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Benforce (Metformin)

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Benforce is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying the absorption of sugar (glucose) from the intestines, and increasing the body's sensitivity to insulin.

Other names for this medication:
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Also known as: Metformin


Glucophage XR is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Glucophage XR is sometimes used together with insulin or other medications, but this medicine is not for treating type 1 diabetes.


Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take MetFORMIN (Eqv-Glucophage XR) with a meal, unless your doctor tells you otherwise. Some forms of MetFORMIN (Eqv-Glucophage XR) are taken only once daily with the evening meal. Follow your doctor's instructions.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Some tablets are made with a shell that is not absorbed or melted in the body. Part of this shell may appear in your stool. This is normal and will not make the medicine less effective.

You may have low blood sugar (hypoglycemia) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda).

Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.

MetFORMIN (Eqv-Glucophage XR) is only part of a complete treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

Store at room temperature away from moisture, heat, and light.

Your doctor may have you take extra vitamin B12 while you are taking MetFORMIN (Eqv-Glucophage XR). Take only the amount of vitamin B12 that your doctor has prescribed.

Detailed Metformin dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Benforce are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Glucophage if you are allergic to metformin, or if you have:

severe kidney disease; or metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment).

If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Glucophage. Be sure your caregivers know ahead of time that you are using this medication.

Tell your doctor if you have ever had:

kidney disease (your kidney function may need to be checked before you take this medicine); high ketone levels in your blood or urine; heart disease, congestive heart failure; liver disease; or if you also use insulin, or other oral diabetes medications.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Follow your doctor's instructions about using Glucophage if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. Tell your doctor if you become pregnant while taking Glucophage.

Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

You should not breastfeed while using this medicine.

Glucophage should not be given to a child younger than 10 years old. Glucophage XR is not approved for use by anyone younger than 18 years old.

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Ejaculatory duct obstruction is a surgically treatable cause of male infertility. Effect of methylene blue on blood pH, oxygen and carbon dioxide content. Role of atypical bacteria and azithromycin therapy for children with recurrent respiratory tract infections. Evaluation of a weight management intervention program in adolescents with insulin-dependent diabetes mellitus. Further advances have been made in the treatment of multiple sclerosis patients. This paper elucidates the status of the different morphological forms of Blastocystis and reports the existence of thin- and thick-walled cysts in B. To determine suitable embolic materials for simultaneous arterioportal embolization through the arterial route, transcatheter arterial embolization (TAE) using iodized oil (Lipiodol) mixed with monomeric n-butyl-2-cyanoacrylate, with absolute ethanol, or mixed with Gelfoam powder was carried out in 14 dogs. Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase.

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Restrictions: Hawthorne effect or bias in the person observed and participants stage fright. Rates and patterns of base change in the small subunit ribosomal RNA gene. Kinetics of PoIFN appearance was analyzed by antiviral and antiproliferative tests in human transformed and nontransformed cells. The modification was in turn abolished by trypsin added to the side of the channel previously exposed to the peptide. Hormonal responses to physical exercise in patients with polycystic ovarian syndrome. Immunohistochemistry revealed that expression of renal HSP72 was suppressed in tubular epithelial cells, and expression of renal HSP25 was suppressed not only in tubular epithelial cells but also in blood vessels in rats with liver cirrhosis. The analysis of pigmentation continues to provide insights into new areas, such as the channeling and intracellular transport of metabolites, regulation of gene expression and RNA interference. We established a sequence database of the tyrosinase gene of Japanese as well as Indian people. The lipopolysaccharide of the smooth strain was shown to confer resistance by blocking access of antibody to the sensitive antigens.

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The interactive parent-child family guidance intervention described in this report, differentiated from typical behavior therapies, is a notably successful mode of psychologically based therapy for these children. This report demonstrates the aggressive potential of histologically low-grade epithelioid hemangioendothelioma and the need for a thorough evaluation for metastases. Furuncle-like lesions in mouse experimental skin infections with Staphylococcus aureus. Influence of the running shoe sole on the pressure in the anterior tibial compartment. Branchiootorenal (BOR) syndrome is a variable, autosomal-dominant disorder of the first and second embryonic branchial arches, kidneys, and urinary tract.

