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Betanase (Glibenclamide)

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Betanase is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying the absorption of sugar (glucose) from the intestines, and increasing the body's sensitivity to insulin.

Other names for this medication:
Aviglen, Bionil, Daocon, Daonil, Diolin, Duotrol, Eumet, Giclamide, Glibact, Glifil, Glime, Glimsug, Glinil, Glucomin, Gluconil, Glucotrac, Glunil, Glybonil, Glybovin, Glybovine, Glycurb, Glycurub, Glymep, Melitus, Monomet, Secrin, Sugatrol, Sycored, Symet, Triglycomet

Similar Products:
Lanoxin, Inderal, Allegra, Phenergan, Avapro, Loxitane, Cardura

Also known as: Glibenclamide


Betanase is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Betanase is in a class of medications called sulfonylureas. Betanase lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Betanase is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated).

Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.


Take glyburide, micronized exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Carefully follow the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed.

Do not change to another brand without checking with your doctor. The number of tablets that you take depends on the brand and strength of the medicine. If you refill your medicine and it looks different, check with your pharmacist.

The dose of glyburide, micronized will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of glyburide, micronized. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For type 2 diabetes: For oral dosage form (micronized tablets): Adults—At first, 1.5 to 3 milligrams (mg) once a day taken with breakfast or the first main meal. Some patients may start at 0.75 mg per day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 12 mg per day. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glyburide overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program.

Side effects

The most common side effects associated with Betanase are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of glyburide in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving glyburide.

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X-ray-induced chromosomal aberrations and cell killing in somatic and germ cells of the scid mouse. A computer assisted book on medical helminthology has been prepared using ZOOM, a teaching computer program, which uses hypermedia technology to link pictures and text. Stenting is the method of choice to relieve jaundice in the patients with inoperable malignant obstructions of the biliary tree. The neuroblastoma cell line SH-SY5Y did not express IL-11 mRNA in response to these agents. Tube feeding in infancy: implications for the development of normal eating and drinking skills. We conclude that GABA-IR amacrine cell types are more numerous and morphologically heterogeneous than GLY-IR amacrine cells.

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In contrast, the Lelystad virus isolate reacted only with the SDOW17 MAb and showed no reactivity with either EP147 or VO17. For example, systemic or organ-based diseases that occasionally involve the peritoneum include eosinophilic gastroenteritis, amyloidosis, extramedullary hematopoiesis, Erdheim-Chester disease, sarcoidosis, and mesenteric cavitary lymph node syndrome. This study examined childhood behavior problems in schizophrenic patients and their healthy siblings. Here we tested the postulate that the costimulatory molecule SLAM may be critical for allergic inflammation in a murine model. Fresh pig corneas were ablated using a clinical excimer laser to study the effects of various energy densities (100-200 mJ/cm2) and beam diameters on ablation rates and on the surface ultrastructure of the ablated cornea. Fascination with 2-5A-dependent RNase: a unique enzyme that functions in interferon action. Prevalence of immediate allergy to respiratory allergens in fodder farmers in Doubs. At concentrations of phosphatidylcholine which provide optimal activity, the enzyme is strongly inhibited by phosphatidylinositol or phosphatidylglycerol.

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The binding constants tend to increase with lipophilicity of the compounds, as characterized by the 1-octanol/water partition coefficients. The bFGF mRNA expression was assessed with Northern blot and protein immunoreactivity with Western blot analysis. This article reviews the current situation of mentally ill offenders in hospitals and explores possible developments in forensic psychiatry. Bone ingrowth into the implants increased with time, although differences were not significant. whether prolonged observation is necessary in survival studies or whether hemodynamic variables have to be measured or whether therapeutic agents only crossreact with primates. Serum cobalamin levels and IFAb were determined in 30 women diagnosed with SLE as well as in 45 controls.

