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Aspitrate (Isosorbide)

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Aspitrate is a medication used for heart-related chest pain, heart failure, and esophageal spasms. It can be used both to treat and to prevent heart-related chest pain; however, it is generally less preferred than beta blockers or calcium channel blockers.

Other names for this medication:
Aspitrate, Dilatrate, Ecosmin, Ismorin, Ismotic, Isoditrate, Isoloprin, Isordil, Isosorbide, Monit, Monoket, Monosprin, Nitren, Nitrofix, Nitroprin, Solosprin, Vasoprin

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Also known as: Isosorbide


Isosorbide mononitrate is used to prevent angina (chest pain) caused by coronary artery disease (heart disease). It does not work fast enough to relieve the pain of an angina attack that has already started.

Isosorbide mononitrate belongs to the group of medicines called nitrates. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. When used regularly on a long-term basis, this helps prevent angina attacks from occurring.

This medicine is available only with your doctor's prescription.


Take Generic Aspitrate tablets orally with or without food. Do not crush or chew it. Take Generic Aspitrate at the same time with water. If you want to achieve most effective results do not stop taking Generic Aspitrate suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of isosorbide mononitrate can be fatal.

Overdose symptoms may include a severe throbbing headache, fever, confusion, severe dizziness, fast or pounding heartbeats, vision problems, nausea, vomiting, stomach pain, bloody diarrhea, trouble breathing, sweating, cold or clammy skin, fainting, and seizure (convulsions).


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Isosorbide mononitrate dosage information

Side effects

The most common side effects associated with Aspitrate are:

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Genetic testing in spinocerebellar ataxias: defining a clinical role. In the neonatal mice of both sexes, the basic C5 was observed at the same levels, but the acidic C5 was only slightly detected. Tumor induced hypoglycemia (TIH) is a rare clinical entity that can be caused by different mechanisms such as secretion of various substances, autoimmune disorders, massive tumoral infiltration of liver, and pituitary or adrenal glands destruction by tumors. Intrabone marrow injection enhances placental mesenchymal stem cellmediated support of hematopoiesis in mice. In this framework, 10 mg/kg of buspirone, of 1-pyrimidine-piperazine and of MJ-13805 proved to be as active as 2.5 mg/kg of alprazolam and as 5 mg/kg of chlordiazepoxide in inhibiting the locus coeruleus-mediated suppression of muricidal aggression. Previously, we showed that pathogenic tuberin amino-acid substitutions disrupt the tuberin-hamartin complex. Uncorrected perfusion lesion volumes overestimated the extent of ischemic injury. The aim of this study was to evaluate the effect of different therapy models on clinical and metabolic status in type 2 diabetic patients during Ramadan. In this study, the transcriptional activity of the cyd operon, encoding the two subunits of the enzyme, was examined under a variety of growth conditions.

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To evaluate a possible higher incidence of intracranial aneurysms, a study of the cerebral vasculature in all AGS patients by using noninvasive imaging techniques should be considered. Using this technique, we demonstrate that such T-cell clones are antigen specific and require I--A compatible antigen-presenting cells for stimulation. Cell surface heparan sulfate proteoglycans from human vascular endothelial cells. These studies suggest that compounds which suppress prostaglandin synthesis can modulate the function of resident and post-surgical peritoneal cells. Cell-to-cell movement of potato virus X involves distinct functions of the coat protein. These are identified as 1,5,8-trihydroxy-3-methoxyxanthone, 1,3,8-trihydroxy-5-methoxyzanthone, 1-hydroxy-3,7,8-trimethoxyxanthone, 1,3,7,8-tetrahydroxyxanthone, 1,3,5,8-tetrahydroxyxanthone, and 1-hydroxy-3,4,7,8-tetramethoxyxanthone by chemical and spectral evidence. Role of nitric oxide signal transduction pathway in regulation of vascular tone. Fast Electrochromic Device Based on Single-Walled Carbon Nanotube Thin Films. Improved oligonucleotide-directed mutagenesis using M13 vectors.