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Size of residual lymph node metastasis after neoadjuvant chemotherapy in locally advanced breast cancer patients is prognostic. Described are the results of mathematic modeling for different types of detectors (with different scintillators for high- and low-energy spectrum ranges) as well as the results of experimental research. Time-dependent covariates in the Cox proportional hazards model. The anti-epileptic phenytoin (DPH), which does not bind to P-gp, can selectively enhance vincristine (VCR) cytotoxicity in wild-type (WT) or multidrug-resistant (MDR) cells. The relationships between epitope topography and agonistic/antagonistic effects of anti-TNF receptor type 1 (TNF-R1) antibodies on TNF-alpha cytotoxic activity have been studied. We evaluated whether risk factors for suicide are more prevalent among patients prescribed venlafaxine than patients prescribed fluoxetine or citalopram. The relative risk of health care utilization was higher in patients with co-morbidity, past history of anxiety, high level of anxiety as well as in older patients. Sequencing sit-to-stand and upright posture for mobility limitation assessment: determination of the timing of the task phases from force platform data. Ancestry of the mammalian preplate and its derivatives: evolutionary relicts or embryonic adaptations?.

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The first exosome-based nanodevices evaluated in the clinic consisted of autologous dexosomes (patient-specific exosomes released by dendritic cells and loaded with tumor antigen-derived peptides). and bone metastasis tumor growth by the androgen-independent PC-3ML-B2 human prostatic carcinoma clone in SCID mice. Calorimetric, density and circular dichroism studies of the reversible structural transition in Pf1 filamentous bacterial virus. The first immunological event apparent in the iodine-treated BB/W rats was a sharp increase in the number of Ia positive dendritic cells at 9 weeks compared with control BB/W and Wistar rats. In response to exposure to the inflammatory cytokines tumor necrosis factor-alpha (TNF) and interferon-gamma (IFN-gamma), murine brain microvascular endothelial cells (MME) synthesize the cell surface molecule, vascular cell adhesion molecule-1 (VCAM-1), and the intracellular enzyme, inducible nitric oxide synthase (iNOS). Immunogenicity of Coxiella burnetii whole cells and their outer membrane components. Pneumatized inferior turbinates were investigated among 2500 consecutive cases with coronal paranasal sinus computed tomography (CT) scans that were performed for different reasons between 2000 and 2004. To support such an application, the prediction rule needs to be validated in other populations. Assessment of depression in chronic musculoskeletal pain patients.

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The contribution of neurogenic reflexes to hypertonic saline-induced bronchoconstriction in asthma. Placement and management of long-term central venous access catheters and ports. Endoscopic retrograde pancreaticocholangiography and transhepatic cholangiography are the most useful diagnostic procedures. A low-electrophoretic-mobility H1 histone subfraction from Kirkman-Robbins hamster hepatoma. Spinal hemiepiphysiodesis using an anatomically based implant and minimally invasive procedures repeatedly induced spine curvature in a normal porcine model. In this article we review the current state of knowledge of the functional neuroanatomy of sleep-wake and circadian rhythms and selected infradian rhythms (eg, menstrual and seasonal). This intervention was not sustainable when the 3 components of the QI intervention were no longer actively maintained.

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Single-well separation allows for the use of regular gamma counters in case Topcount is unavailable. Affinity chromatography of Streptomyces erythreus trypsin-like enzyme on Japanese quail ovomucoid. In particular, the advantages of using tumour vasculature as a target for anticancer gene therapy are outlined. To contribute to a better understanding of the mechanism of such a long-distance regulation, we generated knock-in mice in which a neo(r) gene was inserted downstream of Igamma3 exon leaving intact all the necessary elements for germ line transcription and splicing. A multivariate analysis was performed to investigate the role of overall treatment time on local control rates. Effect of Gymnema sylvestre and Pterocarpus marsupium on glucose tolerance in albino rats. Two reactive metabolites, 3,4-epoxy-1,2-butanediol (EB-diol) and hydroxymethylvinyl ketone (HMVK), are formed during the biotransformation of BD-diol and could potentially be involved in BD-diol associated mutagenicity. The multiple-marker screening test appears to detect Turner syndrome, as well as trisomies 21 and 18. Hawkins outlined the impact of vascular access on patients undergoing hemodialysis treatment while Ms. We retrospectively evaluated the results of electromyography (EMG)-based biofeedback in 34 patients with rectal intussusception without any other major pelvic floor or colonic physiologic disorder.

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A fundamental difficulty is the development of tumor resistance to platinum compounds. The healthy person who begins to drink heavily, first experiences the toxic effects of high concentrations of ethanol. Manometric abnormalities of esophageal and anal sphincter function may provide indirect evidence of amyloid deposition of gastrointestinal smooth muscle in an appropriate clinical setting. The in vitro sensitivity to lysozyme of twelve isolates of Candida (three isolates each of C. Two-dimensional capillary liquid chromatography: pH gradient ion exchange and reversed phase chromatography for rapid separation of proteins. smegmatis were not related, but an increase in the number of cells and intensity of PCR signal correlated well. Quantitative detection of individual cleaved DNA molecules on surfaces using gold nanoparticles and scanning electron microscope imaging. The degree of staining for the ICAM-1, nitrotyrosine, and PAR was significantly reduced by H. This study was designed to investigate the serum protein status in such diseases. In CKD-V vascular calcifications occur both in the subintimal space and in the runica media.

