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Arilan (Aripiprazole)
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Arilan

Arilan is a medication that can be used to treat psychosis and also calm people who are aggressive or agitated due to psychosis. It can be taken by mouth or by injection (intramuscular).

Other names for this medication:
Apicord, Aridus, Arifril, Arilan, Arinex, Aripat, Aripicon, Aripiprazole, Aripra, Arpicin, Asprito, Biliff, Elrip, Pipra, Rizotal, Schizopra

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Also known as: Aripiprazole

Description

The Abilify Maintena brand of aripiprazole is used to treat schizophrenia and bipolar I disorder (manic depression) in adults. The Aristada brand of Abilify Maintena is for use only in treating schizophrenia in adults.

Dosage

This section provides information on the proper use of a number of products that contain aripiprazole. It may not be specific to Abilify Discmelt. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil, then taking the tablet out. Do not push the tablet through the foil. Do not break or split the tablet. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, you may swallow or take a sip of water.

Swallow the tablets whole. Do not break, crush, or chew them.

Abilify Mycite® has a sensor in the tablet, which helps track it inside the stomach or bowels. The Abilify Mycite® System comes with a patch (wearable sensor), a smartphone application (app), and a web-based portal. Follow your doctor's instructions on how to use the medicine.

The Abilify Mycite® tablet is usually detected within 30 minutes after you take it, but there may be a delay of more than 2 hours for the smartphone app and web portal to detect that you have taken the medicine, and sometimes it might not be detected at all.

To apply the Abilify Mycite® patch:

The app will tell you when to apply or remove the patch. It should be changed weekly or sooner as needed. Place the patch to the left side of your body just above the lower edge of your rib cage. Do not put the patch in areas where the skin is scraped, cracked, inflamed, or irritated, or near the area where you had removed the previous patch. The app will help you place the patch in the correct location. You may keep the patch on when showering, swimming, or exercising.

Aripiprazole may be taken with or without food. If your doctor tells you to take it a certain way, follow your doctor's instructions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (tablets and orally disintegrating tablets): For bipolar mania: Abilify® and Abilify Discmelt®: Adults—At first, 15 milligrams (mg) once a day. When it is given with lithium or valproate, the starting dose is 10 to 15 mg once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 30 mg per day. Children 10 years of age and older—At first, 2 mg once a day. The dose will be gradually increased to 10 mg once a day. Your doctor may adjust your dose again as needed. However, the dose is usually not more than 30 mg per day. Children younger than 10 years of age—Use and dose must be determined by your doctor. Abilify Mycite®: Adults—At first, 15 milligrams (mg) once a day. When it is given with lithium or valproate, the starting dose is 10 to 15 mg once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 30 mg per day. Children—Use and dose must be determined by your doctor. For depression: Adults—At first, 2 to 5 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 15 mg per day. Children—Use and dose must be determined by your doctor. For irritability in children with autistic disorder: Children 6 to 17 years of age—At first, 2 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 15 mg per day. Children younger than 6 years of age—Use and dose must be determined by your doctor. For schizophrenia: Abilify® and Abilify Discmelt®: Adults—At first, 10 to 15 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 30 mg per day. Children 13 to 17 years of age—At first, 2 mg once a day. The dose will be gradually increased to 10 mg once a day. Your doctor may adjust your dose again as needed. However, the dose is usually not more than 30 mg per day. Children younger than 13 years of age—Use and dose must be determined by your doctor. Abilify Mycite®: Adults—At first, 10 to 15 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 30 mg per day. Children—Use and dose must be determined by your doctor. For Tourette's disorder: Children 6 to 18 years of age—At first, 2 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 20 mg per day. Children younger than 6 years of age—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include drowsiness, vomiting, aggression, confusion, tremors, fast or slow heart rate, seizure (convulsions), weak or shallow breathing, or fainting.

Storage

Store Arilan at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Arilan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of aripiprazole in elderly patients who have schizophrenia, depression, or bipolar disorder. This medicine should not be used to treat behavioral problems in elderly patients who have dementia or Alzheimer disease.

