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Aptogrel (Clopidogrel)
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Aptogrel

Aptogrel is an antiplatelet medicine. It prevents platelets (a type of blood cell) from sticking together and forming a dangerous blood clot. Taking Aptogrel helps prevent blood clots if you have an increased risk of having them.

Other names for this medication:
Aclotil, Antiplar, Antiplatt, Aplatin, Aptogrel, Asogrel, Atheroz, Blothin, Cenoza, Ceruvin, Cidogrel, Clavix, Clopicure, Clopiriv, Clopisa, Clopitab, Clopivas, Clotsafe, Dospin, Ecosprin, Locric, Myogrel, Nugrel, Orawis, Pidgrel, Platfrin, Platloc, Rozanex, Stagrel, Stromix, Thinrin, Thrombosprin, Torplatt, Welgrel, Zeter

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Also known as: Clopidogrel

Description

Plavix (clopidogrel) prevents platelets in your blood from sticking together to form an unwanted blood clot that could block an artery.

Plavix is used to lower your risk of having a stroke, blood clot, or serious heart problem after you've had a heart attack, severe chest pain (angina), or circulation problems.

Dosage

Usual Adult Dose for Acute Coronary Syndrome:

Unstable Angina (UA)/Non-ST-Elevation Myocardial Infarction (NSTEMI): -Loading dose: 300 mg orally once -Maintenance dose: 75 mg orally once a day -Duration of therapy: Optimal duration unknown. ST-Elevation Myocardial Infarction (STEMI): -Loading dose: 300 mg orally once (OPTIONAL) -Maintenance dose: 75 mg orally once a day, with or without thrombolytics -Duration of therapy: Optimal duration unknown. Comments: -Administer this drug in combination with aspirin 75 mg to 325 mg orally once a day. -The benefit of this drug for patients who undergo primary percutaneous coronary intervention is unknown. Uses: Prevention of atherothrombotic events in patients with non-ST-segment elevation acute coronary syndrome (UA, NSTEMI, those who are to be managed medically, those who are to be managed with coronary revascularization) and STEMI.

Usual Adult Dose for Ischemic Stroke:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Usual Adult Dose for Myocardial Infarction:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Usual Adult Dose for Peripheral Arterial Disease:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Detailed Plavix dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose can cause excessive bleeding.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Aptogrel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Plavix if you are allergic to clopidogrel, or if you have:

any active bleeding; or a stomach ulcer or bleeding in the brain (such as from a head injury).

Tell your doctor if you have ever had:

an ulcer in your stomach or intestines; or a bleeding disorder or blood clotting disorder.

Plavix may not work as well if you have certain genetic factors that affect the breakdown of this medicine in your body. Your doctor may perform a blood test to make sure Plavix is right for you.

This medicine is not expected to harm an unborn baby. Tell your doctor if you are pregnant.

You should not breastfeed while using this medicine.

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These results provide genetic evidence that NK cells alone cannot account for natural resistance to H-2 nonidentical cells of hemopoietic origin. Human colorectal cancer cells not only express the nuclear vitamin D receptor (VDR) but are also endowed with 25-hydroxy-vitamin D(3)-1alpha-hydroxylase activity and therefore are able to produce the specific ligand for the VDR, the hormonally active steroid 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)). Indications for surgery and prognosis in patients with cerebral cavernous angiomas. With the exception of modulus of elasticity, the mechanical properties of resin composites based on UEDMA/HEMA were superior to those of BISGMA/TEGDMA-based materials, even though the improvements in flexural strength and modulus of resilience were most pronounced for the BISGMA/TEGDMA-based resin composites. Histomorphometric parameters of normal full term placenta of Sudanese women. Alterations in hepatic monodeiodination of iodothyronines in the diabetic rat. Anteromedial and posterolateral incisions were used to expose the fractures, resulting in a bipedicle flap over the anterior aspect of the ankle joint at the time of the initial surgery. Immunofluorescent investigation of antibody formation in delayed hypersensitivity. Analysis of the results of biological tests did not show any significant differences between the anticancer activity of bimolane and ICRF-154.

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To examine the efficacy of bispecific antibody-based treatments on in vivo tumor, scid mice bearing early s.c. Gonadal and extragonadal expression of inhibin alpha, beta A, and beta B subunits in various tissues predicts diverse functions. Section staining for electron microscopy using tannic acid as a mordant: a simple method for visualization of glycogen and collagen. We aimed to compare the clinical response of acetaminophen and intra-articular leukocyte-poor PRP (LP-PRP) in early knee OA. In this study, rat jejunal mucosal sheets were exposed for 1-2 min to 10 mM micellar solutions of taurodeoxycholate, dodecylsulfate, Tween 80 or cetyltrimethylammonium bromide containing cholesterol, 0.25 mM. Carbachol also reduced cAMP levels elevated by isoproterenol, but had no significant effect on cAMP levels in the presence of either forskolin or IBMX.

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However, current knowledge concerning the immunopathology, pathophysiology, and treatment of most causes of the nephrotic syndrome is inadequate. The proteinase inhibitor null (Pi-) allele is a rare cause of alpha 1 antitrypsin (AAT) deficiency. To assess the influence of FDCs on viral dynamics during antiretroviral therapy we have developed a mathematical model for treatment of HIV-1 infection that includes FDCs. Contraceptive activity and mechanism of action of combinations of a new 17 alpha-acetoxyprogesterone derivative and ethinyl estradiol. The changing trends are presented, as Israel seems to be drawing slowly toward the Massachusetts position in some of these issues.

