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Aplaket (Ticlopidine)
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Aplaket

Aplaket is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Aplaket is marketed under the brand name Ticlid and is indicated for patients who cannot take aspirin or in whom aspirin has not worked to prevent a thrombotic stroke.

Other names for this medication:
Aplaket, Astic, Taispin, Ticlantin, Ticlobest, Ticlogard, Ticlogaurd, Ticlop, Ticlopid, Ticlopidine, Ticlovas, Tikla, Tikleen, Tilkon, Tyklid

Similar Products:
Plaquenil, Lanoxin, Cycrin, Zebeta, Protonix, Abhigra, Tofranil

Also known as: Ticlopidine

Description

Ticlopidine is used to lessen the chance of having a stroke. It is given to people who have already had a stroke and to people with certain medical problems that may lead to a stroke. Because ticlopidine can cause serious side effects, especially during the first 3 months of treatment, it is used mostly for people who cannot take aspirin to prevent strokes.

A stroke may occur when blood flow to the brain is interrupted by a blood clot. Ticlopidine reduces the chance that a harmful blood clot will form, by preventing certain cells in the blood from clumping together. This effect of ticlopidine may also increase the chance of serious bleeding in some people.

This medicine is available only with a doctor's prescription.

Dosage

Ticlopidine should be taken with food. This increases the amount of medicine that is absorbed into the body. It may also lessen the chance of stomach upset.

Take this medicine only as directed by your doctor. Ticlopidine will not work properly if you take less of it than directed. Taking more ticlopidine than directed may increase the chance of serious side effects without increasing the helpful effects.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets): For prevention of strokes: Adults—1 tablet (250 mg) two times a day, with food. Children—It is not likely that ticlopidine would be used to help prevent strokes in children. If a child needs this medicine, however, the dose would have to be determined by the doctor. For prevention of strokes or heart attack following heart stent procedure: Adults—1 tablet (250 mg) two times a day, with food together with your doctor's recommended dose of aspirin for up to 30 days following the procedure Children—It is not likely that ticlopidine would be used to help prevent strokes or heart attack in children. If a child needs this medicine, however, the dose would have to be determined by the doctor

Overdose

If you overdose Generic Aplaket and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Aplaket overdosage: problems with urinating, hallucinations, seizure.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Ticlid dosage information

Side effects

The most common side effects associated with Aplaket are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

There is no specific information comparing use of ticlopidine in children with use in other age groups.

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Perceived sleep quality was not associated with participation in PT interventions the following day. Multiple microsample analysis of intratumor estrogen receptor distribution in breast cancers by a combined biochemical/immunohistochemical method. We speculate that leishporin could be activated in the protease-rich, low pH, and dissociating environment of parasitophorous vacuole contributing for the release of the parasites from the macrophage. We hypothesized that the standard use of a self-expanding stent graft for the management of ASARVI is feasible and safe. We investigated factors that can affect the MPV values of asthma patients, including infection, atopy, immunotherapy treatment, and severity of asthma exacerbation. While LFA-1 appears very early in neutrophil maturation, it is becoming clear that Mac-1 and p150,95 are upregulated from an intracellular storage pool of peroxidase-negative granules that appear during the myelocyte stage of differentiation. Moreover, the absence seizures induced by these agents are exacerbated by GABAergic agonists, a property unique to experimental absence seizures. The spermine synthase gene is located on X chromosome in mouse and, because the cells used in this study were of XY karyotype, a single targeting event was sufficient to result in null genotype. Suggestions are presented for consideration by future village midwife tutors.

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Our two-step synthesis of Pt nanopeanuts not only enlarges the group of Pt nanoparticles, but also provides a beneficial strategy for the synthesis of novel metal nanoparticles. The attrition rate for each step of the oocyte donor screening process was determined. In this article the otologic significance of the pediatric medical history and physical examination is demonstrated based on 127 case histories of bilateral sensorineural hearing loss seen during the period 1980 to 1982. Repeatable acute rhabdomyolysis with multiple organ dysfunction because of interferon alpha and dacarbazine treatment in metastatic melanoma. On the other hand, asymptomatic carriage, as detected in 98 children by thin blood films in school screening, was as frequent in the SS or AS infantile population as in the general population. A vaccine against Lyme disease is therefore needed, and murine models of Lyme borreliosis have facilitated its development. In contrast, some other NSAIDs had the propensity to significantly suppress chondrocyte synthetic activity. Secondary: to estimate the sensitivity, specificity, and the positive and negative predictive values of PST to peanut performed in those who underwent a peanut challenge.

