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Azithromycin

Azithromycin is a macrolide antibiotic of azalides group. Azithromycin inhibits RNA-dependent protein synthesis of sensitive microorganisms. It active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes group A); gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis.

Other names for this medication:
Azidraw, Azigram, Azihexal, Azimac, Azimakrol, Azimax, Azimex, Azirox, Azithin, Azithromycin, Azithromycinum, Azitrim, Azitrin, Azitrolit, Aziwok, Azomex, Azyter, Azyth, Clearsing, Doromax, Kromicin, Macrozit, Maczith, Misultina, Naxocina, Penalox, Phagocin, Texis, Thiza, Tremac, Tromic, Tromix, Vinzam, Zaret, Zentavion, Zicho, Zitrex, Zitrim, Zitrofar, Zitroken, Zival, Zocin

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Description

Azithromycin (Azithromycin tablets and Azithromycin for oral suspension) contain the active ingredient azithromycin, a macrolide antibacterial drug, for oral administration. Azithromycin has the chemical name (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl) oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one. Azithromycin is derived from erythromycin; however, it differs chemically from erythromycin in that a methyl-substituted nitrogen atom is incorporated into the lactone ring. Its molecular formula is C38H72N2O12, and its molecular weight is 749.00.

Azithromycin, as the dihydrate, is a white crystalline powder with a molecular formula of C38H72N2O12∙2H2O and a molecular weight of 785.0.

Azithromycin is supplied as tablets containing azithromycin dihydrate equivalent to either 250 mg or 500 mg azithromycin and the following inactive ingredients: dibasic calcium phosphate anhydrous, pregelatinized starch, sodium croscarmellose, magnesium stearate, sodium lauryl sulfate, hypromellose, lactose, titanium dioxide, triacetin, and D&C Red #30 aluminum lake.

Azithromycin for oral suspension is supplied in bottles containing azithromycin dihydrate powder equivalent to 300 mg, 600 mg, 900 mg, or 1200 mg azithromycin per bottle and the following inactive ingredients: sucrose; sodium phosphate, tribasic, anhydrous; hydroxypropyl cellulose; xanthan gum; FD&C Red #40; and spray dried artificial cherry, creme de vanilla, and banana flavors. After constitution, each 5 mL of suspension contains 100 mg or 200 mg of azithromycin.

Dosage

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. The dose and length of treatment with Azithromycin may not be the same for every type of infection. Take each tablet or capsule with a full glass (8 ounces) of water. To use the oral suspension single dose packet: Open the packet and pour the medicine into 2 ounces of water. Stir this mixture and drink all of it right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away. Azithromycin capsules must be taken on an empty stomach. Take the capsule at least 1 hour before or 2 hours after eating a meal Azithromycin tablets or powder oral suspension may be taken with or without food. Take the tablet or oral suspension with food if the medicine upsets your stomach. Do not take Azithromycin at the same time as taking an antacid that contains aluminum or magnesium. This includes Rolaids, Maalox, Mylanta, Milk of Magnesia, Pepcid Complete, and others. These antacids can make Azithromycin less effective when taken at the same time. Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Azithromycin will not treat a viral infection such as the common cold or flu. It is important to take Azithromycin regularly to get the most benefit. Store this medication at room temperature away from moisture and heat. Throw away any unused liquid medicine after 10 days.

Overdose

If you overdose Generic Azithromycin and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Azithromycin overdosage: discomfort feeling in stomach, diarrhea, retching, nausea.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not refrigerate or freeze the extended-release oral liquid. After water has been added to the powder, use the dose within 12 hours and throw away any unused liquid after your dose.

You may store the oral liquid at room temperature or in the refrigerator. Do not freeze the bottle. Do not keep the oral liquid for more than 10 days. Throw away any unused liquid after all doses are completed.

Side effects

The most common side effects associated with Azithromycin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take antacids that contain aluminum or magnesium within 2 hours before or after you take azithromycin. This includes Acid Gone, Aldroxicon, Alternagel, Di-Gel, Gaviscon, Gelusil, Genaton, Maalox, Maldroxal, Milk of Magnesia, Mintox, Mylagen, Mylanta, Pepcid Complete, Rolaids, Rulox, and others. These antacids can make azithromycin less effective when taken at the same time.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking azithromycin and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Avoid exposure to sunlight or tanning beds. Azithromycin can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

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To investigate the in vitro effect of vital dyes on toxicity and apoptosis in a human retinal pigment epithelial cell line. Two concepts are applied in the assessment of evaluative instruments: We endorse the recommendation that a distinction be made between sensitivity and responsiveness. Prolactin-mediated progesterone secretion by cultured rat granulosa cells: regulation by purified human glycoprotein hormones and their subunits. Accidental pressure applied at this weak point in any Perclose device during deployment can cause breakage. Synthesis of the major heat-shock proteins, HSP70 and HSP90, is not glucocorticoid-sensitive. Vibration Testing Procedures for Bone Stiffness Assessment in Fractures Treated with External Fixation. Training nonexpert staff in echocardiography requires appropriate methods and materials. 946 healthy Thai women (median age 44, range 18-83) and 61 cervical cancer patients were screened using an HPV pseudovirion-Luminex assay to detect antibodies to genital (HPV-6,-11,-16,-18,-31,-33,-45,-52,-58,-68) and non-genital HPV types (HPV-5,-15,-32,-38 and -76).

