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Arimidex (Anastrozole)

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Arimidex is an aromatase inhibitor approved by the U.S. Food and Drug Administration (FDA) to treat: postmenopausal women diagnosed with hormone-receptor-positive, early-stage breast cancer after surgery (or possibly chemotherapy and radiation) to reduce the risk of the cancer coming back.

Other names for this medication:
Altraz, Altrol, Anabrez, Anastrocare, Anastrozole, Anatero, Anazol, Armilon, Armotraz, Femistra, Femitraz, Qubol, Redest, Rimidex, Stazonex, Xenosoul

Similar Products:
Imitrex, Aristocort, Lipitor, Imuran, Caverta, Lanoxin, Loxitane, Sinequan

Also known as: Anastrozole


Arimidex is approved to treat certain types of breast cancer in women who’ve gone through menopause.

What breast cancer is

Breast cancer develops when cells in your breast start to grow and multiply (make more cells) more quickly than usual. With most breast cancers, the abnormal cells are encouraged to grow by the hormone estrogen.

If your breast cancer is stimulated by hormones, such as estrogen, certain tests will show that the cancer cells have receptors (attachment sites) for those hormones. This type of breast cancer is called hormone receptor-positive (HR+).

HR+ cancers can be treated with hormone therapies that lower the estrogen level in your body. And because most breast cancer is HR+, hormone therapies are also sometimes used to treat breast cancer whose receptor status isn’t known.

What Arimidex does

Arimidex is a hormone therapy that’s used to treat certain forms of breast cancer. It’s a type of drug called an aromatase inhibitor. Arimidex works by stopping (inhibiting) the action of an enzyme called aromatase. (Enzymes are certain proteins that help chemical reactions to happen inside your body.)

The aromatase enzyme makes estrogen out of steroid hormones in your body, such as testosterone. Aromatase is found in various tissues, including your brain, fat, and skin.

Before menopause, estrogen is mainly produced by your ovaries. And just a small amount is made by the aromatase enzyme. But after menopause, your ovaries stop producing estrogen. At that point, the aromatase enzyme is the main way that your body makes estrogen. (And in men, estrogen is also mainly produced by the aromatase enzyme.)

By stopping aromatase from working, Arimidex lowers the amount of estrogen in your body. This helps to stop estrogen from encouraging breast cancer to grow and spread.

How long does it take to work?

Arimidex will start working soon after you begin taking it. But you won’t be able to notice this. Your doctor may order different kinds of tests during your treatment to check and see if the drug is working for you.


This medicine may be taken on an empty stomach or with food. Take this by mouth exactly as directed usually once a day. This is a potent medication. Do not increase your dose, or take this more often than directed. If you want to achieve most effective results do not stop taking Generic Arimidex suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Arimidex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Arimidex can interact with several other medications.

Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe.

Arimidex and other medications

Below are lists of medications that can interact with Arimidex. These lists do not contain all the drugs that may interact with Arimidex.

Before taking Arimidex, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Arimidex and tamoxifen

Like Arimidex, tamoxifen is a hormone therapy that’s used to treat breast cancer. But taking tamoxifen with Arimidex can lower the amount of Arimidex in your body. This can make Arimidex less effective for you.

Because of this interaction, you shouldn’t take tamoxifen with Arimidex. However, if recommended by your doctor, it’s fine to take Arimidex after you’ve finished taking tamoxifen.

Arimidex and drugs that contain estrogen

Taking Arimidex with drugs that contain estrogen could make Arimidex less effective for you. Because of this, you shouldn’t take these types of drugs while you’re using Arimidex.

Examples of drugs that contain estrogen include:

  • hormone replacement therapy (HRT)
  • vaginal estrogen products, such as creams and tablets
  • birth control medications, such as pills, patches, and vaginal rings
If you have questions about using medications that contain estrogen with Arimidex, talk with your doctor.

Arimidex and herbs and supplements

There aren’t any herbs or supplements that have been specifically reported to interact with Arimidex. However, you should still check with your doctor or pharmacist before using any of these products while taking Arimidex.

For example, it’s possible that supplements such as red clover or wild yam could make Arimidex less effective. (These supplements are used by some women to reduce menopausal symptoms, such as hot flashes.)

This interaction is possible because these supplements contain phytoestrogens, which are weak estrogen-like substances found in certain plants. There isn’t enough information available to say for sure whether taking phytoestrogens can affect your breast cancer treatment or not.

Be sure to talk with your doctor before taking any herbs or supplements with Arimidex.

Arimidex and foods

There aren’t any foods that are known to interact with Arimidex. Talk with your doctor to find out if there are any foods you should avoid during Arimidex treatment.

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