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Caldix (Calcitriol)
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Caldix

Caldix is a form of vitamin D3. Vitamin D helps your body absorb calcium from the stomach. Caldix is used to treat hyperparathyroidism (overactive parathyroid glands) and metabolic bone disease in people who have chronic kidney failure and are not receiving dialysis.

Other names for this medication:
Admax, Alfabond, Alfacal, Alfacalcirol, Alfacip, Arachitol, Aristrol, Biocitral, Bonestat, Calbec, Calcigra, Calcimet, Calcit, Calcitriol, Calcor, Calday, Caldix, Calgel, Calosto, Caltin, Caltive, Caltop, Carcal, Citroj, Coecoral, Denscal, Fovit, Ikmag, Kurecal, Nutribone, Osteobel, Ostonex, Politrol, Primacal, Qpcal, Riecal, Ritoca, Rockbon, Roical, Rolsical, Septriol, Solbiocal, Sorvate, Statbone, Sunmic, Tobalt, Trolec, Zaxial

Similar Products:
Trileptal, Amethopterin, Zetia, Microzide, Antabuse, Imuran, Lipitor, Ditropan

Also known as: Calcitriol

Description

Generic Caldix is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Caldix are intestine and bone. Generic Caldix receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Caldix may also act on the kidney and the parathyroid glands. Generic Caldix is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Caldix has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Caldix, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Caldix in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Caldix produces other independent beneficial effects. Caldix is also known as Calcitriol. Generic Caldix treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Caldix is Calcitriol. Brand name of Generic Caldix is Caldix.

Dosage

This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Rocaltrol. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Caldix and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Caldix are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Problems in children have not been reported with intake of normal daily recommended amounts. Some studies have shown that infants who are totally breast-fed, especially with dark-skinned mothers, and have little exposure to sunlight may be at risk of vitamin D deficiency. Your health care professional may prescribe a vitamin/mineral supplement that contains vitamin D. Some infants may be sensitive to even small amounts of alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol. Also, children may show slowed growth when receiving large doses of alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol for a long time.

Studies on doxercalciferol or paricalcitol have been done only in adult patients, and there is no specific information comparing the use of doxercalciferol or paricalcitol in children with use in other age groups.

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Part-time workers are not being discriminated against when they are denied the same rights as their full-time colleagues, the High Court ruled last week when it turned down a judicial review brought by the Equal Opportunities Commission. This study provides the first evidence of a direct link between the adoption of a genetically modified (GM) crop and improvements in human health. Some constructive caveats on action psychology and the study of intention. We find that the experimental results are consistent with a simple band structure model where localized electronic states are available in the band gap (trap states) in the vicinity of the nanoparticles. In parts I and II, PGE2 0.1 microgram/g body wt was given subcutaneously 30 min before ethionine. This could be due to the use of 8-methoxypsoralen in the test so that particularly the shorter UVA range is evaluated. An unusual case of very-late-onset metachromatic leukodystrophy (MLD) with dementia was studied.

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Unlike PADI4, citrullinated protein generally appeared in fibrin deposits that were abundant in the RA synovium. While existing protocols for cell lysis and sample preparation work well for larger samples, scaling to a single-cell level is challenging because of unavoidable analyte dilution and losses. The use of stereoscopic techniques in conjunction with removal of host cytoplasm permits detection of subtle morphological alterations and progressive deterioration of the fungal component. Japanese encephalitis--an important cause of acute childhood encephalopathy in Lucknow, India. We report a case of transitional cell carcinoma in a horseshoe kidney. The patients who died also revealed a pronounced reduction of functional kallikrein inhibition determined by a chromogenic peptide substrate assay.

