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Bigomet

Bigomet is a medicine used to treat type 2 diabetes mellitus. It helps control blood sugar levels and thus prevent serious complications of diabetes. It is also used to treat a menstruation-related disorder known as Polycystic ovary syndrome (PCOS) in women.

Other names for this medication:
Asoride, Bemet, Benforce, Cetapin, Chromet, Diform, Dokmet, Emfor, Enselin, Etformin, Eumet, Exmet, Formet, Glimid, Gluformin, Gluoformin, Glycimex, Glycirest, Glycomet, Glyformin, Glysiss, Insumet, Irmet, Medformin, Mesite, Metalok, Metanorm, Metfor, Metformin, Metkap, Metlife, Metme, Metsmall, Minimet, Okamet, Piokap, Riomet, Risicon, Roftem, Rosimet, Rosinorm, Rosizon, Secrin, Triglucored, Vogic, Vogipax, Zeformin, Zinimet, Zolmelis

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Also known as: Metformin

Description

MetFORMIN (Eqv-Glucophage XR) is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

MetFORMIN (Eqv-Glucophage XR) is sometimes used together with insulin or other medications, but MetFORMIN (Eqv-Glucophage XR) is not for treating type 1 diabetes.

Dosage

Bigomet can be taken in form of pills and extended-release pills which should be taken by mouth. It is better to take Bigomet every day at the same time with meal or without it. Usual Bigomet dosage is taken 2-3 times a day with meals. Bigomet XR (extended-release tablets) is taken once a day with evening meal. Take Bigomet and remember that its dosage depends on patient's health state. Bigomet can't be used by patients under 10 years. Bigomet XR (extended-release tablets) can't be used by patients under 17 years. It can be dangerous to stop Bigomet taking suddenly.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Bigomet are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use MetFORMIN (Eqv-Glucophage XR) if you are allergic to it, or if you have:

severe kidney disease; or metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment).

If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking MetFORMIN (Eqv-Glucophage XR). Be sure your caregivers know ahead of time that you are using this medication.

Tell your doctor if you have ever had:

kidney disease (your kidney function may need to be checked before you take this medicine); high ketone levels in your blood or urine; heart disease, congestive heart failure; liver disease; or if you also use insulin, or other oral diabetes medications.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

MetFORMIN (Eqv-Glucophage XR) may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

You should not breastfeed while using this medicine.

MetFORMIN (Eqv-Glucophage XR) should not be given to a child younger than 10 years old. Some forms of MetFORMIN (Eqv-Glucophage XR) are not approved for use by anyone younger than 18 years old.

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Clinico-radiological findings in a case of albuminous osteomyelitis and periostitis. All six reported patients have been associated with aerosolized pentamidine, and five of the six had documented underlying Pneumocystis pneumonia. Cochleosaccular dysplasia is the most common pathologic finding seen in children with profound congenital sensorineural hearing loss. Chromosome evolution in fish: BrdU replication patterns demonstrate chromosome homeologies in two species of the genus Astyanax. Its differentiation from nonstructural cardiac or pulmonary disease. A clearer understanding of the anatomy of the cavernous sinus has resulted in an increased interest in surgical approaches to this region. Decreased bone mineral density in children with phenylketonuria.

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UP induction by E2 was prominently suppressed by the treatment with actinomycin-D, cycloheximide and tamoxifen. In postmetamorphic axolotls, lymphocytes and polymorphs predominated. Subsequent tests of recall of this response with saline failed to generate any evidence that transfer was hampered following the drug-to-saline state change. Peripheral and intracerebroventricular administration of human chorionic gonadotropin alters several hippocampus-associated behaviors in cycling female rats. A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cells. Hemodynamic variations between end-to-side and end-organ flap systems. Effect of fixation on quantification of the expression of leucocyte function-associated surface antigens. Disorders of 24-h rhythm of blood pressure in patients with chronic glomerulonephritis.

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Fibrinogen was slowly depleted over 24 to 36 hours and the concentration maintained at 0.2 to 0.5 g/L thereafter. The Cys-His motif of Ty3 NC can be contributed by Gag3 or Gag3-Pol3 polyproteins. Attempts to recruit stem cells for repair of acute myocardial infarction: a dose of reality. The problem of determining the location and orientation of straight lines in images is of great importance in the fields of computer vision and image processing. However, we have found that complex fractures with fragmentation are more easily identified on CT scans than conventional tomography because of superior contrast resolution of computed tomography. A specific feature of diphtheria in adults is a high share of toxic forms and a higher incidence of grave combined forms and rare localizations of the disease focus. On reviewing these reported cases out of English and Japanese literature, numerous abdominal complications such as twenty-eight perforations, fifty CSF ascites or pseudocysts, three umbilical perforations, two vaginal perforations, five migrations into scrotum, and some volvulus and bladder perforations can be collected. Result of the application of nystatin in the treatment and prevention of Candida infections. Only one profile was found from the analysis of the ribosomal ribonucleic acid (rRNA) gene restriction patterns of 38 L. Mycobacterium tuberculosis was the causative agent in seven cases followed by Haemophilus influenzae (four), Streptococcus pneumoniae (two), Listeria monocytogenes (one), Escherichia coli (one), Pseudomonas aeruginosa (one) and Staphylococcus aureus (one).

