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Azenate (Azelastine)

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Azenate nasal spray is used to help relieve symptoms (eg, stuffy or runny nose, itching, sneezing) of seasonal (short-term) or perennial (year-round) allergic rhinitis (hay fever), vasomotor rhinitis, or other upper respiratory allergies.

Other names for this medication:
Astepro, Azelast, Azelastine, Azenate, Duonase, Nazomac, Oculast, Optihist, Optivar

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Flagyl, Retin, Kemadrin, Lunesta, Dulcolax

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Also known as: Azelastine


Azelastine nasal spray is used to help relieve symptoms (eg, stuffy or runny nose, itching, sneezing) of seasonal (short-term) or perennial (year-round) allergic rhinitis (hay fever), vasomotor rhinitis, or other upper respiratory allergies.

Azelastine is an antihistamine. It works by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain azelastine. It may not be specific to Astelin Ready-Spray. Please read with care.

Use this medicine only as directed by your doctor. Do not use more of it and do not use it more often than your doctor ordered. To do so may increase the chance of side effects.

This medicine usually comes with patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Follow the instructions on the medicine label if you are using this medicine without a prescription.

This medicine is for use only in the nose. Do not get any of it in your eyes or on your mouth. If it does get on these areas, rinse it off with water and call your doctor right away.

Do not use this medicine for any other nose problem (eg, ulcers or surgery, or injury that has not healed) without checking with your doctor first.

To use the spray:

When you use the azelastine nasal spray for the first time, you must prime the spray. Press down fully 6 times or until a fine spray comes out. Prime the spray after each time you clean the pump, or if you have not used the medicine for 3 days or longer, by spraying the medicine 2 times or until a fine spray comes out. Blow your nose to clear your nostrils. Tilt your head down, looking at your toes, and insert the tip of the nose piece into your nostril. Hold bottle upright and aim the spray tip toward the back of your nose. Tilt your head downward while spraying to avoid a bitter taste in the mouth. Close your other nostril with a finger. Press the pump 1 time and sniff gently at the same time, keeping your head tilted forward and down. Repeat in your other nostril using the same steps. If your healthcare provider tells you to use 2 sprays in each nostril, repeat the steps above for the second spray in each nostril. Do not blow your nose or tip your head back after using the spray. Wipe the tip of the outside of the nose piece with a clean, dry tissue or cloth and put the cap back on.

Do not drink alcohol while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For nasal dosage form (Astelin® spray): For treatment of seasonal allergic rhinitis: Adults and children 12 years of age and older—1 or 2 sprays in each nostril 2 times a day, or 2 sprays in each nostril once a day. Each spray contains 137 or 205.5 micrograms (mcg) of azelastine. Children 6 to 11 years of age—1 spray in each nostril 2 times a day. Each spray contains 137 or 205.5 mcg of azelastine. Children 2 to 5 years of age—1 spray in each nostril 2 times a day. Each spray contains 137 mcg of azelastine. Children younger than 2 years of age—Use and dose must be determined by your doctor. For nasal dosage form (Astepro® spray): For treatment of perennial allergic rhinitis: Children 6 months to 11 years of age—1 spray in each nostril 2 times a day. Each spray contains 137 micrograms (mcg) of azelastine. Children younger than 6 months of age—Use and dose must be determined by your doctor. For treatment of seasonal allergic rhinitis: Adults and children 12 years of age and older—1 or 2 sprays in each nostril 2 times a day. Each spray contains 137 micrograms (mcg) of azelastine. Children 2 to 11 years of age—1 spray in each nostril 2 times a day. Each spray contains 137 mcg of azelastine. Children younger than 2 years of age—Use and dose must be determined by your doctor. For nasal dosage form (Astepro® allergy spray): For treatment of allergic rhinitis or other upper respiratory allergies: Adults and children 12 years of age and older—2 sprays in each nostril once a day or 1 or 2 sprays in each nostril 2 times a day (every 12 hours). Do not use more than 4 sprays in each nostril per day (24 hour period). Each spray contains 205.5 micrograms (mcg) of azelastine. Children 6 to 11 years of age—1 spray in each nostril 2 times a day (every 12 hours). Do not use more than 2 sprays in each nostril per day (24 hour period). Each spray contains 205.5 micrograms (mcg) of azelastine. Children younger than 6 years of age—Use is not recommended.


An overdose of azelastine nasal is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the bottle upright with the pump tightly closed.

Detailed Astelin dosage information

Side effects

The most common side effects associated with Azenate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Azenate if you are allergic to Azenate components. It is not known whether Azenate will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant or breast-feeding. The medicine has a antihistamine in it. Before you start any new medicine, check the label to see if it has an antihistamine (e.g., diphenhydramine) in it too. If it does or if you are not sure, check with your doctor or pharmacist. Azenate may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away. Azenate should be used with extreme caution in children younger than 5 years old; safety and effectiveness in these children have not been confirmed. Do not drink alcohol or use medicines that may cause drowsiness (e.g., sleep aids, muscle relaxers) while you are using Azenate; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. Azenate may cause drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Azenate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Do not stop taking Azenate suddenly.

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The collective data indicate an intimate role for Sac1p in the transport of ATP into the ER lumen. The aim of this study was to compare morbidity and mortality of patients who had epidural analgesia for at least 2 days after transthoracic esophagectomy for cancer with those who did not have epidural analgesia at all or who had it for less than 2 days. Results of surgical treatment of portal hypertension in children. Thus, our data suggest that a pathway distinct from those that signals through MAPK, NFkappaB or PI3-kinase is responsible for the impaired differentiation and apoptosis in 23A2 skeletal myoblasts expressing constitutively active Ras. This process was followed by expression of bone markers (Type I Collagen and Osteocalcin), suggesting endochondral ossification.

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The influenza pandemic of 1918 caused an estimated 20-40 million deaths worldwide. While it is difficult to make a definitive pathological diagnosis preoperatively, percutaneous needle biopsy by Surecut needle is possible. Description of a new CT-guided technique and preliminary results. In ischemic and excess FFA supplemented myocardium, free carnitine and ATP decreased, whereas long chain acyl carnitine and FFA increased. Suppression of COX-2-derived PGI2 or deletion of IP profoundly influences the architectural response of the vasculature to hemodynamic stress. The N-terminal portion of CAP-1 contains a RING finger motif and three zinc finger-like domains similar to those found in several regulatory proteins that interact with DNA or RNA.

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