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Calaptin (Verapamil)

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Calaptin belongs to a group of medicines called calcium channel blockers or calcium antagonists. They work by opening up blood vessels, which lets more blood and oxygen reach the heart and at the same time lowers high blood pressure. Calaptin also helps to control fast or irregular heartbeats.

Other names for this medication:
Calaptin, Covera, Isoptin, Vasopten, Veramil, Verapamil, Verelan, Verpitos, Zolvera

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Also known as: Verapamil


Verapamil is used alone or together with other medicines to treat heart rhythm problems, severe chest pain (angina), or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .

Verapamil is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, verapamil relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload .

This medicine is available only with your doctor's prescription .


This section provides information on the proper use of a number of products that contain verapamil. It may not be specific to Calan. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet .

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well .

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease .

Swallow the extended-release tablet whole with a full glass of water. Do not break, crush, or chew it. It is best to take this medicine with food .

If you cannot swallow the verapamil extended-release capsules, you may open it and sprinkle the pellets contained in the capsule on one tablespoon of applesauce. This mixture must be swallowed immediately with a glass of cool water. The applesauce should not be hot and should be soft enough to be swallowed without chewing. Do not chew or crush the pellets .

If you are taking the extended-release tablets, you may sometimes notice what looks like a tablet in your stool. This is the empty tablet shell that is left after the medicine has been absorbed .

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For chest pain: For oral dosage form (tablets): Adults—The usual dose is 80 to 120 milligrams (mg) three times a day. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor . For oral dosage form (extended-release tablets, 24 hr): Adults—At first, 180 milligrams (mg) once daily at bedtime. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor . For heart rhythm problems: For oral dosage form (tablets): Adults—The total usual dose is 240 to 480 milligrams (mg) divided in three or four equal doses per day. Children—Use and dose must be determined by your doctor . For high blood pressure: For oral dosage form (tablets): Adults—At first, 80 milligrams (mg) three times a day. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor . For oral dosage form (extended-release capsules): Adults—At first, 200 milligrams (mg) once daily at bedtime. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor . For oral dosage form (extended-release tablets): Adults—At first, 180 milligrams (mg) once daily in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor . For oral dosage form (extended-release tablets, 24 hr): Adults—At first, 180 milligrams (mg) once daily at bedtime. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor .


If you overdose Calaptin and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Calaptin overdosage: slow heartbeat, fainting fit.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Calan SR dosage information

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


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These cells appear to be similar to human umbilical vein endothelial cells (HUVEC) in sensitivity to oxidant-induced injury. Analysis of population pharmacokinetics offers an approach by which to examine the roles of various factors which are likely to be clinically relevant for the safe and effective use of drugs.(ABSTRACT TRUNCATED AT 400 WORDS). ECD-SPECT images of three patients displayed a focal decreased uptake in the infarcted lesions, while in infarcted foci, there was almost equivalent or increased CBF compared to normal and unaffected areas, decreased CMRO2, and high HMPAO uptake. Biochemical evidence suggests that methanol catabolism in Methanosarcina species requires the concerted effort of methanol:5-hydroxybenzimidazolylcobamide methyltransferase (MtaB), a corrinoid-containing methyl-accepting protein (MtaC) and Co-methyl-5-hydroxybenzimidazolylcobamide:2-mercapto-ethanesulphonic acid methyltransferase (MtaA). Heart rate variability analysis before SA may predict hypotension after SA with high sensitivity and specificity. NMDA receptor binding declines differentially in three spinal motor nuclei during postnatal development. Calcitriol and CB1093 act synergistically with human recombinant TNF-alpha in activation of TNF-alpha mRNA expression in LNCaP but not in PC-3 cells.

