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Apsolam (Alprazolam)

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Alprazolam, available under the trade name Xanax, is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder, but also in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Apsolam, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Apsolam is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Alcalm, Almac, Alpkair, Alpra, Alpracon, Alpraday, Alpram, Alprasan, Alpron, Alzep, Alzin, Alzokam, Alzopam, Anxizam, Censir, Cqlam, Depwell, Diprex, Ecsit, Ezoprax, Fledore, Fluxozam, Indolam, Isorest, Morecalm, Paxor, Sertamax, Sinaday, Sinozol, Somaspas, Somnirest, Tensfree, Tranisol, Viprax, Welnorm, Xerodep, Zedep, Zodia, Zoldac, Zoloid, Zomark, Zopain, Zotin

Similar Products:
Duricef, Caverta, Artane, Plaquenil, Ultram, Claritin, Sovaldi, Colcrys, Eriacta

Also known as: Alprazolam


Apsolam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). Alprazolam affects chemicals in the brain that may be unbalanced in people with anxiety. Apsolam is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

You should not use Apsolam if you have narrow-angle glaucoma, if you also take itraconazole or ketoconazole, or if you are allergic to Apsolam or similar medicines (Valium, Ativan, Tranxene, and others).

Alprazolam may be habit-forming. Misuse of habit-forming medicine can cause addiction, overdose, or death.

Do not drink alcohol while taking Apsolam. This medication can increase the effects of alcohol. Alprazolam may be habit-forming and should be used only by the person for whom it was prescribed. Keep the medication in a secure place where others cannot get to it.


Usual Adult Dose for Anxiety:

Immediate-release tablets: 0.25 to 0.5 mg orally administered 3 times a day -Maximum dose: 4 mg/day

Usual Adult Dose for Panic Disorder:

Immediate-release tablets: 0.5 mg orally administered 3 times a day -Maximum dose: 10 mg/day Extended-release tablets: -Initial dose: 0.5 to 1 mg orally once a day -Maintenance dose: 3 to 6 mg orally per day, preferably in the morning -Maximum dose: 10 mg/day Comments: -The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently. -Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage. -The daily dosage may be decreased by no more than 0.5 mg every 3 days; however, some patients may require an even slower dosage reduction. -The dose of extended-release tablets may be increased at intervals of 3 to 4 days in increments of no more than 1 mg per day. -The times of administration should be distributed as evenly as possible throughout the waking hours.

Usual Geriatric Dose for Anxiety:

Elderly or debilitated patients: Immediate-release tablets: 0.25 mg orally administered 2 or 3 times a day.

Usual Geriatric Dose for Panic Disorder:

Elderly or debilitated patients: Immediate-release tablets: -Initial dose: 0.25 mg orally administered 2 or 3 times a day Extended-release tablets: -Initial dose: 0.5 mg orally once a day Comments: -If side effects develop, the dose may be lowered. -The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently. -Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage.

Detailed Xanax dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of alprazolam can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Xanax XR dosage information

Side effects

The most common side effects associated with Apsolam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Before taking Apsolam, tell your doctor or pharmacist if you are allergic to it; or to other benzodiazepines (such as diazepam, lorazepam); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: severe lung/breathing problems (such as COPD, sleep apnea), liver disease, kidney disease, drug or alcohol abuse, glaucoma.This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Older adults may be more sensitive to the side effects of this drug, especially loss of coordination and drowsiness. These side effects can increase the risk of falling Apsolam is not recommended for use during pregnancy due to the potential for harm to an unborn baby. Consult your doctor for more details.This drug passes into breast milk and may have undesirable effects on a nursing infant. Therefore, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

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Quantitative genetic variation for oviposition preference with respect to phenylthiocarbamide in Drosophila melanogaster. This makes it difficult to establish structure-function relationships. Intriguingly, coincubation with HU-210 and SR141716A prevented the induction of the early, short-term phase of LTP. Risk behaviors among newly reported Burmese HIV infection in Dehong, Dai and Jingpo Autonomous Prefectures of Yunnan province, 2015. This study suggests that a modern multi-step total-etch adhesive system can produce adhesion even to the less retentive cervical enamel and exposed dentin. The results demonstrated that both feature distributions belonging to genuine and forged groups of samples cannot be distinguished by themselves. Oral administration of alkaloid fraction from Ruta graveolens inhibits oxidative stress and inflammation in hypercholesterolemic rabbits.

