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Aprovel (Irbesartan)
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Aprovel

Aprovel is an angiotensin receptor blocker (ARB) indicated to treat hypertension or diabetic nephropathy. It can also be used as part of a combination product with hydrochlorothiazide for patients not well controlled or not expected to be well controlled on monotherapy.

Other names for this medication:
Aprovel, Irbecard, Irbesartan, Irbesartana, Irbesartanum, Irbest, Irovel

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Also known as: Irbesartan

Description

Avapro (irbesartan) is an angiotensin II receptor blocker (sometimes called an ARB). Irbesartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Avapro is used to treat high blood pressure (hypertension) in adults and children at least 6 years old. Lowering blood pressure may lower your risk of a stroke or heart attack.

Avapro is also used to treat kidney problems caused by type 2 diabetes.

Dosage

Usual Adult Dose for Hypertension:

Initial dose: 150 mg orally once a day Maximum dose: 300 mg orally once a day

Usual Adult Dose for Diabetic Nephropathy:

Target maintenance dose: 300 mg orally once a day

Use: Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (greater than 300 mg/day) in patients with type 2 diabetes and hypertension.

Detailed Avapro dosage information

Overdose

If you overdose Aprovel and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Aprovel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Avapro if you are allergic to irbesartan.

If you have diabetes, do not take Avapro with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking Avapro with aliskiren if you have kidney disease.

To make sure Avapro is safe for you, tell your doctor if you have:

a heart condition other than one being treated with irbesartan; kidney disease (or if you are on dialysis); or if you are on a low-salt diet.

Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Irbesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

If you plan to get pregnant, ask your doctor for a safer medicine to use before and during pregnancy. Having high blood pressure during pregnancy may cause complications in the mother and the baby.

You should not breastfeed while using this medicine.

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Selective stimulation of intrapulpal nerve of rat lower incisor using a bipolar electrode method. Effects of caffeine and caffeine withdrawal on mood and cognitive performance degraded by sleep restriction. Data from 7 randomized, single-blind, cross-over trials were pooled and analyzed. Where gaps, contradictions and anecdotal observations suggest that the current understanding of Brucella is limited, the author has commented on possible explanations. Repeated pairing of the onset of a stationary light (CS) that signalled electrical stimulation of brain-stimulation reward sites in the mesencephalon (US) resulted in autoshaped approach behavior to the CS. The presence of the HBs antigen does not adversely affect survival or increase morbidity on maintenance haemodialysis, at least during the first decade. The storm-time effect of solar proton geomagnetic cutoff decreases on dose variations is estimated. Factors such as tumor volume (intraglandular extent) and tumor subtype are considered category 2 prognostic factors, which show significant promise but require validation in multivariate analysis. Before considering endocrine intervention in these conditions, a detailed understanding of the neuroendocrinology of the stress response is warranted. No abnormal signal intensity on precontrast MR scans nor pathologic enhancement of the membranous labyrinth were identified in the other 42 patients.

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