Also known as: Calcitriol
Description
Generic Calotec is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Calotec are intestine and bone. Generic Calotec receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Calotec may also act on the kidney and the parathyroid glands. Generic Calotec is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Calotec has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Calotec, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Calotec in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Calotec produces other independent beneficial effects. Calotec is also known as Calcitriol. Generic Calotec treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Calotec is Calcitriol. Brand name of Generic Calotec is Calotec.
Dosage
This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Rocaltrol. Please read with care.
For use as a dietary supplement:
Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.
If you have any questions about this, check with your health care professional.
For individuals taking the oral liquid form of this dietary supplement:
This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.
While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.
The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.
For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.
For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.
For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.
For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.
For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.
Overdose
If you overdose Generic Calotec and you don't feel good you should visit your doctor or health care provider immediately.
Storage
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.
Concomitant methylation and synthesis in vitro of Semliki Forest virus (SFV) ss RNAs by a fraction from infected cells. Localized mutagenesis demonstrated that the hrp genes are clustered within a 17.5-kb region of pVir2 and that this cluster probably extends on the genomic region adjacent to the pVir2 insert. Angiogenesis levaquin type of antibiotic , the development of new blood vessels, is essential for both tumour growth and metastasis. coli expression systems to uncover system-inherent specifications in the synthetic M9CA growth medium. The state mental hospital in mid-nineteenth-century America: a social analysis. In addition, Pol Y1 overexpression delayed cell growth at low temperature. The second group of fibers except for the somatostatin fibers is thought to be continuations of the first group of fibers.
Four factors, suspected of influencing the final results of agglutinin-absorption tests used in the diagnosis and classification of leptospires, were investigated in comparative studies: (1) the time required for adequate absorption, (2) the quantitative relationship between antibody titres and amounts of antigen needed for absorption, (3) the possible effect of the Danysz phenomenon, and (4 albenza dosage ) the absorptive potency of live and formol-treated antigen.It was found that a 90-minute absorption time was adequate and that with increasing amounts of antigen, titres were continuously reduced, indicating a certain degree of non-specific absorption. The purpose of this study was to compare acute changes of non-esterified fatty acids (NEFA) in relation to beta cell function (BCF) and insulin resistance in obese patients with type 2 diabetes (T2D) who underwent laparoscopic gastric bypass (GBP), laparoscopic sleeve gastrectomy (SG) or very low calorie diet (VLCD). Involvement of CD14 in lipopolysaccharide- induced liver injury in mice pretreated with Propionibacterium acnes. Peritonitis increases MMP-9 activity in peritoneal effluent from CAPD patients. Here we describe a patient who developed drug-induced acute lung injury shortly after the administration of the dipeptidyl peptidase-4 inhibitor vildagliptin. This permits low levels of ligand radiolabelling and relatively low numbers of cells to be used. In this work the microsomal lauric acid omega-hydroxylation, fatty acid peroxisomal beta-oxidation, and the levels of cytochrome P-450 IVA1 were studied in liver tissue from starved rats. Spinal cord toxoplasmosis in a patient with human immunodeficiency virus infection.
In the post-natal olfactory bulb there was a shift in the localisation of both EphB2 and ephrin-B1 to the dendritic arborisations of mitral cells. Effect of temperature in vivo and in vitro on oxidation and phosphorylation in the myocardial mitochondria of white rats. Some experience with the conservation of red blood cells by freezing using dextran, dimethyl sulfoxide and glycerine. In the perineurium of normal nerve, GGT activity was faint, while in degenerated nerve, it increased. In vitro, poorly iodinated thyroglobulin (Tg) is hydrolysed at the same rate whether it is enclosed in thyroid or in liver lysosomes, while fully iodinated Tg is degraded faster inside liver lysosomes.
