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Capehope (Capecitabine)
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Capehope

Capehope is used together with docetaxel to treat metastatic breast cancer (breast cancer that has spread to other parts of the body) in patients who have received other medicines (eg, paclitaxel) but did not worked well, or in patients who cannot receive cancer medicines anymore.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Addyi, Depakote, Lasix, Naprosyn, Skelaxin, Panadol, Wellbutrin

Also known as: Capecitabine

Description

Xeloda (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

Xeloda is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

Xeloda is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Xeloda for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Xeloda for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Xeloda dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Capehope are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Xeloda if you are allergic to capecitabine or fluorouracil, or if you have:

severe kidney disease.

To make sure Xeloda is safe for you, tell your doctor if you have ever had:

a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency; liver or kidney disease; heart problems; or if you use a blood thinner and you have routine "INR" or prothrombin time tests.

Capecitabine can harm an unborn baby if the mother or the father is using Xeloda .

If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using Xeloda and for at least 6 months after your last dose. If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using Xeloda, and for at least 2 weeks after your last dose.

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The virus induced characteristic severe symptoms of infection in systemically infected plants. Diclofenac acid nanocrystals as an effective strategy to reduce in vivo skin inflammation by improving dermal drug bioavailability. Finger Imaging by RadioVisioGraphy Digital Dental Radiography Imaging System. vera gel, it could be further recommended in the treatment of various bacterial diseases. This is the first report on the presence of antigen to caries-afflicted dentin in the mixed saliva as detected by the complement binding technique. All decay constants were analysed by curve stripping analysis and found to fit a bi-exponential decay. The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) study is the first stroke prevention trial to include protocol-driven intensive management of multiple risk factors. Inhaled anesthetics have many effects on segmental resistance and pressure in the coronary circulation.

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All tissues are inherently viscoelastic and ignoring viscosity biases the velocity-based estimates of elasticity and ignores a potentially important parameter of tissue health. Rapid preparative separation of six bioactive compounds from Gentiana crassicaulis Duthie ex Burk. The left-right difference in thresholds was also positively correlated with state anxiety. This UK project aims to explore, through a combination of job description review and workshops of stakeholders, the common competencies and features of non-clinical roles. The stratum corneum chymotryptic enzyme that mediates shedding and desquamation of skin cells is highly overexpressed in ovarian tumor cells. Here we develop synthetic block copolymers to construct a series of CO2-sensitive self-assembled nanostructures that can simulate controllable deformations of the organelles in different ways. A System for Multi-Domain Contextualization of Personal Health Data. The E-box of the human glycophorin B promoter is involved in the erythroid-specific expression of the GPB gene.

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The staphylococcal flora of the groin and perianal area was studied in 12 patients undergoing aortic grafts and 3 patients having repair of ventral abdominal hernias. To clinically evaluate the prevalence of buccal caries and white spot lesions (WSLs) at debonding in governmental and private orthodontic patients, using the International Caries Detection and Assessment System (ICDAS-II) and the DIAGNOdent Pen, and to study the correlation between the two methods. Specifically, the transport of nanotherapeutics is described using the concept of apparent permeability, which is defined as the net flux of solute across a blood vessel wall per unit surface area of the blood vessel and per unit solute concentration difference across the blood vessel wall. We investigated the long-term outcomes of ESD compared with those of surgery for adenocarcinoma in the EGJ. Draft genomes of 12 host-adapted and environmental isolates of Pseudomonas aeruginosa and their positions in the core genome phylogeny. Effects of nasal positive expiratory pressure on dynamic hyperinflation and 6-minute walk test in patients with COPD. Using the exquisite atomic detail captured by molecular dynamics simulations, we follow the assembly of a co-polymer that consists of polystyrene sulfonate tethered symmetrically to hydrophobic blocks, realizing a new type of long lived solvent-responsive soft nanoparticle. A precision dicing saw was successfully applied in fabricating the pyroelectric cell with a strip form. Endoscopic ultrasonography is not required for staging malignant esophageal strictures that preclude the passage of a diagnostic gastroscope. Torsion was present in all 17 cadaver specimens, with a mean of 47.5 degrees and a range from 21 degrees to 62 degrees.

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The diameter of the aortic annulus and sinus valsalva were wider in patients with BJHS. Only 3 patients showed no response concerning a distinct pain reduction within the first days of therapy. INTERACTION OF RIBOSOMES AND CHEMICALLY MODIFIED POLYDEOXYRIBONUCLEOTIDES. Religious Involvement and Adaptation in Female Family Caregivers. They received an injection of their regular dose of heroin or saline (placebo) before or after the scan. Because the algorithms are independent of the details of the recurrence relations, the software can be easily modified to generate new types of analytical integrals. PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer. Semi-quantitative PCR was performed to explore mRNA expression of growth factors.