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PCC6803 was used to isolate a subcomplex of the enzyme from Triton X-100 solubilized total membranes by immunoaffinity chromatography. Susceptibility differences within the smoking population should be taken into consideration in studies of the pathogenesis of emphysema. A high throughput messenger RNA differential display screen identifies discrete domains of gene expression and novel patterning processes along the developing neural tube. Owing to the equilibrium, the relative electric-field-induced changes of the quantum yields of the LE and exciplex emissions as functions of the magnetic field are linearly connected to each other. Benign mucous membrane pemphigoid with laryngeal stenosis in a patient with thyroid carcinoma. Diagnostic use of ambulary blood pressure monitoring in medical practice. In all patients, left atrial pressure was monitored successfully while central venous pressure was monitored with the second port positioned in the superior vena cava.

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The operation involves the use of a multifingered sheet of Marlex mesh, a material with characteristics that make it ideal for repair of large hernias. Optomotor responses to monocular stimulation: relation to visual system organization. On the etiology and treatment of aphthous diseases, with special consideration of chronic recurring oral aphthosis. Plasma prolactin and cortisol concentrations during the following 5 h increased to a similar extent in all three subject groups, despite increased levels of anxiety and depression (as scored on the Hospital Anxiety and Depression Scale and Beck Depression Inventory) in the IBS and inflammatory bowel disease patients compared with the healthy controls. Effects of culture media on detection of methicillin resistance in Staphylococcus aureus and coagulase negative staphylococci by disc diffusion methods. Stem cell science and politics: a talk with Elizabeth Blackburn. The gene of the CD44 cell surface glycoprotein consists of 20 exons.

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The synergism between G-CSF and ATRA is evident at concentrations of the retinoid between 10(-7) and 10(-5) mol/L and at concentrations of the cytokine between 1 and 10 ng/mL. To compare solubility, microhardness and radiopacity of ProRoot mineral trioxide aggregate (MTA) with two Portland cements (PC: CEM I and CEM II). On the epidemiology of multiple sclerosos based on reaserch in Berlin. Chronic infection and frailty: surrogate markers, associations, and causality. Strong modulation of magnetoresistance and Hall resistance as a function of the gate voltage is observed as the sample thickness approaches the screening length. Levels of polycyclic aromatic hydrocarbons in some coal tar skin preparations. In other words, adenine and thymine are distributed in an asymmetric way between the exon and the complementary strand, and the coding sequence is mostly located in the adenine-rich strand.

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The mechanism of the enhanced activity of BO-2727 against imipenem-resistant Pseudomonas aeruginosa was studied by using a set of four isogenic strains derived from beta-lactamase-deficient P. Comparative pharmacology of nitric oxide and nitric oxide generators on cardiac contractility in mammalian species. Cells were exposed to varying concentrations of CDDP with and without concomitant STS, and 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assays were then performed to determine the effect of treatment on FADU cell growth. Power Doppler sonography was accurate and reliable in measuring tumor vascularity changes in this model. Cochlear implantation in a patient with bilateral temporal bone fractures. Preliminary evidence suggests that interferon therapy given after transplantation entails an unacceptable rate of deterioration in graft function.(ABSTRACT TRUNCATED AT 250 WORDS). Production of a human monoclonal antibody to normal basal and squamous cell carcinoma-associated antigen. Evaluation of exposure reducing measures on parameters of genetic risk in a population occupationally exposed to coal fly ash. However, the use of hemodynamic measures limits the temporal resolution on which the brain process can be followed.

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Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities. In the presence of glutathione (5 mM) the level of AP-sites rose with increasing concentrations of chromate (75-200 microM). To review the indications, diagnostic yields and complications of transbronchial biopsy (TBB) in a tertiary hospital in the State of Qatar. They also showed the greatest declines in forced expiratory volume and forced vital capacity. New antibiotic Sch 725424 and its dehydration product Sch 725428 from Kitasatospora sp. Duodenal NF-E2 mRNA levels were generally low and decreased in the hypoxic and iron-deficient groups, both of which exhibited elevated iron absorption as compared to controls.

