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Azpax (Clonazepam)

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Azpax is used to prevent and control seizures. This medication is known as an anticonvulsant or antiepileptic drug. It is also used to treat panic attacks. Azpax works by calming your brain and nerves. It belongs to a class of drugs called benzodiazepines.

Other names for this medication:
Adnil, Almac, Alrest, Anxiset, Azpax, Catier, Cloam, Clonapax, Clonapik, Clonatrac, Clonax, Clonaxyl, Cloneepam, Clonoasig, Clonopam, Clonotril, Clonzy, Clopam, Clotas, Cloze, Clozep, Clozorix, Convaclon, Cozil, Deptune, Dipwell, Ection, Epicloz, Epitril, Escimax, Escitapax, Esitor, Ezinite, Lonipax, Melzap, Norep, Nupam, Petril, Prasilex, Revozip, Somnotril, Xenotril, Zepam, Zicam, Zolpidox

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Clomid, Differin, Nizoral, Amethopterin, Feldene

Also known as: Clonazepam


Klonopin (clonazepam) is a benzodiazepine. It is thought that clonazepam works by enhancing the activity of certain neurotransmitters in the brain. Clonazepam is also a seizure medicine, also called an anti-epileptic drug.

Klonopin is used to treat certain seizure disorders (including absence seizures or Lennox-Gastaut syndrome in adults and children.

Klonopin is also used to treat panic disorder (including agoraphobia) in adults.


Adults. The initial dose for adults with seizure disorders should not exceed 1.5 mg/day divided into three doses. Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase. Maintenance dosage must be individualized for each patient depending upon response. Maximum recommended daily dose is 20 mg. The use of multiple anticonvulsants may result in an increase of depressant adverse effects. This should be considered before adding Azpax to an existing anticonvulsant regimen.

Pediatric Patients. Azpax is administered orally. In order to minimize drowsiness, the initial dose for infants and children (up to 10 years of age or 30 kg of body weight) should be between 0.01 and 0.03 mg/kg/day but not to exceed 0.05 mg/kg/day given in two or three divided doses. Dosage should be increased by no more than 0.25 to 0.5 mg every third day until a daily maintenance dose of 0.1 to 0.2 mg/kg of body weight has been reached, unless seizures are controlled or side effects preclude further increase. Whenever possible, the daily dose should be divided into three equal doses. If doses are not equally divided, the largest dose should be given before retiring.

Geriatric Patients. There is no clinical trial experience with Azpax in seizure disorder patients 65 years of age and older. In general, elderly patients should be started on low doses of Azpax and observed closely.


Symptoms of clonazepam overdosage, like those produced by other CNS depressants, include somnolence, confusion, coma and diminished reflexes.

Treatment includes monitoring of respiration, pulse and blood pressure, general supportive measures and immediate gastric lavage. Intravenous fluids should be administered and an adequate airway maintained. Hypotension may be combated by the use of levarterenol or metaraminol. Dialysis is of no known value.

Flumazenil, a specific benzodiazepine-receptor antagonist, is indicated for the complete or partial reversal of the sedative effects of benzodiazepines and may be used in situations when an overdose with a benzodiazepine is known or suspected. Prior to the administration of flumazenil, necessary measures should be instituted to secure airway, ventilation and intravenous access. Flumazenil is intended as an adjunct to, not as a substitute for, proper management of benzodiazepine overdose. Patients treated with flumazenil should be monitored for resedation, respiratory depression and other residual benzodiazepine effects for an appropriate period after treatment. The prescriber should be aware of a risk of seizure in association with flumazenil treatment, particularly in long-term benzodiazepine users and in cyclic antidepressant overdose. The complete flumazenil package insert, including CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, should be consulted prior to use.

Flumazenil is not indicated in patients with epilepsy who have been treated with benzodiazepines. Antagonism of the benzodiazepine effect in such patients may provoke seizures.

Serious sequelae are rare unless other drugs or alcohol have been taken concomitantly.