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The activation state of cyclic AMP-dependent protein kinase(s)(ATP:protein phosphotransferase, EC 2.7.1.37) is transiently increased 2-fold as a function of G1 progression in mitotically synchronized Chinese hamster ovary cells. Two active antibacterial subfractions were purified, and the higher active fraction was further fractionated and identified as a single compound of benzylideneacetone (trans-4-phenyl-3-buten-2-one). This free DNA primase had an apparent molecular size of approximately 40 kilodaltons, whereas free HeLa DNA primase had an apparent molecular size of approximately 110 kilodaltons. A new prognostic classification has been developed that is based on a simple scoring system for these variables. Clinical features of renovascular hypertension in infancy: report of a 9-month-old infant. Suppression of a field population of houseflies with Spalangia endius. The various types of cavopulmonary connection are occasionally unsuccessful even when the indications have been strictly fulfilled based on preoperative hemodynamic studies. In non-neuronal tissues, the antibody staining was intense in many types of cells, such as hepatocytes, epithelia of renal convoluted tubules, secretory cells of adrenal medulla and spermatids.

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MG-60, we compared genes differentially expressed by the ethanol producing fungus Phlebia sp. The establishment of minor eye conditions schemes (MECS) within community optometric practices provides a mechanism for the timely assessment of patients presenting with a range of acute eye conditions. Quantitative DW images or ADC maps may provide added information not obtained by visual inspection of the qualitative DW image map. Ophthalmic herpes zoster with total ophthalmoplegia, retrobulbar neuritis and Argyll-Robertson. From 662 patients with MS (86 with RR MS, 259 with SP MS without continued attacks, and 317 with SP MS with continued attacks), 24-hour urine samples were obtained at enrollment in the phase 3 Linomide (roquinimex) drug study. When an exogenous bacterial species, with its array of virulence factors, is introduced into the host, disease does not always occur. The clinical results of the investigated patients demonstrate that the AMC UKA is a successful concept. Dramatic Increases of Soil Microbial Functional Gene Diversity at the Treeline Ecotone of Changbai Mountain. Also between laboratories applying the same method, significant variations in MRD results can be present.

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Isolation and characterization of a cDNA from Cuphea lanceolata encoding a beta-ketoacyl-ACP reductase. The decrease between illusion conditions was also approximated by an increase in a plain background condition with objective size differences. Compliance with the current recommendations for prescribing antibiotics for paediatric community-acquired pneumonia is improving: data from a prospective study in a French network. No pneumatisation was encountered in the sternal ribs, os coxae or coracoid. These findings may form the basis for strategies to improve adherence with the use of hip protectors and with other types of treatment or preventive strategies in older persons. The choice of acute phase protein measurement depends on the diagnostic sensitivity and specificity of the measurement in the particular clinical situation. Sodium butyrate induction of milk-related antigens in human MCF-7 breast carcinoma cells. dubliniensis-infected patient exhibited a characteristic and specific antibody response against a cell wall component of 160-170 kDa. When a foraging ant leaves its nest to return to the prey it initially moves in the general direction of its objective.

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coqui occurs even in the absence of the forelimb but shows no signs of thyroid hormone dependence. The Trx-linked peroxidase activity of HSA sharply increased with elongation in the carbon chain of the acyl moiety of acyl-CoA, showing an optimum activity in the presence of palmitoyl-CoA. Inflammatory pseudo-tumour (IPT), also known as inflammatory myofibroblastic tumour or plasma cell granuloma, is a benign inflammatory solid tumour that may mimic malignancy. Several viral vectors, including adenovirus, adeno-associated virus, retrovirus and herpes simplex virus, are capable of delivering exogenous cDNAs to the synovial lining, enabling effective levels of intra-articular transgene expression following direct injection to the joint. The presence of these determinants appeared to be restricted to a subpopulation of HBsAg associated with IgG and albumin.

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These regions express Fos (a marker of neural activity) during cue-induced reinstatement of cocaine seeking, but only subpopulations of neurons within these regions drive drug seeking. Two variability indices, standard deviation percent mean and amplitude percent mean, provided the greatest separation between subjects with both a diagnosis of asthma and wheeze in the last year and subjects with neither feature and also provided the highest intra-class correlation coefficients. Notebook PC makes patient visits easy for Alabama home health agency nurses. Discordant synthesis and secretion of human chorionic gonadotropin and subunits by cervical carcinoma cells. Recall of food intake in the distant past was a better predictor of historical intake than was current diet. The Conference of Swiss Health Leagues-founded in 1971-unites associations which aim at prevention and control of chronic diseases and their physical and social consequences. Thus, digital space analysis provides a valid and reproducible alternative method in the new era of digital records. These different view images are not mixed but patched to form a complete image. A new method for the simultaneous analysis of unmodified and modified urinary nucleosides and nucleobases by high performance liquid chromatography.