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All strains were facultatively heterofermentative, producing L-lactic acid. To demonstrate that (1) mechanical ventilation with tidal volume (VT) and positive end-expiratory pressure (PEEP) settings used routinely on surgery patients causes ALI/ARDS in normal rats and (2) preemptive application of airway pressure release ventilation (APRV) blocks drivers of lung injury (ie, surfactant deactivation and alveolar edema) and prevents ARDS. Here we evaluated whether cyclooxygenase-2 was induced after a short (10-min) episode of focal ischemia, mild enough not to cause inflammation or cell death. Until further improvements are achieved, prudence is called for in interpreting results obtained through these models. In absence of prompt intervention in the form of airway decompression, morbidity and mortality is very high. With this travel comes the potential for patients to acquire unexpected diseases. When free sugars were substituted for complex carbohydrates, no significant increases were detected in systolic or diastolic blood pressure, and no heterogeneity was observed. Joint diseases are a major cause of disability and are a significant financial burden on health care systems. In the face of ever-increasing incidence and prevalence of kidney disease worldwide, the unmet need for new treatments is unprecedented. The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds.

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The pathology of lymphoid organs in 38 low birth weight (LBW) human infants has been evaluated by morphological and morphometric features. The role that phosphorylation plays in regulating heat shock factor (HSF) function and activity has been the subject of several studies. A new case of psychical disorders during the treatment with cortisone of acute articular rheumatism. Other viruses, such as adenovirus, appear to persist as latent infections in the airways of patients with COPD, and adenoviral E1A protein is capable of amplifying host genes, possibly including those involved in cigarette smoke-induced lung inflammation. Factors required to maintain mating-type silencing also affect centromeric silencing and chromosome segregation. A total of 456 samples were collected from Rio Doce State Park and 142 from Ecological Station of Universidade Federal de Minas Gerais.

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This parameter delineates the boundaries between stable, isotropic cylindrical bundles and anisotropic, twisted-tape bundles. Bendopnea and risk of adverse clinical outcomes in ambulatory patients with systolic heart failure. Here we present a fluorescently labeled and quenched pre-miRNA beacon that can be ligated easily out of two single labeled RNA strands. Among the initially identified candidate somatic single-nucleotide variants (SNVs), 10,279 were validated by manual inspection of the WES data followed by Sanger sequencing. First, we analyse distributional regularities using two novel techniques: a Bayesian ideal learner analysis, and a simple distributional measure. These lesions can be seen anywhere from the oral cavity to the anus, but ileum is the most commonly affected site. Instruments were translated and back translated by bilingual persons from 5 different countries of origin. The objectives of this study were to estimate the cumulative effect and relative importance of environmental exposures on the risk of childhood asthma. Surgical resection is performed in the majority of patients with localized gastrointestinal lymphoma.

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On the other hand, the extra chromosome in two trisomics and the chromosome lacking the triplet in the hypotriploid were cytologically identified as chromosome 10 by consistent presence of a secondary constriction in the proximal region of its short arm. We encircled several Glissonean pedicles that entered the right anterior section along the right side of the RUP. However, fibrin sealant, if found in a controlled trial to have clinical efficacy, could be approved by the FDA for a narrow indication. Atypical fibroxanthoma of the scalp with recurrent and multiple regional cutaneous metastases. Anthocyanins in grape skins showed variations in accumulation pattern, concentration, and distribution depending on variety and to a lesser extent on season. Angiography and image-guided therapy were then used to control bleeding with coil-embolization. The association between cord blood metal concentrations and child characteristics at birth was evaluated using linear regression.

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The ocular lenses were foldable with a forcep (Faulker Folder) and inserted into the eye through a 4 mm incision. SENSORY-INDUCED MODIFICATIONS OF VENTILATION AND HEART RATE IN CRAYFISH. The organization of scientists and its relation to scientific productivity: Perceptions of Chinese stem cell researchers. Evaluation of the validity of the Psychology Experiment Building Language tests of vigilance, auditory memory, and decision making. A liquid crystal polymer-based neuromodulation system: an application on animal model of neuropathic pain. Like most people, nurses need support in adopting healthy behaviors. A NADP-glutamate dehydrogenase mutant of the petit-negative yeast Kluyveromyces lactis uses the glutamine synthetase-glutamate synthase pathway for glutamate biosynthesis. Apoptotic cytosol facilitates Bax translocation to mitochondria that involves cytosolic factor regulated by Bcl-2. The heparins, well-known for their anticoagulant properties, may also have anti-inflammatory effects that could contribute to their effectiveness in the treatment of venous thromboembolism and other vascular diseases.

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Five months later, she underwent endovascular stent-graft repair of the descending thoracic aortic aneurysm. Since many patients with LCNEC suffer through the use of ineffective therapeutic strategies, a clinical trial using the TRKB inhibitor for LCNEC is urgently required. To evaluate the psychometric properties of the Brazilian version of the Peer Aggressive and Reactive Behaviors Questionnaire (PARB-Q), a self-report instrument comprising two independent scales that assess aggressive behavior and reactions to peer aggression. An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase. Male breast cancer in a multi-gene panel testing cohort: insights and unexpected results. We retrospectively analyzed a total of 1,765 cases of patients who had undergone general anesthesia at our ambulatory surgery unit. Low plasma levels of adiponectin, a circulating hormone-like molecule, have been implicated as a possible mechanism for this association.