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Mendeleev Moscow Chemical Technological Institute (MCTI) was used in combined therapy of hepatic failure. Phosphatidylserine translocation was significantly increased only with H2O2 treatment. Genetic mapping of the gene encoding the alphal subunit of neuronal calcium channels. The cavefish lens vesicle was also shown to express a gamma-crystallin gene, suggesting that Prox 1 is functional in cavefish lens development. When large amounts of the G188E variant were applied to the column, small but significant amounts of high affinity, active enzyme were recovered. Distinctive CSF findings included elevated human immunodeficiency virus-specific indices. beta-Adrenergic receptors stimulated peroxidase secretion from rat lacrimal gland. The utilisation of MUC1 related immunogens to stimulate immune responses to tumours could lead to the improved management of patients and the development of new immunotherapeutic strategies aimed at the eradication of MUC1 mucin expressing cancers. If food was withheld during stimulation, there was a large increase in the glucose level and alarge decrease in the insulin level.

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Synthesis and characterization of the L-cysteine-glutathione mixed disulfide. We determined if IgE in sera of patients who have had life-threatening systemic reactions to English walnut bound protein extracts from all tested walnut cvs (57 cvs total) or species (six) by Western immunoblot. Twenty-six out of twenty-seven LE-factor-positive sera contained antinuclear antibodies that cross-reacted with plasma membranes of viable leucocytes (referred to as X-ANA). Outbreaks of classical swine influenza in pigs in England in 1986. Electron microscopic observations on the epithelium of the chorionic villi of the human placenta. Polyclonal activation of Ts cells with antiserum directed against an IGH-1 linked candidate for a T-cell receptor constant region marker. In none of the cases could any titer of HES-reactive antibodies be detected. We found by proteomic analysis that allantopyrone A, a metabolite isolated from an endophytic fungus, upregulates the expression of proteins that are regulated by the transcription factor Nrf2. Moreover, both drugs caused a significant shortening of the euglobulin lysis time and a diminution of platelet adhesiveness.

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Antispasmodic effects of the essential oil of Croton nepetaefolius on guinea-pig ileum: a myogenic activity. Different effects of platinum, palladium, and rhodium salts on lymphocyte proliferation and cytokine release. Mild myasthenia gravis patients were compared with normals with respect to the capacity of their motor nerve endings (MNEs) to generate a neostigmine-induced postactivation repetition (PAR). Taking into account strong dependence of the volume rate of filling the capillaries with the solution upon the capilliary radii (r-4) one may come to the conclusion that Ca-45 saturation of the paracapillary spaces in the wide capillaries occurs much sooner than in the narrow ones. The frequency distribution of the blood group phenotypes ABO was examined in retrospect in a selected group of 241 Patients with grass pollen hayfever.

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Consumption of drugs for sea lice infestations in Norwegian fish farms: methods for assessment of treatment patterns and treatment rate. Although no beta-galactosidase activity could be induced in Escherichia coli K12 during uridine starvation, material which cross-reacted with antiserum against beta-galactosidase could be detected. This study aimed to assess the association of mid-regional (MR) pro-adrenomedullin (MR-proADM) and MR-pro-A-type natriuretic peptide (MR-proANP) antabuse 400mg tablets in comparison to N-terminal pro-natriuretic peptide (NT-proBNP) with outcome in patients with aortic stenosis (AS) treated with transcatheter aortic valve implantation (TAVI). For deforming organs including the liver, intraoperative geometric measurements play an essential role in computer surgery in addition to pre-operative geometric information from CT/MRI. Loop-specific tipmost nearest neighbors are revealed at longer tips: CUC(UUCG)GAG, GUA(GCAA)UAC with a maximum at tip sizes 5-6, and GWG(CUUG)CWC. Requirement of serum pretreatment for induction of alkaline phosphatase activity with prednisolone, butyrate, dibutyryl cyclic adenosine monophosphate and NaCl in human liver cells continuously cultured in serum-free medium. Cloning of the Aspergillus oryzae 5-aminolevulinate synthase gene and its use as a selectable marker.

