor stem functions as a negative identity element against seryl-tRNA synthetase. Yet, when sputum cytology was added to chest radiograph in the largest early-screening-of-lung-cancer study carried out to date, the three-arm trial sponsored by the National Cancer Institute, no major outcome benefit was shown. Influence of micelles on the electrochemical behaviors of catechol and hydroquinone and their simultaneous determination. Glyceraldehyde-3-phosphate, fructose 1,6-bisphosphate, dihydroxyacetone, and glyceraldehyde, failed to act as substrates. The high hepatitis B vaccination coverage among young and healthy adults indicates the success of the intensified hepatitis B vaccination policy since 1995. Critical observations on x-irradiations of hemangiomas in childhood, with reference to late unexpected radiation injuries.

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