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The present studies demonstrate that morphine can increase, decrease, or not affect plasma catecholamines depending on the dose and on the experimental conditions under which it is given. Disruption of the gene results in (i) a pronounced slow-growth phenotype, (ii) hypersensitivity to FK506 and cyclosporin A, (iii) a slight increase in sensitivity to echinocandin, and (iv) a significant reduction in 1,3-beta-D-glucan synthase activity in vitro. The aim of this paper is to emphasize the extreme importance of the rectal examination and exact palpation of the abdomen in cases of obscure abdominal pain, especially as it is purely a question of a simple and inexpensive diagnostical procedure. In this study, the micro-localization of mRNAs coding for AT1 receptor and angiotensinogen was carried out in the rat kidney, using an assay of reverse transcription and polymerase chain reaction (RT-PCR) in individual microdissected renal tubule segments along the nephron, glomeruli, vasa recta bundle, and arcuate arteries. Structure-activity relationships of novel neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata. If data sampled at maternity clinics or hospitals are once transmitted to the data server on LAN via the public telephone circuit, these data are available for the specialists on LAN. Polyneuropathy from thiamin deficiency associated with thyrotoxicosis.

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It is rarely necessary to use a prosthetic material for the purpose of chest wall stabilization during the reconstruction of full-thickness defects. Nicotinamide--biological actions and therapeutic potential in diabetes prevention. Comparison of leaf life span, photosynthesis and defensive traits across seven species of deciduous broad-leaf tree seedlings. After catheter functionality had been demonstrated, electromechanical mapping was used to assess the viability in the region of ASM transplantation, and echocardiography, electrocardiogram, and angiography tests were used to assess cardiac function 2 months after ASM transplantation. In vitro vasorelaxant effects of indolocarbazole and bis-indole protein kinase C inhibitors on rabbit renal arteries. NCAM, tenascin and fibronectin, therefore, may play crucial roles on the proliferation of myoepithelial cells and the subsequent development of cartilaginous tissue in canine mammary mixed tumor. The described ratios of the various modifications indicate that the damage most probably results from a reaction of DNA with singlet oxygen (type II reaction) or directly with an excited endogenous photosensitizer (type I reaction) and is not mediated by hydroxyl radicals. Anti-tumor activity of zinostatin stimalamer (YM 881) examined by human hepatoma cells in vitro and VX2 liver tumor in vivo.

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On the radiomimetic effect of various cytostatics in a mutation experiment on Drosophila. Interactions of water molecules with the N-terminal polar sidechains lead to a conformational transition from right- to left-handed supercoils during these stimulations. With a simple pupillographic technique, the pupil diameter of male, S.D. POF would thus appear to protect cells from the toxic effects of active oxygens on chromosomes and tissue damage by not only inhibition of active oxygen production in leukocytes but also by scavenging activity of active oxygens. Evaluation of antileukemic agents employing advanced leukemia L-1210 in mice. Editing of rps3/rpl16 transcripts creates a premature truncation of the rpl16 open reading frame. We have reported that chaperone-rich cell lysate (CRCL) is an effective anticancer vaccine in immunocompetent mice. In the transport computations the surface backscattering has been duly taken into account. Since there is an intimate morphological relationship between Sertoli cells and germ cells, we next examined the effect of germ cell-conditioned medium (GCCM) on Sertoli cell alpha 2-MG and clusterin mRNA expression.

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Using SSCP and direct sequencing, we detected six single-nucleotide polymorphisms within a 294-bp prolactin gene fragment involving exon 4. This note describes a method for the measurement of hydroxyl free radical concentration due to collapse acoustic cavitation in medical ultrasound fields using aqueous terephthalic acid (TA) solution. Osteolysis of the lateral clavicular end after compressed air damage. Using probes for rat neural nitric oxide synthase (NOS) mRNA and GnRH mRNA, we performed in situ hybridization to survey NOS mRNA distribution within the hypothalamus of the male and female rat and sought evidence for its expression in GnRH neurons. The measurements of these cellular parameters used the technique of electron microscopic stereoscopic morphometry. The non-nitrosated smokeless-tobacco extracts showed activity only on YG1024 in the presence of S9, with the highest amount of activity occurring in the snuff sample.

