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Bigomet (Metformin)

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Bigomet is a medicine used to treat type 2 diabetes mellitus. It helps control blood sugar levels and thus prevent serious complications of diabetes. It is also used to treat a menstruation-related disorder known as Polycystic ovary syndrome (PCOS) in women.

Other names for this medication:
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Also known as: Metformin


MetFORMIN (Eqv-Glucophage XR) is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

MetFORMIN (Eqv-Glucophage XR) is sometimes used together with insulin or other medications, but MetFORMIN (Eqv-Glucophage XR) is not for treating type 1 diabetes.


Bigomet can be taken in form of pills and extended-release pills which should be taken by mouth. It is better to take Bigomet every day at the same time with meal or without it. Usual Bigomet dosage is taken 2-3 times a day with meals. Bigomet XR (extended-release tablets) is taken once a day with evening meal. Take Bigomet and remember that its dosage depends on patient's health state. Bigomet can't be used by patients under 10 years. Bigomet XR (extended-release tablets) can't be used by patients under 17 years. It can be dangerous to stop Bigomet taking suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Bigomet are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use MetFORMIN (Eqv-Glucophage XR) if you are allergic to it, or if you have:

severe kidney disease; or metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment).

If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking MetFORMIN (Eqv-Glucophage XR). Be sure your caregivers know ahead of time that you are using this medication.

Tell your doctor if you have ever had:

kidney disease (your kidney function may need to be checked before you take this medicine); high ketone levels in your blood or urine; heart disease, congestive heart failure; liver disease; or if you also use insulin, or other oral diabetes medications.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

MetFORMIN (Eqv-Glucophage XR) may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

You should not breastfeed while using this medicine.

MetFORMIN (Eqv-Glucophage XR) should not be given to a child younger than 10 years old. Some forms of MetFORMIN (Eqv-Glucophage XR) are not approved for use by anyone younger than 18 years old.

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Clinico-radiological findings in a case of albuminous osteomyelitis and periostitis. All six reported patients have been associated with aerosolized pentamidine, and five of the six had documented underlying Pneumocystis pneumonia. Cochleosaccular dysplasia is the most common pathologic finding seen in children with profound congenital sensorineural hearing loss. Chromosome evolution in fish: BrdU replication patterns demonstrate chromosome homeologies in two species of the genus Astyanax. Its differentiation from nonstructural cardiac or pulmonary disease. A clearer understanding of the anatomy of the cavernous sinus has resulted in an increased interest in surgical approaches to this region. Decreased bone mineral density in children with phenylketonuria.

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The present studies demonstrate that morphine can increase, decrease, or not affect plasma catecholamines depending on the dose and on the experimental conditions under which it is given. Disruption of the gene results in (i) a pronounced slow-growth phenotype, (ii) hypersensitivity to FK506 and cyclosporin A, (iii) a slight increase in sensitivity to echinocandin, and (iv) a significant reduction in 1,3-beta-D-glucan synthase activity in vitro. The aim of this paper is to emphasize the extreme importance of the rectal examination and exact palpation of the abdomen in cases of obscure abdominal pain, especially as it is purely a question of a simple and inexpensive diagnostical procedure. In this study, the micro-localization of mRNAs coding for AT1 receptor and angiotensinogen was carried out in the rat kidney, using an assay of reverse transcription and polymerase chain reaction (RT-PCR) in individual microdissected renal tubule segments along the nephron, glomeruli, vasa recta bundle, and arcuate arteries. Structure-activity relationships of novel neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata. If data sampled at maternity clinics or hospitals are once transmitted to the data server on LAN via the public telephone circuit, these data are available for the specialists on LAN. Polyneuropathy from thiamin deficiency associated with thyrotoxicosis.

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It is rarely necessary to use a prosthetic material for the purpose of chest wall stabilization during the reconstruction of full-thickness defects. Nicotinamide--biological actions and therapeutic potential in diabetes prevention. Comparison of leaf life span, photosynthesis and defensive traits across seven species of deciduous broad-leaf tree seedlings. After catheter functionality had been demonstrated, electromechanical mapping was used to assess the viability in the region of ASM transplantation, and echocardiography, electrocardiogram, and angiography tests were used to assess cardiac function 2 months after ASM transplantation. In vitro vasorelaxant effects of indolocarbazole and bis-indole protein kinase C inhibitors on rabbit renal arteries. NCAM, tenascin and fibronectin, therefore, may play crucial roles on the proliferation of myoepithelial cells and the subsequent development of cartilaginous tissue in canine mammary mixed tumor. The described ratios of the various modifications indicate that the damage most probably results from a reaction of DNA with singlet oxygen (type II reaction) or directly with an excited endogenous photosensitizer (type I reaction) and is not mediated by hydroxyl radicals. Anti-tumor activity of zinostatin stimalamer (YM 881) examined by human hepatoma cells in vitro and VX2 liver tumor in vivo.