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Ensemble-averaged MD simulations of the L29F mutant of myoglobin after ligand dissociation reproduce the direction, amplitude, and time scales of crystallographically determined structural changes. In group A, three wound infections and an intraperitoneal abscess were identified, while in group B only one wound infection was seen. Objective It is difficult to compare directly the practical effects of lifestyle modifications and antihypertensive medications on reducing cardiovascular disease (CVD). Recent meta-analyses have shown that weight loss achieved with ad libitum low-fat diets is typically in the range of 3-4 kg. The genetic or mythical ancestry of descent groups: lessons from the Y chromosome. Synthetic multimers of this region were found to be sufficient to permit a transcriptional response to cAMP or TRH in GH3 cells and cAMP in Rat-1 cells.(ABSTRACT TRUNCATED AT 250 WORDS). Proceedings: A statistical description of neuronal activity in the cerebral cortex of the unrestrained cat. Raman spectra of dipalmitoyl phosphatidylcholine and structurally related molecules are examined and vibrational transitions assigned for the C-C, phosphate and C-H stretching modes of these molecules. Anti-pulmonary fibrosis effect of acexamic acid in bleomycin therapy. The proliferative phase underpins endometrial development: Altered cytokine profiles in uterine lavage fluid of women with idiopathic infertility.

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Blood serum secretin-pancreozymin test in diagnosis of chronic pancreatitis. MFH and liposarcoma may have a common origin from the perivascular mesenchymal cells that are supposed to have a potential for multidirectional differentiation. Agitated confusional states in patients with right hemisphere infarctions. The increased level of antibody to Epstein-Barr virus (EBV) induced antigens in patients with RA resembles the antibody pattern observed against cytomegalovirus (CMV) induced antigens, which suggests the presence of a pathological condition in patients with RA that can reactivate latent viral infections. The aim of this study was to define the dynamics of airway and alveolar NO during specific inhalation challenge (SIC) with isocyanates and the role of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase. Assay of augmentation of natural killer cell activity and antibody-dependent cell-mediated cytotoxicity by interferon.

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Bovine staphylococcic mastitis: an immunohistochemical study of the cellular sites of antibody formation. Clinical findings do not necessarily indicate the presence or absence of C. The findings have relevance for the evolution of autonomous systems that are characterised by one-shot interactions. The 11 patients included 7 females and 4 males with a mean age of 45 (range, 33-60) years. L-arginine enhances aerobic exercise capacity in association with augmented nitric oxide production. Analysis results show that 9c,12c and 9t,12t fatty acids from trilinolein and trilinoelaidin molecules undergo chemical bond rotation, migration and degradation, leading to the formation of non-conjugated linoleic acids (NLAs), conjugated linoleic acids (CLAs) and aldehydes.

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This method visualizes the meridian by measuring skin current with an improved electrode using the acupoint discrimination system. Our data supports the hypothesis that miR-15a/16 deficient stem cells and B1Ps experience a maturation blockage, which contributes to B1 cells bias in development. However, this effect rapidly diminishes after the end of administration and no dose-dependency between 40 microg and 60 microg Alprostadil is observed. Morphology of bacterial attachment to cardiac pacemaker leads and power packs. Once the cortex was involved and cortical bone destruction had occurred, large amounts of woven bone resembling fracture callus were laid down. However, inhibitor development remains the largest problem, particularly in children. On the other hand, the cells having a large number of nuclei belonging initially to late S- or G2-phase took longer to reach mitosis. The cytological findings in the CSF, together with the clinical signs of brain death, constitute an intravital morphological indication of brain tissue autolysis.

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Reflux studies were obtained for 40 children from the study group and 41 from the control group. The difference suggests the need for a specific correction factor for this population to avoid underestimation of risk for fetal aneuploidies or placental disorders when using PAPP-A and PlGF MoM for screening purposes. Emphasis is placed on a concept describing distinct subsets of memory T cells according to their primary residence in peripheral blood, secondary lymphoid tissues, or peripheral (extralymphoid) tissues. This study reports on the full-length cDNA cloning of a gene identified on the basis of its preferential expression in nerve growth factor, compared with neurotrophin-3-dependent neurons. The immunoelectrophoretic purity of the exonuclease preparation, isolated from Crotalus adamanteus venom according to a procedure previously published (Dolapchiev, L.B., Sulkowski, E. Moreover, tranilast scarcely affected the fibronectin production. Our results further substantiate the concept that the vagus nerve is the afferent pathway for the pulmonary depressor reflex, and it may be concluded that during this reflex the sympathetic efferent activities are inhibited. Cultures were grown under these conditions in the presence of C(14)-glucose or C(14)-pyruvate. Annual variations in the plasma thyroxine level in Microcebus murinus. Using data analysis methods, our normal population analysis investigates the effects of age, sex and muscle.

