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Capecitabine

Capecitabine is used in the treatment of cancer of breast, colon, and rectum. It may be also used to treat other conditions, as determined by the doctor. It is used alone or in combination with some other medicine as a part of chemotherapy.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Avodart, Claritin, Levaquin, Zocor, Elavil, Prilosec, Medrol

Description

Xeloda (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

Xeloda is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

Xeloda is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Xeloda for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Xeloda for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Xeloda dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Capecitabine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Xeloda if you are allergic to capecitabine or fluorouracil, or if you have:

severe kidney disease.

To make sure Xeloda is safe for you, tell your doctor if you have ever had:

a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency; liver or kidney disease; heart problems; or if you use a blood thinner and you have routine "INR" or prothrombin time tests.

Capecitabine can harm an unborn baby if the mother or the father is using Xeloda .

If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using Xeloda and for at least 6 months after your last dose. If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using Xeloda, and for at least 2 weeks after your last dose.

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Relation of heart-type fatty acid-binding protein with the degree and extent of atherosclerosis in patients with non-ST elevation acute coronary syndrome. Water self-aggregation enhances water-surface interaction on all studied surfaces due to hydrogen bond (network) formation. Enzymes use binding energy to stabilize their substrates in high-energy states that are otherwise inaccessible at ambient temperature. On experimental trypanosoma infection of the mouse as a biological procedure. The relation of food and exercise to atherosclerosis and coronary thrombosis. Anthropometric measures and blood samples provided 20 parameters of nutritional status. In the present study, using genome-wide methylation analysis and bisulfite pyrosequencing with specimens from HB tumors, we detected nine methylated genes.

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Commonly, the bispecific approach is used to achieve simultaneous cross-linking of CD3 and a tumor antigen such as epithelial cell adhesion molecule (EpCAM), thereby recruiting T-cell activation to the tumor cell surface. There was a significant negative correlation between glucose metabolism in frontal brain areas and the BDHI. After training with three stimuli, each student could construct the correct sentence for 24 untrained stimuli. The thorium conglomerates could be identified, and images of microdistributions of thorium in the organ slices were obtained. Imaging VCAM-1 as an indicator of treatment efficacy in metastatic ovarian cancer. Yield of the admission complete blood count in medical inpatients.

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Nick Jakubovics speaks to Hannah Branch, Commissioning Editor Nick Jakubovics attended the University of Cambridge (UK) where he obtained a BSc in Biochemistry, which was followed by the completion of a PhD in Microbiology at the University of Warwick (UK). MCs accomplish this via activation of the PDGF pathway, downregulation of miR-145/143, and modulation of the myocardin-Klf4 axis. Technological advances now make it feasible to administer cognitive assessments at-home on mobile and touch-screen devices such as an iPad or tablet computer. Aryl hydrocarbon receptor ligands inhibit igf-ii and adipokine stimulated breast cancer cell proliferation. The observed and calculated frequencies are found to be in good agreement. Salmonella is one of the most important foodborne pathogens around the world. After a 2-hour basal period, subjects received intravenous dichloroacetate, 35 mg/kg, over 30 minutes. cTT may be useful tool to disclose small-vessel disease in demented patients. Postoperative morbidity, mortality, and length of stay were recorded. A prospective study predicting the outcome of chronic low back pain and physical therapy: the role of fear-avoidance beliefs and extraspinal pain.

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Morphine at 1 mg/kg produced a moderate decrease in slow wave sleep which was prevented by concomitant administration of 100 mg/kg of glucose. Connectivities of the striatal grafts in adult rat brain: a rich afference and scant striatonigral efference. The factor analytical method presented here is the most objective way to separate Na and B peaks from each other, and the factorizing method can be applied in different forms of spectral analysis. SQA-NPFF was hydrolyzed by an unidentified degrading activity to generate NPFF, and NPFF accounted for a larger part of SQA-NPFF degradation in the hindbrain and cervical spinal cord than in the cerebrum slices. A review of some basic tenets of opioid analgesia based on current published knowledge and experiences about this important healthcare imperative is warranted. On the basis of medical history, malignancy, and primary treatment, the modality of bisphosphonate therapy, and existing comorbidities and medication were analyzed. The authors describe a clinical case of a young woman admitted with the diagnosis of ACS.