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Resident microglia and hematogenous macrophages as phagocytes in adoptively transferred experimental autoimmune encephalomyelitis: an investigation using rat radiation bone marrow chimeras. The increasing therapeutic use of transcranial magnetic stimulation (TMS) in disorders of cortical excitability raises the need for reliable stimulus variables. We then examined the abilities of these cells to coaggregate with each other and with other cadherin-expressing cells in short-term aggregation assays. Regional and temporal pattern of expression of nerve growth factor and basic fibroblast growth factor mRNA in rat brain following electroconvulsive shock. Five steps in the pathogenic process involved in the tension headache pathogenesis are suggested from a 100 patients clinical study. Repeated administration of apomorphine, 1.0 mg/kg/day, for 12 days, induced a significant increase in submissive gestures comparable to amphetamine in monkeys who had previously received chronic d-amphetamine treatment. Keratinocyte conditioned medium stimulates type IV collagenase synthesis in cultured human keratinocytes and fibroblasts. Alcohol problems and psychological health in a remote Indigenous Australian community: a preliminary quantitative study. Equation of state of gluon plasma from a fundamental modular region. Predictability of the droplet count was confirmed by a positive correlation (P less than 0.01) between chemical fat and droplets when serially diluting stool containing high fat.

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Recent research into same-sex attracted youth (SSAY) suicide and rural youth suicide suggests there may be an association between the two. Analysis of the primary structure of insulin-like growth factor binding protein-3 cDNA from Werner syndrome fibroblasts. Satisfactory sedation was achieved in the majority of children and the anticholinergic effects were also adequate. Rhabdoid tumor of the kidney in an adult: review of the acticin literature and report of a case responding to interleukin-2. Under these circumstances, difficult clinical conditions can be effectively treated with the judicious application of this device. Treating young children, working through an intermediary (the parenting adult), obtaining informed consent, and reporting suspected child abuse bring extra pressures to the dentist and staff members unless the protocol for each step is established and followed precisely. In the experiments presented here, T cells were cocultured with VCAM-1-positive and -negative endothelial cells grown in a monolayer in order to study the expression of 72-kD gelatinase upon T cell adhesion. Molecular cloning and characterization of the filarial LIM domain proteins AvL3-1 and OvL3-1.

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Moreover, it has become evident that clinical efficacy is partly determined by efficacy of gene delivery. The significance of self-reported anxious symptoms in first grade children: prediction to anxious symptoms and adaptive functioning in fifth grade. The Cunningham equation provides an accurate estimate of RMR when determining energy needs of highly active people. It was suggested that the tumor was receiving blood flow from the aortic system by IVDSA and dynamic CT, right bronchial angiogram demonstrated a dilatation and aneurysm formation associated with anastomosis of the pulmonary artery. Although gefitinib-resistant clones are cross-resistant to related anilinoquinazolines, they demonstrate sensitivity to a class of irreversible inhibitors of EGFR. Applied dose per IMBT fraction was 15 Gy, prescribed on the target (TRUS visible tumor) surface. Immunohistochemical detection of myelin basic protein is a sensitive marker of myelination in second trimester human fetal spinal cord. Genetic evidence for in vivo cross-specificity of the CaaX-box protein prenyltransferases farnesyltransferase and geranylgeranyltransferase-I in Saccharomyces cerevisiae. There were no differences between the groups in the other values. Tumor necrosis factor alpha (TNF-alpha) and interferon alpha (IFN-alpha) as well glucophage 500 mg cost as granulocyte-macrophage colony-stimulating factor (GM-CSF) were applied either alone or in combination, and TNF-alpha was also combined with etoposide (ETP).

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Although an effective instrument in PTD prevention is still elusive, the studies conducted so far have led to a shift in our understanding of cervical insufficiency, infection-mediated PTD, and hormonal influences in human parturition. Aqueous levels of methicillin were measured after intravitreal injection and were found to be when we have to take albendazole tablet adequate to inhibit penicillinase-producing S. Heterogeneity of sulfated microdomains within basement membranes of pulmonary airway epithelium. Although extensively characterized at the biochemical level, little is known about the localization of these protein kinases in the brain. A case story is presented of a diabetic woman (White group F/R), who in her first pregnancy had shown several signs of increasing nephropathy.