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A computerized record chart for the study of chronic daily headache. Color changes of resin composites in the reflectance and transmittance modes. These novel reagents exploit the ubiquitin-mediated proteasome degradation pathway to target the ligand-bound protein for intracellular degradation. Cellular and molecular aspects of the multistage progression of mammary carcinogenesis in humans and rats. The goal of this study was to investigate the value of biplanar transesophageal echocardiography (TEE) as a screening tool for aortic tear in unstable trauma patients. Co-existence of Chiari I malformation and myelomeningocele is uncommon.

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Here we articulate a model based on Autopoietic theory and nonlinear quantitative analysis that stands to provide a method and a metric to feldene medication generic explore how psychotherapy processes lead to a measurable outcome. Early morning stiffness was pronounced in two and minimal in the rest. A patient who experienced painless intolerance to light (dazzle) three months after a right posterior cerebral artery occlusion was shown by computerized tomography to have right occipital and right thalamic infarctions. Components in the extract were separated by reverse-phase high-pressure liquid chromatography. Participation of aldosterone in the vascular inflammatory response of spontaneously hypertensive rats: role of the NFkappaB/IkappaB system. Strategies used in the approach to genome studies are discussed. As with the internal energy or heat-capacity calculation, different estimators yield different variances (and therefore different convergence properties) in a Monte Carlo calculation. Rural proofing is a systematic methodology that will help policy makers take account of health needs in rural areas and will hold public bodies accountable to their rural communities. With a brief survey of anatomy and classification as well as the pathology they provoked: urinary infection and incontinence.

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The paper discussed the implications of this form of randomization for the design and analysis of the trial. meningitidis determines its ability to withstand complement-mediated lysis, through the intimate relationship between metabolism and virulence in the bacterium. In this technique I first extract a complex hologram of a thick object by using optical scanning holography. Mapping of the 19p13 breakpoint in an ovarian carcinoma between the INSR and TCF3 loci. Sensitivity of 3T3 cells to low serum concentration and the associated problems of serum withdrawal. Some regional differences may account for an altered in vivo efficacy of this drug. Peptide 3 (YEKEPTPPTRTPDQ) and peptide 6 (TPEDPTDPTDPQDPSS), accessible on the native SR protein as demonstrated by their reactivity in enzyme-linked immunosorbent assays with rat antisera raised against protein SR, correspond to immunodominant regions of SR. Effects of adeno-associated virus DNA hairpin structure on recombination. As a consequence of more intensive bone marrow toxic therapeutic approaches there is an increased use of platelet transfusion, and the refractory state is encountered in about half of young patients treated for haematological malignancies. To investigate the role of the sympathetic nervous system in the early cardiovascular response to IL-1 beta in humans, we recorded the heart rate, blood pressure, and changes in hand vein compliance in five patients with malignant melanoma treated with a 30-min infusion of 10,000-20,000 U/kg of human recombinant IL-1 beta.

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The gene responsible for the appearance of NADH-dependent sulfite reductase activity was cloned into a vector plasmid pBR322 to give a 5.7-kb hybrid plasmid, pTHS1, which contains a 1.3-kb DNA fragment of T. Mutations have been identified in the genes encoding IFN-gamma-receptor-1, IFN-gamma-receptor-2 and Stat-1. Grade III leukopenia and neutropenia were seen in seven patients, but were only severe enough in two to require discontinuation. The authors compare common anthropometric measurements in an effort to determine which is the most suitable for the individual assessment of malnutrition. On the basis of electron microscopic analysis of replication intermediates, we confirmed that the plasmid levaquin uti dosing replicates unidirectionally by a theta mechanism. Socio-economic factors, particularly education, the health care system and the perceived or actual cost of fertility regulation as compared to benefits expected from children also powerfully influence contraceptive use. 18FDG-PET and electroencephalographic findings in a patient suffering from musical hallucinations. Locomotion of the mesencephalic cat evoked by pyramidal stimulation. Occurrence of renal pelvic refluxes during rising urine flow rate in rats and hamsters. Extracapsular growth of lymph node metastases in squamous cell carcinoma of the vulva.