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On the so-called detention syndromes: review and notes on several cases. Validation of a screening battery for psychogeriatric assessment. An analysis of 50 fatal cases compared with 400 surviving patients in a consecutive series. This is the last of three articles explaining theories of learning with particular relevance to clinical areas. Inducing developmental redirection of adult liver offers the potential of a cell-replacement therapy for diabetics by allowing the patient to be the donor of his own insulin-producing tissue. Further accumulation of similar unusual cases may be helpful in evaluation of its biologic behavior. There is no real solution to prevent lymphocele after inguinal lymphadenectomy. (2) Cross-links that cause turbidity in the original suspension.

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Clinical experiences with 2 new antitubercular agents: ethioniamide (iridoncin) and diisoamylhydroxythiocarbanilide (isoxyl). On the other hand, the results suggest that the relative contribution of the short-wave cone mechanism increases between fovea and 17 degrees, stays essentially constant between 17 and 28 degrees, and decreases between 28 and 65 degrees. A pilot project for the prevention of substance abuse in schools (PASE) has been developed in 1988-90 in sixth and seventh grades (12-14 years-old) in 11 primary schools in the city of Barcelona (Spain). The direct current was applied for 30 min at a density of 0.1 and 0.2 mA/cm2. Five patients, each with a brain abscess, were examined by means of 1H MR spectroscopic imaging in vivo.

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Promoting physical activity in low-income African-American communities: the PARR project. The mechanism regulating expression of this cluster, through which the balance between atherosclerosis and thrombosis is achieved, is far from been fully understood. These antibodies bind to specific and distinct epitopes within tumor and trophoblast-derived oncofetal fibronectin. After mastectomy ipsilateral to the metastasis proved negative for tumor, a histologic comparison of the previous contralateral tumor with that in the lymph node was performed, followed by biopsy of the clinically and mammographically negative original lumpectomy site. Extracellular matrix interactions in early human embryos: implications for normal implantation events. An 18 kDa protein is associated to complex I in the inner membrane and in a purified preparation of this complex where it can be phosphorylated by the isolated catalytic subunit of PKA. In all 7 cases, the treatment was successful without early or delayed complications.

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Parent interview data from a representative sample of Medicaid children in two Southern states were used to generate information from standardized questionnaires on physical health status, chronic illnesses, physical functioning, emotional and behavioral symptoms, and psychosocial functioning. Fifteen patients from each arm were excluded from efficacy analysis due to protocol violation. It is important to understand the underlying pathophysiology involved so the appropriate inotrope can be chosen on a rational basis. A controlled, prospective evaluation of intracranial pressure during continuous rotation therapy. Cell cycle analysis showed that treatment of cells with compound 1 arrested cells in the S-phase. To retrieve the records of all salivary gland cancer (SGC) patients diagnosed in Finland between 1991 and 1996 and to evaluate the incidence, histological type and location of SGC, the treatment given and the outcome. Differences in distribution of age, hemoglobin values, location and number of ulcers, activities of gastric secretion, associated conditions, treatment and prognoses between bleeding and non-bleeding gastric ulcer patients were studied.

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A Hitrap-mouse recombinant His-tag-saposin A antibody column bound NPF, pulled down the NPF activity in TCGF, and the antibody recognized a 16kDa molecule in western-blotting of TCGF. Cytochrome c upregulation was also observed in cytosolic fractions of the PK-15 and HeLa cells infected with SIV. The insulin response to gastric glucose is reduced in PAC1 and GRP receptor gene deleted mice. Long-term failure of renal transplants: adding insult to injury. An in vivo model of granulocyte mediated inflammation has been developed in our laboratory.

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Evoked extracellular dopamine in vivo in the medial prefrontal cortex. For the binary system, the depletion interaction develops extra features due to polydispersity, specifically a repulsive interaction with range twice the average particle diameter. Chorioretinal striae and pigment mottling did not appear to decrease visual acuity. Nicorandil improved LVDP and decreased LVEDP at 30 min of reperfusion in both SHR and WKY rats dose-dependently. Recently, the crystal structure of human TK1 has been solved and has revealed that enzymes with fundamentally different origins and folds catalyze similar, crucial cellular reactions. A glutamate racemase gene of Lactobacillus brevis ATCC 8287 was cloned into Escherichia coli TM93 by the phenotypic complementation of a phosphoenolpyruvate carboxylase deficiency on minimum agar medium containing D-glutamate. Prior episodes of CPSE had been correctly treated and remained without permanent brain damage.