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Shiga toxin producing Escherichia coli (STEC) are bacterial pathogens involved in food-borne diseases. Target organs were typical for an antifolate and included gastrointestinal tract, lymphoid tissues, and the hematopoietic and male reproductive systems. The use of diadynamic currents in pain syndromes in patients with herpes zoster. However, even after controlling for gingivitis, the presence of subgingival periodontitis was associated with an altered supragingival plaque. Any improvement in functional outcome distribution has value, and herein we provide an assessment of the effect of tenormin generic alteplase on the distribution of the functional level by treatment delay, age, and stroke severity. In the gastrointestinal tract malignant lymphoma, centrocytic, produces a characteristic classic clinicopathological picture (MLP).

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LNCaP tumors in the mouse prostate (but not PC-3M tumors) elaborated detectable levels of human prostate-specific antigen (PSA) in the serum, even when tumors were small (1.5 mm in diameter). A carbonyl rather than hydroxyl group at position C-1 of the indan is most beneficial for reversible antagonism. In the pars intermedia immunoreactive cells containing ACTH beta(1-24), ACTHbetap(17-39), bMSHbeta and/or bMSH alpha were observed. Treatment modalities for zithromax 500 mg daily metastatic bone tumors and associated issues: focusing on surgical indications and techniques for metastatic lesions in limb bones. Variations in the prevalence of enterovirus infections in Ontario, 1956-1965. All 60 patients undergoing a Fontan type procedure at the National Heart Hospital, London, during the study period (mean age (SD) 12.3 (6.8) years). The tissue distribution mechanism of adriamycin (ADR), its relatives, daunomycin (DNR), adriamycinol (ADR-ol), daunorubicinol (DNR-ol) and actinomycin D (ACT-D) has been studied in rats and rabbits. Children with perinatal HIV infection were randomly selected from a large, long-term, follow-up protocol. Production of primate D-type virus interspecies-specific antigen during cocultivation of human breast fibroadenoma cells with bat lung cells.

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The anterior commissure, medial and lateral bed nuclei of the stria terminalis and both sides of the medial prefrontal cortex showed a progressive increasing of wheat germ agglutinin-horseradish peroxidase labeling (WGA-HRP) in successive stages of amygdaline kindling, after 48 h of a right amygdala WGA-HRP injection. The central nucleus acts as a focus for a number of converging/diverging peptide pathways and incoming catecholaminergic afferents. In contrast to AICN, in PHN no pronounced changes of the glomerular ECM occurred, except for transient expression of type I collagen mRNA in whole glomerular RNA and type I collagen protein the GEC cytoplasm. These include the amide nitrogen of glutamine, the alpha-amino nitrogens of glutamate and other amino acids, the guanidino nitrogens of arginine, the ureido nitrogen of citrulline, the side-chain nitrogens of ornithine or lysine, or both, and uridine diphosphates. Planarian regeneration involves the generation of new tissue at the wound site via cell proliferation (blastema formation), and the remodeling of pre-existing tissues to restore symmetry and proportion (morphallaxis). The clinical presentation may be heralded by the development of dyspnea, congestive heart failure, angina, endocarditis, dysrhythmias or myocardial infarction.

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Bacterial expression of an immunologically reactive PCV2 ORF2 fusion protein. Lack of gastritis and of an adaptive immune response in interferon regulatory factor-1- rebetol dosage deficient mice infected with Helicobacter pylori. Melittin, a naturally occurring antimicrobial peptide, exhibits strong lytic activity against both eukaryotic and prokaryotic cells. Potassium sorbate as a widespread industrial preservative and glucose are two important oxidants that can be involved in oxidative stress. Lateral face reconstruction with the medial-based cervicopectoral flap. The authors found a significant decrease in IL-8 serum levels in patients undergoing a paclitaxel-containing chemotherapy regimen, indicating that IL-8 possibly acts as a useful monitoring marker in patients with ovarian carcinoma. Immunoglobulin A level in human milk from mothers delivering preterm. Role of Intra-Aortic Balloon Pump and Extracorporeal Membrane Oxygenation in Early Graft Failure After Cardiac Transplantation. An immobilized glucose isomerase for the continuous conversion of glucose to fructose. Our study questions the validity of previous studies and necessitates the need for standardizing the description of disc degeneration, phenotype selection, study sample size, age, and other variables in future studies.

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