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Laboratory procedures developed for detection of possible anti-plaque compounds. Although all 12 SSPE cases had higher IgG indices and increased rate of intra blood-brain barrier (BBB) IgG synthesis in comparison to patients with other neurological diseases, the values did not significantly differ between the first and follow-up specimens. We hypothesized that miR-204-5p overexpression induces cancer cell apoptosis by repressing BCL2 expression. The cardiorespiratory rate monitor accurately identified true bradypneic episodes in five of the eight patients. Hyalinizing trabecular tumor of the thyroid gland: much ado about nothing?. All sera (14 MS patients, 8 patients with other neurological diseases, and 11 normal individuals) showed positive oligodendrocyte staining by indirect immunofluorescence. The present article is based on more than 10 years experience in performing microdialysis experiments in freely moving animals with inexpensive self-made microdialysis probes and accessories for monitoring of intracerebral neuropeptide release. The incidence of myocardial infarction in hospitalized patients and the risk factors of myocardial infarction.

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Two alternative routes for the formation of ALA have been proposed: one involves the condensation of Succinyl CoA and glycine catalyzed by ALA synthetase taking place in the mitochondria, and the second one is the so called 5-carbon route, occurring in the stroma of plastids. Leptin may be one of the mechanistic links explaining the development of congestive heart failure in obese subjects. At baseline, the lowest BV and BF were associated with the poorest outcomes regardless of the subsequent treatment. Method of using the lysosomal-cation test in laboratory diagnostic practice. The model surgeries were performed using 3D mandibular models and cutting guides to check their accuracy. The clinical and pathological features of the fifteen balloon cell melanomas found in the literature are reviewed. The author suggests that coordinated action by governments and International Agencies should be taken to halve the infant mortality rate by the year 2.000. The Mayak Worker Dosimetry System (MWDS-2013): Estimate of Pu Content in Lungs and Thoracic Lymph Nodes From a Limited Set of Organ Autopsy Samples.

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Diagnosis of congenital cystic adenomatoid malformation of the lung (CCAM) in association with recombinant chromosome 18. Increased beat to beat variability index may be associated with the presence of electrophysiologic instability and can predict early ventricular fibrillation. Loss of constitutional heterozygosity in colon carcinoma from patients with familial polyposis coli. Progranulin (PGRN) is an autocrine growth factor with tumorigenic roles in various tumors including cervical cancer. Similar to other cardiac valves, quantification of TV biaxial mechanical properties is essential in developing accurate computational models.

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A calcium-dependent formation of citrulline was found in the cervix indicating NO formation. The virus of hepatitis A was the only enterovirus tested which was not recognized by these monoclonal antibodies. Ethanol (1 g/kg and 2 x 1.5 g/kg, i.p.) did not affect the 5-HT level, but at the higher dose it significantly increased the 5-HIAA level. Current use of endovascular grafts for the treatment of abdominal aortic aneurysms. When they discriminated pitch patterns embedded in English words, the homologous area in the right hemisphere activated as it did in English-speaking listeners discriminating pitch patterns embedded in either Mandarin or English words. Unchanged or deteriorating radiological findings may be associated with clinical improvement or deterioration. Beyond that, magnetic resonance imaging (MRI) is effective in evaluating the vitality and loosening of an osseous dissecate. Our work provides support for multiple adjuvant strategies, while also suggesting that the combination of an SOS inhibitor with a DNA-damaging antibiotic could offer the best potential for lowering MICs and decreasing acquired drug resistance.