A retrospective study was done at Adama Referral hospital, Adama city, Ethiopia during March-May 2014. The distribution of melanin concentrating hormone (MCH) in the central nervous system of the locust Locusta migratoria was studied by the indirect immunofluorescence technique, using antibodies against salmon MCH. Despite recent advances in our understanding of pain mechanisms, the satisfactory management of pathological pain eludes amaryl 8 mg current treatment strategies. The results indicate that not only a word but a physical stimulus which deviates from a semantic context can elicit the N400 component. In 34 healthy children at school-age the availability of the 3rd platelet factor was determined using plasma of mean concentrations of 100 000 and 342 000 platelets/mm3. Except for one variable all the others failed to show a significant difference by statistical analysis between both treatments, however, the surgical treatment resulted in higher values when compared to the medical one. A 57-year-old man with small cell lung carcinoma developed benign, obstructing endobronchial bands five months after external beam radiation therapy. Time interval from castration in premenopausal women to development of excessive coronary atherosclerosis. In this study, hamsters inoculated intranasally with parainfluenza virus type 3 produced local interferon, which was detected in lung washes obtained by in situ lavage.
Therefore, the MudE transposon can be utilized to produce specific mutants in oral streptococci as well as in other transformable Gram-positive bacteria expressing an erythromycin-resistance marker. Peripheral blood lymphocytes, lymphoblastoid T- and B-cell lines, platelets and spermatozoa could remove varying amounts of both reactivities from HATG and SA beta 2mG. The antifertility effect of a copper intrauterine device appears to occur in the late preimplantation stage of pregnancy in the rabbit. Several monoclonal antibodies to neurofilaments did not react with these cells in immunofluorescence or immunoblotting, though they recognize either all or individual mouse neurofilament triplet proteins. Eight out of ten suitable triploids were diagnosed as partial mole. Voxel-based morphometry of patients with schizophrenia or bipolar disorder and their unaffected relatives. Results of wedge-shaped excision from the auricle with cartilage removal in the treatment of chronic nodular chondrodermatitis of the helix. In 12 patients a non-inflammatory effusion occurred during the course of a painful crisis, in 12 patients an ankle effusion occurred in association with spontaneous development or deterioration of leg ulceration, and in 13 patients there was a group of miscellaneous arthritides. We further argue that our model does not predict any effect of the adult sex ratio (ASR) that is independent of the source of ASR variation. The training of general dental practitioners in a program that emphasizes the care of the special patient is described.
1.4 kb Ha-ras RNA transcripts were observed in all RNA species from leukemic mice. Considering this issue, the aims of this study are to (i) investigate L. Surgical therapy included iridectomy, iridocyclectomy and enucleation. Within 9 and 11 months, respectively, 2 horses were sound and back in competition as reining horses. Self-esteem as a moderator of the relationship between self-perceived abilities and vocational choice. The binding of pharmacological preparations with the brain protein fraction in the model system was also investigated. Gene cloning, expression, crystallization and preliminary X-ray analysis of Thermus thermophilus arginyl-tRNA synthetase.
The incidence of primary central nervous system lymphoma (PCNSL) has been on the rise in the setting of immunodeficiency syndromes such as acquired immune deficiency syndrome (AIDS). Together, these results suggest that lincRNAs have potential functional roles in potato defence responses. The sixth cervical DRG of newborn rats contained 70 pg of SP, and the ganglionic content increased 5.5-fold during the first 5 weeks of life. High occurrence of rhinitis symptoms in hairdressing apprentices. These contradicting results prompted us to explore in zantac generic side effects this study the effect of magnetic field exposure on the DNA stability in vivo when the heat shock response of the cell was suppressed. Coding and analysis of the data was performed in NVivo10 based on the constant comparative approach. Despite this increased risk, and because little is known about the relation between other forms of antihypertensive treatment and diabetes, diuretics and beta blockers should remain the treatments of choice in arterial hypertension. The extent of moulting had a clear effect on the post-moult heat production, and the differences were still present after 6 months in the second year of laying. Imaginal, semantic, and surface-level processing of concrete and abstract words: an electrophysiological investigation.