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Quality of life and family functioning in caregivers of relatives with mood disorders. The search strategy aimed to find both published and unpublished studies through electronic databases, reference lists, and the World Wide Web. Furthermore, the final document of the Italian Consensus clearly indicated the need that specialists involved in the management of knee OA strongly encourage the dissemination of the EULAR 2003 recommendations also in Italy. Osteotomy at the midpoint between the tibial crest and the outermost portion of the medial tibial plateau, including the covering articular cartilage, was performed using a surgical blade. injection of the allergen extract to be tested and human serum albumin (HSA) as reference (standard) allergen. These novel approaches appear to be so effective that urologists may now be able to cease using the traditional retropubic space for reservoir placement, even in the case of virgin pelves. Re: Microcirculation in women with severe pre-eclampsia and HELLP syndrome: a case control study: Effect of timing of extracorporeal membrane oxygenation during HELLP syndrome. The sublingual gland presented a well developed cytomorphological structure at birth, whereas the parotid and the submaxillary ones, immature at birth, gradually reached the overall appearance of adult glands, the former at 5--6 weeks, the latter at 8 weeks. CLB-RAg 201 does not inhibit the binding of 125I-von Willebrand factor to extracellular matrices of endothelial cells, to smooth muscle cells, or to the subendothelium.

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Binaural presentation of the acoustic stimulus simultaneously with the tap yielded more reflex augmentation than when that same stimulus was presented monaurally. A new computer-based method for continuous gauging of momentary, visuomotor coordination under simultaneous EEG control proved both effective and suitable for children. Autophagy protects cardiomyocytes from the myocardial ischaemia-reperfusion injury through the clearance of CLP36. Ultrastructural and biochemical alterations induced by propranolol treatment in experimental myocardial ischaemia. Increase of serotonin metabolism within the dorsal horn of the spinal cord during nucleus raphe magnus stimulation, as revealed by in vivo electrochemical detection. The authors have studied the bucco-facial apraxia (BFA) in 20 aphasic patients, examining 10 isolated oral gesture (IOG) and 10 combined oral gesture (COG). Characterization and role in autoimmune diseases of the polyclonal B-cell activator produced by T-cells-the helper factor.

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Though physicians treating large populations of patients with HIV are well aware of this complication, only one other report of nevirapine-associated SJS has been documented in the dermatology literature. Possible implication of B cell derived cytokines and sCD23 in the control of T lymphocyte development. Tissue culture plaque assay characterization of the 42 human isolates from Maryland and California and of 91 representative food isolates revealed significantly higher average infectivity and cell-to-cell spread for the human isolates, further supporting the hypothesis that food and human isolates form distinct populations. The DR3-restricted peptide, MT 65 kDa 3-13, was used to develop a DR3-specific binding assay. Proceedings: Diagnostic value of dynamic compliance in the immediate neonatal period. Double valve replacement for secondary atrioventricular regurgitation due to dilated cardiomyopathy--a case report. In this study we tempted to demonstrate that some of these modifications could involve impairment of neurotrophic factors.