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The c-erbB-2 oncoprotein was expressed only in malignant inverted papillomas. Sodium dodecyl sulfate adsorption onto positively charged surfaces: monolayer formation with opposing headgroup orientations. Such findings permit cautious optimism about the eventual development of a gene treatment for arthritis and other disorders of the joint. Treatment Results of Gamma Knife Radiosurgery for Central Neurocytoma: Report of a Japanese Multi-Institutional Cooperative Study. In this review we describe this activity on the basis of the available literature. The aim of this study was to evaluate the influence of manual versus mechanical glide path (GP) on the surface changes of two different nickel-titanium rotary instruments used during root canal therapy in a moderately curved root canal. It is important to evaluate the presence of anxiety disorders in children and adolescents with 22q11.2DS, as they are major risk factors for the emergence of psychotic disorders, which usually occur during late adolescence in this at-risk population. Little research has been done to analyse these problems objectively and scientifically. This review summarizes recent advances in the understanding of drug resistance and focuses especially on the association between EMT and drug resistance. To study the acupoint specificity through the comprehensive evaluation of the acupuncture effect on rat model with the middle cerebral artery occlusion (MCAO).

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Good to excellent clinical results can be achieved with the presented surgical technique. Metaplastic epithelial cells can be a source of elevated PGE-MUM in IPF. Positive chronotropic effect of increasing right atrial pressure in the isolated mammalian heart. Compared with splenocytes isolated from control primed mice, the splenocytes from TLI-primed mice failed to proliferate to immunogen in mixed leukocyte reaction cultures but proliferated normally to third-party alloantigen. At the same time the results of the investigation should provide more information to workers of the Ministry of Health and Social Affairs of the CSR on the state of training in the discipline of social medicine and organization of health services and on the training of workers engaged in the discipline as well as those who are starting work in the discipline. Uterine contractions in the placental and post-placental periods. Between-group analyses of principal components revealed significant heterogeneity in skull shape, pelage color variation and loud calls across all seven populations. Initial Experience with Elective Perventricular Melody Valve Placement in Small Patients. Necessary steps need to be taken to harmonize drug information available across various sources so as to provide reliable and uniform drug information thereby promoting rational drug use.

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A 60-year-old male presented to an emergency department (ED) with priapism following a sore throat illness. A complete scheme of therapy is presented which includes vasodilators, vitamins, biostimulants, sedatives, physiotherapy. The precision of ultrasonographic criteria in predicting the risk of stroke was also assessed. They highlighted that being asked was an important factor in engaging them in dementia research. TYROSINE METABOLISM DISORDERS IN THE MOUSE LIVER IN EXPERIMENTAL LEUKEMIA. This analysis included 203 patients from three prospective studies.

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However, subependymal hemorrhage occurred at the third ventricle 6 days after the operation. By combining all our results, optimization recipes to create ultrashallow doped junctions at the nanoscale are finally proposed. We investigated the composition of these study sections to identify the prevalence of urological expertise (or lack thereof). Synthesis of tight binding inhibitors and their action on the proprotein-processing enzyme furin. First results of cholecystography with telepaque as a contrast medium. Hypoxia is a major driving force in vascularization and vascular remodeling.

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One important component of this process is the uptake of bile acids from the portal circulation into hepatocytes by the bile acid uptake transporter sodium taurocholate cotransporting polypeptide (NTCP). As a result, the primary action of pizotifen in the canine basilar artery system appears to be calcium channel blockade and not selective antagonism of serotonin or norepinephrine. The interaction of these enzymes with the milk proteins and the main proteolytic enzymes becomes important in determining the quality of the milk. Complications of nonunion, heterotopic bone formation, delayed wound healing, functional loss of motion, and need for revision surgery are reported. The bait plants exhibited PMTV-characteristic v-shaped yellow leaf markings in Nicotiana debneyi plants grown in putative viruliferious soils from 20/26 locations. We present a highly unusual case of bilateral, atraumatic, anterior shoulder dislocation with concomitant comminuted greater tuberosity fracture on the right side, secondary to seizure, in a patient without known epilepsy, induced by oral chloroquine medication. An unstable transmembrane segment in the cystic fibrosis transmembrane conductance regulator. To synthesize the current knowledge on possible environmental risk factors for Obsessive-Compulsive Disorder (OCD). Use of thrombolytics for the treatment of thromboembolic disease during pregnancy.