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aeruginosa siderophore receptor genes still remain to be characterized. In the second treatment phase, crown lengthening of the maxillary front teeth was performed and one implant placed to replace a maxillary premolar. Determination of anti-lipid A and lipid A by enzyme immunoassay. p53 protein expression in fine-needle aspirates of breast cancer: an immunocytochemical assay for identifying high-grade ductal carcinomas. The study confirms the independent prognostic importance of the ER content and points to its potential value as a stratification criterion in adjuvant therapy trials. On a case of traumatic interventricular communication confirmed by heart catheterization.

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In a previous study we demonstrated that incompatibility regarding ligands for inhibitory killer immunoglobulin-like receptors (KIRs) is associated with a survival advantage following unrelated donor-hematopoietic cell transplantation (URD-HCT). The changes in COX-2 paralleled metabolic abnormalities, and were at least in part a four consequence of hyperinsulinemia. A stable tetrahedral phosphate ester is compared with a labile tetrahedral orthocarbonyl ester and a relatively stable pentagonal enzyme-phosphate ester complex is compared with a pentagonal enzyme-carbonyl substrate complex. Anastomoses between branches of the right and left coronary arteries occur in the septum. Hexane-extracted shallot and garlic had the highest antioxidant activity, followed by water extracts, bulb pressings, and commercial products. The effect of an aldosterone antagonist upon the electrolyte response to surgical trauma. Rhizobitoxine modulates plant-microbe interactions by ethylene inhibition. No patient with the early onset pauciarticular disease subset, which is associated with iridocyclitis and antinuclear antibody (ANA) positivity was seen. When drugs were administered after venom injection, only prazosin and indomethacin were effective in reducing edema.

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These data indicate that the epigenetic aberrance of promoter CpG island hypermethylation of the GSTP1 gene may contribute to the hepatopathogenesis of HCC and is a potential valuable biomarker for noninvasive disease monitoring and HCC early diagnosis. A case report of such a child is presented and the management is discussed. Transection of posterior ligaments predominantly increased specimen flexion for all bending moments applied. The therapeutic use of DHEA in humans may be limited by its sex hormonal side effects. The three-dimensional X-ray crystal structure of the aspartic proteinase native to Trichoderma reesei complexed with a renin inhibitor CP-80794. In this study we have investigated the ability of lipopolysaccharide (LPS) to suppress binding and phagocytosis of erythrocytes via various receptors on mouse macrophages. The separation mechanism seems to be the hydrogen-bonding interaction between the imidazolium cations of IL and the flavonoids. This area was ultimately resected because of persistence of a severe seizure disorder. Western blotting analysis was performed to verify the specificity of anti-DDC and anti-HDC antibodies.

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This study investigated whether wound healing after the use of purely muscular flaps for intraoral defect coverage is negatively influenced by insipient muscular atrophy and the absence of a covering layer. On success in the treatment of breast carcinoma with a combination of surgery with local and total body roentgen irradiation. Outcomes after pylorus preserving gastrectomy for early gastric cancer. The basal release of nitric oxide by the endothelium plays an important role in regulating blood flow and pressure and mediates most of the endothelium-dependent vasodilation. Lymphokine mRNA production was also enriched in donor T cells isolated from the spinal cord compared with donor T cells isolated from the spleen. Hyperleptinaemia and hypoadiponectinaemia are associated with gallstone disease. In the luteal tissue, both the small and large luteal cells of early luteal (Days 14-19) and midluteal (Days 20-25) phase expressed GM-CSF mRNA and protein as well as GM-CSF alpha R and beta R proteins, and their immunostaining intensity was similar to that seen with theca cells.