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The role of warfarin in ischemic cerebrovascular disease is unknown. Assessment of toxicity of heavy metal contaminated soils by the toxicity characteristic leaching procedure. Intracavernosal etilefrine self-injection therapy for recurrent priapism: one decade of follow-up. A regional mail survey was conducted among pediatricians to assess their knowledge and perceptions on smallpox and smallpox vaccine. The possibility that the effect of styrene is mediated by monoamine oxidase (MAO) inhibition is discussed. Global satisfaction with hospital services was examined in a comprehensive population study (age group 20-62) in the county of Finnmark, Norway. The time differences between latencies by magnetic stimulation and peripheral motor conduction times by F technique were significantly prolonged. The signal intensity of the calcified regions was varied and nonspecific on both T1- and T2- adalat xl drug card weighted images. Pt nanoparticles were in situ synthesized in the gamma-alumina matrix and annealed at different temperatures in N(2) atmosphere.

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Radiology/pathology conference at Robert Wood Johnson Medical School. Serum IgA cross-reactivity between glycine-alanine repeat sequence of EBNA-1 and keratin or collagen in nasopharyngeal carcinoma. Patients with achalasia lack nitric oxide synthase in the gastro-oesophageal junction. METHODS: Specific key cellular and connective tissue components were identified by infrared microspectroscopy and using a chemical imaging method. These alterations are increased during pathological processes such as cardiovascular diseases. Successful treatment of a squamous papilloma of the hypopharynx-esophagus by local injections of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine. Binding parameters of defined immune complexes to rat basophilic leukaemia (RBL) cells. Members of the recently discovered family of cyclin-dependent kinases inhibitors (CKIs) appear to play an essential regulatory role in the control of cell proliferation. However, nup157 null mutants, while lethal in combination with nup170 and nup188 null alleles, are not synthetically lethal with pom152 null alleles.

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An EMG-assisted model of trunk loading during free-dynamic lifting. Contrary to prediction, the tasks failed to differentiate the groups, although each task appeared to elicit the expected pattern of cardiovascular response across groups. A follow-up study of 134 cases of pulmonary tuberculosis treated with adequate chemotherapy in 1953-1954. Functional dependency is defined as needing help with or being unable to perform one or more activities of daily living or residence in a long-term care facility. Usefulness of chest pain character and location as diagnostic indicators of an acute coronary syndrome. Neither age nor sex affected basal gastrin and pepsinogen concentrations in H pylori negative subjects.

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Despite the increasing numbers of pediatric heart and lung transplants being performed worldwide, longitudinal psychological evaluation of children and adolescents undergoing transplantation remains uncommon. In comparison with literature observations, the altitude-associated difference in birth weight was smallest in Tibetans, intermediate in South America, and greatest in North America. Morphology and function of the menisco-femoral ligaments of the knee joint in man. Neurological disorders, obesity, secondary hypogonadism, and thirst as a result of diabetes insipidus, dominate the clinical picture of hypothalanmic sarcoidosis. Processing of viable group A streptococci leads to major histocompatibility complex class II presentation of T cell epitopes from the major protective antigen. The performance of the method is found to depend on the resolution of food concentrations, that is, on how many food concentrations are examined and how far they are spaced on the food concentration axis. T cells to modified epitopes induced by activation of APC may be a component of antimicrobial immunity and autoimmune reactions. The personality disposition to anxiety sensitivity refers to beliefs about negative consequences of bodily arousal. A novel mutation (K317M) in the MAPT gene causes FTDP and motor neuron disease. Anorexia nervosa remains a rare disorder and there is no evidence of a secular increase in its incidence.

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