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Cardalin (Nifedipine)
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Cardalin

Cardalin is a dihydropyridine calcium channel blocker. Cardalin is used to: treat high blood pressure (hypertension), prevent chronic stable angina (chest pain). Cardalin was the first calcium channel blocker to be shown to significantly reduce the development of new overt heart failure in patients with coronary artery disease. Excellent blood-pressure control in recent clinical trials has been shown to result in significant protection against stroke. Cardalin works by opening up blood vessels in the body to lower blood pressure and improve the supply of blood and oxygen to the heart. Calcium channel blockers do not change the amount of calcium in your blood or bones.

Other names for this medication:
Addos, Adefin, Afeditab, Amarkor, Antrolin, Bresben, Calchan, Calcheck, Casanmil, Cobalat, Coral, Cordafen, Corinfar, Depicor, Depin, Farmalat, Ficard, Lemar, Menoprizin, Milfadin, Nedipin, Nidicard, Nifangin, Nifecap, Nifecor, Nifedical, Nilol, Nipress, Nyefax, Pabalat, Pressolat, Siopelmin, Tredalat, Viscard

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Also known as: Nifedipine

Description

Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.

Dosage

Cardalin should be taken orally with or without food. It is better to take Cardalin at the same time every day. Take on an empty stomach. Avoid grapefruit juice during treatment with Cardalin. If you want to achieve most effective results do not stop taking Cardalin suddenly.

Overdose

If you overdose Cardalin and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Cardalin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

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These findings support the contention that translation of mRNA to lactase is impaired in weaned animals, which may also be responsible for the maturational decline in lactase activity in adult rat intestine. Although CLLRP shows sequence homology to the true lectins, it is devoid of carbohydrate binding activity. Racial differences in size variation of the short arm of acrocentric chromosomes. Malignant tumors associated with various degrees of metabolic derangements are all associated with decreased plasma arginine concentrations, even without weight loss. If such were the case, the simpler protocol would streamline activities in clinical electrophysiology laboratories. Complement fixing antibodies were detected in both groups at the 4th day post infection and agglutinins appeared in circulation at the 7th day post infection when homologous antigens were used.

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An interferometric and radioautographic study of the proteins of the ganglionic cells of the mouse retina as a function of stimulus intensity. Here we provide evidence that beta-arrestin, otherwise known to be involved in the regulation of G protein-coupled receptors, serves as an adaptor to bring the oncoprotein E3 ubiquitin ligase MDM2 to the IGF-1R. Total plasma CK activity was only slightly increased in dystrophic animals but plasma from both normal and dystrophic mice showed large amounts of the BB isoenzyme of creatine kinase. Short-term, reversible, and long-term methods of implementing this resistance-based dendrodendritic plasticity are discussed as well as the partial dependence of the reciprocal increase/lateral decrease effect on a broad synaptic gradation. Research on the energy requirements of women during pregnancy and lactation.

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In patients with a moderate degree of renal insufficiency, phosphate restriction suppresses PTH secretion by increasing serum calcitriol. Having seen a provider in the preceding 12 months was associated with a lower risk of chlamydial infection for men only. The effects of some Mannich bases on heat shock proteins HSC70 and GRP75, and thioredoxin and glutaredoxin levels in Jurkat cells. The data derived from this study are in excellent agreement with earlier RNA protection experiments performed in the same system to characterize expression of the same genes. Interaction of PCBs with thyroid hormone levels and time of hatching in chicken embryos. Twenty-six serum samples were obtained from adult patients with latex allergy, both hospital workers and non-hospital workers. The histone deacetylase 1 (HDAC1) gene has been implicated in controlling the transcription of core cell cycle regulators, but the in vivo role of HDACs in cell cycle regulation is still poorly understood. pylori acquisition with subsequent iron deficiency and growth retardation. Normalization of soleus H-reflex recruitment curves in controls and a population of spastic patients.

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Replacement of active-site residues of quinoline 2-oxidoreductase involved in substrate recognition and specificity. Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics. Genetic testing and counselling for congenital bilateral absence of the vas deferens. Anyway the shape of the time correlation functions of the scattered intensity should be reported or at least inspected as they provide information on the reproducibility of the experiments hence safegarding the value of the physical meaning of the final value of droplet size (Rh). The cytochrome P450-dependent metabolism of benzo(a)pyrene and other xenobiotics has been investigated in liver microsomes prepared from a local marine safi fish, Siganus canaliculatus. When changes in the karyotype were seen in a series of isolates, additional interrepeat PCR and Southern blotting with a repeat DNA sequence from the 27A family were performed. Mean diffusivity and fractional anisotropy maps were derived from DT images. Role of chlorophyllin as an in vivo anticlastogen: protection against gamma-radiation and chemical clastogens. Ultrastructural aspects of lymph-nodes in infantile papular acrodermatitis.