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Regeneration and tolerance factor: a correlate of human immunodeficiency virus-associated T-cell activation. this was an assessment of reproducibility tests conducted in a angiology clinic of a university hospital. In this case series we aim to describe the treatment and progress of a number of patients in a secure psychiatric hospital in the UK. Sodium channel blockers are vasodilator as well as natriuretic and diuretic agents. To determine the prevalence of keratoconus in the 40- to 64-year-old population of Shahroud, Iran. Pre and intraoperative scintigraphic detection of sentinel nodes in breast cancer. Quality of life after heart surgery interventions including transplantation. The temperature of the latter step transition is different for the head and tail regions of the drug-containing vesicles: FT-IR spectra demonstrate that the hydrophobic acyl chains transition starts at a temperature well above that of the interfacial region whereas the transition of the entire vesicle, explored by QLS, is broad and covers both temperature ranges. In normal rabbits, the permeability of lesion-susceptible branch sites of the abdominal aorta was about four times that of the lesion-resistant, nonbranched areas. However, the Franco regime brought a halt to the process of professionalisation.

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All patients with functioning renal transplants and critical limb ischemia (CLI) treated with endovascular techniques between 2003 and 2010 were retrospectively reviewed for limb salvage, reintervention, pre- and postprocedure creatinine, and estimated glomerular filtration rate (eGFR), and overall survival. The effect of biomass fuel exposure on the prevalence of asthma in adults in India - review of current evidence. The necessary and sufficient conditions of achieving both consensus and stability of the closed-loop networked multiagent control systems are derived. Intensity based image registration by minimizing exponential function weighted residual complexity. Nosocomial epidemic of active tuberculosis among HIV-infected patients. Although current knowledge of proteins exhibiting only partial peroxisomal targeting is far from being complete, we speculate that the metabolic capacity of peroxisomes might be larger than previously assumed.

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Efficacy and tolerability of topiramate-augmentation therapy for schizophrenia: a systematic review and meta-analysis of randomized controlled trials. A sulphated glycoprotein found in the urine of patients with cancer cachexia is capable of directly inducing protein catabolism in skeletal muscle by a process involving an increase in prostaglandin E2. The course of tardive dyskinesia in patients on long-term neuroleptics. During the procedure, the nurse monitors the level of dissection and assesses for clogging of the suction. Polyclonal antibodies to plasma FXI recognize a 220 kD platelet membrane protein distinct in structure from plasma FXI.

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Infections were long-lasting: populations of adult worms could survive for over 2 years in grouse, with little mortality. Sample size requirements for precise estimates of reliability, generalizability, and validity coefficients. This paper reports the changes that were noted in the innervation of rabbit CMJ tissues following surgical induction of ADD. We conducted a systematic review and meta-analysis to characterize the association between GD and NAFLD. We report the development of PCR-gel-based markers for eight yield-related functional genes (Gn1a, OsSPL14, SCM2, Ghd7, DEP1, SPIKE, GS5, and TGW6) to introduce yield-positive alleles from the donor lines. Utility measurement and the allocation of health care resources. Verbal recall and measures derived from the process-dissociation procedure revealed that younger adults acquired more explicit memory about the sequence than older adults, potentially causing age differences in RT gains in later stages of learning. Two routes of synthesis of 2-acetyl-7-hydroxy-6-methoxy-3-methylbenzofuran and some of its aminoalkanol ethers are described. Previous incubation of carboxypeptidase B with phenothiazines and zinc ions greatly reduced the enzymatic inhibition by the phenothiazines, which indicated a possible chelating action by these inhibitors on the metalo-enzyme carboxypeptidase B. Carpatica) berries and leaves were analysed by UHPLC/PDA-ESI/MS.

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Sub-mental Intubation in Oral and Maxillofacial Trauma Patients. Knowledge of MS among the therapists as well as collaboration with the zyrtec pediatric dosage chart multidisciplinary MS care may facilitate participation in CBT. HIF2A rs13419896 and VEGFA rs833061 were significantly related to lung cancer risk, with possible interaction between polymorphisms and cigarette smoking. Mechanisms by which T7 lysozyme specifically regulates T7 RNA polymerase during different phases of transcription. Adjustment and the discrepancy between self concept and inferred self. PY effected regional vasodilatation in the heart, brain and skeletal muscle. To assess the efficacy and adverse effects of single dose oral dexibuprofen for acute postoperative pain using methods that permit comparison with other analgesics evaluated in standardised studies using almost identical methods and outcomes. Cerebral hemodynamics in persons subjected to exposure to intensive industrial noise.