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On the radiomimetic effect of various cytostatics in a mutation experiment on Drosophila. Interactions of water molecules with the N-terminal polar sidechains lead to a conformational transition from right- to left-handed supercoils during these stimulations. With a simple pupillographic technique, the pupil diameter of male, S.D. POF would thus appear to protect cells from the toxic effects of active oxygens on chromosomes and tissue damage by not only inhibition of active oxygen production in leukocytes but also by scavenging activity of active oxygens. Evaluation of antileukemic agents employing advanced leukemia L-1210 in mice. Editing of rps3/rpl16 transcripts creates a premature truncation of the rpl16 open reading frame. We have reported that chaperone-rich cell lysate (CRCL) is an effective anticancer vaccine in immunocompetent mice. In the transport computations the surface backscattering has been duly taken into account. Since there is an intimate morphological relationship between Sertoli cells and germ cells, we next examined the effect of germ cell-conditioned medium (GCCM) on Sertoli cell alpha 2-MG and clusterin mRNA expression.

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Analysis of cDNA molecules prepared with gcaD-prs-ctc-specified mRNA as the template revealed an RNA transcript that encompassed all three cistrons. Hydrogeology is a field closely related to the needs of society. Regulation of palmitate esterification/oxidation by glucagon in isolated hepatocytes: the role of alpha-glycerophosphate concentration. Distribution of 5,5-dimethyl-2,4-oxazolidinedione (DMO) in intraocular fluids. Multiple needle biopsy specimens were obtained from inflamed knee joints on entry to the study. Cost depakote generic brand -effective screening of schoolchildren for refractive errors. Multifocal malignant pheochromocytoma presenting as a lung tumor. Donor-specific unresponsiveness induced by intraportal grafting and FK506 in rat islet allografts: importance of low temperature culture and transplant site on induction and maintenance. Impact of the HIV/AIDS pandemic on non-communicable disease prevention.

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Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor. This paper reviews the background of the Prozac controversy and summarizes the current psychiatric and medical uses of the drug. Clinical experience with Montgomery salivary bypass diamox medication high altitude stents in the esophagus. SE lead to a dramatic time-dependent increase in clusterin mRNA in non-nerve cells resembling astrocytes in the hippocampus beginning after 24 h. For this reason pretracheal, paratracheal, and retrosternal dissection has been performed in patients with subglottic lesions since 1968 in the Otolaryngology Department of the Hacettepe Faculty of Medicine. As shown by Northern analysis and reverse transcription PCR, VEGF and flk-1 mRNA (3.9 and 5.8 kb, respectively) were already present in the unincubated blastodisc at low levels and were largely upregulated during gastrulation at Embryonic Day 1. Clinical, laboratory, and physiopathologic aspects are discussed. Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 up-regulation. This article focuses on the most current information available regarding the RNAi mechanism and its uses in models of cancer and infectious diseases.

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Of the 3 substances tested GRF-adhesive and Avitene appeared to give reasonably good results in splenic injuries, but a supplementary suturing procedure or a ligation of the vessels seemed desirable. Characteristics of the changes in the hemostatic system in dogs immediate by following massive blood transfusion. Because of a potential impact on thrombus formation, this study determines the degree of blood back flow into catheters filled with different fluids. The degradation, absorption, and solubility of volatile anesthetics in soda lime depend on water content. The grafted precursors expressed the mature neuronal markers NeuN and MAP2, the astrocytic marker GFAP, the oligodendrocytic markers RIP, NG2 and Sox-10, and the synaptic marker synaptophysin. If current efforts to increase the duration of breastfeeding among WIC participants are successful, the importance of WIC in improving hemoglobin concentration among young children also will increase.

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Three key technical challenges, viz., scatter correction, dynamic range extension, and temporal resolution improvement, must be addressed for successful implementation of a VCT scanner. When therapeutic treatment was intensive in the control calves, the ingestion of probiotics reduced the percentage of calves that required therapy and the amount of treatments needed against digestive or respiratory diseases. Effects of irradiation on thyroid diseases such as thyroid nodules and autoimmune thyroid diseases have not been evaluated among people exposed to radiation more than 50 years in the past. Branchial cleftlike cysts of the thyroid gland are rare lesions. Re: Transurethral microwave thermotherapy for benign prostate hyperplasia: separating truth from marketing hype. To examine the effects of such molecules, we have developed a new method for the quantitation of several parameters associated with the morphology of neurons in culture.