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The tumor promoter receptor protein kinase C: a novel target for chemoprevention and therapy of human colon cancer. When cells were released from late G1 block, the activity of p44mapk and p42mapk increased transiently, and then rapidly declined to baseline values during G1 to S phase transition. The centers of gravity provide a set of geometrical references for the study of shape in normal and diseased hearts. This was confined to two populations of mature secretory granules, referred to as small and large mature secretory granules, which both derived from immature secretory granules. The site of calcium binding in relation to the activation of myofibrillar contraction. Multiple courses of chemotherapy were provided, in addition to a wide range of advanced and aggressive therapies to treat the cancer, as well as prolong life. Association of schizophrenia in African Americans to polymorphism in synapsin III gene.

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Monochlorobimane does not selectively label glutathione in peripheral blood mononuclear cells. Coexpression of cdk2/cdc2 and retinoblastoma gene products in colorectal cancer. Employment of caregivers as trainers is an imperative in the training and treatment of mentally retarded persons. Secreted material was further enriched in this same set of phospholipid species but was characterized by increased contents of short-chain monounsaturated and disaturated species other than dipalmitoyl PC (PC16:0/16:0), principally palmitoylmyristoyl PC (PC16:0/14:0) and palmitoylpalmitoleoyl PC (PC16:0/16:1). Effects of environmental uncertainties on sonar detection performance prediction. The BVOCs with high chemical reactivity may affect the chemical compositions of lower atmosphere, and promote photochemistry air pollution. We consider a two-field model for inflation where the second order metric perturbations can be amplified by a parametric resonance during preheating. The primary outcome was to be an improvement in the overall fertilization rate. L-NAME has been shown to block also other behavioural and biochemical effects of PCP in previous studies and these results and the present findings suggest that at least some of the effects PCP are dependent on NO and possibly also that some NOS inhibitors may exert antipsychotic properties. A subgroup of patients with chronic pancreatitis overexpress the c-erb B-2 protooncogene.

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Clinical effectiveness was measured by recording whether an EGD resulted in changes in diagnosis, medical therapy, or clinical management. To evaluate the role contrast material plays in the development of post-ERCP pancreatitis, the Midwest Pancreaticobiliary Group performed a prospective double-blind controlled study. Ischemia-reperfusion injury (IRI) in liver and other organs is manifested as an injury phase followed by recovery and resolution. These studies indicate that the regional expression of recombinant dystrophin in dystrophic muscle leads to regional restoration of normal muscle morphology. It is argued that the nature of the perception-action interface depends on the ideomotor compatibility of the task. Stretch-induced CCR2 downregulation may favour MCP-1 paracrine activity. An assessment of the fibrogenic potential of two refractory fibres by intraperitoneal injection in rats. Eosinophilic meningitis after implantation of a rifampin and minocycline-impregnated ventriculostomy catheter in a child. Varying polymer concentration, viscosity follows a polynomial development of Huggins equation in which the coefficients can be calculated from the Huggins constant determined in the dilute domain (Matsuoka-Cowman equation).

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These migratory cells give rise to recurrent tumours following surgical and adjuvant chemo- and radio-therapeutic intervention. On radiation exposure to long-lived artificial radionuclides in the atmosphere. The amino acid sequence of this connecting peptide was found to be Arg-Arg-Glu-Ala-Gln-Asn-Pro-Gln-Ala-Gly-Ala-Val-Glu-Leu-Gly-Gly-Gly-Leu-Gly-Gly-Leu-Gln-Ala-Leu-Ala-Leu-Glu-Gly-Pro-Pro-Gln-Lys-Arg. Critical point drying: contamination in transitional fluid supply cylinders. Measuring sorption of hydrophilic organic compounds in soils by an unsaturated transient flow method. Rapid recovery of renal function was observed in 5 patients whereas in 2 oliguric children the recovery of renal function ensued within 1 and 2 months, respectively. Men and women participating in a health screening project completed the International Prostate Symptom Score (IPSS). The susceptibility of mice at different developmental stages to a relatively low titer of cell culture-passaged murine cytomegalovirus (MCMV) infection was compared in terms of the urinary excretion of MCMV examined by plaque assay and in terms of the distribution of viral infection, determined by immunohistochemistry, using antibodies specific to the early nuclear antigen of MCMV. Discoordination of gastroduodenal myoelectrical activity during immobilization stress in rabbits.