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The test of histamine release on whole blood or on leucocypte suspension enables by the study of effect-dose curves to differentiate the histamine release mechanisms: bell shaped curve in the case of immunitary processus and ascending curve for an irrative phenomenon. The implications of these findings are discussed within the theoretical framework of metacognition. Data were obtained for BAL fluids from 10 patients with pulmonary sarcoidosis and from five normal volunteers. The free-radical gas nitric oxide (NO) plays an important role in a diverse range of physiological processes. Collected data included the age, gender, etiology, length of hospitalization, APACHE II score at admission, local and organ/systemic complications of the patients. Quantitative Echocardiographic Assessment of Left Ventricular Shape. Social Contact and Cognitive Functioning: The Role of Personality. Before treatment mean body weight was 95.4 kg (Study I) and 99.3 kg (Study II). In his Perspective, Baulcombe examines new findings (Wu-Scharf et al.) showing that in a green alga the gene responsible for RNA silencing encodes an RNA helicase (related to proteins in worms and other organisms) that is required for regulation of gene expression at the RNA level. Elevating CLIC4 in Multiple Cell Types Reveals a TGF- Dependent Induction of a Dominant Negative Smad7 Splice Variant.

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ticlopidine dosing 2020-08-10

Pregnancy outcome of patients conceiving within one year after chemotherapy for gestational trophoblastic tumor: a clinical report of 22 cases. This important sex difference was shown to be related to the presence of oestrogens and/or progesterone. A new approach was developed to take into account the imperfections of the test. This article (first of a series of four papers on diagnostic clinical parasitology) presents various collection methods and diagnostic procedures which are available for laboratory diagnosis of human parasitic infections. Glycosylation of 2-(trimethylsilyl)ethyl O-(6-O-benzoyl-beta-D-galactopyranosyl)-(1----4)-2,6-di- O-benzoyl-beta-D-glucopyranoside with the methyl 2-thioglycoside derivatives of the respective deoxy-N-acetylneuraminic acids, using dimethyl(methylthio)sulfonium triflate as a promoter, gave the four required 2-(trimethylsilyl)ethyl alpha-sialosyl-(2----3b)-beta-lactosides. This study was conducted to investigate the activity of cefepime against clinical isolates by determining the activities of cefepime and three other parenteral beta-lactam agents in standard and high inoculum MIC tests. Concomitantly, a progressively greater percentage of the cells became multinucleated such that, after 4 weeks of drug treatment, 18 per cent of the cells contained more than one nucleus. Viral particles contained in the intestinal contents of infected embryos were purified by differential and isopycnic centrifugation in sucrose gradients.

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Access for hemodialysis by means of long-term central venous catheters. We observed a ninefold increase in plasma levels of NO3- in patients after 7 days of treatment (P less zovirax ointment dosage than .0001). Colopexy was considered a viable technique to prevent recurrence of large colon displacement or volvulus in selected predisposed populations. Synthesis of lanosterol analogs with lengthened side chains and their effects on cholesterol biosynthesis from lanosterol. Interaction between drug discriminative stimuli and exteroceptive, sensory signals. The relative rates of DNA and protein synthesis were unbalanced during growth, however, with the cellular concentration of DNA increasing slightly faster than that of protein. Effect of hypokinesia on nucleic acid and protein metabolism in the lymphoid organs of rats. Those with gross disease experience a high mortality, which constitutes a major public health problem in communities where the syndrome affects a majority of adults. Diffusion and adoption of CDC guidelines for the prevention and control of nosocomial infections in US hospitals. Intraventricular capsaicin: alterations in analgesic responsivity without depletion of substance P.

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Large systemic collateral arteries developing late after total repair of tetralogy of Fallot. Despite a lengthy illness, the patient recovered with preservation of renal function. The clinical experience of the 1990s demonstrated efficacy and safety. coli, MNNG treatment results in rapid induction of a system which removes O6-methylguanine. Hemodynamic effects of rapidly injected hypertonic solutions into the heart and great vessels. Hemisphere differences in the acquisition and use of descriptive systems. After equilibration, 100 molecular dynamic snapshots are minimized and zithromax tooth infection analyzed. Inactivation of herpes simplex virus types 1 and 2 by synthetic histidine peptides.

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129/Ao/Boy, inbred mice, were inoculated intranasally with influenza virus. The character of the bonds involved in the interaction and the possible biological significance of the experiments are discussed. Consequently, little is known about expressed-HM feeding as an infant feeding strategy. At this stage of healing, bone characteristics were more related to a nonspecific (vascular) bone remodeling phenomenon than to a stress-shielding effect. To observe the effects of functional electrical stimulation(FES) based on normal gait pattern on walking function in subjects with recovery of stroke.