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Our results indicate that increased intracellular calcium causing signal transduction activation through the calmodulin pathway is a necessary, but insufficient, component of the LPS signaling in M phi. Global absence is nearly always unilateral and is most often seen with blunt abdominal trauma with renal pedicle injury. Sub-acute and sub-chronic toxicity of mono-2-ethylhexyl phthalate in the rat. Generalised reliability characteristics for probabilistic networks. The literature regarding the complications of pulse methylprednisolone therapy is reviewed, with particular emphasis on the incidence and pathogenesis of arrhythmias. The effect of recombinant human tumor necrosis factor alpha (TNF-alpha) on tumor growth and tumor cell proliferation of a human renal cell carcinoma transplanted into nude mice as well as on the body weight of the tumor-bearing animals has been studied. In an example the algorithm is applied to the diagnosis assistance of some neuropathies. In contrast to results reported previously for cold-blooded vertebrates, introduction of 20 mM GABA into the superfusate had no influence upon the response properties of cat retinal horizontal cells (HCs). Altered brain sensitivity to ethanol in mice after MPTP treatment.

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The effect of early antiretroviral therapy (ART) on the early progression of perinatal human immunodeficiency virus (HIV) infection is not well defined. Streptozotocin-induced chromosomal aberrations, SCEs and mutations in CHO-9 parental cells and in EM-C11 mutant cell line. Viral load in samples from hepatitis C virus (HCV)-infected patients with various clinical conditions. The action of expectorant herbs results primarily from their influence on the gastric mucosa and following a reflex stimulation which leads to an increase in secretion of the bronchial glands. SNARK is a member of the AMPK subfamily of serine/threonine protein kinases. Recent data showed that certain probiotic species decrease relapse of UC. Synthesis of amaryl starting dose phosphatidyl-dCMP in human lymphocytes and its enhancement by chlorpromazine. We have established IgG rheumatoid factor (RF)-secreting hybridoma cell lines from the synovial tissues of two patients (TS and SJ) with rheumatoid arthritis (RA) and one (KL) with the polyarticular form of juvenile rheumatoid arthritis (JRA).

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Only 13 of the 24 patients (54 per cent) did not have either disseminated or residual tumor postoperatively. In the HAART era, systematic screening revealed a high rate of anal condyloma in all HIV positive pts (not only in homosexual men). Interactive interviews with 26 nurses were used to elicit explanations of the meaning of coping and stories from their practice that illustrated coping. In a sample of baboons, pelvic support loss consistent with POP was not identified. Analysis of the sites of expression of clock genes suggests that the biological clock for reproductive photoperiodic time measurement is in the medial basal hypothalamus.

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Peptide phage libraries were created by appending six randomized amino acid residues to the C-terminus or to the N-terminus of an 18-mer alpha-helix peptide containing lysine residues. Low output syndrome rarely improved with volume load alone and required inotropic and vasoactive drugs. Monolayered conduits as well as structures comprising two and three layers were engineered in vitro, and their compliance and burst strength were determined. Sixteen ribotypes were determined, and there was no association with virulence genes profiles or serotypes. Here, we have explored the process of dimerization of human 5-HT4 receptor (h5-HT4R) by means of co-immunoprecipitation and bioluminescence resonance energy transfer (BRET). Accordingly, symptoms need to be effectively evaluated not only because symptom alleviation is a target for treatment, but also because they guide prognosis in patients with CHF. Nitric oxide generated by this enzyme contributes to the modulation of the adhesive properties of the endothelial cells. Child behavior and dramamine dosage forms parent management strategies at mealtimes in families with a school-age child with cystic fibrosis. The results from the present study demonstrate how GH can be modulated during both abiotic and biotic stress in fish.