Data were transcribed, qualitatively coded and analyzed, initially using an editing approach and then a template approach with NPT as a guiding framework. Idazoxan might be a partial agonist for imidazoline I(1) receptors. mansoni infection while Para-5 was preferentially recognized by individuals resistant to reinfection. Dissection of the UVA-induced signalling pathways revealed that TC-22 could suppress the activation of JNK and caspase 3, but not of ERK and p38. The AHL for AFP provided a means of assessing efficacy of treatment. Ten can i take 20 mg of zyrtec a day milligrams per kilogram, even daily for 24 days, was without effect on hepatic or pancreatic GSH. Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. We evaluate the safety and efficacy of a single dose of hyoscyamine sulfate in combination with ketorolac tromethamine for the reduction of pain in emergency department patients with ureteral colic. Besides measurement of MBF, the amount of substrates (glucose, lactate, pyruvate and free fatty acids (FFA) was also determined in arterial and coronary sinus blood samples.
trachomatis staining (species-specific monoclonal antibody) of the inclusions was used to determine the infectivity of the various types of epithelial cells. This increase in tissue weight was not associated with hyperplasia of the gastric fundus as in no instance did total DNA contents from mated females differ significantly from those of the unmated controls. Two of these genes were generated by the duplication of a pseudogene about 1.5 X 10(5) years ago. Estrogen receptor beta immunoreactivity in differentiating cells of the developing rat cerebellum. However, the intracellular amount and the tyrosine-specific protein kinase activity of the Abelson virus oncogene product, P120v-abl, were not affected by differentiation of the leukemic cells. They also conducted sensitivity analyses to assess patterns of the cost-effectiveness across different populations using various assumptions. Like ephrin-A5, ephrin-A6 has high affinity for EphA4 and activates this receptor in cultured retinal cells. Nuclear bag2 fibers reacted with all three antibodies, chain fibers with two, and nuclear bag1 fibers with only one. B virus (Macacine herpesvirus 1) can cause deadly zoonotic disease in humans.
Functionality of the endogenous cannabinoid system undergoes relevant changes in reward-related brain areas in animal models of opiate addiction. Together with Smad2/4, it forms the activin response factor (ARF) that binds to the Mix.2 promoter in Xenopus embryos. Electron microscopic observations of the mesenchymal cells in region 2 revealed 70A microfilaments along the cell periphery and packed in fliopodia-like projections which course between the cells. Clear trophic effects were also found for the N-terminal part of the pro-opiomelanocortin molecule N-POC (optimum 0.1 nmol/l) and N-POC(51-62) (optimum 0.1 pmol/l). Donovanosis and squamous cell carcinoma: The relationship conundrum!. Periodontal disease is an inflammatory disease caused by bacterial infection of tooth-supporting structures, which results in the destruction of alveolar bone.
Radioactive chromic phosphates: comparative study of the in vivo distribution and feasibility of preparation. Specificity was achieved by absorbing the resulting serum with hamster blood cells and peritoneal macrophages. Viral plaque autoradiography permitted the quantitation of proportions of thymidine kinase-negative and thymidine kinase-positive herpes simplex virus in the mixed virus populations. A new second locus HL-A antigen in linkage disequilibrium with HL-A2 in cantonese chinese. Absorbance changes of the 503 m-mu pigment as related to the respiration of yeast cells.
To evaluate the link among thyroid function, glucose/insulin metabolism and steroid hormones in women with polycystic ovary syndrome (PCOS), and to verify if the body mass index (BMI) might influence the interplay between PCOS features and subclinical hypothyroidism (SCH). Transaminase and alkaline phosphatase activities were not significantly modified, indicating absence of liver injury. Approximate linkage equilibrium between two polymorphic sites within the gene for human complement component 3. In patients with agitated depression, the noradrenaline content in the urine was higher than in patients with melancholic depression. These results demonstrate that the alpha 2 subunit differs from other known agonist-binding alpha-subunits of nAChRs in its distribution in the brain and in its pharmacology. Effect of des-Tyr1-gamma-endorphin on serotonin metabolism in rat brain regions. Endoclips versus heater probe in preventing early recurrent bleeding from peptic ulcer: a prospective and randomized trial. In three clinical studies it was investigated, which patients could be given a single drug treatment with calcium antagonists.