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Diffusion-weighted MR imaging in multiple sclerosis: comparison with contrast-enhanced study. ALT level did not correlate with pretreatment and posttreatment levels of HCV RNA or histopathological changes. This study was undertaken to determine the influence of single intra-articular or intra muscular injections of methylprednisolone acetate on the hypothalamic-pituitary-adrenal axis. Escitalopram is effective in treating depression in patients with diabetes mellitus, and has beneficial effects on glycemic control. The combination of an incision widely diverging from the handle of the racket is in danger of severing the dorsal metatarsal artery, its bifurcation, or the digital branch to the adjacent toe. Patients suffering from peritonitis and/or sepsis were excluded from the laparoscopic approach. Only in this manner is it possible to establish a basis for national and international registries and double-blind randomized treatment trials for the etiologically differentiated treatment of myocarditis, which appear promising due to numerous studies in recent years.

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Studies using a new method for perfusing the rat spleen with do flagyl cause a yeast infection whole blood. Concentration of DXR in the serum after administration was below the lowest determinable level while those in the bile maintained a considerably high concentration 4 hours after the administration. Follow-up angiography 18 months later revealed a new, asymptomatic, pial arteriovenous fistula between the previously thrombosed left superficial middle cerebral vein and a small sylvian branch of the left middle cerebral artery. With shortened hospital stays, providing applicable and evidence-based websites and other online services for caregivers can complement other healthcare services. Noninvasive determination of myocardial blood flow, oxygen consumption and efficiency in normal humans by carbon-11 acetate positron emission tomography imaging. The paradigm assumes 30 new head and neck surgeons each year and includes the appropriate mortality rate for each cohort. Nitric oxide level did not change significantly in either group despite the increase in endothelial nitric oxide synthase immediately after flap elevation and at 3 days postoperatively.

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Load-displacement data were used to calculate the instantaneous stiffness in both the heel and forefoot regions, as well as hysteresis associated with each foot. The French national screening programme for colorectal cancer (CRC) was rolled out nationwide from 2008. Since several proteins have been specifically localized to the focal adhesion site, we examined whether they were also present at the apical stress fiber-membrane association site by using immunocytochemical methods and image reconstruction techniques. 23 general practices, each of which notified at least 20 asthmatic patients aged 15-60 years for each principal. Neither of the two xenografts were sensitive to bevacizumab or trastuzumab, but the MAKSAX xenograft showed intermediate response to cetuximab. Why do fragile X carrier frequencies differ between Asian and non-Asian populations?. Outer limiting membrane and inner and outer segment junction disruption scores were well correlated with BCVA both pre- and postoperatively, and significant visual improvement was demonstrated in each subgroup except in those with the highest scores. The earliest change in the kidneys in the generalized Shwartzman reaction was the appearance of homogeneous, eosinophilic material, resembling fibrinoid, within the lumen of the glomerular capillaries. Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that plays a major role in the development of resistance to conventional anti-cancer drugs in many types of cancer, when constitutively activated.

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To investigate the impact of population movements on virus spreading, a large-scale population-based survey was performed in a pilgrimage- tourism area, the great Mashhad, capital city of Khorasan province. Predominantly, NPs first bind to the membrane and, subsequently, CCPs form at this site. The effects and the fate of malononitrile and related compounds in animals tissues. Evidence for evolutionary changes in ontogeny: paleontological, comparative-morphological, and molecular aspects. Recent publications enhance our understanding of appropriate patient selection as well as the effectiveness of, and the complications associated with, this procedure. Amylobarbitone sodium, chloral hydrate, trichloroethanol, methylpentynol, methylpentynol carbamate, paraldehyde, procaine hydrochloride and troxidone reduced the presynaptic release of acetylcholine from the ganglion. Coupling liposome with pVAC-1-mCTLA-4 could break tolerance to self-antigen in BALB/c mice and induce potent immunity against murine CTLA-4, and suppress growth of subcutaneous renal cell carcinoma (Renca).

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The analysis of clinical and laboratory parameters predisposing to immunoglobulin resistance and coronary complica-tions in children hospitalised due to KD. A cause of residual pain after arthroplasty of the trapezio-metacarpal joint. Subsequently, the fraction doses were calculated by aligning the treatment plan according to a bony anatomy- and a fiducial marker-based registration. Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFbeta growth factors. The purpose of this study was to determine whether randomized trials of treatments for substance dependence differ from those for other medical disorders on quality of enrollment information reporting and sample representativeness. Assessment of pulmonary hemodynamics in patients with idiopathic pulmonary fibrosis. Individual subcellular compartments are defined by a fluorescent marker protein and the intensity of a target GFP-tagged protein is then quantified within each compartment. Qualitative provider perceptions of the program were also collected.

