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Calosto (Calcitriol)
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Calosto

Calosto is a synthetic version of Vitamin D3 used to treat calcium deficiency with hypoparathyroidism (decreased functioning of the parathyroid glands) and metabolic bone disease in people with chronic kidney failure.

Other names for this medication:
Admax, Alcee, Alfacal, Alfacalcirol, Alfacip, Alfarich, Arcium, Aristrol, Biocal, Calbec, Calcibest, Calcigra, Calcikind, Calcirol, Calcit, Calcitriol, Calcor, Calfa, Calosto, Calsonic, Caltin, Calvical, Cholical, Citroj, Devita, Dmcal, Duracal, Fovit, Kurecal, Lctrol, Netxod, Nutribone, Rical, Riecal, Ritoca, Rockbon, Roical, Rolsical, Romical, Septriol, Solbiocal, Statbone, Trolec, Vezocal, Zaxial

Similar Products:
Ventolin, Silagra, Benicar, Xenical, Kamagra, Alprostadil

Also known as: Calcitriol

Description

Generic Calosto is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Calosto are intestine and bone. Generic Calosto receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Calosto may also act on the kidney and the parathyroid glands. Generic Calosto is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Calosto has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Calosto, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Calosto in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Calosto produces other independent beneficial effects. Calosto is also known as Calcitriol. Generic Calosto treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Calosto is Calcitriol. Brand name of Generic Calosto is Calosto.

Dosage

This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Rocaltrol. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Calosto and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Calosto are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Calosto if you are allergic to Generic Calosto components. Do not take Generic Calosto if you are pregnant, planning to become pregnant, or are breast-feeding. It is not known if this medication appears in breast milk. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Be careful with Generic Calosto if you have heart disease, kidney disease or kidney stones, coronary artery disease (hardening of the arteries). Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. It can be dangerous to stop Generic Calosto taking suddenly.

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Expression of the catalytic activity of plasminogen activator under physiologic conditions. This striking polarization of the nodal axon region is discussed and tentatively interpreted as the consequence of a physiological damming-up of both somatofugally- and somatopetally-transported materials. Forty-one ureters were implanted primarily, 8 ureters secondarily due to stricture of former UIA. Many of the cells acquired locomotor morphologies with front-tail polarity which was unlike the short-term multipolar morphology. Invasive mechanical ventilation (IMV) has been previously associated with a poor outcome for patients with cystic fibrosis (CF), but with improved survival and the availability of lung transplantation intensive care unit (ICU) admission is being increasingly considered. Both liquids contained alpha 1-microglobulin in mono- and dimeric forms, while the presence of higher polymeric forms, as characterized in plasma, could not be demonstrated. These data point out that Dacarbazine can induce a marked reduction of blast cells as well as severe myelotoxicity in leukemic patients. Nonpharmacological treatments such as cognitive behavioral therapy are available but the data in pregnancy is often lacking. penicillin and streptomycin, which act only on multiplying bacteria, may be antagonized by some bacteriostatic antibiotics, e.g. Various problems in the determination of electrodermal responses.

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Coronary heart disease risk factors and antihypertensive drug selection. Measurement of oxygenation curves of hemoglobin, blood and erythrocyte suspension. Inguinal lymph nodes reduced in size, and the patient reported increased well-being and less fatigue. A more detailed analysis of the structural interactions between Th-cell and B-cell epitope donor peptides revealed that the peptides must be linked to observe the enhanced antibody response. OmpC overexpression did not cause a significant decrease in expression of a LamB-LacZ hybrid protein produced from a lamB-lacZ fusion in which the fusion joint was at the second amino acid of the LamB signal sequence. Correlation between twitching motility and possession of polar fimbriae in Acinetobacter calcoaceticus. Background matters: the effects of estrogen receptor alpha gene disruption on male sexual behavior are modified by background strain. A PA of the brain with spinal metastasis at presentation has never been reported in an adult. Such intervention has been shown to be safe and therefore might enhance participation in exercise programs for older adults.

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A simple slide holder for use in stripping film autoradiography. A variant of prealbumin from amyloid fibrils in familial polyneuropathy of Jewish origin. Methylation-associated silencing of the Wnt antagonist SFRP1 gene in human ovarian cancers. In four patients, in vitro death of cells exposed to vindesine in vitro correlated with clinical response to therapy. Preformed monoclonal IgG and IgA immune complexes stimulated dose-dependent O2-. The maximum 1 cm(2) area-averaged induced current densities for the central nervous system tissues, such as the brain and the spinal cord, were within the reference level of 10 mA/m(2) as suggested in the ICNIRP guidelines for magnetic fields (0.417 mT at 60 Hz). The influence of radiation quality and oxygen on strand breakage in dry DNA. Sudden death and partial absence of the right ventricular myocardium: a report of three cases and a review of the literature. Pulmonary venous obstruction following correction for total anomalous pulmonary venous drainage: a challenge. Pre-incubation of cells in the presence of MPKT produced a residual antiviral effect.