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Surface interactions of gold nanorods and polysaccharides: From clusters to individual nanoparticles. Histologic examination was consistent with an Antoni A-type neurilemoma. These quantitative differences may express differences in cerebellar microcircuitry and fibre connections in the cortex of Wistar and Sprague-Dawley rats. A neural network ActiveX based integrated image processing environment. We have now isolated cDNAs encoding two additional GABAA receptor alpha-subunits, confirming the heterogeneous nature of the receptor/chloride channel complex and demonstrating a molecular basis for it. Hypoglycemic effect and toxicity of Eleutherococcus senticosus following acute and chronic administration in mice.

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Comparison of intestinal absorption in the rat of elaidic, oleic and stearic acids administered in the form of mixed triglycerides containing of 5 randomly distributed fatty acids. Our success in constructing an array of optimized N-rGOAs able to withstand input power as high as 40 W demonstrates that a practical thermoacoustic loudspeaker can be fabricated using the proposed mass-producible solution-based process. A decrease in sweat chloride concentration after insulin iontophoresis in comparison with the vehicle was observed in both the CF (P smaller than 0.005) and heterozygote (P smaller than 0.01) samples. This framework could provide insights into atypical prosocial behavior in those with disorders of social cognition. We report short term results of open surgical treatment for symptomatic femoroacetabular impingement (FAI) in patients over the age of 30 years.

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We report here the isolation of a mab-21 homolog, XMab21l2, from Xenopus. T cell recognition pattern of bovine milk alphaS1-casein and its peptides. Development and use of a system for routine production of monodisperse particles of 238 PuO2 and evaluation of gamma emitting labels. The behaviour of rigid, microscopic resin spheres in the terminal circulation of tumours. Prevention--an experiment in interdisciplinary cooperation between teachers and mental health workers. Effects of stimulation of the cingulate gyrus on insulin secretion. In all six patients with idiopathic hypertrophic subaortic stenosis the septum had a catenoidal configuration and showed significantly less (p less than 0.05) septal change in the curvature thickness index during the cardiac cycle than it did in the control groups.

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Antihypertensive efficacy and effects of nitrendipine on cardiac and renal hemodynamics in mild to moderate hypertensive patients: randomized controlled trial versus hydrochlorothiazide. Complications in the first week after stroke: a 10-year comparison. It was found that Candida species can penetrate, invade, develop and proliferate within the deep layers of intact cells of the cervix and vaginal mucosal epithelium. Dilution of the protein by addition of excess lipid in order to eliminate the purple membrane crystal lattice also did not alter the cooperativity. Late amputation associated with failure of extraanatomic bypass initially required to avoid infected tissue beds might be reduced if delayed anatomic aortic prosthetic reconstruction could be safely employed. Women without medical or health-care training are reliable in judging the color changes on the OvuQuick test pads and recording these results in a menstrual diary. The macroscopic and microscopic appearance of villous atrophy in weaned pigs orally infected with Salmonella cholerae-suis is lasix drug names furosemide described.

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Non-small cell lung cancer has seen an unprecedented augmentation of therapeutic options over the last couple of years. Glucose supplementation of the spent plasma maintained chemotactic activity. Effects of captopril on metabolic and hemodynamic alterations in global ischemia and reperfusion in the isolated working rat heart. Bibliography of publications by the Dental Research Section of the National Bureau of Standards. The outer segment renewal rate is accelerated in frogs when ambient temperature is raised, and is elevated in both frogs and rats when the intensity of retinal illumination is increased. The phagocytosis of bacteria induced upregulation of Dictyostelium genes encoding the copper uptake transporter p80 and a triad of Cu(I)-translocating PIB -type ATPases. The 95,000 dalton gelatinase was separated from anastrozole 1mg tab the 60,000 dalton gelatinase by affinity chromatography on Ricinus communis agglutinin-agarose, and the former activity was markedly increased in highly metastatic cell lines as compared with its activity in poorly metastatic cell lines. In contrast, no increase in 32P incorporation into PI was seen when two NK-resistant TC were used. Poor and un-emphatic behaviour towards a patient and their relatives can have its origin in untreated traumatic experiences.

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Thus, many HBV infected patients are co-infected with other viral pathogens. Electrogenic steps of light-driven proton transport in ESR, a retinal protein from Exiguobacterium sibiricum. Distribution of low-molecular-weight RNAs in avian erythroblast nuclear ribonucleoprotein complexes associated with pre-messenger RNA. One cationic fraction (CEF6) containing egg antigens omega 1 and alpha 1, was found to be highly reactive with a S. Decarboxylation of N-acetylamino-acids with lead tetra-acetate in N,N-dimethylformamide. Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents. A total of 3,002 embryos, including 521 transferred embryos with known implantation, from 626 IVF cycles that were incubated in a conventional incubator and monitored with an automatic time-lapse test. A 2.0- detrol 2 mg dosage fold increase in the potency of oxotremorine was also observed at 2 weeks.

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