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The length of hospital stay during the admission and complications were recorded 6 months post-operatively. After clinical examination, mice were bled and antibodies against BCG and VCN were measured. Vagal stimulation is probably the single most important factor in PP release, and it is possible that diminished PP release in the gastric ulcer patients is a reflection of vagal underactivity. A novel serine protease inhibitor was uncovered during our targeted screen, which is involved in collagen maturation, proper cuticle assembly and the moulting process. Neuroblast long-term cell cultures from human fetal olfactory epithelium respond to odors. Use of a quantitative electrocardiography method in the diagnosis of ischemic heart disease. Lung and heart lesions from intravascular platelet clumping and its sequelae.

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The results of the present study, when combined, revealed that the S group had a lower resting metabolic rate throughout the follow-up period with the differences being significant at 24 and 36 months of follow-up, associated with an increase in the rate of weight gain and a decrease in lean mass, when compared to the N group. Most of the mutants are also more resistant to Km than the wt, although the level of resistance is low and the variation small. Approaches to labeling and identification of active site residues in glycosidases. The suitability of these agents as therapeutic tools is discussed. No correlation was found between the choriocapillaris plexus architecture revealed by the plastic corrosion casts and the observed choriocapillaris lobular filling. The karyotypic characteristics of a skin fibroblast line from the Indian muntjac cultured with different sera. Hamster chromosome-specific DNA sequences were amplified by primer directed DNA amplification using mixed base oligonucleotides in an arbitrarily primed polymerase chain reaction (AP-PCR) protocol.

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We also examined the effects of WMH located in the dorsolateral frontal regions with the hypothesis that dorsal PFC WMH would be strongly associated with not tramadol 50 mg vs lortab only PFC function, but also with areas that are anatomically and functionally linked to the PFC in a task-dependent manner. During the first postnatal week, milk immunoreactive prolactin concentrations were lower for women with IDDM than for control and reference women and the inverse relationship between lactose and milk prolactin, which was significant at day 2 postpartum for reference women, was delayed until day 14 postpartum for women with IDDM. Pharmacotherapy of the depressions with protriptyline (Vivactil). Thrombolytic therapy is recommended in haemodynamically compromised patients, since it yields accelerated clot lysis and pulmonary reperfusion. They can, for example, be engineered to destroy specific pathogens or tumor cells, to protect normal cells from chemotoxicity, or to activate prodrugs at the target site. Gallbladder remnant and cystic duct stump calculus as a cause of postcholecystectomy syndrome.

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After inspection under stereomicroscopy the instruments were classified into three categories: (i) plastically deformed but not fractured, (ii) fractured with plastic deformation and (iii) fractured without plastic deformation. To assess the effectiveness of two serial registry reminder protocols and the interactive effects of reminders with child characteristics on immunization rates. Typical symptoms in children include dizziness, Stokes-Adams syncopal attacks, fatigue, daytime somnolence, and other somatic complaints. Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast. Sexual abuse of female children and adolescents--detection, examination and primary care. The risk factors of the disease are related to nutrition and environment. Clinical examinations included the cognitive portion of the Alzheimer Disease Assessment Scale, the Mini-Mental State Examination, and the Neuropsychiatric Inventory.

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Inactivation of lipoprotein lipase in buffered saline solutions. The mainframe of the hospital information system (HIS) is connected with a data server in the perinatal care area via LAN. Moreover, mitochondria and sub-surface vesicles occupied a significantly smaller percentage of the cell in the freeze-dried tissue than they did in the conventionally prepared tissue. All organisms possess mechanisms to repair double strand breaks (dsbs) generated in their DNA by damaging agents. Independence of protein kinase C-delta activity from activation loop phosphorylation: structural basis and altered functions in cells. The construction of this article was oriented to the following key questions: Where an osteoclast starts to its first resorption site?. In both models, cytochrome-c oxidase activity and nuclear-encoded mRNAs remained fairly constant, whereas levels of mitochondrial mRNAs were transiently decreased 24 h after the growth stimulus. Consequently, it is important to decide whether the procedure concerned could safely be performed by dental staffs in the dental clinic. During a sham procedure, the microwave applicator was installed in the urethra as in the real TUMT treatment and a complete procedure was simulated by the microwave delivery system (Prostatron).

