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Biortan (Losartan)

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Biortan belongs to a family of medications known as angiotensin II receptor blockers. These medications are used in adults and children over the age of six to lower mild-to-moderate hypertension (high blood pressure).

Other names for this medication:
Aratan, Araten, Cardon, Cartan, Covance, Cozzar, Czartan, Fensartan, Hizaar, Hypozar, Lavestra, Lifezar, Loben, Loctenk, Logika, Lopernal, Losacor, Losagen, Losamet, Losan, Losap, Losapres, Losar, Losarb, Losart, Losartanum, Losavik, Losazide, Lospre, Lotar, Lyosan, Portiron, Prelow, Prosan, Sarilen, Sartens, Sarvas, Sarvastan, Sarve, Sortal, Tacicul, Tanlozid, Temisartan, Tensartan

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Also known as: Losartan


Biortan is indicated for the treatment of hypertension in adults and pediatric patients 6 years of age and older, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and nonfatal cardiovascular (CV) events, primarily strokes and myocardial infarction. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including losartan.

Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than 1 drug to achieve blood pressure goals. For specific advice on goals and management

Biortan is indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy, but there is evidence that this benefit does not apply to Black patients

Biortan is indicated for the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria in patients with type 2 diabetes and a history of hypertension. In this population, Biortan reduces the rate of progression of nephropathy as measured by the occurrence of doubling of serum creatinine or end stage renal disease


Usual Adult Dose for Diabetic Nephropathy:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Adult Dose for Hypertension:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Pediatric Dose for Hypertension:

6 Years or Older: Initial dose: 0.7 mg/kg orally once a day (up to 50 mg total) Comments: -May be given as a tablet or suspension. -Doses above 1.4 mg/kg (or 100 mg) daily have not been studied in pediatric patients.

Detailed Cozaar dosage information


If you overdose Biortan and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Biortan overdosage: fainting, feeling lightheaded, rapid heartbeat.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Biortan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Biortan as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Biortan. Correct volume or salt depletion prior to administration of Biortan.

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We report the case of a patient in whom oral squamous cell carcinoma and a fatal reactive form of histiocytosis were simultaneously manifested. Prognostic significance of morphological features of the tumor front in the presence of micrometastases in laryngeal carcinoma--cytokeration antigens expression in lymph nodes. The authors suggest that formal monitoring of compensation equity is an important and feasible administrative undertaking to correct historical inequities. Several procedures were tried but the best results were obtained from tissue that had been quenched in liquid nitrogen, sectioned at 25 micro in a cryostat, fixed for 30 to 90 minutes at 4 degrees C in formalin-sucrose buffered to pH 7.2, incubated with substrate, and then osmicated and prepared for electron microscopy in the usual way. Targetted expression of a Drosophila NOS (dNOS) transgene to only principal cells of the tubule main segment using the GAL4/UAS system increases diptericin expression. The clinical and metabolic benefits were lost as the dose of GH was increased to 28 U/m2 per week. In this study, we report the relationship between uric acid and various cardiovascular risk factors in 1,027 healthy Taiwanese adults living in Alien, an agricultural town in subtropical South Taiwan.

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Drug-induced changes in renal hippurate clearance as a measure of renal blood flow. (2) failure to develop a salivary protein pattern unique to male mice, and (3) attainment of higher levels of fasting blood glucose than found in female diabetic mice. Nine patients with chronic hepatitis C virus (HCV) infection and no complete response to the first treatment with natural interferon (IFN)-alpha, were prescribed a second treatment with IFN. Diabetic neuropathy: effects of intensified glycaemic control with multiple insulin injections. Sympathectomy also enhanced CGRP and SP mRNA and peptide content in DRG. Melatonin and the light-dark cycle separately influence daily behavioral and hormonal rhythms in the pregnant ewe and sheep fetus. Moreover, when the dose of ethanol on day 1 was large enough to induce rapid tolerance per se, D-cycloserine did not further enhance the tolerance. Computer methods in neuroanatomy: determining mutual orientation of whole neuronal arbors.