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The aim of the National QC System for Neonatal Screening is evaluation of the accuracy of the tests and evaluation of the ability to detect suspicious samples with very mild abnormalities. Echocardiography is a useful non-invasive technique to study the changes in cardiac structure and function. Prolonged latency times and decreased amplitudes of the posterior tibial nerve (PTN) somatosensory evoked potentials (SEPs) were found in the majority of the patients. Before embarking on such an exercise, the clinician must be familiar with the advantages and pitfalls of each MRI sequence, and must appreciate the risks associated with the transportation of the sedated and ventilated patient from ICU to the MRI suite. Individuals in this age group often have several concomitant diseases that require treatment with multiple medications. The role of central and peripheral vision in the production of linear vection was assessed by using displays in which flow structure and sources of internal and external depth information were manipulated. Hence, GoM may complement existing strategies that sometimes fail in the presence of heterogeneity or when case definition is not well established. X-irradiation effects on protein synthesis and synthesis of messenger ribonucleic acid from peanut cotyledons. If we also assume that potential costs to society are not roughly approximated by any benefits, we may engender inappropriate attempts at cost reduction by effectively discouraging screening in the highest risk groups.

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The confounding problem of polydrug use in recreational ecstasy/MDMA users: a brief overview. Nature, distribution and origin of polycyclic aromatic hydrocarbons (PAHs) in the sediments of Olbia harbor (Northern Sardinia, Italy). Restriction of food intake did not increase intestinal mucosal weight, but significantly increased the specific and total activities of disaccharidases in parallel with the increase of sucrase-isomaltase content. Using previous reports and our experience on the Palliative Care Unit at the Edmonton General Hospital, we have developed a basic approach to bowel obstruction management. Persistent coughing and bloody sputum developed in a 75-year-old man with mycosis fungoides.

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The purpose of this work is the study of the application of three different lasers in the treatment of facial AF. Bio- and histochemical investigations on neuraxial proteins in experimental allergic demyelinating encephalomyelitis. Highly metastatic IV Cl 1 cells expressed approximately 5 fold lower levels of protein encoded by NME genes than non-metastatic IV Cl 3 cells. Keratinocyte growth factor and acidic fibroblast growth factor are mitogens for primary cultures of mammary epithelium. Pregnancies were classified as ectopic pregnancy, complete miscarriage, incomplete protonix generic nea miscarriage or ongoing pregnancy. The monitoring of the rate of mortality and disabilities associated with being homebound should be continued. Recent evidence suggests that repeated apheresis platelet donations may adversely effect thrombopoiesis as well as bone mineralization. Importance of events per independent variable in proportional hazards regression analysis.

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Twelve cats with insulin-dependent diabetes mellitus were treated with lente insulin. We report a case of panophthalmitis in an AIDS patient where the eviscerated tissue on histopathologic and microbiologic examination showed the fungus Rhizopus. Serum protein excretion in stool of healthy children and in certain disease states in the light of immunochemical studies. The IVC pressure correlated well with CVP in the patients without abdominal distention, but the disparity was wider in those with abdominal distention. The clinical implication of these results is that there are important differences in anti-fracture efficacy among currently available agents. Moreover, anti-Id mAb immunized the patients after removal of metastatic lesions. Operations to correct stress urinary incontinence are common procedures and are performed by both urologists and gynaecologists. This article briefly reviews physiological and contiguous considerations of choosing and administering regional anesthesia technique for the trauma patient. Demonstration of fibronectin receptor and mouse macrophage marker on the plasma membrane revealed that these glycoproteins were rapidly endocytosed within the first minutes after isolation.

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Mean pain rating was 22.28 mm for Xeroform and 15.29 mm for SkinTemp. Nucleotide sequence analysis of the carbomycin biosynthetic genes including the 3-O-acyltransferase gene from Streptomyces thermotolerans. Western blot analyses demonstrated that the mutant and wild-type receptors were processed through a similar series of precursors and that a mature 95-kilodalton form of the mutant TSH-R was produced, consistent with its insertion into the plasma membrane. Forebrain sections of adult male Wistar rats were processed for the immunohistochemical detection of the GABAA receptor alpha 1 subunit. Their location is consistent with the existence of a parasympathetic innervation of the rat kidney. Studies examining ecological dynamics will clarify the reasons behind, and significance of, increased levels of h in contaminated areas. Substance use and other psychiatric disorders in first-degree relatives of opioid-dependent males: a case-controlled study from India. There was no statistical evidence of a relationship with onchocerciasis and the content of mineral microparticles in lymphatic tissues of the lower legs was again established.

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