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This indicated that some of the enzymes (GF-1, CF-5, CF-8) may appear in polymeric/aggregate forms. The advantage of such a stereochemical theory over the frozen accident theory is discussed. On gel filtration of the conditioned medium with Sephadex G-100, CSF was eluted between the larger D-factor and the smaller one. Peak concentrations occurred at a time when nocturnal wheezing is likely. Correlation between pharmacological response, kinetics of plasma concentration and in vitro receptor affinities exemplified with beta-adrenoceptor blocking drugs. Adding copper to the diet resulted in considerable accumulation of selenium in the liver, which was evident even at the lower levels of added selenium. Design, Synthesis, and Evaluation of a Neurokinin-1 Receptor-Targeted Near-IR Dye for Fluorescence-Guided Surgery of Neuroendocrine Cancers. These observations define the immediate effects of intravenous oxprenolol over a relatively wide dose range and confirm its relative haemodynamic safety in patients with stable coronary heart disease. Until the mechanisms involved in oocyte quality are elucidated, any effort to use assisted reproductive technologies in animals for production or biomedical purposes will be cozaar 100 mg tablet inefficient at best. S-Adenosyl-L-methionine decarboxylase (EC has been purified more than 1000-fold from rat liver.

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Polarization of Tissue-Resident TFH-Like Cells in Human Hepatoma Bridges Innate Monocyte Inflammation and M2b Macrophage Polarization. In addition, mechanical cleansing of the bowel was done in all cases. Histological examination of the resected specimen confirmed the diagnosis of SPN. Monoclonal antibodies (MAB) to each of the 3 major structural proteins of transmissible gastroenteritis virus (TGEV) of swine were compared, using their virus-neutralizing (VN) activity in the presence or absence of guinea pig, rabbit, is theophylline an antibiotic or swine complement. Complications of cochlear implant surgery: A ten-year experience in a referral hospital in Peru, 2006-2015. Plans for trials of VZ vaccine in immunocompromised North American children are outlined. Cells were stimulated by the addition of 200 units/ml interferon gamma (IFN gamma). The results are interpreted as indicating that mammary adenocarcinoma in general exhibit a high degree of stability of the nuclear DNA content during the history of the disease.

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In the present study, we investigated the developmental control of topo II isoforms in two different neuronal lineages, cerebellar Purkinje cells and granule cells, by immunohistochemical analysis with isoform-specific monoclonal antibodies zyloprim 300mg tab . Between-limb measures of pressure sensitivity were not significantly different in any group. Lipid raft on gametic cells as a functional domain for sperm-egg interaction coupled with signal transduction. The role of EBV on the occurrence of HPCS and T-ML is also discussed. Neurodegenerative diseases, suicide and depressive symptoms in relation to EMF. Role of the granulocyte in the pyrogenic response to intra-cisternal endotoxin. They suggest also that the processes responsible for blocking and overshadowing are different from those which produce the dimensional transfer effect. The accessing of phonological representations as a possible explanation for the effect is discussed. This study aims to describe preferences for therapeutic modes in undergraduate occupational therapy students, as well as to explore factors associated to each of the therapeutic modes. The aim of this study was to quantify kinematic, kinetic and performance changes that occur in the serve throughout a prolonged tennis match play.

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Species richness values predicted by the null models of the MDE and those values predicted by Net Primary Productivity, a surrogate variable expressing the effect of available energy, were compared in order to evaluate which hypothesis better predicts the observed values. (4) The distributions of 3H-SP and 3H-NKB binding sites were markedly different. Linear relationship exists between the ratio and concentration for each steroid. Progressive weakening of the response of key enzymes of liver glycogen metabolism to permanently increased plasma epinephrine levels. Mutational inactivation of the Saccharomyces cerevisiae RAD4 gene in Escherichia coli. Aging changes of the retina and choroid in the macular region in humans.

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A case of atypical male anorexia nervosa: a tumor in the area of the 3d ventricle. Trasylol had a slight beneficial effect on experimental pancreatitis when assessed by its effect on the pancreatic hemodynamics. Autoradiographic measurements of local CBF showed that the procedure reduced CBF in neocortical areas, hippocampus, and caudoputamen to near-zero values, flow rates in a number of subcortical areas being variable. The uptake and metabolism of 3H-oestradiol by breast tumour tissue was studied in three postmenopausal women before, after 1 week of treatment with ethynyl-oestradiol (EE, 10 micrograms/day) and again two weeks later after treatment with medroxyprogesterone acetate (MPA, 500mg/day, i.m.). However, these correlations all show a large degree of scatter, preventing accurate quantitative prediction of gross chemical composition of the oils. The impact of rejection and immunosuppressive therapy (ALG) on the one hand and the recovery of suppressor activity on the other hand during long-term graft survival could be demonstrated. Dorsomedial hypothalamic NPY affects cholecystokinin-induced satiety via modulation of brain stem catecholamine neuronal signaling. It is important to focus health promotion efforts around preventing the otherwise expected increase of obesity among the young adult generation. The difference between means (1:17 and 1:42) was statistically significant (p less then 0,01). Dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivo.