Tablets should be kept at room temperature, between 15 C and 30 C (59 F and 86 F).

Side effects

The most common side effects associated with Azpax are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Before taking Azpax,

tell your doctor and pharmacist if you are allergic to Azpax, other benzodiazepines such as alprazolam (Xanax), chlordiazepoxide (Librium, in Librax), clorazepate (Gen-Xene, Tranxene), diazepam (Diastat, Valium), estazolam, flurazepam, lorazepam (Ativan), midazolam (Versed), oxazepam, temazepam (Restoril), triazolam (Halcion), any other medications, or any of the ingredients in Azpax tablets. Ask your pharmacist for a list of the ingredients.

tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Nexterone, Pacerone); certain antibiotics such as clarithromycin (Biaxin, in Prevpac), erythromycin (Erythrocin, E-mycin, others), and troleandomycin (TAO) (not available in the US); antidepressants; certain antifungal medications such as itraconazole (Onmel. Sporanox) and ketoconazole (Nizoral); antihistamines; certain calcium channel blockers such as diltiazem (Cardizem, Tiazac, others) and verapamil (Calan, Covera, Verelan, in Tarka); cimetidine (Tagamet); HIV protease inhibitors including indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); medications for anxiety, colds or allergies, or mental illness; other medications for seizures such as carbamazepine (Epitol, Tegretol, Teril), phenobarbital, phenytoin (Dilantin, Phenytek), or valproic acid (Depakene); muscle relaxants; nefazodone; rifampin (Rifadin, Rimactane); sedatives; certain selective serotonin reuptake inhibitors (SSRIs) such as fluvoxamine (Luvox); other sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor what herbal products you are taking, especially St. John's wort.

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The vertical rectus abdominis myocutaneous flap was superior to the gracilis flap in terms of the overall reduction of complications. Association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and essential hypertension in young Pakistani patients. Expression of mature bovine H-protein of the glycine cleavage system in Escherichia coli and in vitro lipoylation of the apoform. Difficulties diagnosing the multiple personality syndrome in a death penalty case. The impact of pre-freezing temperatures on ice crystal growth was explained as combining ice crystal growth rate with nucleation rate, while the impacts of KGM and glyceryl monostearate concentration on ice crystal growth were interpreted based on their influences on sol network structure. A competition radio immunoassay demonstrated that the two antibodies bind to distinct epitopes.

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Effects of systematic lymphadenectomy on length of survival in patients with gastric carcinoma. Initially, a diverting colostomy was performed at the age of one month. Cell co-culture, cell apoptosis assay, fluorescence and MS detection of intracellular drug absorption could be simultaneously conducted on this platform. Natural development of epizootics due to the fungus Coelomomyces iliensis and their importance in regulating the number of blood-sucking mosquitoes of the genus Culex in Kazakhstan. We show here that CMT-3 displays multiple modes of action: inhibiting MMP activity, reducing levels of MMP expression, and exhibiting selective cytotoxicity towards some of the tumor cell lines. A partial correlation analysis indicated that the components of the visual Wulst that were responsible for the acuity changes were the accessory hyperstriatum and the hyperstriatum ventrale.

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SGHTL-34, a thyrotrophin-responsive immortalised human thyroid cell line generated by transfection. The largest follicular diameter was compared to the mean diameter of two and three directions, respectively. The emphasis will be on the epidemiology, pathology, clinical presentation, diagnostic evaluation, therapeutic approach, and ultimate prognosis. Derivatives of diiodofumaric acid as potential new x-ray contrast media. On the basis of the MAb results in HAI tests a dendrogram of the similarity coefficients between the viruses was constructed and showed that the viruses could be placed into three major groups. Surgical correction of blepharoptosis is an appropriate treatment option in patients with myasthenia gravis who fail medical therapy. Advance notification of surgeons and neonatalogists has reduced the delays of postnatal evaluation and treatment that contribute, significantly, to complications and death. Droplet digital PCR (ddPCR) is a recently introduced technology that overcomes the normalization issue and may facilitate miRNA measurement.