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Lower intestinal hemorrhage, defined as bleeding originating below the ligament of Treitz, is a common clinical problem frequently requiring hospital admission. Alterations in sample preparation increase sensitivity of PCR assay for diagnosis of chancroid. We used gadolinium-enhanced fat-suppressed MRI to investigate 67 patients with persistent pain after lumbar discectomy. We also show that fibers run rostrocaudally over the surface of the telencephalic vesicles. Critical comparative analyses of anti-alpha-actinin and glomerulus-bound antibodies in human and murine lupus nephritis. The next milestone was the introduction of the estrogen-free OC by Martinez-Manautou and his collaborators in 1966. Major emphasis is placed on the various aspects of malignant lesions: basal cell carcinomas prevail in the more exposed areas of the face. However, acticin studies performed in skeletal muscle have identified insulin-sensitive as well as insulin-insensitive intracellular GLUT4-containing membranes. The patient had bilateral blindness, quadriplegia, and dyspnea of acute onset and died without remission 7 weeks later. Foot and arm visual tracking precision, as determined by position and velocity errors, increased in both directions.

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One hundred and twenty random PCR amplifications were performed with the cDNAs, which generated 382, 394, 393 cDNA fragments from each developmental stage. The numbers of Ag-NORs were significantly greater in patients with diffuse lung diseases than in control subjects. Microvessels were identified by immunohistochemical staining of endothelial cells for factor VIII-related antigen in formalin-fixed, paraffin-embedded tissue. Subtypes of HLA-DR4 were determined by allele specific oligonucleotide typing. We also describe a novel algorithm for inferring classes from a graphical model. On the other hand, inhibition of ERK1/2 activation with MEK1 inhibitor PD98059 failed to offer protection against PEITC-induced apoptosis in DU145 cells. Autoimmune diseases, which are characterized by an abnormal activation of the immune system, probably result from the failure of normal self-tolerance mechanisms. The chitin-binding domain is an all-beta protein with two tryptophan residues (Trp59 and Trp60) aligned on the surface. Oxygen saturation to detect asymptomatic congenital heart disease of newborns.

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In addition, beads also induce the formation of acetylcholine receptor clusters and myotendinous junction-like specializations. A phosphorothioate oligonucleotide blocks reverse transcription via an antisense mechanism. The preputial and clitoral glands of 111-114-week-old B6C3F1-mice from a carcinogenesis experiment showed histomorphological characteristics. Kinetics of technetium-labeled heparin in hemodialyzed patients. Target molecules, sensitive to ethanol, include the NMDA receptors as well as downstream molecules of the glutamatergic system, glutamate transporters, and associated regulatory proteins.

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A total of 124 polio survivors (49 males and 75 females), ages 35 to 77 years, and 261 healthy control subjects (139 males and 122 females) of similar age. Thus, the results encourage further studies on the potential diagnostic use of keratin expression in premalignant oral lesions. These results are discussed in terms normal po ativan dose of similarities of T cell recognition of hapten-modified self antigens and of alloantigens. Several years have elapsed since the publication by Johnson et al. CT scan revealed a ring-like enhanced mass with perifocal edema in the right rectal gyrus. The mouse lymphoma (L5178Y) cell mutant M10 is defective in rejoining DNA double-strand breaks and is hypersensitive to ionizing radiation.

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We also hypothesized that intra- and postoperative transient biochemical disorders, such as hypoalbuminemia, hemodilution, liver, and renal insufficiency and stress can be involved in this process. Intercellular passage of tritium-thymidine-labeled DNA from donor lymphocytes to recipient bone marrow cells. Neutropenic enterocolitis is a life-threatening complication most frequently occurring after intensive chemotherapy in acute leukaemias. The data were analyzed immediately after they were acquired, again on formal rounds twice daily, and at a formal data review after completion of monitoring. The results provide a basis for autoimmune reactions involving anti-Gal from chronic Chagasic patients. COMFORT-Behavior scores and Bispectral Index values were recorded simultaneously. We investigated the molecular mechanisms responsible for LPS-induced TNF-alpha and IL-13 production in mast cells. DNA samples were isolated from the sera and analyzed for the functional glyburide dosage in cats -675 4G/5G promotor polymorphisms of the plasminogen activator inhibitor 1 gene. Mutant p53 oncogene expression in keratoacanthoma and squamous cell carcinoma. A national survey of radiological complications: interim report.

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