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However, their analysis was based on bias measures that can be shown a priori to be nonindependent of discrimination. The UVO-PS surfaces present a new way of producing tissue culture grade polystyrene (TCPS) in a highly controllable method, which would ensure greater consistency in TCPS surfaces. In this paper, we demonstrate that casein kinase II (CKII) phosphorylates p34cdc2 in vivo and in vitro at Ser39 during the G1 phase of HeLa cell division cycle. Silver reactions, fluorescence, and serotonin content of the cytoplasmic granules. Chromogranin A expression in childhood peripheral neuroectodermal tumors. Preventive Services Task Force-recommended interventions, using the 1999 Veterans Health Survey. Pinocytotic uptake and intracellular distribution of colloidal thorium dioxide by cultured sensory neurites. The apoptotic action of cleocin and breastfeeding glucocorticoids on lymphocytes makes them effective therapeutics for many lymphoid malignancies.

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Orthodontic treatment in unilateral cleft lip and palate patients with crossbite. Decline in BI values and average BIs at 24 months were found to be similar for both groups. There was no difference between depressive patients (taken as a whole), bipolar patients undergoing a manic phase and controls in the prolactin response to thyrotropin-releasing hormone. The metabolic inhibition directly connected with the FV3 would thus result not in producing the hepatocytolysis but in rendering any cellular regeneration impossible. Pericarditis and heart tamponade in patients on regular hemodialysis. Domain-specific and cell type-specific localization of two types of cell wall matrix polysaccharides in the clover root tip. The effectiveness of the Act at improving the care of the mentally incapacitated adult will depend largely on how successful it is at encouraging communication and decision making in advance of incapacity occurring. New mathematics has often been inspired by new insights into the natural world. Thus, the increase in alpha 2 beta 1 protein which accompanies the megakaryocytic differentiation of K562 cells is a consequence of the increased steady-state level of alpha 2 mRNA due to transcriptional activation of the alpha 2 gene. By SDS disc electrophoresis, however, the alpha-subunit moved faster than hCG-alpha separated by mercaptoethanol reduction.

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Two-dimensional speckle tracking cardiac mechanics and constrictive pericarditis: systematic review. The changes in cell volume (notably in the extracellular reservoir) occurring throughout the pregnancy cycle are illustrated in electron micrographs, and a one hundred-fold volume increase in the reservoir volume between the inactive phase and the active period is illustrated and discussed in terms of membrane modulation of the limiting membrane of the reservoir. It is shown that a consequence of the observed organization is that the gain of the Ia mediated stretch reflex would be approximately proportional to the developed force. Overexpression of a slit homologue impairs convergent extension of the mesoderm and causes cyclopia in embryonic zebrafish. Serum HCG was found to be in the normal range of monozygotic and dizygotic pregnancies. These include the tight control that somatic support cells exert on every aspect of GSC function and the similar molecular mechanisms for physical attachment, cell-cell signaling and gap-junction communication. In a first evaluation, similar results were shown for serotype 2, however there are not yet sufficient data on serotype 1. Failure of methylhistidines to inhibit platelet aggregation at concentrations found in uremic plasma.

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The results suggested that the detection of high levels of Ross River virus IgA antibodies was of potential value in differentiating between recent and past infection, especially in those patients with persisting IgM antibodies. A statistically significant difference was observed for both AUC and half-life of metoclopramide when administered alone or after 5 days of treatment with ranitidine. The deletion mutants were used to study the role of the F glycoprotein and the contributions of SH and G with respect to virus attachment. Computational deconvolution methods enable researchers to investigate immune cell quantities in complex tissues based on transcriptome data. Additional functional experiments showed that the PL-NAcC pathway was recruited by drug-associated cues in a dopamine-dependent manner to drive cocaine-seeking, but not sucrose-seeking, behavior.

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