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By virtue of adapting to grow in an environment having a high partial pressure of oxygen, the melanoma cells located on the skin may have developed a better antioxidant defense mechanism than cells that metastasize to, and grow in, other parts of the body having lower partial pressures of oxygen such as lymph nodes, brain and viscera. The histochemical technique stained serous acinar cells weakly and rarely found mucous acinar cells strongly in the parotid gland, mucous acinar cells moderately to strongly and serous acinar cells weakly in the sublingual gland, and central and demilunar acinar cells moderately to strongly in the submandibular gland. The phosphoglycerate kinase and glyceraldehyde-3-phosphate dehydrogenase genes from the thermophilic archaeon Sulfolobus solfataricus overlap by 8-bp. Experiences with the Shirodkar operation during pregnancy in habitual abortion and premature delivery. Discrimination between the origins and functional implications of haze and halo at night after photorefractive keratectomy. The neurones were stained with both fDHP and the voltage-sensitive styryl dye RH414. Early development of encephalomyocarditis (EMC) virus-induced orchitis in Syrian hamsters. Microarrays used for gene expression studies yield large amounts of data. Sensitive nested reverse transcription polymerase chain reaction detection of circulating prostatic tumor cells: comparison of prostate-specific membrane antigen and prostate-specific antigen-based assays.

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Observations on siderosis in rats with experimental hepatic damage. MMBP-3 activity was detected in proliferating C2C12 and C3H/10T1/2 cells, and down regulated when the growth of these cells was inhibited. Increasing concentrations of urapidil (25-150 microM) caused a dose dependent improvement of the erythrocyte rigidity index as well as inhibited adrenaline induced platelet aggregation. A high level of radiosensitivity was confirmed, but additional data are required to clarify the clinical benefit of radiation therapy. Action of hypercalcium and hypocalcium milieu on the ventricular myocardium, studied with the aid of microelectrodes in the guinea pig. In contrast, based on the measure of the inhibition constant Ki, the anticodon minihelix carrying the methionine anticodon CAU is specifically bound to the synthetase and with an affinity comparable to that of the full-length tRNA. Conversely, activation of the heterologous thymidine kinase promoter by the enhancer required the introduction of GAG. Spontaneous recrudescence of spermatogenesis in the photoinhibited male Djungarian hamster, Phodopus sungorus. Our primary aim was to investigate the role of the placenta in the metabolism of ADMA during normal pregnancy and PE.

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The mean diameter and enclosing efficiency were almost constant because they were independent of solvent evaporation conditions. Agreeing with predictions obtained by modelling binding, both inhibitors (1 and 10muM) enhanced the amplitude of electric light responses of the isolated rat retina, however, the enhancement was smaller for the more efficacious inhibitor sildenafil. Only 17 cases of traumatic cerebral artery aneurysms have been reported in this site. Phenotypic and genetic polymorphism was studied amongst four Theileria annulata isolates collected from three different parts of India. In this study we evaluated potential neuroprotective adaptations by examining the alteration of intracellular MAPK pathways that may be modulated by hypoperfusion/reperfusion in AGS during hibernation and arousal. During curarization the ability to detect the presence of a small inspiratory resistive load was not significantly impaired. Saturation binding assays in brain homogenates indicated that chronic morphine did not produce changes in receptor number or affinity for the antagonist. We observed that PGRP-SC1/2-depleted flies present a specific over-activation of the IMD (immune deficiency) signaling pathway after bacterial challenge.

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In our laboratory, C3H10T1/2 murine fibroblasts have been found to express a variety of proteins in various subcellular fractions which are relevant to experimental transformation and carcinogenesis. Chronic renal replacement therapy patients exhibit reduction in skeletal muscle function as a result of a combination of metabolic effects and muscle fibre size reduction. The stimulatory effect of LATS was not abolished by anti-TSH antibody capable of neutralizing human TSH. Towards novel anti-cancer strategies based on cystatin function. We report herein the second case of conjunctival dirofilariasis in a 21-year-old woman residing in Tunis (Tunisia).