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Weight-bearing dorsoplantar foot radiographs were obtained from 95 subjects (31 men and 64 women) aged 62-94 yr (mean 78.6, s.d. An increase of the stimulation intensity evoked activation of neighbouring structures. Beds for general hospital assistance in the Paraiba Valley, Brazil, 1974. Physiological regeneration of colonic epithelium entails proliferation at the crypt base and cell loss by shedding or cell death. The generalized Smoluchowski convective-diffusion equation, determined analytically from a combination of the particle-phase pressure tensor and the inertial acceleration term, contains a shear-dependent cross derivative term and an additional term along the streamwise direction, neurontin 300 mg dosage quadratic in the particle Stokes number. The key areas addressed in this review include PCOS and the development of type 2 diabetes mellitus and gestational diabetes, as well as the use of insulin-sensitizing agents, particularly metformin, in the management of infertility in obese and non-obese PCOS women. Results with the Austin Moore prosthesis and the Smith-Petersen cup. While the motor domain remains in a state similar to rigor, the light-chain-binding domain swings through approximately 32 degrees, resulting in a approximately 50-A movement at the end of the region visualized (the second calmodulin light chain). Type I collagen was a major factor in collagen matrix formation, especially in the relatively late phase. Detection of aldehyde dehydrogenase deficiency in Chachi Indians, Ecuador.

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Isolation and characterization of heparan sulfate from crude porcine intestinal mucosal peptidoglycan heparin. Double-immunofluorescence labeling with antibodies against stathmin and PCNA, a marker of cell proliferation, demonstrated colocalization of stathmin and PCNA at 48 and 72 h of reperfusion in hepatocytes, indicating the initiation of cell proliferation. All patients were followed for a minimum of 5 months after loading of the implants. The treatment was well tolerated and progression of HIV disease was not seen. We describe seven families with genetically transmitted hypertrophic cardiomyopathy that were studied with echocardiography or necropsy, or both, and were selected because they were known to include relatives who had incurred either premature sudden cardiac death or the end-stage phase of the disease. Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo. At fracture healing the mean radial height was 11 mm, mean radial inclination was 21 degrees, and mean volar tilt was 5 degrees.

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Laser surgery in laryngeal diseases in children (preliminary report). Intraoperative gallbladder perforation is a common complication encountered during the surgery. Clinical clomid dosing male observations of the electrocardiographic two-step exercise test. Environmental variables related to community placement failure in mentally retarded adults. Inclusion of CoCl2 during the purification of recombinant UCRP blocks the proteolytic inactivation of the polypeptide occurring by cleavage of the carboxyl-terminal glycine dipeptide required for activation and subsequent ligation. Furthermore, multiparous and primiparous parents did not differ significantly in the extent to which they perceived themselves to be prepared for infant care. glauca and the Rirol genes of Agrobacterium rhizogenes, we performed fluorometric and histochemical analysis of transgenic genetic tumors on the hybrid of Nicotiana glauca x N. Therefore, GRP receptors may not only stimulate tumor cell proliferation, but also affect tumor microcirculation.

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Clinical considerations on epidural hematoma at the vertex of the cranium. The shortest latencies in area V2 were observed in the infragranular layers and they did not differ significantly from those found in the infragranular layers in V1. So far only subtherapeutic levels of protein have been produced but human trials are starting and progress can be expected. Improved ankyloglossia correction with four-flap Z-frenuloplasty. Hydrogenated oils and fats: the presence of chemically-modified fatty acids in human adipose tissue. The percentage of spermatozoa with normal morphology was higher in the cervical mucus than in the semen. Further evidence for an acetylator phenotype difference in the metabolism of hydralazine in man. It may be presumed that these abnormal MIBG findings were caused by high plasma catecholamines concentration. Molecular action mechanisms of the therapeutic agents for kidney diseases: Immunosuppressants.

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