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A review of the English literature was conducted to identify articles describing the MALT variant of PRL. No significant increase of lung and renal inflammation markers were observed in USRP-instilled animals. New Ulvaceae (Ulvophyceae, Chlorophyta) from mesophotic ecosystems across the Hawaiian Archipelago. Although endocytosis of AMPARs can be induced by high concentrations of AMPA without concomitant activation of N-methyl-D-aspartate (NMDA) receptors (NMDARs), NMDAR activation is required for detectable endocytosis induced by synaptically released glutamate. Not only does it afford the rapid isolation of stable high-level producer cell lines, but also VP16-expressing cells have been found to rival COS cells in their ability to express proteins transiently. Essentials Methods were developed to image the hemostatic response in mouse femoral arteries in real time. Moderate to severe respiratory depression was detected in 14 patients more than 2 h after operation. Modern day contemporaries, such as cnidarians, suggest that the LCMA consisted of two cell layers: a basal endoderm and a mucus-secreting ectoderm, which formed a surface mucus layer (SML). The analysis of the data led to the extraction of four themes: maintaining health, person/client, nursing responsibility and environment.

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Isolation of a soluble fibrinolytic activator from animal tissue. Corneal-Wavefront guided transepithelial PRK ablation profiles after conventional CXL yields to good visual, optical, and refractive results. The de homozygous mice died during midgestation and manifested devastating failure in embryonic development and reduced numbers of hematopoietic progenitors, whereas uc homozygous mice displayed no apparent defects. Evaluation of the lymphatic drainage pattern with real-time NIR light fluorescent technique is feasible. VALUE OF PEROPERATIVE CHOLANGIOGRAPHY IN REPARATIVE BILIARY SURGERY. In this study, we designed a combinatorial scheme to screen the optimum combination of pharmacophores from a pool of hypotheses established based on 162 OCT2 inhibitors. The concentrations of the glucuronide conjugates of 8-hydroxyclomipramine and 8-hydroxy-N-desmethylclomipramine were assayed via enzymatic hydrolysis. Here we report that migration and invasion of A549 human lung cancer cells are suppressed by the inhibition of CK2 induced by CX4945. However, the combination of clorgyline and deprenyl followed by reserpine does so.

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Three drug-naive subjects were enrolled in this study who were infected with HIV-1 Korean clade B. Local and global processing in blind and sighted children in a naming and drawing task. A 55-year-old woman with a history of essential hypertension, diabetes, and nephrotic syndrome was presented with blurred vision in both eyes. Tyrosine hydroxylase from human pheochromocytoma was found to be remarkably activated by cyclic AMP-dependent protein kinase. Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3. This has promising implications to introduce targeted screening colonoscopy into the healthcare system in Iran and other developing nations. As a physiologic entity, the levoatriocardinal vein provides a mechanism for decompression of pulmonary venous return primarily in patients with left ventricular inflow obstruction. To compare the results of the teaching process evaluation between students studying according to the Bologna system and the old system of education. Magnetic resonance imaging versus X-ray computed tomography--which is the appropriate first imaging examination?. Here, we develop a whole-brain sMRI pipeline and validate sMRI metrics with quantitative measures of tumor infiltration.

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Distinctions previously observed at 2 min incubation times may actually represent metabolic (and not transport) differences. Body fat mass increased until the late 50s and then had a decrease through senescence. Systematic Approximations to Susceptible-Infectious-Susceptible Dynamics on Networks. The aim of this study was to examine the effect of alkylphenols on pDC functions in vitro and in vivo and then further explored the involved signaling pathways and epigenetic changes. We recommend distinguishing these 2 injury types in clinical practice as different open-globe injuries. When these substances were combined with TPA, morphological differentiation and growth inhibition of the cells were potentiated. Targeting Snail may provide a feasible strategy for the treatment of CRC. Transcriptional analysis showed that the toxR defect in ATR is not caused by decreased cadA transcription.

