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Azpax (Clonazepam)
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Azpax

Azpax is used to prevent and control seizures. This medication is known as an anticonvulsant or antiepileptic drug. It is also used to treat panic attacks. Azpax works by calming your brain and nerves. It belongs to a class of drugs called benzodiazepines.

Other names for this medication:
Adnil, Almac, Alrest, Anxiset, Azpax, Catier, Cloam, Clonapax, Clonapik, Clonatrac, Clonax, Clonaxyl, Cloneepam, Clonoasig, Clonopam, Clonotril, Clonzy, Clopam, Clotas, Cloze, Clozep, Clozorix, Convaclon, Cozil, Deptune, Dipwell, Ection, Epicloz, Epitril, Escimax, Escitapax, Esitor, Ezinite, Lonipax, Melzap, Norep, Nupam, Petril, Prasilex, Revozip, Somnotril, Xenotril, Zepam, Zicam, Zolpidox

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Clomid, Differin, Nizoral, Amethopterin, Feldene

Also known as: Clonazepam

Description

Klonopin (clonazepam) is a benzodiazepine. It is thought that clonazepam works by enhancing the activity of certain neurotransmitters in the brain. Clonazepam is also a seizure medicine, also called an anti-epileptic drug.

Klonopin is used to treat certain seizure disorders (including absence seizures or Lennox-Gastaut syndrome in adults and children.

Klonopin is also used to treat panic disorder (including agoraphobia) in adults.

Dosage

Adults. The initial dose for adults with seizure disorders should not exceed 1.5 mg/day divided into three doses. Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase. Maintenance dosage must be individualized for each patient depending upon response. Maximum recommended daily dose is 20 mg. The use of multiple anticonvulsants may result in an increase of depressant adverse effects. This should be considered before adding Azpax to an existing anticonvulsant regimen.

Pediatric Patients. Azpax is administered orally. In order to minimize drowsiness, the initial dose for infants and children (up to 10 years of age or 30 kg of body weight) should be between 0.01 and 0.03 mg/kg/day but not to exceed 0.05 mg/kg/day given in two or three divided doses. Dosage should be increased by no more than 0.25 to 0.5 mg every third day until a daily maintenance dose of 0.1 to 0.2 mg/kg of body weight has been reached, unless seizures are controlled or side effects preclude further increase. Whenever possible, the daily dose should be divided into three equal doses. If doses are not equally divided, the largest dose should be given before retiring.

Geriatric Patients. There is no clinical trial experience with Azpax in seizure disorder patients 65 years of age and older. In general, elderly patients should be started on low doses of Azpax and observed closely.

Overdose

Symptoms of clonazepam overdosage, like those produced by other CNS depressants, include somnolence, confusion, coma and diminished reflexes.

Treatment includes monitoring of respiration, pulse and blood pressure, general supportive measures and immediate gastric lavage. Intravenous fluids should be administered and an adequate airway maintained. Hypotension may be combated by the use of levarterenol or metaraminol. Dialysis is of no known value.

Flumazenil, a specific benzodiazepine-receptor antagonist, is indicated for the complete or partial reversal of the sedative effects of benzodiazepines and may be used in situations when an overdose with a benzodiazepine is known or suspected. Prior to the administration of flumazenil, necessary measures should be instituted to secure airway, ventilation and intravenous access. Flumazenil is intended as an adjunct to, not as a substitute for, proper management of benzodiazepine overdose. Patients treated with flumazenil should be monitored for resedation, respiratory depression and other residual benzodiazepine effects for an appropriate period after treatment. The prescriber should be aware of a risk of seizure in association with flumazenil treatment, particularly in long-term benzodiazepine users and in cyclic antidepressant overdose. The complete flumazenil package insert, including CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, should be consulted prior to use.

Flumazenil is not indicated in patients with epilepsy who have been treated with benzodiazepines. Antagonism of the benzodiazepine effect in such patients may provoke seizures.

Serious sequelae are rare unless other drugs or alcohol have been taken concomitantly.

Storage

Tablets should be kept at room temperature, between 15 C and 30 C (59 F and 86 F).

Side effects

The most common side effects associated with Azpax are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Before taking Azpax,

tell your doctor and pharmacist if you are allergic to Azpax, other benzodiazepines such as alprazolam (Xanax), chlordiazepoxide (Librium, in Librax), clorazepate (Gen-Xene, Tranxene), diazepam (Diastat, Valium), estazolam, flurazepam, lorazepam (Ativan), midazolam (Versed), oxazepam, temazepam (Restoril), triazolam (Halcion), any other medications, or any of the ingredients in Azpax tablets. Ask your pharmacist for a list of the ingredients.

tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Nexterone, Pacerone); certain antibiotics such as clarithromycin (Biaxin, in Prevpac), erythromycin (Erythrocin, E-mycin, others), and troleandomycin (TAO) (not available in the US); antidepressants; certain antifungal medications such as itraconazole (Onmel. Sporanox) and ketoconazole (Nizoral); antihistamines; certain calcium channel blockers such as diltiazem (Cardizem, Tiazac, others) and verapamil (Calan, Covera, Verelan, in Tarka); cimetidine (Tagamet); HIV protease inhibitors including indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); medications for anxiety, colds or allergies, or mental illness; other medications for seizures such as carbamazepine (Epitol, Tegretol, Teril), phenobarbital, phenytoin (Dilantin, Phenytek), or valproic acid (Depakene); muscle relaxants; nefazodone; rifampin (Rifadin, Rimactane); sedatives; certain selective serotonin reuptake inhibitors (SSRIs) such as fluvoxamine (Luvox); other sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor what herbal products you are taking, especially St. John's wort.

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Effects of systematic lymphadenectomy on length of survival in patients with gastric carcinoma. Initially, a diverting colostomy was performed at the age of one month. Cell co-culture, cell apoptosis assay, fluorescence and MS detection of intracellular drug absorption could be simultaneously conducted on this platform. Natural development of epizootics due to the fungus Coelomomyces iliensis and their importance in regulating the number of blood-sucking mosquitoes of the genus Culex in Kazakhstan. We show here that CMT-3 displays multiple modes of action: inhibiting MMP activity, reducing levels of MMP expression, and exhibiting selective cytotoxicity towards some of the tumor cell lines. A partial correlation analysis indicated that the components of the visual Wulst that were responsible for the acuity changes were the accessory hyperstriatum and the hyperstriatum ventrale.

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Preventing misfolding of the prion protein by trimethylamine N-oxide. This finding suggests the presence of early lung parenchymal damage in chronic pancreatitis secondary to either emphysema or pulmonary fibrosis. Passenger car dynamometer simulation and driving cycles are adequate for determining mass emission rates. The motor representation of the various body parts was shown to coincide with the sensory projections, demonstrating the existence in a Eutherian mammal of a sensorimotor amalgam, identical to that described in marsupials. Evidence against the smooth endoplasmic reticulum as a continuous channel for the retrograde axonal transport of horseradish peroxidase. Inpatient management of hospitalized patients with type 2 diabetes. Morphology, topography and clinical signi cance of the jugular foramen.

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