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Metastatic disease is responsible for the majority of prostate cancer deaths. However, critically, a posterior-to-anterior functional gradient emerged within this region. At a mean follow-up of 17 months, all patients were asymptomatic, and hydronephrosis was relieved in 9 cases. Thirty three unselected patients attending neurology and epilepsy clinics were identified as taking vigabatrin and asked to attend for neuro-ophthalmic evaluation. Fluorodeoxyglucose positron emission tomography-computed tomography findings in a case of xanthogranulomatous pyelonephritis. After pre-culture for 36 hr when the polyamine content returned to constant levels, we tested the effects of superoxide dismutase (SOD) and alpha-tocopherol on the paraquat-induced increase in N1-acetylspermidine (N1-acetyl-SPD) and PUT in the culture. Adsorption of Iodine Based on a Tetrazolate Framework with Microporous Cages and Mesoporous Cages. Interleukin 1beta induces expression of human herpesvirus 8 encoded genes in BCBL-1 cells. Pathogenesis and preventive measures have not yet been determined. Proton speciation and microspeciation of vinpocetine and related compounds in aqueous and biomimetic media.

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On the other hand, less is known about the spatiotemporal dynamics of the spontaneous activity of the brain. The patient continues to be free of recurrence 2 years after surgery. We have studied the growth of a SrTiO3 shell on self-catalyzed GaAs nanowires grown by vapor-liquid-solid assisted molecular beam epitaxy on Si(111) substrates. Two BC1 populations and an F2 population derived from a cross between P. GDD methods complemented quality-improvement methods to generate prototypes consistent with clinical and research aims, as well as the goals of patient disease management. To determine the in vitro activity of a polyhexanide-betaine solution against collection strains and multidrug-resistant (MDR) nosocomial isolates, including high-risk clones. Methamphetamine inhibits voltage-gated potassium currents in NG108-15 cells: possible contribution of large-conductance calcium-activated potassium channels.

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This phenotype has only previously been reported in pediatric cases. Experimental studies on combination chemotherapy of cisplatin with peplomycin against human squamous cell carcinomas in nude mice. The investigations included socio-demographic data, health status, lifestyle and anthropometric measurements. The known compound bakuchiol (1) was isolated from an extract of Otholobium pubescens (Fabaceae) by bioassay-guided fractionation using the db/db mouse model for type 2 diabetes. This chapter covers the recent advancement in biosensing applications of DNAzyme-functionalized gold nanoparticles, including the detection of metal ions, small molecules, and intracellular imaging. Compared with the tetracyclines resistance genes, the absolute copy number and relative abundance of the sulfonamides resistance genes were 4.3 times and 2.3 times higher in water and sediment from the mariculture sites, with the dominant resistance genes being sul2. A first overview of textile fibers, including microplastics, in indoor and outdoor environments. In vitro regeneration, through somatic embryogenesis or organogenesis, is discussed because they are prerequisites for the subsequent Agrobacterium tumefaciens-mediated transferred (T)-DNA or direct DNA transfer methods to produce transgenic plants.

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Admission health status differences of black and white indigent nursing home residents. Ubiquitin is a common post-translational modifier and its conjugation is a key signal for proteolysis by the proteasome. Preparing for influenza epidemics and pandemics in the new millennium. Localization of cardiac defects by flonase nasal spray drug classification dye-dilution curves recorded after injection of T-1824 at multiple sites in the heart and great vessels during cardiac catheterization. To deal with these problems, we first build the design on the basis of success probabilities. In a prospective pilot study, 32 patients with advanced inoperable squamous cell carcinoma of the head and neck were treated with polychemotherapy and hyaluronidase combined with radiation therapy. In vitro studies suggest that persistent enteroviruses mutate, evolving into forms that are less lytic and display altered tropism, but it is less clear whether these mechanisms operate in vivo.

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Histone variants are incorporated at specific locations by the concerted action of histone chaperones and ATP-dependent chromatin remodelers. SEQUENTIAL FORMATION AND ACCUMULATION OF PRIMARY AND SECONDARY SHUNT METABOLIC PRODUCTS IN CLAVICEPS PURPUREA. The purpose of this study was to examine the relationship between changes in motivational factors and perceptions of control among participants of the Norwegian Olympic Soccer Team for Women, prior to and during the 1996 Summer Olympic Games in Atlanta. The undulation pump total artificial heart (UPTAH) was developed by using small-size continuous-flow displacement-type blood pumps (undulation pump). This study shows that selection criteria for patients with mucinous peritoneal carcinomatosis are available on a preoperative CT scan of the abdomen and pelvis. A comparison of resting images from two myocardial perfusion tracers.

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EFFECT OF TOTAL ADRENALECTOMY ON GASTRIC SECRETION IN CHRONIC GASTRIC FISTULA RATS. The RF can be successfully prepared by the technological process in this study. A first glance at the literature leads to the weird impression that working memory capacity reaches adult levels during infancy but then regresses during childhood. Diffuse shear wave imaging: toward passive elastography using low-frame rate spectral-domain optical coherence tomography. Cultured midbrain (dopaminergic) neurons from Nogo-A knock-out mice exhibited decreased prilosec dose dogs numbers of neurites and branches when compared with neurons from wild-type (WT) mice. We conclude that the target genes of the BR-C in oogenesis include a protein essential for endoreplication and chorion gene amplification.

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