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Among the canonical transient receptor potential (TRPC) channels, the TRPC4 non-selective cation channel is one of the most abundantly expressed subtypes within mammalian corticolimbic brain regions, but its functional and behavioral role is unknown. There was evidence showing that DESs are associated with a decrease in the risk of myocardial infarction and, in particular, a decrease in non-Q-wave myocardial infarction. Copy number variation analysis and methylome profiling of a GNAQ-mutant primary meningeal melanocytic tumor and its liver metastasis. We aimed to identify novel mediators involved in AAA pathophysiology, which could lead to novel therapeutic approaches. The association between partner status and socioeconomic status (SES) and outcomes in chronic HF requires further study. There is therefore an urgent need for educational awareness, simplification of the ADR reporting process, and implementation of imperative measures to practice PV among healthcare professionals. We investigated the effects of a novel selective D3 receptor antagonist, SR 21502, on cocaine reward, cocaine-seeking, food reward, spontaneous locomotor activity and cocaine-induced locomotor activity in rats. Night shift workers may require additional support for oral health maintenance.

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Hybrid quantum mechanical methods can assist in the interpretation and prediction of the electronic spectra of large molecular structures. The importance of hemolysis in the lethal effects of equnatoxin II, a protein from the sea anemone Actinia equina (L.). Isolation and structure elucidation of an alpha-amylase inhibitor, AI-3688, from Streptomyces aureofaciens. A number of variations exist in the techniques used for insertion, withdrawal of needle from vascular access ports, blood sampling and unblocking procedure. Induction of nonspecific cytotoxicity by monoclonal anti-T3 antibodies. Age-dependent changes of the antioxidant system in rat livers are accompanied by altered MAPK activation and a decline in motor signaling. It is, therefore, very tempting to speculate that an immunological defect represents the basic abnormality which later leads to the occurrence of the disease. Treatment of this highly prevalent condition can drastically improve the quality of life of individuals and prevent damage to the ocular surface. A new surgical approach allows for early active mobilization without a specific rehabilitation period.

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The present study aimed to describe the socio-economic inequality in stunting and its determinants in Iran for the first time. Clinical significance of interleukin-6 gene expression in the bone marrow of patients with multiple myeloma. We investigated only inpatients and therefore could not comment on outpatients. Immunochemical determination of placenta-specific and interorganic antigens in placental extract and blood serum in pregnant rats. 2: postoperative functional and anatomical evaluation of ruptures of the rotator cuff. This tract from the nasopharynx to the brain is common and carries a potential risk for infection. These tests are of paramount importance for understanding the anatomy of both fetuses/children, as well as for prognosis and surgical plan determination. Profile of functional interhemispheric asymmetry and EEG features of stuttering children. Although this was a small and limited study, results suggest that using apps may be a feasible and personalized approach to managing challenging behaviors. Through analysis of mixed hydrate nucleation in a prototypical CH4/H2S/H2O system, we demonstrate that high-level kinetic similarities between mixed hydrate systems and corresponding pure hydrate systems are not a reliable basis for estimating the composition of early stage mixed hydrate enalapril 20 mg dose maxima nuclei.

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A computed tomographic scan revealed a hyperdense process located in the pons. Recently, this procedure has been well applied to hepatocellular carcinoma. Neither orientation nor grooming alone facilitated the sucking drive to any significant extent. Obesity continues to disproportionately affect medically vulnerable populations. Validation of cell-based fluorescence assays: practice guidelines from the ICSH and ICCS - part I - rationale and aims. Cadaverine is completely removed from the different carbohydrate preparations, whereas cleocin cream and alcohol spermidine is the main polyamine occurring in association with sugarcane carbohydrates, as free or acid-soluble form in LMMC preparation or as acid-soluble and -insoluble forms in both MMMC and HMMC preparations. Chlamydia trachomatis remains a significant public health problem. This includes RNA binding proteins that control mRNA localization, decay and translation, as well as the cytoplasmic mRNA decay pathway.