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Preventing misfolding of the prion protein by trimethylamine N-oxide. This finding suggests the presence of early lung parenchymal damage in chronic pancreatitis secondary to either emphysema or pulmonary fibrosis. Passenger car dynamometer simulation and driving cycles are adequate for determining mass emission rates. The motor representation of the various body parts was shown to coincide with the sensory projections, demonstrating the existence in a Eutherian mammal of a sensorimotor amalgam, identical to that described in marsupials. Evidence against the smooth endoplasmic reticulum as a continuous channel for the retrograde axonal transport of horseradish peroxidase. Inpatient management of hospitalized patients with type 2 diabetes. Morphology, topography and clinical signi cance of the jugular foramen.

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Horse serum cholinesterase (acylcholine acylhydrolase, EC was reversibly inhibited by a variety of alkyl- and areneboronic acids with Ki values ranging from 6.2 mM (methaneboronic acid) to 3.1 microM (diphenylboric acid). The amino-terminal sequence of the isolated Mr 32,000 polypeptide was determined and used to map the putative structural gene for the vaccinia topoisomerase to the H7r open reading frame of the vaccinia genome. A ribonucleic acid-specific antibody produced during autoimmune disease: evidence for nucleotide sequence specificity. According to our results, the most common misconducts among Iranian authors are guest authorship and falsification of the methodology. In the present paper, we studied the evolution of ten morphological characters, currently used in stylasterid taxonomy, using a phylogenetic approach. A exaggerated right ventricular hypertrophy, in comparison with that expected in the usual case of tetralogy of Fallot, is a useful parison with that expected in the usual case of tetralogy of Fallot, is a useful electrocardiographic sign. The impairment of the immunological response is a well-known aspect of myeloma, although this usually takes the form of recurrent respiratory infections. None of the intermolecular contacts found in the molecular fibers was present in crystals of this variant.

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Evaluation of gene transfer efficiency by viral vectors to murine bladder epithelium. The effects of norepinephrine (NE) on inhibitory synaptic potentials were studied on CA1 pyramidal neurons in the hippocampal slice in vitro. Interaction of elavil overdose side effects monolayers of concanavalin A with mono- and polysaccharides. The AVA were found in the course of branches of the glomic arteries leaving the main vessel before its entrance into the carotid body tissue. Recently relations between occupational silica exposure and several diseases were reported. We report a case of extensive subcutaneous emphysema of the lower extremity mimicking gas gangrene following perforation of the rectum in a 38-yr-old man. The hernial contents included the stomach, omentum, small intestine, and colon.

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The role of the electrocardiogram in the diagnosis of myocardial infarction does cipro cure a sinus infection . The test-retest reliability of the methods used was quite satisfactory. Alpha-adrenergic stimulation of growth hormone release in perifused rat anterior pituitary reaggregate cell cultures. A histological review of radical orchiectomy specimens was performed to assess the impact of testicular cancer on spermatogenesis. Significance and mechanisms of cellular regulation of the immune response.

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Rapid histochemical identification of motor and sensory fascicles: preparation of solutions. The procedure involves the formation of a blue indophenol by reacting phenol with 2,6-dibromoquinone-4-chloroimide which can be measured spectrophotometrically. Two virus clones were isolated from a defective SSPE virus, the Yamagata-1 strain, and designated as the YA and YF clones. Such a restoration can be accomplished with the entire fascia lata from one thigh utilized as a free graft extending from one pelvic wall to the other and from the symphysis to the pubic rami. In untreated HIV infection, the main driver of endothelial dysfunction was viral replication. Male Sprague-Dawley rats received microinfusions of selected compounds into the SI via a chronic indwelling cannula. In all subjects investigated the levels of all the hormones measured were low in comparison with the values in euthyroid women. Interstitial radiotherapy in treatment of superficial tumours of the lower alveolar ridge. National mortality statistics derived from death certificates are a flawed source of information on deaths from anorexia nervosa when taken at face value.

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