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Breakthrough pain has traditionally been managed by the administration of supplemental oral analgesia (rescue medication) at a dose proportional to the total around-the-clock (ATC) opioid dose. In normal (nonsurgically treated) animals the abductor was innervated by two excitatory motoneurons and an inhibitor while two excitors innervated the adductor. The resulting SAFT-VR Mie EOS can now be applied to molecular fluids characterized by a broad range of interactions spanning from soft to very repulsive and short-ranged Mie potentials. The numbers of both neutrophils and macrophages recruited to the lesion site were significantly higher in the spinal cord than in the brain, and the recruitment of these cells into the surrounding parenchyma was also more widespread in the cord. Tuberculosis in antiretroviral treatment programs in lower income countries: availability and use of diagnostics and screening. Structural features of the 2-amino-5-nitrobenzophenone by means of vibrational spectroscopy HF and DFT, first order hyperpolarizability, NBO, HOMO-LUMO and theromodynamic properties. There is an absence of robust evidence for the cost-effectiveness and benefit of using assistive technology and telecare.

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Thermal generation of volatiles in nine model reactions was studied and compared. Methods of Rapid Microbiological Assay and Their Application to Pharmaceutical and Medical Device Fabrication. Examination of how N- or C-terminal domain deletions alter the sub-cellular localisation of each protein in mammalian cells identified distinct contributions of the LisH domains to protein localisation or folding/stability. Bodily distress syndrome (BDS) was recently introduced as an empirically based, unifying diagnosis for so-called medically unexplained symptoms and syndromes. Validation of a gastrointestinal explant system for measurement of mucosal antibody production. Reactive arthritis: urogenital swab culture is the only useful diagnostic method for the detection of the arthritogenic infection in extra-articularly asymptomatic patients with undifferentiated oligoarthritis. While these apparently disparate elements affect all of medicine and health care, at the present time they appear to be changing pathology and laboratory medicine to a far greater extent than many other medical specialties. RADIUM IMPLANTATION IN CERVICAL CARCINOMA WITH A NEEDLE AND RECTANGULAR PLATE. Anesthesia in cesarean section in the Belgrade Clinic of Gynecology and Obstetrics. We observed an exaggerated early inflammatory response and an augmented lung fibrosis in bleomycin-challenged MMP-13(-/-) versus wild-type mice, with elevated lung collagen content 28d after bleomycin challenge in the MMP-13(-/-) mice.

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A total of 222 OCL people were investigated using the Posttraumatic Growth Inventory and the Connor-Davidson Resilience Scale. HCF1 and OCT2 Cooperate with EBNA1 To Enhance OriP-Dependent Transcription and Episome Maintenance of Latent Epstein-Barr Virus. Using proper longitudinal methods a new SF height growth chart was constructed. There is a substantial body of literature documenting the deleterious effects of both alcohol consumption and age on driving performance. We propose a heuristic algorithm, called ARG4WG, to build plausible ancestral recombination graphs (ARGs) from thousands of whole genome samples. In this process, hydrogen will gain increasing importance as secondary energy vector. Emergency surgery due to acute abdomen was performed under the diagnosis of pedicle torsion of the ovarian tumor. Close liaison between oncologists and other specialists can result in faster diagnosis and improve treatment outcomes.

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Microsatellite results indicated that not only did a few birds recently disperse long distance during their return migrations and change their natal breeding areas, but also that a group of allochthonous birds together founded a new colony. Here we identified, using a combination of a custom-made receptor kinase (RK) expression library and exhaustive photoaffinity labeling, three leucine-rich repeat RKs (LRR-RKs) that directly interact with RGF peptides in Arabidopsis These three LRR-RKs, which we named RGFR1, RGFR2, and RGFR3, are expressed in root tissues including the proximal meristem, ultram drug classification the elongation zone, and the differentiation zone. GENETIC EFFECTS OF SPERMATOGONIAL X-IRRADIATION ON PRODUCTIVITY OF F1 FEMALE MICE. Testing of differences between variances based on correlated variates. The natural history of Chlamydia trachomatis infection in women: a multi-parameter evidence synthesis. Using an antibody specific for microsomal cytochrome b5, we found newly synthesized microsomal cytochrome b5 in both mitochondria and a mitochondria associated membrane fraction as well as in microsomes.

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