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To evaluate the effects of a quality improvement program to introduce early mobilization on the outcomes of patients with mechanical ventilation (MV) in the intensive care unit (ICU). Here we report that microinjection of antibodies specific for amino acid 12 of the oncogenic v-Ki-ras protein into cells transformed by this protein causes a transient reversion of the cells to a normal phenotype. The overlap in pathology and of genetic factors, particularly C9ORF72 as common cause of ALS and FTLD, provides molecular evidence that both conditions represent a spectrum of diseases sharing similar pathomechanisms. To evaluate the relationship between serum and amniotic fluid (AF) estradiol (E2), estriol (E3), progesterone (Po), cortisol (Co), human placental lactogen (hPL) concentrations and uterine contractions. Case of death caused by myocardial infarction caused by electric discharge. Increased vasopressor actions of intraventricular neuropeptide Y-(13-36) in spontaneously hypertensive versus normotensive Wistar-Kyoto rats.

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The analgesic action of nitrous oxide is dependent on the release of norepinephrine in the dorsal horn of the spinal cord. Making a place for teaching about family violence in medical school. Exposure Characteristics of Construction Painters to Organic Solvents. DNA oriented automated malignancy diagnosis and malignancy grading in prostatic cancer. Analyses by gas chromatography coupled to mass spectrometry revealed the presence of only two constituents. In addition, the emerging field of research focusing on miRNA single nucleotide polymorphisms (miRSNPs) in genes of the miRNA biogenesis pathway, in miRNA genes themselves, and in their target sites may provide new insights on gene expression changes in these genes. A direct comparison with the normal population of different regions was available from the General Register Office of Scotland, obviating the need to use female statistics for comparison.

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Immune function in dairy cows related to energy balance and metabolic status in early lactation. The 69 remaining patients were evaluated for their pre- and postoperative erectile function and posttreatment satisfaction for themselves and their partners. All patients had a prosthesis with a knee joint with mechanical swing phase control (the Otto Bock 3R20) before entering the study. However, the cell lines were less sensitive to the Helenalin treatment than the PBMC. In vitro interaction of heterologous platelets with isolated neoplastic cells from a murine mammary gland tumor. However, in contrast to the direct mutational activation of Ras found in cancer and developmental disorders, Rho GTPases are activated most commonly in disease by indirect mechanisms.

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Due to our involvement in deciphering 5-HT4R transduction mechanisms, we improved and set up new procedures to study 5-HT4R dimers, by classical methods or modern tools. The performance of the proposed algorithm is evaluated on public datasets. That thyroid hormone deficiency was responsible for this proliferation defect was established by demonstrating that treatment of hypothyroid mice with thyroxine resulted in a specific increase in the frequency and total number of cycling pro-B cells. DISCUSSION on the surgical management of uncomplicated duodenal ulcer. Activation of nuclear factor kappaB by polyamines in breast cancer cells.

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Although current treatments such as inotropes, antibiotics and ventilation are supportive, there is an urgent need for novel therapies that specifically target the affected intestine. The mortality rate is estimated at 10 to 30 percent, with complete recovery rates of 50 percent cited. Preventive care can play an important role in patients with chronic liver diseases. Automatic Approach for Lung Segmentation with Juxta-Pleural Nodules from Thoracic CT Based on Contour Tracing and Correction. Direct measurement of singlet oxygen by using a photomultiplier tube-based detection system.

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Regulation of Exacerbated Immune Responses in Human Peripheral Blood Cells by Hydrolysed Egg White Proteins. After sacrifice, serum and mesenteric lymph nodes (MLN) were imovane medication collected for further analysis. Personality and coping styles significantly correlated with psychosomatic status in bereaved and non-bereaved survivors. Implementing a carefully developed clinical pathway may reduce cost without compromising the quality of care for patients undergoing total laryngectomy. Ghrelin prevents the development of dermal fibrosis in bleomycin-induced scleroderma. This demonstrated a higher feto-maternal concentration gradient in PVDR pigs than in control pigs. New technique of osseous ligation in fractures of the odontoid apophysis with anterior dislocation of the atlas.

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