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In many cases structures consisting of a living ccw5ccw6ccw7ccw8 (multiple Pir-protein mutant) mother with two methylene blue-stained daughters could be seen. Comparison of the canine and feline prion protein sequences suggests a set of amino acid replacements relative to bovine PrP that might relate to the observed different susceptibilities of the two species to TSE infection by ingestion of BSE-infected beef. To analyze the role of Daxx in the developmental motoneuron cell death, we studied Fas-dependent cell death in motoneurons from transgenic mice that overexpress a dominant-negative form of Daxx. Thirteen days after surgery she was discharged without neurological deficits, except mild papilledema. The amplitude of the stapedial response to sustained stimulation was reduced when recorded from the affected side, suggesting the facial nerve was affected proximal to the stapedius muscle.

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Complications were few and patients returned to work sooner than after an open operation. SP content increased 4.5-fold during the first 5 weeks, from 56 pg per ganglion at birth. Oral vs intravenous dipyridamole echocardiography for detecting coronary artery disease. Compound II, which was not hepatotoxic, gave very little liver pyrrole. Eight antagonists and specimens of each material were tested in a pin-on-block design with oscillating sliding of an aluminum oxide antagonist (Degussit antagonist, 5 mm diameter). These end-points were chosen to indicate if this serine protease inhibitor caused alterations in the control of haemostatic function by endothelium, in the light of the improvement in haemostasis seen in patients given aprotinin therapy at the time of open heart surgery. Compounds (III) and (IV) adopt a strongly distorted propeller shape with pivotal tetrahedral C1 atoms. Expression of stress-activated kinases c-Jun N-terminal kinase (SAPK/JNK-P) and p38 kinase (p38-P), and tau hyperphosphorylation in neurites surrounding betaA plaques in APP Tg2576 mice. Effect of interferon on transient shut-off of cellular RNA and protein synthesis induced by Mengo virus infection.

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Non-alcoholic male subjects were given either a placebo or zimelidine (100, 200 or 300 mg, p.o.) 2 h prior to consumption of alcohol (1 g/kg) or a non-alcoholic mixer. We re-estimated the anaphylaxis deaths that occurred in Brazil during the period 2008 to 2010, utilizing this new framework and the database of the Brazilian mortality information system that had initially been extracted in May 2011. Component analysis of verbal fluency in patients with schizophrenia. However, the indirect tests are simpler to do and appear to be comparable to the secretin test at detecting pancreatic exocrine insufficiency. Mutant cells lackng chlorophyll, chloroplasts, and chloroplast DNA were produced by irradiating Euglena gracilis in aerobic conditions with visible or red light (greater than 610 nanometers) of an intensity equivalent to that of direct sunlight. The harmonic polarization state is fully controlled by the laser-plasma parameters. We employed the surface of the bead as a reactor where we mixed two different actin polymerization-activating factors, the Arp2/3 complex and the vasodilator-stimulated phosphoprotein (VASP), to examine their contribution to actin-based movement and filament organization. Combined multichannel intraluminal impedance and pH-metry: a novel technique to improve detection of gastro-oesophageal reflux literature review.

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The focal nature of protein synthesis inhibition in brain during seizures suggests that the systemic effects of convulsions (e.g. The patients had higher nocturnal temperatures and decreased 24-hour amplitudes when depressed than when they had recovered and compared to the controls. It appeared to make no difference to their recall if they were given this information on a preadmission clinic or on admission. In addition to the pulvinar nucleus, Pbg projections were found to terminate in layers 4 and 5 of the dorsal lateral geniculate nucleus and the central lateral nucleus. Both normal platelets and Bernard-Soulier syndrome (BSS) platelets which lack glycoprotein (GP) Ib. Antiatherosclerotic effects of antioxidants are lesion-specific when evaluated in hypercholesterolemic New Zealand white rabbits. As a result a consistent reduction in the size and edema of the affected areas was noted. Mechanisms of motor neuron interaction in the isolated spinal cord of rat pups. Other differences between practices appeared to be related to the interests and training of the individual physicians.

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The quality of reporting of studies at ICS is so poor that it is difficult to interpret the results. Of 66 babies under the age of 3 months, who were examined during a 6-month period for excessive or unusual crying, and who showed no signs of fever, diarrhoea, vomiting, blocked nose, skin eruptions, and difficulties with breast- or bottle-feeding, 9 had pus or mucus in the middle ear. These changes were essentially restricted to the first pulse that occurred immediately after naloxone administration. Renal effects of angiotensin II in normotensive subjects on short-term cilazapril treatment. As most vascular surgery patients are elderly and reimbursed via CMS, improving their outcomes will be critical for durable financial stability. While CdCl2 also caused a concentration-dependent inhibition of liver microsomal ethylmorphine N-demethylase activity, NiCl2 increased the enzyme activity between the concentrations 10(-5) and 10(-3) M and caused a rather abrupt decline at higher concentrations. By the aid of new constructed lines it was possible to interpret the peculiar growth of the occipital region and of the posterior fossa. The subtle differences in the functional properties of the sodium channel isoforms result in unique conductances in specific cell types, which have important physiological effects for the organism.