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Reengineering of the human pyruvate dehydrogenase complex: from disintegration to highly active agglomerates. To compare selumetinib and MK-2206 vs modified FOLFOX (mFOLFOX) in patients with metastatic pancreatic cancer for whom gemcitabine-based therapy had failed. This indicates that the occupational treatment of dental alloys leads to an internal exposure to these metals which is distinctly higher than that from automobile exhaust exposure. Peak systolic (PSV) and end-diastolic velocities (EDV) were measured at the proximal CCA and ICA within the jet of turbulence. Based on the super-low-frequency (SLF) electromagnetic detection technology, the advanced detection for the buried fault in the coalfield is still at the exploratory stage, while the technology has a strong practical significance for production and design of the coal mine. T.Bil may evaluate a liver function that is not measured by nuclear imaging techniques, so we should take T.Bil results into account before considering TAE. In this review, the role of the PAR2 signalling pathway in pain processes, basic mechanism of PAR2 activation and expression of PAR2 in the nervous system is covered. Continued evolution in access technology has resulted in next generation catheters that afford improved trackability and proximal support. Role of the HIN domain in regulation of innate immune responses.

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A case report is presented of a woman whose emotional deprivation led to feelings theolair of rejection and the inability to develop empathic relationships. The present study assesses the effects of a local injection of bFGF on the rate of orthodontic tooth movement. This protein was capable of causing increased haptoglobin production and decreased albumin production in primary cultured bovine hepatocytes. In vitro experiments indicated that amino acids, peptides and depsipeptides mimicking the peptide moiety of the nascent peptidoglycan significantly interfered with the acylation of PBP1 by the antibiotics. A multi-country comparison of reasons for dental non-attendance. Charts were examined for these anomalies: agenesis, supernumerary, impaction and delayed tooth eruption.

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For this purpose, confluent fibroblast cultures (derived from lung tissue from a nonasthmatic donor) were stimulated for 4 h with interleukin (IL)-1beta, tumour necrosis factor (TNF)alpha, interferon (IFN)gamma, IL-4, IL-5 or transforming growth factor (TGF)beta. Due to rhinosinusitis symptoms severity and relatively high treatment resistance, excipients, supplementing basic pharmacological and surgical treatment, have played a significant role in the recent years. Photoscreening has emerged as one of the newest means of screening children to detect amblyogenic factors. The rates presented for 1984-1986 are higher than those previously described for England and Wales. Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Application of certain tests for the study of basic properties of the higher nervous function in cattle. Practice guidelines to manage children admitted in a general pediatric department with very mild or mild acute infective diarrhea. Recognizing that human health suffers when low income communities are passive, disenfranchised and disorganized, in order to change this status quo, understanding that human capital is the greatest asset is the urgent challenge to the field of MCH. Effects of Contamination by Hemostatic Agents and Use of Cleaning Agent on Etch- atarax medication picture and-Rinse Dentin Bond Strength.

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Cysteine sulfinic acid decarboxylase regulation: A role for farnesoid X receptor and small heterodimer partner in murine hepatic taurine metabolism. Protrusion of the tongue is a common, though often neglected finding in fire fatalities. Lethal Fournier gangrene following cardiac surgery with cardiopulmonary bypass. To establish an integrated disease-associated database, disease vocabularies used in different databases are mapped to Disease Ontology (DO) through semantic match. Cerebral open flow microperfusion (cOFM) is a new in-vivo technique for continuous sampling of the interstitial fluid in brain tissue. Strategies for resolving the heterogeneity of schizophrenics and their relatives using cognitive measures. At plasma concentrations greater than 800 ng/ml, BALF methylprednisolone concentrations increased exponentially, whereas the increase for prednisolone remained linear. With one targeting motif, NGR-LDP-AE acts on both liver CSCs and angiogenic endothelial cells.

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A new study combining behavioral and physiological approaches has given new life to the old idea that the hippocampus is critically involved in familiarity-based recognition memory. IL-10(-/-) mice and IL-10-treated tibial organ cultures were used to study loss and gain of IL-10 functions, respectively, during endochondral bone formation. Our method allows the protein and nucleic acid signals to be separated by spectral decomposition such that sedimentation information from each individual species, including any complexes, can be clearly identified based on their spectral signatures. Radiation-induced apoptosis: effects of cell age and dose fractionation. Acetylsalicylic acid inhibited the secondary aggregation enhanced by TPO, but not the TPO-induced potentiation of the primary aggregation. The tumor was classified as the follicular variant of papillary carcinoma of the thyroid with several foci of mucoepidermoid carcinoma.

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