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Cardiac decompression sickness: report and discussion of a case. Proliferation of megaloblasts in pernicious anemia as observed from nucleic acid metabolism. Why we favor a compulsory hospitalization insurance with diagnostic services. Influence of variations in dietary intake of chlorides upon diverse necrotizing cardiopathies. Thus the results indicate that physical and psychological stress exert a synergistic impact on cardiac performance, but not necessarily on respiratory performance. Instead, cadherin-mediated adhesion is likely to be involved in Sertoli cell-germ cell interactions. Fibers from the foveal-to-peripheral axis of the temporal retina show substantially cipro eye drops generic no retinotopy owing to a marked overlap of fibers in the anterolateral and the posterocentral parts of the ipsilateral hemichiasm. We have investigated the granule size distributions in human and horse eosinophils by time-resolved patch-clamp capacitance measurements.

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Abnormal conduction and repolarization in late-activated myocardium of dyssynchronously contracting hearts. Reconstruction of the explosion site of a hand granade on an automobile seat. Effects of intimacy and familiarity on self-assertive strategy in interpersonal conflicts among preschool children. Neutral mucins, acidic sulphomucins, and sialomucins were identified within the villous adenoma and adjacent areas of cystitis glandularis. Actinidia polygama is one of the well known herb used in oriental medicine for treatment of anti-inflammatory and many allergic diseases. Over a period of 28 days, 10 Trichophyton mentagrophytes strains were examined for their ability to secrete keratinolytic enzymes. Both organophosphorous compounds produced a dose-dependent rise in blood pressure, bradycardia and twitch potentiation after i.v. A discrepancy between the distribution of iodo compounds when estimated by I 131 and by I 127. The experimental results showed that the investigated benzoxazole derivatives are sensitive to the polarity of its microenvironment even in the glassy matrices and in the solid state. One year later, the CT scan was normal but, 4 years after surgery, it showed supra-and infratentorial tumors.

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Pain intensity, disability, and health measurements differentiate subgroups of lumbopelvic pain in pregnancy. A midline incision or a wide transverse incision offers good access to the abdominal cavity. Plant mitochondrial nucleic acid sequences as a tool for phylogenetic analysis. Implicit associative learning engages the hippocampus and interacts with explicit associative learning. Interestingly, much shorter segments will also suffice to stop translocation, but these must be composed of more highly hydrophobic residues (e.g. While the NW has an unfavourable risk factor profile compared with the South, the North does not. Evidence is presented to indicate that placebos are far more effective in producing carefully defined relief of pathological pain than they are in the case of experimental pain. A method for stratifying malariogenic territories in order to construct a system of mathematical models of the prevalence of malaria. These surfaces are widely used in cementless prosthetic components, although osteoblasts behavior on this treated alloy has not been evaluated to date. A policy development toolkit was used to improve the rural urgent care systems through engagement with community members.

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Racial, cultural, and ethnic factors influencing end-of-life imodium 2 mg tablett care. Vaginal IgA antibodies have the secretory component and J chain suggesting that they are of secretory origin. This method allows penetration under direct vision with minimal controlled axial force, and without the requirement for fascial sutures or other cumbersome aspects of the traditional open technique. Plasmapheresis and the addition of cyclophosphamide led to an improvement in the renal disease in 1 case, whereas no treatment was able to reverse the renal failure in the other case. The offerings include phylogenetically ordered alignments of ribosomal RNA (rRNA) sequences, derived phylogenetic trees, rRNA secondary structure diagrams, and various software for handling, analyzing and displaying alignments and trees.

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The effects of bilateral adrenalectomy on the spermatogenetic and steroidogenic activity of the testis in different phases of the reproductive cycle of Mabuya carinata have been investigated. Aspartate is the common precursor of the essential amino acids lysine, threonine, methionine and isoleucine in higher plants. In a Chinese population, low serum Apo AI and high Apo B are risk factors for myocardial infarction of a comparable magnitude to smoking, hypertension and obesity. Immunoblotting with polyclonal antibodies prepared against MP-73 localized it xeloda dose reduction to the inner mitochondrial membrane. Association study of catechol-O-methyltransferase gene polymorphism in Korean male alcoholics.

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