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The effects of two other antagonists at opioid receptors (LY117413 and MR2266) were also tested. We report a case of a healthy 20-year-old male patient with the diagnosis of acute appendicitis. The recent identification of a unique system of general protein glycosylation in C. Osteoclasts generated in vitro displayed the same inability to form ruffled borders and resorb bone as seen in bone biopsies. This study indicates that expression of the CFTR gene is regulated during the regenerative process of the liver.

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We believe that the risk of significant hyponatremia after treatment with intravenous DDAVP may be higher than is generally appreciated and that patients undergoing surgical procedures, who often receive multiple doses of DDAVP and intravenous hydration, are at particular risk for this complication. The enhancing activity was thus considered to be mediated by an afferent blockage of immune responses. Biodegradation of nanocrystalline cellulose by two environmentally-relevant consortia. Evidence from the literature suggests that the nervous and the immune systems closely interact via neuromediators, which affect the immune system, and cytokines, which control nerve cell growth and activity. Using RT-PCR we also show that mRNA for the polymeric immunoglobulin receptor (PIgR), which transports IgA across mucosal epithelia, is expressed only in the prostate but not in other regions of the male reproductive ducts upstream of the prostate. Although most of these problems could have been solved with other imaging methods, magnetic resonance tomography did add some valuable diagnostic information. Implantation of a phakic IOL in a highly myopic eye of a patient between 30 and 50 years of age can be considered an adequate technique with a lower risk for loss of BCVA than CLE. Lumbar cerebrospinal fluid from 36 unmedicated and six medicated schizophrenic patients and 23 controls was analyzed by gas chromatograph-mass spectrometer. The shortening of TC at 12 hr is manily due to an effect on tramadol 100mg dose TG1, which is shortened from 8-55 hr in untreated animals to 1-8 hr in estradiol treated animals.

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Clostridium botulinum type E antigens prepared from washed cells by either Formalin treatment or heating at 100 C were used for immunizing rabbits. We speculate that these subunits can presumably form a nucleosome-like structure on DNA, which would allow PCAF to contribute to the maintenance of an active state of chromatin. The competitive reaction between copper(II) and zinc(II) ions for the native copper sites of copper free bovine superoxide dismutase was also investigated. However, the time course and progression of weight loss before and after diagnosis have not been thoroughly evaluated. However, controlled studies are needed to investigate the use of AEDs in patients with PTSD and bipolar disorder. The synthesis was abolished by the stereoselective inhibitors of NO synthase, NG-monomethyl-L-arginine and NG-nitro-L-arginine-benzylester.

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Effects of prostaglandins and thromboxane analogues on bullock and dog iris sphincter preparations. The differentiation between sample stimulus and comparison stimuli, indispensable in MTS, implies operational difficulties for simulations. Transglutaminase 2 (TG2) is highly expressed during chondrocyte maturation and contributes to the formation of a mineralised scaffold by introducing crosslinks between extracellular matrix (ECM) proteins. Surgical complications in prolonged therapy with steroid hormones. Both the in vivo priming and the in vitro activation were shown to require the presence of living parasites.

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Diphtheria antitoxin levels and the Schick reaction in mothers and their newborns. They support a variety of functions in the information system, ranging from structured documentation to knowledgebased functions. In this paper, we show that in activated eggs lacking the material that originates from the oocyte nucleus, MPF and kinase oscillations occur in the absence of surface contraction waves. All compounds produced dosage-dependent decreases in motor activity. Acute promyelocytic leukemia with a PLZF-RARalpha fusion protein. Biochemical changes in rat liver after acute beryllium poisoning. This protection was greater than that offered by addition of the known antioxidant vitamins ascorbic acid and alpha-tocopherol, or the compounds 17beta-oestradiol and altace and alcohol Tamoxifen which have similar structures to isoflavonoids and are known to have weak antioxidant properties.

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SSD has not been as widely implemented as the other components and patients are undergoing re-intubation to facilitate it. Broader clinical and anatomical experience with cerebral pain operations. One possibility is that GAPDH ultimately provides energy in the form of ATP. Coarse and fine N1 tuning for print in younger and older Chinese children: Orthography, phonology, or semantics driven?. In both elastase and saline theolair 250 mg hond exposed rats, the saline volume-pressure curves expressed as a percentage of maximal lung volume were similar in fed and starved groups. Model 2 takes into account the spatial particle fluence distribution in the PS plane. NRCs arise from midline structures in young people, and NRCs with BRD4-NUT are highly lethal, despite intensive therapies.

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TB case notifications, treatment outcomes and information on TB/HIV coinfection are analysed descriptively. Participants took either 1.5mg of LNG as a single dose or in two doses 12h apart, up to 120h of unprotected intercourse. Retrospective study of the clinical records for a random sample of 10-year-old children who had a DGA before November 1998. The only urodynamic parameter 6 months postoperatively that differed significantly from the preoperative value was the functional urethral length, 1.6 and 4.3 cm., respectively. Orthodromic responses to contralateral cortical stimulation consisted of brief excitatory postsynaptic potentials that were followed by powerful and loxapine 25 mg tablet longer-lasting inhibitory postsynaptic potentials. Tissue and species conservation of the vertebrate and arthropod forms of the low molecular weight (16-18000) proteins of gap junctions.

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