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Anionic sites in glomerular basement membrane of rats with serum sickness nephritis: quick-freezing and deep-etching study. In tumors, RT-PCR reveals expression of a wide range of splice variants, including new ones that are not detected in normal breast tissue, e.g. We observed that the number of turn or zero-crossing points tends to saturate with the increase in the MUAP number in surface EMG, limiting the utility of these measures as estimates of MUAP number. The former can bind guanine nucleotides but not initiator tRNA, and also exhibits a substantially reduced rate of initiation factor eIF-2B-mediated GDP/GTP-exchange. A study was undertaken to investigate the experiences of a group of fundholders. Quantitative electroencephalography in aging brain and cerebrovascular disease: the effects of almitrine-raubasine. ACR20 and ACR50 seem to be similar in distinguishing active from control treatments in clinical trials on rheumatoid arthritis reported since 1997.

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Adolescent cigarette smoking is generally more common than alcohol and illicit drug use, and these results highlight its multifarious linkages with use of other substances and mental health symptoms. R56865 is antifibrillatory in reperfused ischemic guinea-pig hearts, even when given only during reperfusion. Allogeneic mouse T cell lines distinguish three Balb/c leukemias from each other and from non-leukemic lymphocytes. Except for deaths from unintentional injury norfloxacin capsules , US troops in the Persian Gulf region did not experience significantly higher mortality rates than US troops serving elsewhere. Fetuses were delivered by Caesarean section in the morning of the 21st gestational day. HCV-RNA was identified using a polymerase chain reaction (PCR) technique and a variation of this method was used for HCV genotyping. Surgical approaches to prostate cancer continue to evolve and patient demand for prostatectomy continues to increase. The effects of Phytolacca americana mitogen and Sambucus sieboldiana agglutinin were different. TNF-alpha, IL-1 beta and IL-1ra levels were measured by enzyme-linked immunosorbent assay (ELISA) in the culture supernatants, and MHC class II expression was examined on the monocytes/macrophages by flow cytometry.

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Electron microscopy of the mouse retina prepared by freeze-substitution. Hymenotomy resolved all of the laboratory and clinical abnormalities of the patient and the baby was sent home healthy. We studied here the possibility that PI-3 kinase, which is directly linked to mitogenic responses in growth factor receptors, is tyrosine-phosphorylated after stimulation of the IL-7R. The effects of acute episodes of maternal uterine ischemia on the cardiovascular system of New Zealand white rabbit embryos were studied by in vivo microscopic methods. Work limitations and employer adjustments for employees with chronic illness. To explore regulation and function of cyclin D2, a candidate cell cycle-regulatory proto-oncogene, we examined subcellular localisation, cell type- and cell cycle-dependent expression, and requirement of cyclin D2 protein for G1 progression, in a panel of 40 human normal and cancer cell types. In the present study, we examined the relationship of pain responses between PGs and N/OFQ using the N/OFQ receptor (NOP) antagonist, N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxy-methyl)benzamide monohydrochloride (JTC-801), and in mice lacking the N/OFQ prepropeptide (ppN/OFQ(-/-)) and the NOP receptor (NOP(-/-)). PTF1 encodes an essential protein in Saccharomyces cerevisiae, which shows strong homology with a new putative family of PPIases. Excitatory action of the chemoreceptive afferents on the posterior hypothalamus in the acute thalamic cat.

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Molecular dynamics simulations and rigid body (TLS) analysis of aspartate carbamoyltransferase: evidence for an uncoupled R state. Safety of tracheotomy in neutropenic patients: a retrospective study of 26 consecutive cases. These compounds are isolated from this plant for the first time. Strengths and weaknesses of in vitro assays for estrogenic and androgenic activity. Target cells were leukemia blasts obtained from a patient with common ALL.

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When underlying distributions are unknown and sample sizes are small, permutation tests may have superior features to parametric tests, such as smaller type I error and more accurate probability values when testing the null hypothesis. Characteristics of periodontal microflora in acute myocardial infarction. Seven patients had elevated anti-thyroid antibodies at baseline. In light microscopy, nephritic control rats showed thickening of the glomerular basement membrane and spike formation in the glomeruli. The effect of stelazine on oxygen consumption and glycolytic activity on brain tissue. The second case demonstrates CT findings of ethmoidal sinus and frontal lobe inflammatory change. Histopathological studies also show the effectiveness of vitamin E on PER administered rats in protecting the cellular architecture of liver and kidney from PER induced cytotoxicity. In this second article of common skin, hair, and nail problems during the first six months of life, issues related to pigmentation changes in the skin are addressed.

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