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Sertoli-Leydig cell tumors: a clinicopathologic study of 34 cases. Recent research on the types and contents of carotenoids in food emphasis has been increasingly placed on obtaining more accurate data. New hygienic methods of blockage of climate disadaptation and climate-related reactions. Fine structure and possible functions of the epidermal cells of the vegetative thallus. Should we use digit preference as an indicator of quality control?. Increased NF-kappaB activity in fibroblasts lacking the vitamin D receptor.

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Optimization of a mouse immunization protocol with Paracoccidioides brasiliensis antigens. The role of cystic duct resistance in the pathogenesis of cholesterol gallstones. The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families. The plasma membrane-structural order parameter of the transfectants was measured by labeling cells with Laurdan. Two stable human antibody secreting clones could be produced which exhibited functional activity against the autologous tumour cells (inhibition of cell adhesion and immunofluorescence staining of the membranes). Elevated mean airway pressure or positive end-expiratory pressure had no effect on the relationship of IVC to CVP. The Norwegian island of Spitzbergen, Svalbard offers a unique setting for validation studies on self-reported alcohol consumption. Caspase recruitment domain of procaspase-2 could be a target for SUMO-1 modification through Ubc9. Button gastrostomy is a useful alternative to the traditional gastrostomy tube for the pediatric population.

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Patients who underwent surgery within the first four hours had a 30 per cent mortality rate, as compared with 90 percent in those who had surgery after four hours (P less than 0.0001). Amikacin and gentamicin accumulation pharmacokinetics and nephrotoxicity in critically ill patients. Using this non-invasive functional MRI (fMRI) method, it is possible to localize functional brain activation, in normal individuals, with an accuracy of millimeters and a temporal resolution of seconds. An analysis of the prevalence of respiratory symptomatology in the general population. Therefore ultram urine drug screen , the kidney can be a villain or a victim during atherogenesis. Perspective determinants of visual size-constancy in binocular and monocular cats. In comparison with the glucocorticoids cortisol and corticosterone, the mineralocorticoid aldosterone is a minority hormone of the mammalian adrenal cortex, and its proper function is dependent upon protective physiological mechanisms. The Prostate Cancer Intervention Versus Observation Trial: a randomized trial comparing radical prostatectomy versus expectant management for the treatment of clinically localized prostate cancer. The results suggest that lower blood selenium levels in this group of nasopharyngeal cancer patients may be a consequence of their disease, rather than the cause of the cancer.

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If the patient requires intubation, weaning and extubation should be an orderly transition to spontaneous ventilation. We describe a polymerase chain reaction (PCR) based approach to the detection and identification of pathogenic fungi which has potential for the diagnosis of systemic mycoses. Composition of the ovarian fluid in 4 salmonid species: Oncorhynchus mykiss, Salmo trutta f lacustris, Salvelinus alpinus and Hucho hucho. Factors regulating the slow electrogenic phase in green algae and higher plants. Two human cell lines that were used for the initial temporary clustering were omitted from the final targets. Using a custom-designed implantable radiofrequency coil, we acquired angiograms from normal and injured cords. Furthermore, the TR alpha 1 amino terminus antagonizes homodimer formation on the positive TREs studied. Twenty one patients of lepromatous leprosy were investigated for evidence of renal diseases.

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In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection. The routine use of health-related quality of life measures in the care of patients with epilepsy: rationale and research agenda. Crosstalk between Jagged1 and GDNF/Ret/GFRalpha1 signalling regulates ureteric budding and branching. These included intraperitoneal fluid, fluid in the lesser sac, extraperitoneal fluid, pancreatic edema or hematoma, and thickening of the anterior renal fascia. In this study we examined BRCA1 deficient human and mouse cells for the presence of chromosomal aberrations indicative of telomere dysfunction. The adsorption equilibrium of benzoic acid, benzylamine, and m-xylylenediamine on all the metal surfaces followed a Langmuir-type equation, while those of phthalic acid, mellitic acid, and Peptide-A4D4 could be fitted to the modified Langmuir-type adsorption equation. The mean age at the time of final follow-up was sixty-six years. We assess the heparin dose, partial thromboplastin time before dialysis and at 3 and 120 min during the procedure, arterio-venous fistula compression time, clot formation in the circuit and residual volume of filters. The rostral reticular nucleus can be divided into a medial region, with densely packed fusiform neurons, and a lateral region, with less densely packed, polymorphic neurons.

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