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The results of this study indicate that while galanin has the ability to stimulate GH release from dispersed pituitary cells of normal rats it has potent direct inhibitory effects on GH release from tumor rat cells. Preliminary steps to a hospital-nursing home patient transfer agreement. Hip fractures are among the most important causes for disability, reduced quality of life, and death in older persons. Two hydration prediction algorithms, AUTO-SOL and AQUARIUS2, showed significant increases in apparent efficacy using these consensus water sites, suggesting that our proposed set of consensus hydration sites is truly a better representation of the hydration properties of FKBP12 in solution. This system can be either ordered (on a hexagonal structure) or disordered depending on the flow rate. Polyester nets in the operative management of hernias of the anterior abdominal wall. On Western blots, mNGF antibodies reacted with all three neurotrophins but less well with hrBDNF and hrNT-3 than with mNGF. Overweight, weight loss, and risk of coronary heart disease in older women. Both functional magnetic resonance imaging (fMRI) data and real-time behavioral ratings were acquired during the 1-h SA period. These results show that the higher adherence of serotype III strains may be a virulence factor and contribute to the finding that this serotype dominates in invasive group B streptococcal disease.

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Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor. This paper reviews the background of the Prozac controversy and summarizes the current psychiatric and medical uses of the drug. Clinical experience with Montgomery salivary bypass diamox medication high altitude stents in the esophagus. SE lead to a dramatic time-dependent increase in clusterin mRNA in non-nerve cells resembling astrocytes in the hippocampus beginning after 24 h. For this reason pretracheal, paratracheal, and retrosternal dissection has been performed in patients with subglottic lesions since 1968 in the Otolaryngology Department of the Hacettepe Faculty of Medicine. As shown by Northern analysis and reverse transcription PCR, VEGF and flk-1 mRNA (3.9 and 5.8 kb, respectively) were already present in the unincubated blastodisc at low levels and were largely upregulated during gastrulation at Embryonic Day 1. Clinical, laboratory, and physiopathologic aspects are discussed. Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 up-regulation. This article focuses on the most current information available regarding the RNAi mechanism and its uses in models of cancer and infectious diseases.

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The confounding problem of polydrug use in recreational ecstasy/MDMA users: a brief overview. Nature, distribution and origin of polycyclic aromatic hydrocarbons (PAHs) in the sediments of Olbia harbor (Northern Sardinia, Italy). Restriction of food intake did not increase intestinal mucosal weight, but significantly increased the specific and total activities of disaccharidases in parallel with the increase of sucrase-isomaltase content. Using previous reports and our experience on the Palliative Care Unit at the Edmonton General Hospital, we have developed a basic approach to bowel obstruction management. Persistent coughing and bloody sputum developed in a 75-year-old man with mycosis fungoides.

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Twelve cats with insulin-dependent diabetes mellitus were treated with lente insulin. We report a case of panophthalmitis in an AIDS patient where the eviscerated tissue on histopathologic and microbiologic examination showed the fungus Rhizopus. Serum protein excretion in stool of healthy children and in certain disease states in the light of immunochemical studies. The IVC pressure correlated well with CVP in the patients without abdominal distention, but the disparity was wider in those with abdominal distention. The clinical implication of these results is that there are important differences in anti-fracture efficacy among currently available agents. Moreover, anti-Id mAb immunized the patients after removal of metastatic lesions. Operations to correct stress urinary incontinence are common procedures and are performed by both urologists and gynaecologists. This article briefly reviews physiological and contiguous considerations of choosing and administering regional anesthesia technique for the trauma patient. Demonstration of fibronectin receptor and mouse macrophage marker on the plasma membrane revealed that these glycoproteins were rapidly endocytosed within the first minutes after isolation.

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Mean pain rating was 22.28 mm for Xeroform and 15.29 mm for SkinTemp. Nucleotide sequence analysis of the carbomycin biosynthetic genes including the 3-O-acyltransferase gene from Streptomyces thermotolerans. Western blot analyses demonstrated that the mutant and wild-type receptors were processed through a similar series of precursors and that a mature 95-kilodalton form of the mutant TSH-R was produced, consistent with its insertion into the plasma membrane. Forebrain sections of adult male Wistar rats were processed for the immunohistochemical detection of the GABAA receptor alpha 1 subunit. Their location is consistent with the existence of a parasympathetic innervation of the rat kidney. Studies examining ecological dynamics will clarify the reasons behind, and significance of, increased levels of h in contaminated areas. Substance use and other psychiatric disorders in first-degree relatives of opioid-dependent males: a case-controlled study from India. There was no statistical evidence of a relationship with onchocerciasis and the content of mineral microparticles in lymphatic tissues of the lower legs was again established.

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