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On the basis of the present results, we propose a heuristic model of bleomycin-induced DNA damage repair. 1-beta-D-arabinofuranosylcytosine-induced malignant transformation of hamster and rat cells in culture. Serum superoxide dismutase (SOD), glutathione (GSH) activities, red cell count (RBC), white cell count (WBC), lysozyme (LYZ) activity, complement C3 content of fish in group 2 reflected the lowest, but malondialdehyde content was the highest. In this study a significant increase of SCE frequency after the application of various concentrations of MAM acetate could be observed both in vivo and in vivo. Response surface methodology (RSM) was used to model and optimize the conditions for synthesis of the photocatalyst. The approach described provides a high level of precision in parallel and directed assembly of DNA sequences and appended cargo and is useful for the preparation of novel hybrid bionanomaterials. Urinary Metabolites of Organophosphate and Pyrethroid Pesticides and Neurobehavioral Effects in Chinese Children. Anti-RAINBOW dye-specific antibodies as universal tools for the visualization of prestained protein molecular weight markers in Western blot analysis.

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The change in propionate metabolism induced by fasting is, however, not entirely due to its conversion to glyceride-glycerol, since the latter was almost completely blocked by malonate while part of the promoting effect on fatty acid synthesis persisted. The cells transfected by Pep-1/GFP and CADY-2/GFP complexes at a molar ratio of 20 : 1 demonstrated spreading green regions using fluorescent microscopy. Rat L6E9 muscle cells commit to terminal differentiation by forming a large muscle syncitia complete with the expression of a large number of muscle- indocin oral suspension specific contractile protein genes. The kinetic properties of desensitization onset of excitatory cholinergic responses were studied in isolated, voltage-clamped Aplysia neurons. Calculations demonstrate the ability of molecular docking programs to accurately reproduce crystallized ligand poses and conformations and to calculate a free energy of binding with satisfactory accuracy. Molecular biology and chemistry of the alternative pathway of complement. Centromere function is remarkably conserved between species, yet the satellite sequences that make up centromeric DNA are highly divergent. Asian patients with unstable angina pectoris appear to have clinical and angiographic differences from their White counterparts, and are less likely to have invasive cardiac procedures deployed. Also, in our implementation, a few patient-specific parameters are used to improve the accuracy of the lesion prediction.

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We suggest that cerebral perfusion is affected during and at 10 min after surfactant instillation. Volleys in corticospinal fibres, in addition to the disynaptic IPSPs, evoke late IPSPs in the PNs. Comparative activity of mezlocillin, penicillin, ampicillin, carbenicillin, and ticarcillin against gram-positive bacteria and Haemophilus influenzae. Immunohistochemical Characterization of Antioxidant Enzymes in Human Breast Cancer. This kind of treatment does not seem to reduce the recurrence rate. The effect of diazepam on pentagastrin-stimulated and nocturnal (sleeping) gastric secretion in man. In cats, three subdivisions of the nucleus are distinguished, two of which are distinct in ferrets also.

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bottae that corresponds to southern and northern segments of its can levaquin cause bladder infection current distribution. Treatment of the NCI-H929 cells with ET-1 increased proliferation, while co-incubation of these cells with ET-1 and BTZ decreased BTZ efficacy with concomitant upregulation of 20S proteasomal activity. Epidemic investigation of genital mycoplasma hominis infection in women. Screening of asymptomatic subjects over the age of 40 years for fecal occult blood seems to detect cancers before they become invasive. Pattern of Onset and Risk Factors for Peripheral Oedema During Vildagliptin Use: Analysis from the Vildagliptin Prescription-Event Monitoring Study in England. We showed that the constitutive expression of MMP-9 was dependent on p38-activity and inhibition of p38 strongly downregulated MMP-9 expression. A circadian rhythm was found in the concentration of the NE metabolite, 3-methoxy-4-hydroxyphenylglycol (MHPG), in the hippocampus. The androgen receptor (AR) amino-terminus imposes androgen-specific regulation of AR gene expression via an exonic enhancer.

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A marked reduction of the thymic medulla following treatment was clearly demonstrated by staining with OX18 (MHC class I) and OX6 (MHC class II). A small subset is responsible for proliferation to allogeneic cells or to soluble antigens and for helper activity for B cell differentiation. 1966.-A decrease in the uptake of tetracycline occurred concurrently with a rise in the level of resistance of a multiple drug resistant strain of Escherichia coli grown in the presence of tetracycline. Chemical synthesis and 2H NMR investigations of polyisoprenols: dynamics in model membranes. The depolarizing response involved Na, K and Ca ions, but not Cl ions. The experiments were performed on sheep tibia and femora in vitro and in vivo. Resolution of the input images and amount of the vessel pixels in the ground truth are used as predictors.

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