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Bufferin (Ibuprofen)

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Bufferin is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation. Bufferin comes as a tablet to take by mouth. It is usually taken three or four times a day for arthritis or every 4 to 6 hours as needed for pain.

Other names for this medication:
Advil, Alfam, Answell, Arthophen, Brudex, Brufen, Bruffen, Brutiz, Bruzen, Bufferin, Buftiz, Calpol, Citanz, Combidin, Cypaflam, Diplodac, Dolgesic, Elbugesic, Emflam, Genpril, Gesic, Haltran, Ibuclin, Ibucon, Ibular, Ibulite, Iburic, Iburin, Ibuspa, Infen, Ipecee, Maxofen, Methoriv, Nildol, Nuprin, Parvon, Spinach, Sugafen, Tabalon, Tidifen, Tizapam, Tricofen

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Also known as: Ibuprofen


Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, and helps to relieve symptoms of arthritis (osteoarthritis, rheumatoid arthritis, or juvenile arthritis), such as inflammation, swelling, stiffness, and joint pain. This medicine does not cure arthritis and will help you only as long as you continue to take it .

In addition, ibuprofen can be used to treat fever, menstrual cramps, and other conditions as determined by your doctor .

This medicine is available both over-the-counter (OTC) and with your doctor's prescription .


This section provides information on the proper use of a number of products that contain ibuprofen. It may not be specific to Children's Motrin Grape Flavor. Please read with care.

For safe and effective use of this medicine, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of this medicine may increase the chance of unwanted effects, especially in elderly patients .

When used for severe or continuing arthritis, this medicine must be taken regularly as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine .

To lessen stomach upset, you may take this medicine with food or milk .

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets and suspension): For fever: Children over 2 years of age—Use and dose must be determined by your doctor. Children 6 months of age up to 2 years—Dose is based on body weight and body temperature, and must be determined by your doctor. For fever lower than 102.5 °F (39.2 °C), the dose usually is 5 milligrams (mg) per kilogram (kg) (about 2.2 mg per pound) of body weight. For higher fever, the dose usually is 10 mg per kg (about 4.5 mg per pound) of body weight. The medicine may be given every six to eight hours, as needed, up to 40 mg per kg per day. Infants younger than 6 months of age—Use and dose must be determined by your doctor . For menstrual cramps: Adults—400 milligrams (mg) every four hours, as needed. Children—Use and dose must be determined by your doctor . For mild to moderate pain: Adults and teenagers—400 milligrams (mg) every four to six hours, as needed. Children over 6 months of age—Dose is based on body weight and must be determined by your doctor. The dose usually is 10 milligrams (mg) per kilogram (kg) of body weight every six to eight hours, as needed, up to 40 mg per kg per day. Infants younger than 6 months of age—Use and dose must be determined by your doctor . For osteoarthritis and rheumatoid arthritis: Adults and teenagers—1200 milligrams (mg) up to 3200 mg per day divided into three or four equal doses. Children—Dose is based on body weight and must be determined by your doctor. The dose usually is 30 milligrams (mg) to 40 mg per kilogram (kg) of body weight per day, divided into three or four doses. Infants younger than 6 months of age—Use and dose must be determined by your doctor .


If you overdose Bufferin and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Bufferin overdosage: uncontrolled eye movements, blue color around lips, mouth, and nose, slow breathing, feeling lightheaded.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Motrin Childrens dosage information

Side effects

The most common side effects associated with Bufferin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Seventeen specialist cardiac surgery centres in UK NHS hospitals. Localised disturbance of aeration in children is as often the result of mucosal swelling due to infection as resulting from an inhaled foreign body. Cage activity in the can you take 40 mg of prilosec a day laboratory beagle: a preliminary study to evaluate a method of comparing cage size to physical activity. Anopheles funestus is one of the major malaria vectors in tropical Africa, notably in Senegal. This facilitated surgery by eliminating the major blood supply to the tumor and resulted in collapse of the large collateral veins and created edema within the perirenal tissue. One of the purposes of this study was to examine a wide range of parameters to establish a better understanding of the effects of field strength and pulse length. Targeted gene disrupted mice can be efficiently generated by expressing a single guide RNA (sgRNA)/CAS9 complex in the zygote.

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Viral DNA was found before histologic evidence of fibroblast proliferation and persisted in low copy number, compared with viral DNA of naturally developing fibromas. In a Neighbor-Net analysis of sequence similarity with homologues from numerous prokaryotes and eukaryotes, cytosolic phosphoglycerate kinase of E. Concentration-response curves for the contractile effects of noradrenaline and the alpha 1-adrenoceptor agonist methoxamine, obtained in strips of rabbit main pulmonary artery under various experimental conditions, characterized methoxamine as a full agonist with approximately one-third of the potency of noradrenaline. Data from 230 residents (82 men, 148 women) in the model area of Town A, aged 65 or over, were analyzed in the present study. Eight percent of these cases were not diagnosed by an initial ultrasonographic evaluation. Methods were established for the detection of parvovirus DNA in human serum using single-stranded RNA probes. K562 cells that overexpressed p28 continued to divide, had fewer hemoglobin-producing cells, had a smaller mean cell diameter and had a 5.5-fold increase in cell survival. Detection of shared H-2Kk and H-2Dk antigens that function as self determinants for cell-mediated lympholysis to trinitrophenyl-self.

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No effect of phenobarbital pretreatment of rats on methotrexate pharmacokinetics in the isolated liver perfused in a single-pass way. Several cardioactive peptides have been identified in insects and most of them are likely to act on the heart as neurohormones. In this study, we found that invertebrate Aurora-A and Aurora-B kinases are highly divergent protein families from their chordate counterparts. Activation of Eph receptors or ephrins can lead either to cell repulsion or to cell adhesion and invasion, and recent work has found that cells can switch between these distinct responses. Engagement of CD3 and CD28 specifically up-regulated CXCR-3 expression and chemotaxis to monokine induced by IFN-gamma and IFN-gamma-inducible protein-10, whereas this stimulation down-regulated CCR-7 expression and chemotaxis to MIP-3beta and 6Ckine in PB T cells, but not in CB T cells. From April 2004 to July 2013, we treated eleven patients (new method group) with Hoffa fracture using the new fixation method (fixed with intercondylar screw and crossed screws) and sixteen patients (traditional method group) using the traditional fixation method (fixed with anteroposteriorly placed screws). This region of the FtsE protein is highly conserved in a large family of proteins involved in diverse transport processes in all living cells, from bacteria to man. Thus, it was confirmed that the TNF receptor is internalized as a TNF-receptor complex in the presence of TNF.

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This congruency effect was asymmetrical, with tactile motion distractors having a stronger influence on auditory motion perception than vice versa In Experiment 2, we used auditory motion targets and tactile motion distractors while participants adopted one of two possible postures: arms uncrossed or arms crossed. Human red blood cells (RBC) infected in vitro with Plasmodium falciparum were employed to prepare several types of antigens (sonicated, infected RBC and purified, sonicated merozoites and schizonts). Renovascular disease is a common, but complex disorder, the most common causes of which are fibromuscular dysplasia and atherosclerosis. Effect of exercise on hepatic gene expression in rats: a microarray analysis. Platelet aggregation was not inhibited by smooth muscle cells that had been pretreated with interleukin-1 beta in combination with either TGF-beta 1, PDGFAB or PDGFBB but not with PDGFAA. To determine whether any sequence changes accompany gene amplification and hence to define more precisely the mechanism of activation of the N-myc gene, we have sequenced a germ-line N-myc gene.

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